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| 1 | Serum Hepatitis B Surface Antigen Quantitation Can Reflect Hepatitis B Virus in the Liver and Predict Treatment Response显示文摘 | Henry Lik–Yuen Chan Vincent Wai–Sun Wong Ada Mei–Ling Tse Chi–Hang Tse Angel Mei–Ling Chim Hoi–Yun Chan Grace Lai–Hung Wong Joseph Jao–Yiu Sung | 2007 | Clinical Gastroenterology and Hepatology2007，，12： | 7 |
| 2 | Clinical significance of hepatic derangement in severe acute respiratory syndrome显示文摘AIM: Elevation of alanine aminotransferase (ALT) level is commonly seen among patients suffering from severe acute respiratory syndrome (SARS). We report the progression and clinical significance of liver derangement in a large cohort of SARS patient.METHODS: Serial assay of serum ALT was followed in patients who fulfilled the WHO criteria of SARS. Those with elevated ALT were compared with those with normal liver functions for clinical outcome. Serology for hepatitis B virus (HBV) infection was checked. Adverse outcomes were defined as oxygen desaturation, need of intensive care unit (ICU) and mechanical ventilation and death.RESULTS: Two hundred and ninety-four patients were included in this study. Seventy (24%) patients had elevated serum ALT on admission and 204 (69%) patients had elevated ALT during the subsequent course of illness. Using peak ALT >5×ULN as a cut-off and after adjusting for potential confounding factors, the odds ratio of peak ALT>5x ULN for oxygen desaturation was 3.24 (95%CI 1.23-8.59, P = 0.018), ICU care was 3.70 (95% CI 1.38-9.89, P = 0.009), mechanical ventilation was 6.64 (95%CI 2.22-19.81, P = 0.001) and death was 7.34(95%CI 2.28-24.89, P = 0.001). Ninety-three percent of the survived patients had ALT levels normalized or were on the improving trend during follow-up. Chronic hepatitis B was not associated with worse clinical outcomes.CONCLUSION: Reactive hepatitis is a common complication of SARS-coronavirus infection. Those patients with severe hepatitis had worse clinical outcome. | Henry Lik-Yuen Chan Ambrose Chi-Pong Kwan Ka-Fai To Sik-To Lai Paul Kay-Sheung Chan Wai-Keung Leung Nelson Lee Alan Wu Joseph Jao-Yiu Sung | 2005 | World Journal of Gastroenterology2005，11，14： | 4 |
| 3 | 良性前列腺增生合并迟发性性腺功能减退大鼠模型的构建显示文摘目的探讨良性前列腺增生(BPH)合并迟发性性腺功能减退症(LOH)动物模型的建立方法,并分析其特点。方法选取80只SD大鼠,随机分为对照组、BPH合并LOH组、BPH组、LOH组,每组均为20只。BPH合并LOH组给予环磷酰胺[20 mg/(kg·d)]腹腔内连续注射5d,而后给予丙酸睾酮[50 mg/(kg·d)]腹腔内连续注射28d;BPH组以同等体积生理盐水代替环磷酰胺,LOH组以同等体积橄榄油代替丙酸睾酮,对照组以同等体积生理盐水代替环磷酰胺、同等体积橄榄油代替丙酸睾酮,给药方法同BPH合并LOH组。停药2d后,进行悬尾实验、负重游泳实验及交配实验,并通过断尾法取血以检测血清睾酮含量。完成全部操作后,通过颈椎脱臼法处死全部实验动物,解剖观察前列腺、称量并行组织病理学检查。结果 LOH组、BPH合并LOH组、对照组、BPH组大鼠平均前列腺指数分别为1.58±0.13、2.93±0.19、2.33±0.13、3.23±0.11,血清睾酮含量分别为(4.91±1.06)、(9.52±1.02)、(12.59±0.70)、(19.69±0.56)ng/mL,悬尾挣扎次数分别为(97.40±15.86)、(120.40±14.06)、(223.83±16.51)、(235.29±18.77)次,各组间差异均有统计学意义(P<0.05,P<0.01);LOH组、BPH合并LOH组、对照组、BPH组大鼠平均负重游泳时间分别为(74.27±9.29)、(167.47±23.35)、(302.33±30.10)、(261.59±35.13)s,嗅阴次数分别为(1.53±0.52)、(3.07±0.88)、(9.17±1.30)、(9.59±1.12)次,除对照组和BPH组差异无统计学意义外,其余各组间差异均有统计学意义(P<0.01);LOH组、BPH合并LOH组、对照组、BPH组大鼠平均骑跨次数分别为(0.33±0.49)、(0.47±0.52)、(2.11±0.47)、(2.29±0.47)次,除对照组与BPH组、BPH合并LOH组与LOH组差异无统计学意义外,其余各组间差异均有统计学意义(P<0.01)。结论通过腹腔注射环磷酰胺及丙酸睾酮可获得BPH合并LOH大鼠模型。 | 秦盛斐 徐剑 翦晓明 陈光华 肖广安 何妙侠 LAI H. Henry 周铁 | 2017 | 第二军医大学学报2017，38，7： | 3 |
| 4 | Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression显示文摘 | Chi-Chiu Lau Tingting Sun Arthur K.K. Ching Mian He Jing-Woei Li Alissa M. Wong Ngai Na Co Anthony W.H. Chan Pik-Shan Li Raymond W.M. Lung Joanna H.M. Tong Paul B.S. Lai Henry L.Y. Chan Ka-Fai To Ting-Fung Chan Nathalie Wong | 2014 | Cancer Cell2014，，3： | 2 |
| 5 | Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial显示文摘 | Vincent Wai-Sun Wong Ruth Suk-Mei Chan Grace Lai-Hung Wong Bernice Ho-Ki Cheung Winnie Chiu-Wing Chu David Ka-Wai Yeung Angel Mei-Ling Chim Jennifer Wing-Yan Lai Liz Sin Li Mandy Man-Mei Sea Francis Ka-Leung Chan Joseph Jao-Yiu Sung Jean Woo Henry Lik-Yue | 2013 | Journal of Hepatology2013，，3： | 2 |
