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| 1 | First Report of the Multiresistance Gene cfr in Streptococcus suis显示文摘 | Yang Wang Dexi Li Li Song Yang Liu Tao He Hebing Liu Congming Wu Stefan Schwarz Jianzhong Shen | 2013 | Antimicrobial Agents and Chemotherapy2013，，8： | 1 |
| 2 | Quality evaluation of land reclamation in mining area based on remote sensing显示文摘Several deficiencies exist in the present evaluation of land reclamation quality in mining areas.These include the absence of an established set of evaluation index systems and standard acceptance criteria,as well as the use of traditional sam-pling techniques,which are costly and in eficiency,and time-consuming.Compared with the traditional sampling survey methods,remote sensing has the advantages of a wide detection range,diverse information collection,multiple data-acquiring strategies,high speed,and short cycle.In this study,we used the Xinzhuang coal mining field in Yongcheng,Henan Province as an example to extract information and invert surface parameters using remote sensing techniques,based on national and local reclamation regulations and standards.Subsequently,using remote sensing,we constructed an index system for evaluating land reclamation quality in three aspects:reclaiming project quality,soil quality,and ecological benefits.Through the grading standards of evaluation indicators and quantitative remote sensing models,we determined the extracted information on the area of indicators,roads,ditches,soil moisture,organic matter,and ecological benefits after reclamation.Based on this,we established a quality evaluation model for mining land reclamation using an improved index and method.The evaluation units were divided,and the weight of the evaluation index was determined using the analytic hierarchy process and data envelopment analysis(AHP-DEA)method.The land reclamation quality in the study area was comprehensively evaluated,field accuracy was verified,and the results were analyzed.The results show that,except for the removal of roads,houses,and fishponds in the study area,all 13 evaluation units achieved a score of 60 points or higher.The quality of reclamation met the standards,and the evaluation results were consistent with the conclusions of the field investigation and project acceptance report,demonstrating the reliability and feasibility of the method developed in this study.The research results will provide technical support for the scientific evaluation of land reclamation quality. | Shidong Wang Jjianhua Guo Yang Yu Pujie Shi Hebing Zhang | 2023 | International Journal of Coal Science & Technology2023，10，3： | 0 |
| 3 | Nano-TiO_(2) coate d nee dle carbon fib er reinforced phenolic aerogel composite with low density, excellent heat-insulating and infrared radiation shielding performance显示文摘High-performance thermal protection materials(TPMs)for spacecraft are becoming current research hotspots.Lightweight polymer-based ablators are considered to be the most promising candidates for TPMs due to their excellent designability and versatility.In this study,a unique nano-TiO_(2) coated needled carbon fiber felt/phenolic resin aerogel composite(TiCF/PR)is reported.Wherein the anatase nano-TiO_(2) was in-situ coated on the surface of carbon fibers uniformly through the sol-gel and calcination method,then,the phenolic resin aerogel was in-situ synthesized in the nano-TiO_(2) coated needled carbon fiber felt(TiCF)preform through vacuum impregnation and solvothermal method.The as-prepared aerogel com-posite possesses a low density(0.30–0.32 g/cm^(3)),low thermal conductivity(0.034 and 0.312 W/(m K)in the z and xy directions),and excellent thermal stability with 13.86%residual weight at 1300℃ in air.It is worthwhile to note that the TiCF/PR composite exhibits excellent antioxidant ablation and infrared(IR)radiation shielding properties in a high-temperature heating environment.With an oxygen-acetylene blaze heating of 1.5 MW/m^(2) for 150 s,the linear ablation rates decreased by 13.4%,and the backside temperature reduced from 322.3 to 179.1℃ compared to that of the sample without nano-TiO_(2) coating.The experimental and theoretical analysis showed that the present TiCF/PR nanocomposite has competitive and potential application prospects in the field of future TPMs. | Yiwu Pan Xiangyu Jin Hebing Wang He Huang Can Wu Xiaojie Yan Changqing Hong Xinghong Zhang | 2023 | Journal of Materials Science & Technology2023，，21： | 0 |
| 4 | 3D genomic organization in cancers显示文摘Background:The hierarchical three-dimensional(3D)architectures of chromatin play an important role in fundamental biological processes,such as cell differentiation,cellular senescence,and transcriptional regulation.Aberrant chromatin 3D structural alterations often present in human diseases and even cancers,but their underlying mechanisms remain unclear.Results:3D chromatin structures(chromatin compartment A/B,topologically associated domains,and enhancerpromoter interactions)play key roles in cancer development,metastasis,and drug resistance.Bioinformatics techniques based on machine learning and deep learning have shown great potential in the study of 3D cancer genome.Conclusion:Current advances in the study of the 3D cancer genome have expanded our understanding of the mechanisms underlying tumorigenesis and development.It will provide new insights into precise diagnosis and personalized treatment for cancers. | Junting Wang Huan Tao Hao Li Xiaochen Bo Hebing Chen | 2023 | Quantitative Biology2023，11，2： | 0 |
