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| 1 | SMALL ORGAN SIZE 1 and SMALL ORGAN SIZE 2/DWARF AND LOW-TILLERING Form aComplex to Integrate Auxin and Brassinosteroid Signaling in Rice显示文摘尽管植物生长素和 brassinosteroid (BR ) synergistically 控制各种各样的植物回答,位于 auxin-BR 串音下面的分子的机制很好没被理解。我们以前识别了 SMOS1,一个调整植物生长素的 APETALA2 类型抄写因素,作为小机关的原因的基因缩放 1 (smos1 ) 被各种各样的机关的一种减少的最后的尺寸在米饭描绘的异种。在这研究,我们识别了另一 smos 异种, smos2,哪个表演与 smos1 难区分的显型。SMOS2 与以前报导的矮子和 LOW-TILLERING (DLT ) 相同,它编码涉及 BR 发信号的 GRAS 蛋白质。SMOS1 和 SMOS2/DLT 身体上交往合作地在酵母并且在米饭原子核提高 transcriptional transactivation 活动。一致地, OsPHI-1 的表示, SMOS1 的一个直接目标,当 SMOS1 和 SMOS2/DLT 蛋白质两个都是在米饭房间的现在时,仅仅是 upregulated。一起拿,我们的结果建议 SMOS1 和 SMOS2/DLT 在在米饭表明串音的 auxin-BR 上形成重点建筑群。 | Ko Hirano Hideki Yoshida Koichiro Aya Mayuko Kawamura Makoto Hayashi Tokunori Hobo Karma Sato-lzawa Hidemi Kitano Miyako Ueguchi-Tanaka Makoto Matsuoka | 2017 | Molecular Plant2017，10，4： | 20 |
| 2 | Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy显示文摘Treatment strategies,whether as follow-up or'total incisional biopsy'for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic treatment.Based on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive tumors.Therefore,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during follow-up.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade neoplasms.Future studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness. | Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya Yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 18 |
| 3 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 4 | Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis显示文摘AIM:To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive methods.METHODS:The subjects for this study consisted of 27 healthy volunteers,59 patients with chronic viral hepatitis,and 74 patients with viral cirrhosis,from urban areas.We assessed the biochemical blood tests,anthropometric parameters,diet,lifestyle and physical activity of the patients.A homeostasis model assessment-insulin resistance(HOMA-IR) value of ≥ 2.5 was considered to indicate insulin resistance.We measured height,weight,waist circumference,arm circumference,triceps skin-fold thickness,and handgrip strength,and calculated body mass index,arm muscle circumference(AMC),and arm muscle area(AMA).We interviewed the subjects about their dietary habits and lifestyle using health assessment computer software.We surveyed daily physical activity using a pedometer.Univariate and multivariate logistic regression modeling were used to identify the relevant factors for insulin resistance.RESULTS:The rate of patients with HOMA-IR ≥ 2.5(which was considered to indicate insulin resistance) was 14(35.9%) in the chronic hepatitis and 17(37.8%) in the cirrhotic patients.AMC(%)(control vs chronic hepatitis,111.9% ± 10.5% vs 104.9% ± 10.7%,P = 0.021;control vs cirrhosis,111.9% ± 10.5% vs 102.7% ± 10.8%,P = 0.001) and AMA(%)(control vs chronic hepatitis,128.2% ± 25.1% vs 112.2% ± 22.9%,P = 0.013;control vs cirrhosis,128.2% ± 25.1% vs 107.5% ± 22.5%,P = 0.001) in patients with chronic hepatitis and liver cirrhosis were significantly lower than in the control subjects.Handgrip strength(%) in the cirrhosis group was significantly lower than in the controls(control vs cirrhosis,92.1% ± 16.2% vs 66.9% ± 17.6%,P < 0.001).The results might reflect a decrease in muscle mass.The total nutrition intake and amounts of carbohydrates,protein and fat were not significantly different amongst the groups.Physical activity levels(kcal/d)(control vs cirrhosis,210 ± 113 kcal/d vs 125 ± 74 kcal/d,P = 0.001),number of steps(step/d)(control vs cirrhosis,8070 ±3027 step/d vs 5789 ± 3368 