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| 1 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 2 | Preparation of Gd 2 O 3 :Yb,Er and Gd 2 O 2 S:Yb,Er infrared-to-visible conversion phosphor ultrafine particles using an emulsion liquid membrane system显示文摘 | Takayuki Hirai Takuya Orikoshi | 2003 | Journal of Colloid And Interface Science2003，，1： | 2 |
| 3 | The preparation of spherical calcium phosphate fine particles using an emulsion liquid membrane system 显示文摘 | TAKAYUKI HIRAI MASAYUKI HODONO ISAO KOMASAWA | 2000 | Langmuir2000，16，3： | 1 |
| 4 | 显示文摘 | Takayuki Hirai Yusuke Kawamura | 2004 | J Phys Chem B2004，108，12： | 1 |
| 5 | The prep- aration of spherical calcium phosphate fine particles using an emul- sion liquid membrane system显示文摘 | Takayuki Hirai Masayuki Hodono Isao Komasawa | 2000 | Langmuir2000，16，3： | 1 |
| 6 | Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: A multicenter study显示文摘 | Hirotoshi Kobayashi Hidetaka Mochizuki Kenichi Sugihara Takayuki Morita Kenjiro Kotake Tatsuo Teramoto Shingo Kameoka Yukio Saito Keiichi Takahashi Kazuo Hase Masatoshi Oya Koutarou Maeda Takashi Hirai Masao Kameyama Kazuo Shirouzu Tetsuichiro Muto | 2007 | Surgery2007，，1： | 1 |
| 7 | Preparation of Gd203:Yb,Er and Gd202S:Yb,Er infrared-to-visible conversion phosphor ultrafine particles using an emulsion liquid membrane system显示文摘 | HIRAI Takayuki ORIKOSHI Takuya | 2004 | Collid lnterf Sci2004，269，： | 1 |
| 8 | Preparation of semiconductor nanoparticle-polymer composites by direct reverse micelle polymerization using polymerizable surfactants显示文摘 | Takayuki Hirai Tatsufumi Watanabe Isao Komasawa | 2000 | J Phys Chem B2000，104，： | 1 |
| 9 | Desulfurization and dinitrogenation process for light oils based chemical oxidation followed by liquid-liquid extraction显示文摘 | Yasuhiro Shiraishi Takayuki Hirai | 2002 | Ind Eng Chem Res2002，41，： | 1 |
| 10 | Advanced liq- uid-liquid extraction systems for the separation of rare earth ions by combination of the metal species with chemical reaetion显示文摘 | Syouhei Nishihama Takayuki Hirai Isao Komasawa | 2003 | Journal of Solid State Chemistry2003，171，： | 1 |
| 11 | Separation and recovery of gallium and indium from simulated zinc refinery residue by liquid-liquid extraction 显示文摘 | NISHIHAMA Syouhei HIRAI Takayuki KOMASAWA Isao | 1999 | Industrial & Engineering Chemistry Research ACS1999，38，3： | 1 |
| 12 | Yanadosihcate moteeutar sieve as a catalyst for oxidative desulfurization of light oil 显示文摘 | Yasuhiro Shiraishi Tomoko Naito Takayuki Hirai | 2003 | Japan Ind Eng Chem Res2003，42，24： | 1 |
| 13 | Biomimetic Synthesis of Calcium Carbonate Parlieles in a Pseudovesicular Double Emulsion显示文摘 | HIRAI Takayuki HARIGUCHI Shuichi KOMASAWA Isao | 1997 | Langmuir1997，13，： | 1 |
| 14 | Biomimetic synthesis of calcium carbonate particles in a pseudo vesicular double emulsion显示文摘 | Takayuki Hirai Shuichi Hariguchi Isao Komasawa | 1997 | American Chemical Society1997，13，： | 1 |
| 15 | The 2nd edition of consensus statements for the diagnosis and management of intestinal Beh?et’s disease: indication of anti-TNFα monoclonal antibodies显示文摘 | Tadakazu Hisamatsu Fumiaki Ueno Takayuki Matsumoto Kiyonori Kobayashi Kazutaka Koganei Reiko Kunisaki Fumihito Hirai Masakazu Nagahori Mitsunobu Matsushita Kenji Kobayashi Mitsumasa Kishimoto Mitsuhiro Takeno Masanori Tanaka Nagamu Inoue Toshifumi Hibi | 2014 | Journal of Gastroenterology2014，，1： | 1 |
| 16 | Preparation and photocatalytic reactions of titanium dioxide ultrafine particles in reverse micellar systems显示文摘 | Shiojiri Susumu Hirai Takayuki Komasawa Isao | 1997 | Journal of Chemical Engineering of Japan1997，30，1： | 1 |
| 17 | Preparation of semiconductor nanopaticle polymer composites by direct reverse micelle polymerization using polymerizable surfacrants显示文摘 | Takayuki Hirai Tatsufumi Watanabe Isao Komasawa | 2000 | J Phys Chem2000，，104： | 1 |
| 18 | Preparation of yttrium oxysulfide phosphor nanoparticles with infrared-to-green and -blue upconversion emission using an emulsion liquid membrane system 显示文摘 | TAKAYUKI Hirai TAKUYA Orikoshi | 2004 | J Colloid Interface Sci2004，，273： | 1 |
| 19 | Preparation and Photocatalytic Properties of Composite CdS Nanopartieles - Titanium Dioxide Particles 显示文摘 | Takayuki Hirai Keiko Suzuki Isao Komasawa | 2001 | Journal of Colloid and Interface Science2001，244，： | 1 |
| 20 | TiO2 - mediated photocatalytic desulfurization process for light oils using an organic two - phase system显示文摘 | Yasuhiro Shiraishi Takayuki Hirai Isao Komasawa | 2002 | Journal of chemical engineering of Japan2002，35，5： | 1 |
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