| 5 | Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer显示文摘Endocrine-resistance remains a major challenge in estrogen receptorαpositive(ERα^(+))breast cancer(BC)treatment and constitutively active somatic mutations in ERαare a common mechanism.There is an urgent need to develop novel drugs with new mode of mechanism to fight endocrineresistance.Given aberrant ERαactivity,we herein report the identification of novel covalent selective estrogen receptor degraders(cSERDs)possessing the advantages of both covalent and degradation strategies.A highly potent cSERD 29c was identified with superior anti-proliferative activity than fulvestrant against a panel of ERa+breast cancer cell lines including mutant ERα.Crystal structure of ERα-29c complex alongside intact mass spectrometry revealed that 29c disrupted ERa protein homeostasis through covalent targeting C530 and strong hydrophobic interaction collied on H11,thus enforcing a unique antagonist conformation and driving the ERαdegradation.These significant effects of the cSERD on ERαhomeostasis,unlike typical ERαdegraders that occur directly via long side chains perturbing the morphology of H12,demonstrating a distinct mechanism of action(MoA).In vivo,29c showed potent antitumor activity in MCF-7 tumor xenograft models and low toxicity.This proof-of-principle study verifies that novel cSERDs offering new opportunities for the development of innovative therapies for endocrine-resistant BC. | Yubo Wang Jian Min Xiangping Deng Tian Feng Hebing Hu Xinyi Guo Yan Cheng Baohua Xie Yu Yang Chun-Chi Chen Rey-Ting Guo Chune Dong Hai-Bing Zhou | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 6 | Uber EKG-Kennzeichungen der atrioventrikul ren akzessorischen Leitungsbahnen von Rechtsmittelsepta und Linksmittelsepta显示文摘In der Studie wurden 20 Patienten mit AV-Reentry Tachykardie unter Einbezug einer mittelseptalen gelegenen atrioventricul ren akzessorischen Leitungsbahn(MS) eingeschlossen, die seit 4 Jahren in unserem Elektrophysiologischen Untersuchungslabor mittels Katheters erfolgreich abladiert wurden. Die 20 Patienten hatten 26 akzessorische Leitungsbahnen. Daunter waren 21 MS (rechtsmittelseptal (RMS) zu linksmittelseptal(LMS)=17:4). 18 akzessorische Leitungsbahnen waren offen. Die Lokalisation der akzessorischen Leitungsbahnen wurde aufgrund der Stelle erfolgreich abladiert bestimmt. Die Ergebnisse zeigten, da die RMS und LMS den gleichen Charakter in den meisten Ableitungen des EKGs hatten, und jedoch der wenige Unterschied bei diesen beiden akzessorischen Lritungsbahnen besteht. Wenn die positive Polaritat der Delta Welle in der Ableitung V 1 bei der Patienten mit MS auftritt, mu sich berlegen, ob die M glichkeit der Lokalisation der akzessorischen Leitungsbahn im Linksmittelseptum besteht. | WANG Lin Ouyang F ST.Georg Klinikum Hamburg Deutschland Cappato R Hebe J Volkmer M Antz M Ernst S Kuck K H 王琳 | 2001 | Journal of Huazhong University of Science and Technology(Medical Sciences)2001，21，1： | 0 |
| 7 | Treatment patterns and a prognostic scoring system for elderly acute myeloid leukemia patients:a retrospective multicenter cohort study in China显示文摘Objective:Acute myeloid leukemia(AML)is primarily a malignant disorder affecting the elderly.We aimed to compare the outcomes of different treatment patterns in elderly AML patients and to propose a prognostic scoring system that could predict survival and aid therapeutic decisions.Methods:Patients aged≥60 years who had been diagnosed with AML at 7 hospitals in China were enrolled(n=228).Treatment patterns included standard chemotherapy,low intensity therapy,and best supportive care(BSC).Results:The early mortality rates were 31%,6.8%,and 6.3%for the BSC,low intensity therapy,and standard chemotherapy groups,respectively.The complete remission rate of the standard chemotherapy group was higher than that of the low intensity therapy group.The median overall survival(OS)was 561 days and 222 days for the standard chemotherapy and low intensity therapy groups,respectively,and were both longer than that of the BSC group(86 days).Based on multivariate analyses,we defined a prognostic scoring system that enabled classification of patients into 3 risk groups,in an attempt to predict the OS of patients receiving chemotherapies and low intensity therapies.Low and intermediate risk patients benefited more from standard chemotherapies than from low intensity therapies.However,the median OS was comparable between standard chemotherapies and low intensity therapies in high risk patients.Conclusions:Our prognostic scoring system could predict survival and help select appropriate therapies for elderly AML patients.Standard chemotherapy is important for elderly AML patients,particularly for those categorized into low and intermediate risk groups. | Chunli Zhang Wei Wan Shuai Zhang Jingwen Wang Ru Feng Jiangtao Li Junyue Chai Hebing Zhou Liru Wang Yuping Zhong Xiaodong Mo Mengzhu Shen Hongmei Jing Hui Liu | 2022 | Cancer Biology & Medicine2022，19，6： | 0 |
| 8 | Continuous Process Optimization and Computational Fluid Dynamics Simulation of a Methyl Anthranilate Jet Reactor显示文摘Methyl anthranilate(MA)is an important material for the synthesis of sodium saccharin,but the yield and quality of MA are not stable due to the batch operation conditions.In this study,the optimum conditions obtained by an orthogonal test in a batch reactor were a volume ratio of methanol to amide solution of 5:4,volume ratio of sodium hypochlorite to amide solution of 7:4,Hoffmann degradation reaction duration of 10 min,Hoffmann degradation reaction temperature of 10℃,esterification reaction duration of 10 min,and esterification reaction temperature of 40℃.The working flow velocity and allowable working viscosity range of a Venturi ejector inlet were both determined by a computational fluid dynamics(CFD)simulation.Based on the above experimental data,the continuous operation of the process was tested in a three-stage continuous reactor,which improved the product yield and quality of the process. | Chen Zhuohang Xu Lin Wang Xiaoping Song Jianhua Long Haoyu Li Xinping Liu Dianhua Xu Yongjing Chen Hebing Liu Hui Zhang Ying Lei Wei | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，2： | 0 |
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