step/d,P = 0.011),and exercise(Ex)(Ex/wk)(control vs cirrhosis,12.4 ± 9.3 Ex/wk vs 7.0 ± 7.7 Ex/wk,P = 0.013) in the cirrhosis group was significantly lower than the control group.The results indicate that the physical activity level of the chronic hepatitis and cirrhosis groups were low.Univariate and multivariate logistic regression modeling suggested that Ex was associated with insulin resistance(odds ratio,6.809;95% CI,1.288-36.001;P = 0.024).The results seem to point towards decreased physical activity being a relevant factor for insulin resistance.CONCLUSION:Non-hospitalized cirrhotic patients may need to maintain an adequate dietary intake and receive lifestyle guidance to increase their physical activity levels. | Fumikazu Hayashi Chika Momoki Miho Yuikawa Yuko Simotani Etsushi Kawamura Atsushi Hagihara Hideki Fujii Sawako Kobayashi Shuji Iwai Hiroyasu Morikawa Masaru Enomoto Akihiro Tamori Norifumi Kawada Satoko Ohfuji Wakaba Fukusima Daiki Habu | 2012 | World Journal of Gastroenterology2012，18，40： | 11 |
| 5 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 6 | Distribution of late gadolinium enhancement in various types of cardiomyopathies:Significance in differential diagnosis, clinical features and prognosis显示文摘The recent development of cardiac magnetic resonance(CMR)techniques has allowed detailed analyses of cardiac function and tissue characterization with high spatial resolution.We review characteristic CMR features in ischemic and non-ischemic cardiomyopathies(ICM and NICM),especially in terms of the location and distribution of late gadolinium enhancement(LGE).CMR in ICM shows segmental wall motion abnormalities or wall thinning in a particular coronary arterial territory,and the subendocardial or transmural LGE.LGE in NICM generally does not correspond to any particular coronary artery distribution and is located mostly in the mid-wall to subepicardial layer.The analysis of LGE distribution is valuable to differentiate NICM with diffusely impaired systolic function,including dilated cardiomyopathy,end-stage hypertrophic cardiomyopathy(HCM),cardiac sarcoidosis,and myocarditis,and those with diffuse left ventricular(LV)hypertrophy including HCM,cardiac amyloidosis and Anderson-Fabry disease.A transient low signal intensity LGE in regions of severe LV dysfunction is a particular feature of stress cardiomyopathy.In arrhythmogenic right ventricular cardiomyopathy/dysplasia,an enhancement of right ventricular(RV)wall with functional and morphological changes of RV becomes apparent.Finally,the analyses of LGE distribution have potentials to predict cardiac outcomes and response to treatments. | Hiroshi Satoh Makoto Sano Kenichiro Suwa Takeji Saitoh Mamoru Nobuhara Masao Saotome Tsuyoshi Urushida Hideki Katoh Hideharu Hayashi | 2014 | World Journal of Cardiology2014，6，7： | 8 |
| 7 | Choroidal and cutaneous metastasis from gastric adenocarcinoma显示文摘Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions. | Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 8 | Endoscopic surveillance strategy after endoscopic resection for early gastric cancer显示文摘Early detection of early gastric cancer(EGC)is important to improve the prognosis of patients with gastric cancer.Recent advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and high-frequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection,a therapeutic option for gastric intraepithelial neoplasia.Consequently,short-term outcomes of endoscopic resection(ER)for EGC have improved.Therefore,surveillance with endoscopy after ER for EGC is becoming more important,but how to perform endoscopic surveillance after ER has not been established,even though the follow-up strategy for more advanced gastric cancer has been outlined.Therefore,a surveillance strategy for patients with EGC after ER is needed. | Tsutomu Nishida Masahiko Tsujii Motohiko Kato Yoshito Hayashi Tomofumi Akasaka Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 4 |
