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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Effect of acupotomy on nitric oxide synthase and beta-endorphin in third lumbar vertebrae transverse process syndrome model rats显示文摘OBJECTIVE: To explore the long-term effects and pain relief mechanism of acupotomy by observing changes in nitric oxide synthase(NOS) and beta-endorphin(β-EP) in the hypothalamus, spinal cord,and peripheral blood of rats with third lumbar vertebrae(L3) transverse process syndrome.METHODS:Twenty-eight SD rats were randomly assigned to normal, model, electroacupuncture(EA),and acupotomy group. The last three groups were put through an operation to emulate L3transverse process syndrome. Fourteen days after the simulation operation, EA and acupotomy treatments were applied to the respective groups. Fifty-six days afterthe simulation operation, biochemistry tests and enzyme-linked immunosorbent assay were used to measure NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood.RESULTS: Rats with the simulation operation showed significantly higher levels of NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood than those in the normal group. The EA and acupotomy groups had significantly lower levels of NOS and β-EP than those in the model group.There was no statistical difference between the EA and acupotomy groups.CONCLUSION: EA and acupotomy treatments significantly lowered NOS and β-EP levels in the hypothalamus, spinal cord, and peripheral blood and alleviated L3transverse process syndrome. | Changqing Guo Naigang Liu Xiaohong Li Hongmei Sun Bo Hu Jing Lu Yan Guo Chuxi Liang Hong Xu Haixia Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 15 |
| 3 | An Epigenetic Role for Disrupted Paternal Gene Expression in Postzygotic Seed Abortion in Arabidopsis Interspecific Hybrids显示文摘种间的混血儿经常增加杂合现象和混合活力的层次,而是一些种间的混合种子立即在授精以后被放弃。在这 postzygotic 种子流产后面的机制糟糕被理解。这里,我们在在在 Arabidopsis thaliana (关口, Ler,或 C24 ) 和 Arabidopsis arenosa 之间的三个 F1 种间的十字开发 siliques 和种子报导突变而产生之遗传的表示变化的染色体宽的分析。似母亲的多数表示了基因(MEG ) 而 272 父亲一般地表示的基因(木钉) 的 ∼90% 仅仅在一或二个 F1 十字被发现,在所有三个 F1 种间的十字之中被分享,在在不同十字变化的种子流产为破坏父亲的基因表示建议一个角色。与这个观点一致,在不肥沃的种间的混血儿的 12 个木钉在肥沃的 intraspecific 混血儿匹配 MEG。在种间的混血儿的木钉的这混乱与在在一位双母亲和一位 hexaploid 父亲之间的父亲过量的 interploidy 十字(2X6 ) 的基因的 upregulation 一致,导致种子流产。而且,在种间的十字的木钉的一个子集也是在 intraspecific 混血儿 met1XWT 或 meaXWT 的 upregulated,在哪个 MET1 (DNA METHYLTRANSFERASE1 ) 的异种或美狄亚, Polycomb 压抑的 Complex2gene,被用作母亲的父母。这些数据建议母亲的 epigenetic 因素和父亲的基因表示在种间的混血儿或 neo-allopolyploids 在 postzygotic 种子流产起重要作用。 | Ryan C. Kirkbride Helen Hong Yu Gyoungju Nah Changqing Zhang Xiaoli Shi Z. Jeffrey Chen | 2015 | Molecular Plant2015，8，12： | 5 |
| 4 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 5 | New Genus and Species of Fossil Dragonflies (Insecta: Odonata) from the Yixian Formation of Northeastern China显示文摘Two well-preserved fossil dragonflies from the Late Mesozoic Yixian Formation, Liaoning Province, China are described and assigned to a new genus, Sopholibellula gen. nov. in Araripelibellulidae Bechly, 1996, closely related to the type genus Araripelibellula. This new genus differs from Araripelibellula in the following characters: origins of RP and MA distinctly separated at arculus in both pairs of wings; anal loop wider and shorter, with Y-shaped veins inside; MA and IR2 not zigzag; several small intercalary veins present in the postdiscoidal area of hindwing; cells smaller and much more dense, especially in the apex and hind margin; bigger in size. Structures, including head, abdomen and parts of legs, were first described in details of this family. | ZHANG Binglan REN Dong ZHOU Changqing PANG Hong | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 4 |
| 6 | Optimal joint relay selection and resource allocation with QoS constraints in multiuser OFDM-based cellular networks显示文摘 | Chen Dan Ji Hong Li Xi Luo Changqing | 2011 | High Technology Letters2011，17，3： | 2 |
