|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Polysaccharide-based nanomedicines for cancer immunotherapy:A review显示文摘Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics.However,direct administration of“naked”immunotherapeutic agents(such as nucleic acids,cytokines,adjuvants or antigens without delivery vehicles)often results in:(1)an unsatisfactory efficacy due to suboptimal pharmacokinetics;(2)strong toxic and side effects due to low targeting(or off-target)efficiency.To overcome these shortcomings,a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects.Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties,as they could interact with immune system to stimulate an enhanced immune response.Their structures offer versatility in synthesizing multifunctional nanocomposites,which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues.This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics. | Yujun Zeng Yufan Xiang Ruilong Sheng Helena Tomás João Rodrigues Zhongwei Gu Hu Zhang Qiyong Gong Kui Luo | 2021 | Bioactive Materials2021，6，10： | 3 |
| 2 | Adverse effects of cadmium exposure on mouse sperm显示文摘 | Helena Oliveira Marcello Spanò Concei??o Santos Maria de Lourdes Pereira | 2009 | Reproductive Toxicology2009，，4： | 2 |
| 3 | Low temperature induced changes in activity and protein levels of the enzymes associated to conversion of starch to sucrose in banana fruit显示文摘 | Roberta Ghedini Der Agopian Fernanda Helena Gon?alves Peroni-Okita Claudinéia Aparecida Soares Janaína Aparecida Mainardi Jo?o Roberto Oliveira do Nascimento Beatriz Rosana Cordenunsi Franco Maria Lajolo Eduardo Purgatto | 2011 | Postharvest Biology and Technology2011，，2： | 2 |
| 4 | The effect of dietary protein replacement by crystalline amino acid on growth and nitrogen utilization of turbot Scophthalmus mazimus juveniles 显示文摘 | Helena P Aires O T | 2005 | Aquaculture2005，250，75： | 1 |
| 5 | Comparative Life Cycle Analysis of Steel-concrete Composite Bridges显示文摘 | Helena Gervadsio Luis Sire o ES DA Silva | 2008 | Structure and Infrastructure Engineering2008，4，4： | 1 |
| 6 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 7 | Lysine requirement and efficiency of lysine utilization in turbot (Scophthalmus maximus) juveniles显示文摘 | HELENA P AIRES O T | 2008 | Aquaculture2008，275，： | 1 |
| 8 | New design solutions for low-power energy production in water pipe systems显示文摘This study is the result of ongoing research for a European Union 7th Framework Program Project regarding energy converters for very low heads,and aims to analyze optimization of new cost-effective hydraulic turbine designs for possible implementation in water supply systems(WSSs) or in other pressurized water pipe infrastructures,such as irrigation,wastewater,or drainage systems.A new methodology is presented based on a theoretical,technical and economic analysis.Viability studies focused on small power values for different pipe systems were investigated.Detailed analyses of alternative typical volumetric energy converters were conducted on the basis of mathematical and physical fundamentals as well as computational fluid dynamics(CFD) associated with the interaction between the flow conditions and the system operation.Important constraints(e.g.,size,stability,efficiency,and continuous steady flow conditions) can be identified and a search for alternative rotary volumetric converters is being conducted.As promising cost-effective solutions for the coming years,adapted rotor-dynamic turbomachines and non-conventional axial propeller devices were analyzed based on the basic principles of pumps operating as turbines,as well as through an extensive comparison between simulations and experimental tests. | Helena M.RAMOS Alexandre BORGA Mariana SIMO | 2009 | Water Science and Engineering2009，2，4： | 1 |
| 9 | Features of In Vitro Ultrasound Biomicroscopic Imaging and Colonoscopy for Detection of Colon Tumor in Mice显示文摘 | Kelly Z. Alves Helena L. Borges Rossana C. Soletti Anália L.P. Viana Lorena I. Petrella M?nica Soldan Vera L. Chagas Alberto Schanaider Jo?o C. Machado | 2011 | Ultrasound in Medicine & Biology2011，，12： | 1 |
| 10 | Blood Transfusion and Infection After Cardiac Surgery显示文摘 | Keith A. Horvath Michael A. Acker Helena Chang Emilia Bagiella Peter K. Smith Alexander Iribarne Irving L. Kron Pamela Lackner Michael Argenziano Deborah D. Ascheim Annetine C. Gelijns Robert E. Michler Danielle Van Patten John D. Puskas Karen O’Sullivan | 2013 | The Annals of Thoracic Surgery2013，，6： | 1 |
| 11 | Study of vertical transmission of fowl adenoviruses显示文摘 | HELENA G CYNTHIA P DAVPR O | 2006 | Can J Vet Res2006，70，： | 1 |
| 12 | Evaluation of an aroma similar to that of sparkling wine:Sensory and gas chromatography analyses of fermented grape musts显示文摘 | Maria E O Mamede Helena M A B Cardello Glaucia M Pastore | 2005 | Food Chemistry2005，89，： | 1 |
| 13 | Serologic monitoring of a broiler breeder flock previously affected by inclusion body hepatitis and testing of the progeny for vertical transmission of fowl adenoviruses显示文摘 | CYNTHIA P HELENA G DAVOR O | 2007 | Can J Vet Res2007，71，： | 1 |
| 14 | Heterologous protein expression in filamentous fungi显示文摘 | K.M. Helena Nevalainen Valentino S.J. Te’o Peter L. Bergquist | 2005 | Trends in Biotechnology2005，，9： | 1 |
| 15 | A model for assessing the economic viability of construction and demolition waste recycling The case of Ireland显示文摘 | Xavier Duran Helena Lenihan Bernadette O'Regan | 2006 | Resources Conservation and Recycling2006，46，： | 1 |
| 16 | Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome显示文摘 | Tathiana Name Colado Sim?o Marcell Alysson Batisti Lozovoy Andréa Name Colado Sim?o Sayonara Rangel Oliveira Danielle Venturini Helena Kaminami Morimoto Lúcia Helena Silva Miglioranza Isaias Dichi | 2013 | British Journal of Nutrition2013，，10： | 1 |
| 17 | Neonatal respiratory distress secondary to bilateral intranasal dacryocystocoeles显示文摘 | David S. Leonard Michael O’Keefe Helena Rowley Joseph P. Hughes | 2008 | International Journal of Pediatric Otorhinolaryngology2008，，12： | 1 |
| 18 | A novel WRKY transcription factor, SUSIBA2, participates in sugar signaling in barley by binding to the sugar-responsive elements of the isol promoter显示文摘 | Sun C X Anna-Stina H Helena O | 2003 | The Plant Cell2003，15，： | 1 |
| 19 | The effect of dietary protein replacement by crystalline amino acid on growth and nitrogen utilization of turbot Scophthalmus maximus juveniles 显示文摘 | Helena P Aires O T | 2005 | Aquaculture2005，250，： | 1 |
| 20 | Percutaneous Embolization of Transhepatic Tracks for Biliary Intervention显示文摘 | Stuart M. Lyon Olaf Terhaar Mark F. Given Helena M. O'Dwyer Frank P. McGrath Michael J. Lee | 2006 | CardioVascular and Interventional Radiology2006，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员