| 6 | Liver fibrosis progression in chronic hepatitis B patients positive for hepatitis B e antigen: A prospective cohort study with paired transient elastography examination显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Zhuo Yu Hoi‐Yun Chan Chi‐Hang Tse Vincent Wai‐Sun Wong | 2013 | J Gastroenterol Hepatol2013，，11： | 2 |
| 7 | Accuracy of Risk Scores for Patients With Chronic Hepatitis B Receiving Entecavir Treatment显示文摘 | Grace Lai–Hung Wong Henry Lik–Yuen Chan Hoi–Yun Chan Pete Chi–Hang Tse Yee–Kit Tse Christy Wing–Hin Mak Stanley King–Yeung Lee Zoe Man–Yi Ip Andrew Ting–Ho Lam Henry Wing–Hang Iu Joyce May–Sum Leung Vincent Wai–Sun Wong | 2013 | Gastroenterology2013，，5： | 2 |
| 8 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009，，2： | 2 |
| 9 | Liver fibrosis progression is uncommon in patients with inactive chronic hepatitis B : A prospective cohort study with paired transient elastography examination显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Zhuo Yu Hoi‐Yun Chan Chi‐Hang Tse Vincent Wai‐Sun Wong | 2013 | J Gastroenterol Hepatol2013，，12： | 2 |
| 10 | Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients With liver cirrhosis显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Christy Wing‐Hin Mak Stanley King‐Yeung Lee Zoe Man‐Yi Ip Andrew Ting‐Ho Lam Henry Wing‐Hang Iu Joyce May‐Sum Leung Jennifer Wing‐Yan Lai Angeline Oi‐Shan Lo Hoi‐Yun Chan Vincent Wai‐Sun Wong | 2013 | Hepatology2013，，5： | 1 |
| 11 | Surveillance programme for hepatocellular carcinoma improves the survival of patients with chronic viral hepatitis显示文摘 | Grace Lai‐HungWong Vincent Wai‐SunWong Guang‐MingTan Ka‐IanIp Wing‐KwanLai Yuk‐WahLi Mercedes Shun‐ChiMak Paul Bo‐SanLai Joseph Jao‐YiuSung Henry Lik‐YuenChan | 2007 | Liver International2007，，1： | 1 |
| 12 | A Hybrid Risk Management Model:A Case Study of the Textile Industry 显示文摘 | Lai Ivan K W Lan Henry C W | 2012 | Journal of Manufacturing Technology Man- agement2012，23，5： | 1 |
| 13 | Liver Stiffness Measurement by Transient Elastography as a Predictor on Posthepatectomy Outcomes显示文摘 | Jeff Siu-Wang Wong Grace Lai-Hung Wong Anthony Wing-Hung Chan Vincent Wai-Sun Wong Yue-Sun Cheung Ching-Ning Chong John Wong Kit-Fai Lee Henry Lik-Yuen Chan Paul Bo-San Lai | 2013 | Annals of Surgery2013，，5： | 1 |
| 14 | 13 Years of Experience With Artificial Urinary Sphincter Implantation at Baylor College of Medicine显示文摘 | H. Henry Lai Elias I. Hsu Bin S. Teh E. Brian Butler Timothy B. Boone | 2007 | The Journal of Urology2007，，3： | 1 |
| 15 | Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin 显示文摘 | Henry Lai Narendra P Singh N P | 1995 | Cancer Lett1995，91，： | 1 |
| 16 | Development of artemisinin compounds for cancer treatment显示文摘 | Henry C. Lai Narendra P. Singh Tomikazu Sasaki | 2013 | Investigational New Drugs2013，，1： | 1 |
| 17 | Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma显示文摘 | Tian Yuan Wong Vincent W.S. Wong Grace L.H. Yang Weiqin Sun Hanyong Shen Jiayun Tong Joanna H.M. Go Minnie Y.Y. Cheung Yue S. Lai Paul B.S. Zhou Mingyan Xu Gang Huang Tim H.M. Yu Jun To Ka F. Cheng Alfred S.L. Chan Henry L.Y | 2015 | Cancer Research2015，，22： | 1 |
| 18 | Exchange rates, exchange risk, and Asian export revenue 显示文摘 | WenShwo Fang Yihao Lai Thompson Henry | 2007 | International Review of Economics and Finance2007，，： | 1 |
| 19 | Surrogate End Points and Long-Term Outcome in Patients With Chronic Hepatitis B显示文摘 | Vincent Wai–Sun Wong Grace Lai–Hung Wong Angel Mei–Ling Chim Paul Cheung–Lung Choi Anthony Wing–Hung Chan Steven Woon–Choy Tsang Alex Yui Hui Hoi–Yun Chan Joseph Jao–Yiu Sung Henry Lik–Yuen Chan | 2009 | Clinical Gastroenterology and Hepatology2009，，10： | 1 |
| 20 | Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells显示文摘 | Narendra P. Singh Henry Lai | 2001 | Life Sciences2001，，1： | 1 |
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