| 7 | Comparison of ablative and compressive mechanical behavior of several PICA-like ablative materials显示文摘It is significant to compare the ablative and compressive mechanical behavior of different PICA-like materials in the engineering applications.The plasma wind tunnel ablation tests with high-entropy air and CO2 atmospheres,and compressive experiments in the ambient and 150℃,were conducted for three kinds of PICA-like materials(CF/PR-Si,CBCF/PR-SiOC and NQF/PR-Si composites).The traditional carbon/phenolic(C/PR)braided composites were also used for comparison.PICA-like materials have the better thermal insulation than traditional C/PR composite,especially for CBCF/PR-SiOC composite.The ablation behavior of CF/PR-Si and CBCF/PR-SiOC PICA-like materials in the CO2 atmosphere can produce a large amount of SiO2 in the form of coatings,oxide layers and skeletons on the ablated surface,which are greatly different from that in the air atmosphere.The compressive behavior of PICA-like material is greatly depended on the fiber fabrics,and exhibits the large discrete characteristics.The longer fiber in the PICA-like materials plays the role in maintaining the material integrity,while it may increase the thermal conductivity. | ZHANG Jun FANG GuoDong YANG LingWei LI Wei HONG ChangQing MENG SongHe | 2020 | Science China(Technological Sciences)2020，63，8： | 2 |
| 8 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 9 | Cross-layer Design for TCP Performance Improvement in Cognitive Radio Networks 显示文摘 | Changqing Luo Hong Ji | 2010 | IEEE Transactions on Vehicular Technology2010，59，5： | 1 |
| 10 | Thermal effects in kilowatt fiber lasers显示文摘 | Wang Yong Xu Changqing Po Hong | 2004 | IEEE Photonics Technology Letters2004，16，1： | 1 |
| 11 | Cross-layer Design for TCP Performance Improvement in Cognitive Radio Networks显示文摘 | Luo Changqing Yu F R Ji Hong | | 0，，05： | 1 |
| 12 | Analysis of Raman and thermal effects in kilowatt fiber lasers显示文摘 | Wang Yong Xu Changqing Po Hong | 2004 | Opt Commun2004，242，9： | 1 |
| 13 | Cross-Layer Design for TCP Perfonmnce Improvement in Cognitive Radio Networks 显示文摘 | LUO Changqing YU F R JI Hong et at | 2010 | IEEE Transactions on Vehicular Technology2010，59，5： | 1 |
| 14 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 15 | Thermal effects in kilowatt fiber lasers显示文摘 | YONG W CHANGQING X HONG P | 2004 | IEEE Photo Tech Lett2004，16，1： | 1 |
| 16 | Phase stability, electronic structure and mechanical properties of molybdenum disili- cide: a first-prlnciples investigation 显示文摘 | Qiao Yingjie Zhang Hexin Hong Changqing | 2009 | J Phys D: Appl Phys2009，42，10： | 1 |
| 17 | Investigation on growth and laser properties of new laser crystal Nd:Gd_(0.8)La_(0.2)VO_4显示文摘LASER-DIODE (LD) pumped solid-state lasers have a variety of applications in military, industry, medical treatment and scientific researches due to their high stability, compactness, high efficiency and long lifetime, and become one of the hot points in the laser field. In this field, Nd: YVO4 laser has been commercialized. Nd:GdVO4 crystal has a big absorption coefficient, high thermal conductivity, and excellent laser properties. Nd: Gd0.5La0.5VO4 crystal formed by La3+ ions replacing some Gd3+ ions in Nd:GdVO4 has larger FWHM (full width at half maximum) than Nd: GdVO4 crystal. To combine the merits of Nd : GdVO4 and Nd : Gd0.5 La0.5 VO4, we grow the crystal doped with 20% La (Nd: Gd0.8La0.2VO4, and study its properties. Now we introduce the laser and spectroscopic properties of the crystal in brief. | ZHANG Huaijin , MENG Xianlin , ZHU Li ZHANG Hongzhen , WANG Pu , Judith Dawes , WANG Changqing and Y. T. ChowInstitute of Crystal Materials and National Laboratory of Crystal Materials , Shandong University , Jinan 250100, China Center for Lasers and Applications , Macquarie University , NSW2109, Australia Department of Electronic Engineering , City University of Hong Kong , China | 1999 | Chinese Science Bulletin1999，44，9： | 1 |
| 18 | Lightweight carbon-bonded carbon fiber composites prepared by pressure filtration technique显示文摘 | Chen Liu Jiecai Han Xinghong Zhang Changqing Hong Shanyi Du | 2013 | Carbon2013，，： | 1 |
| 19 | Adenovirus-Mediated Dual Gene Expression of Human Interleukin-10 and Hepatic Growth Factor Exerts Protective Effect Against CCl4-Induced Hepatocyte Injury in Rats显示文摘 | Hong Qiu Yan Yan Jicheng Xing Yuerong Zhu Lin Fang Xiangrong Cao Changqing Su | 2012 | Digestive Diseases and Sciences2012，，7： | 1 |
| 20 | Cationic cyanine as a near- infrared fluorescent probe for the determination of nucleic acids显示文摘 | Zheng Hong Li Donghui Zhu Changqing | 2000 | Fresenius J Anal Chem2000，366，： | 1 |
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