| 9 | 微导通孔的电镀填孔技术显示文摘本文主介绍了电镀填孔技术,并探讨了DC和PPR电镀填孔技术的优缺点和影响填孔效果的相关因素。 | George Allardyce Mark Lefebvre Hideki Tsuchida Masaru Kusaka Shinjiro Hayashi 张伯兴 | 2004 | 印制电路信息2004，，10： | 4 |
| 10 | 心室颤动期间心脏动作电位和细胞内钙瞬变显示文摘目的探讨心室颤动(室颤)期间细胞内钙瞬变(CaT)与心脏动作电位(AP)之间的分离是否与室颤时快速的心脏活动频率有关。方法使用光学标测系统同步标测9个离体心脏的CaT和AP。Pinacidil用于缩短动作电位时间(APD)以达到快速起搏或诱发室性心动过速(室速)的频率与室颤的频率相近。计算快速起搏、快速室速和室颤时CaT与AP之间的相互关联性(MI)。结果Pinacidil(40μmol/L)显著缩短APD。室颤的平均周长为(77±13)ms,而Pinacidil灌注后最快室速的周长为76ms。快速起搏(周长80ms)的MI(1.13±0.15)bits和快速室速的MI(0.88±0.18)bits均高于基线室颤的MI(0.39±0.11)bits、Pinacidil灌注后室颤的MI(0.21±0.07)bits和洗脱Pinacidil后室颤的MI(0.364-0.15)bits。快速起搏和快速室速的MI高于相同优势频率室颤的MI。结论快速起搏和快速室速时CaT与AP密切关联,室颤时两者MI显著下降。室颤时下降的MI不是继发于快速的心室活动频率。 | 吴素华 Hideki Hayashi LIN Shien-fong 马虹 | 2008 | 中华心血管病杂志2008，36，5： | 2 |
| 11 | Clinical problems with antithrombotic therapy for endoscopic submucosal dissection for gastric neoplasms显示文摘Endoscopic submucosal dissection(ESD) is minimally invasive and thus has become a widely accepted treatment for gastric neoplasms,particularly for patients with comorbidities.Antithrombotic agents are used to prevent thrombotic events in patients with comorbidities such as cardio-cerebrovascular diseases and atrial fibrillation.With appropriate cessation,antithrombotic therapy does not increase delayed bleeding in low thrombosis-risk patients.However,high thrombosisrisk patients are often treated with combination therapy with antithrombotic agents and occasionally require the continuation of antithrombotic agents or heparin bridge therapy(HBT) in the perioperative period.Dual antiplatelet therapy(DAPT),a representative combination therapy,is frequently used after placement of drug-eluting stents and has a high risk of delayed bleeding.In patients receiving DAPT,gastric ESD may be postponed until DAPT is no longer required.HBT is often required for patients treated with anticoagulants and has an extremely high bleeding risk.The continuous use of warfarin or direct oral anticoagulants may be possible alternatives.Here,we show that some antithrombotic therapies in high thrombosis-risk patients increase delayed bleeding after gastric ESD,whereas most antithrombotic therapies do not.The management of high thrombosis-risk patients is crucial for improved outcomes. | Toshiyuki Yoshio Tsutomu Nishida Yoshito Hayashi Hideki Iijima Masahiko Tsujii Junko Fujisaki Tetsuo Takehara | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 12 | CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis显示文摘 | Yoshito Hayashi Masahiko Tsujii Jun Wang Jumpei Kondo Tomofumi Akasaka Ying Jin Wei Li Toru Nakamura Tsutomu Nishida Hideki Iijima Shingo Tsuji Sunao Kawano Norio Hayashi Tetsuo Takehara | 2013 | Gut2013，，11： | 2 |
| 13 | 藁本内酯对神经干细胞/祖细胞的增殖作用及机制研究显示文摘目的研究藁本内酯对神经干/祖细胞(neural stem/progenitor cells,NS/PCs)的增殖作用及机制。方法孕14 d Wistar大鼠脱颈椎处死,分离胎鼠脑皮层部位NS/PCs,采用悬浮法原代培养7 d。采用WST-1法检测藁本内酯对NS/PCs存活率的影响;采用Western blotting法检测藁本内酯对NS/PCs增殖相关蛋白磷酸化蛋白激酶B(phosphorylated protein kinase B,p-Akt)、Akt、磷酸化糖原合成酶激酶(phosphorylated glycose synthase kinase 3β,p-GSK3β)、GSK3β和active-β-catenin表达;给予藁本内酯第1-3天,观察NS/PCs神经球生长状态并测量其直径;分化培养基诱导NS/PCs分化5 d后,采用免疫荧光法检测藁本内酯对NS/PCs分化类型的影响,并采用WST-1法检测藁本内酯对分化细胞存活率的影响。结果藁本内酯(25μmol/L)显著促进NS/PCs存活率(P<0.05),显著上调增殖相关蛋白p-Akt/Akt和active-β-catenin表达(P<0.05);给予藁本内酯第1-3天,可增加NS/PCs神经球直径,但无统计学差异;藁本内酯对神经元、星型胶质细胞方向分化无显著影响,但分化后细胞存活率显著升高(P<0.05)。结论藁本内酯可促进NS/PCs增殖,其作用机制与Akt/β-catenin通路有关。藁本内酯可能对神经元、星型胶质细胞以外的其他分化类型细胞有干预作用。 | 王敏 Hideki Hayashi 刘建勋 Norio Takagi 任钧国 | 2021 | 中草药2021，52，20： | 2 |
