|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Scramble com- petition in Callosobruchus analis ( Coleoptera: Btuehidae) 显示文摘 | Hiroyuki Mano Yukihiko Toquenaga Koichi Fujii | 2002 | The Society of Population Ecology2002，44，： | 1 |
| 2 | Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells显示文摘 | Tadaaki Yamada Shinji Takeuchi Junya Nakade Kenji Kita Takayuki Nakagawa Shigeki Nanjo Takahiro Nakamura Kunio Matsumoto Manabu Soda Hiroyuki Mano Toshimitsu Uenaka Seiji Yano | 2012 | Clinical Cancer Research2012，，13： | 1 |
| 3 | Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway显示文摘 | Eiji Sakai Masaki Fukuyo Ken Ohata Keisuke Matsusaka Noriteru Doi Yasunobu Mano Kiyoko Takane Hiroyuki Abe Koichi Yagi Nobuyuki Matsuhashi Junichi Fukushima Masashi Fukayama Kiwamu Akagi Hiroyuki Aburatani Atsushi Nakajima Atsushi Kaneda | 2016 | Int. J. Cancer2016，，： | 1 |
| 4 | EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers显示文摘 | Kentaro Inamura Kengo Takeuchi Yuki Togashi Kimie Nomura Hironori Ninomiya Michiyo Okui Yukitoshi Satoh Sakae Okumura Ken Nakagawa Manabu Soda Young Lim Choi Toshiro Niki Hiroyuki Mano Yuichi Ishikawa | 2008 | Journal of Thoracic Oncology2008，，1： | 1 |
| 5 | Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36–38weeks of gestation显示文摘 | Hiroyuki Tsuda Tomomi Kotani Seiji Sumigama Yukio Mano Li Hua Hiromi Hayakawa Masahiro Hayakawa Yoshiaki Sato Fumitaka Kikkawa | 2013 | Early Human Development2013，，： | 1 |
| 6 | Treatment of primary malignant melanoma of the esophagus with endoscopic injection of interferon-β combined with systemic chemotherapy: A case report显示文摘 | Hisako Sakamoto Noriya Uedo Hiroyasu Iishi Koji Higashino Ryu Ishihara Kenichirou Mitani Hiroyuki Narahara Masaharu Tatsuta Masayuki Mano Shingo Ishiguro | 2003 | Gastrointestinal Endoscopy2003，，6： | 1 |
| 7 | Scramble competition in Callosobruchus analis(Coleoptera:Btuchidae)显示文摘 | Hiroyuki Mano Yukihiko Toquenaga Koichi Fujii | 2002 | The Society of Population Ecology2002，44，： | 1 |
| 8 | Epigenetic abnormalities in cardiac hypertrophy and heart failure显示文摘 | Hiroyuki Mano | 2008 | Environmental Health and Preventive Medicine2008，，1： | 1 |
| 9 | Genomic medicine in clinical practice:national genomic medicine program in Japan显示文摘Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~1.Since statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in Japan.Cancer surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has increased.Approximately 38,000 people died of cancer in 2021.The National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry. | Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno | 2024 | Cancer Biology & Medicine2024，21，1： | 0 |
| 10 | The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan显示文摘The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer research.At the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and beyond.Although CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of cancer.Looking back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be developed.The quantity and quality of these samples will be compatible with omics analyses.All biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer. | Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno | 2024 | Cancer Biology & Medicine2024，21，1： | 0 |
| 11 | Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence显示文摘AIM: To investigate epigenomic and gene expression alterations during cellular senescence induced by oncogenic Raf. METHODS: Cellular senescence was induced into mouse embryonic fibroblasts(MEFs) by infecting retrovirus to express oncogenic Raf(RafV 600E). RNA was collected from RafV 600 E cells as well as MEFs without infection and MEFs with mock infection, and a genome-wide gene expression analysis was performed using microarray. The epigenomic status for active H3K4me3 and repressive H3K27me3 histone marks was analyzed by chromatin immunoprecipitation-sequencing for RafV 600 E cells on day 7 and for MEFs without infection. These data for Raf-induced senescence were compared with data for Ras-induced senescence that were obtained in our previous study. Gene knockdown and overexpression were done by retrovirus infection. RESULTS: Although the expression of some genes including secreted factors was specifically altered in either Ras- or Raf-induced senescence, many genes showed similar alteration pattern in Raf- and Ras-induced senescence. A total of 841 commonly upregulated 841 genes and 573 commonly downregulated genes showed a significant enrichment of genes related to signal and secreted proteins, suggesting the importance of alterations in secreted factors. Bmp2, a secreted protein to activate Bmp2-Smad signaling, was highly upregulated with gain of H3K4me3 and loss of H3K27me3 during Raf-induced senescence, as previously detected in Ras-induced senescence, and the knockdown of Bmp2 by sh RNA lead to escape from Raf-induced senescence. Bmp2-Smad inhibitor Smad6 was strongly repressed with H3K4me3 loss in Raf-induced senescence, as detected in Ras-induced senescence, and senescence was also bypassed by Smad6 induction in Raf-activated cells. Different from Ras-induced senescence, however, gain of H3K27me3 did not occur in the Smad6 promoter region during Raf-induced senescence. When comparing genome-wide alteration between Ras- and Raf-induced senescence, genes showing loss of H3K27me3 during senescence significantly overlapped; genes showing H3K4me3 gain, or those showing H3K4me3 loss, also well-overlapped between Ras- and Raf-induced senescence. However, genes with gain of H3K27me3 overlapped significantly rarely, compared with those with H3K27me3 loss, with H3K4me3 gain, or with H3K4me3 loss.CONCLUSION: Although epigenetic alterations are partly different, Bmp2 upregulation and Smad6 repression occur and contribute to Raf-induced senescence, as detected in Ras-induced senescence. | Mai Fujimoto Yasunobu Mano Motonobu Anai Shogo Yamamoto Masaki Fukuyo Hiroyuki Aburatani Atsushi Kaneda | 2016 | World Journal of Biological Chemistry2016，7，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员