| 14 | Intra-cardiac distribution of late gadolinium enhancement in cardiac sarcoidosis and dilated cardiomyopathy显示文摘Cardiac involvement of sarcoid lesions is diagnosed by myocardial biopsy which is frequently false-negative,and patients with cardiac sarcoidosis(CS) who have impaired left ventricular(LV) systolic function are sometimes diagnosed with dilated cardiomyopathy(DCM).Late gadolinium enhancement(LE) in magnetic resonance imaging is now a critical finding in diagnosing CS,and the novel Japanese guideline considers myocardial LE to be a major criterion of CS.This article describes the value of LE in patients with CS who have impaired LV systolic function,particularly the diagnostic and clinical significance of LE distribution in comparison with DCM.LE existed at all LV segments and myocardial layers in patients with CS,whereas it was localized predominantly in the midwall of basal to mid septum in those with DCM.Transmural(nodular),circumferential,and subepicardial and subendocardial LE distribution were highly specific in patients with CS,whereas the prevalence of striated midwall LE were high both in patients with CS and with DCM.Since sarcoidosis patients with LE have higher incidences of heart failure symptoms,ventricular tachyarrhythmia and sudden cardiac death,the analyses of extent and distribution of LE are crucial in early diagnosis and therapeutic approach for patients with CS. | Makoto Sano Hiroshi Satoh Kenichiro Suwa Masao Saotome Tsuyoshi Urushida Hideki Katoh Hideharu Hayashi Takeji Saitoh | 2016 | World Journal of Cardiology2016，8，9： | 2 |
| 15 | An angiotensin II AT 1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes显示文摘 | Muneya Fujimoto Hiroaki Masuzaki Tomohiro Tanaka Shintaro Yasue Tsutomu Tomita Kayoko Okazawa Junji Fujikura Hideki Chusho Ken Ebihara Tatsuya Hayashi Kiminori Hosoda Kazuwa Nakao | 2004 | FEBS Letters2004，，3： | 1 |
| 16 | Usefulness of enhanced recovery after surgery protocol as compared with conventional perioperative care in gastric surgery显示文摘 | Takanobu Yamada Tsutomu Hayashi Haruhiko Cho Takaki Yoshikawa Hideki Taniguchi Ryoji Fukushima Akira Tsuburaya | 2012 | Gastric Cancer2012，，1： | 1 |
| 17 | Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin显示文摘 | Tsugiko Oze Naoki Hiramatsu Changho Song Takayuki Yakushijin Sadaharu Iio Yoshinobu Doi Masahide Oshita Hideki Hagiwara Eiji Mita Toshifumi Ito Yoshiaki Inui Taizo Hijioka Shinji Tamura Harumasa Yoshihara Atsuo Inoue Yasuharu Imai Eijiro Hayashi Michio Ka | 2012 | Journal of Gastroenterology2012，，3： | 1 |
| 18 | Generation of a recombinant single-chain variable fragment (scFv) targeting 5-methyl-2'-deoxycytidine显示文摘 | Motohiro Ohshima Tomomi Tadakuma Hideki Hayashi Kazuyuki Inoue and Kunihiko Itoh | 2010 | The Journal of Biochemistry2010，147，1： | 1 |
| 19 | The effects of walking at the anaerobic threshold level on vertebral bone loss in postmenopausal women显示文摘 | Masako Hatori Akira Hasegawa Hitoshi Adachi Akemi Shínozaki Rikuro Hayashi Hiroya Okano Hideki Mizunuma Kazuhiko Murata | 1993 | Calcified Tissue International1993，，6： | 1 |
| 20 | Salivary amylase activity is useful for assessing perioperative stress in response to pain in patients undergoing endoscopic submucosal dissection of gastric tumors under deep sedation显示文摘 | Masaya Uesato Yoshihiro Nabeya Takashi Akai Masahito Inoue Yoshiyuki Watanabe Hiroshi Kawahira Toshitaka Mamiya Yoshihito Ohta Ryuji Motojima Akiko Kagaya Yorihiko Muto Hideki Hayashi Hisahiro Matsubara | 2010 | Gastric Cancer2010，，2： | 1 |
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