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| 1 | Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy显示文摘瞄准:在部分肝切除术以后在肝新生上学习妨碍的黄疸的效果。方法: Hepatocyte 生长因素( HGF ),它的受体, 遇见c ,脉管的内皮生长因素( VEGF )和转变生长在肝织物和孤立的肝细胞的 factor-beta1 ( TGF-beta1 ) mRNA 表示被量的反向抄写的聚合酶链反应( RT-PCR )用 LightCycler 在胆汁的阻塞( BO )以后调查。为 desmin 和 alpha 光滑的肌肉肌动朊(alpha-SMA ) 染色的 Immunohistochemical 也被学习。标记的原子抗原(PCNA ) 索引的再生肝重量和增殖的房间,和生长因素表示然后与伴随物在 70% 肝切除术以后被评估在 BO 老鼠或假冒操作老鼠的内部胆汁的排水。结果:肝的 TGF-beta1 mRNA 层次显著地在 BO 以后增加了 14 天,并且进一步与胆汁郁积的持续时间增加了。同时, HGF 和 VEGF 趋于增加,但是不是重要的。在房间孤立, TGF-beta1 mRNA 主要在肝的星形的房间(HSC ) 被发现部分。Immunohistochemical 研究揭示了 HSC (desmin 积极的房间) 的一个增加的数字并且在 BO 以后在门区域激活 HSC (alpha-SMA-positive 房间) 。在一个肝切除术模型,肝新生在 BO 老鼠被推迟,作为与假冒操作老鼠相比。在肝切除术,和更早的 HGF mRNA 山峰沉醉于 BO 老鼠以后, TGF-beta1 mRNA 是显著地起来调整的直到 48 h。结论:BO 导致 HSC 增长和激活,导致 TGF-beta1 mRNA 的起来规定和在肝的 HGF mRNA 的抑制。这些改变的表示模式可以强烈与妨碍的黄疸在肝切除术以后涉及推迟的肝新生。 | Hironobu Makino Hiroaki Shimizu Hiroshi Ito Fumio Kimura Satoshi Ambiru Akira Togawa Masayuki Ohtsuka Hiroyuki Yoshidome Atsushi Kato Hideyuki Yoshitomi Shigeaki Sawada Masaru Miyazaki | 2006 | World Journal of Gastroenterology2006，12，13： | 32 |
| 2 | Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats显示文摘AIM: To study the regulatory mechanisms of sinusoidal regeneration after partial hepatectomy.METHODS: We investigated the expression of angiopoietin (Ang)-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in regenerating liver tissue by quantitative reverse-transcription polymerase chain reaction (RT-PCR) using a LightCycler (Roche Diagnostics) and also immunohistochemical staining after 70% hepatectomy in rats. In the next step, we isolated liver cells (hepatocytes,sinusoidal endothelial cell (SEC), Kupffer cell, and hepatic stellate cells (HSC)) from regenerating liver tissue by in situ collagenase perfusion and counterflow elutriation,to determine potential cellular sources of these angiogenic factors after hepatectomy. Proliferation and apoptosis of SECs were also evaluated by proliferating cell nuclear antigen (PCNA) staining and the terminal deoxynucleotidyl transferase d-uridine triphosphate nick end labeling (TUNEL) assay, respectively.RESULTS: VEGF mRNA expression increased with a peak at 72 h after hepatectomy, decreasing thereafter.The expression of Ang-1 mRNA was present at detectable levels before hepatectomy and increased slowly with a peak at 96 h. Meanwhile, Ang-2 mRNA was hardly detected before hepatectomy, but was remarkably induced at 120 and 144 h. In isolated cells, VEGF mRNA expression was found mainly in the hepatocyte fraction.Meanwhile, mRNA for Ang-1 and Ang-2 was foundin the SEC and HSC fractions, but was more prominent in the latter. The PCNA labeling index of SECs increased slowly,reaching a peak at 72 h, whereas apoptotic SECs were detected between 120 h and 144 h.CONCLUSION: Ang-Tie system, together with VEGF,plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after hepatectomy. However, the VEGF system plays a more important role in the early phase of sinusoidal regeneration than angiopoietin/Tie system. | Hiroaki Shimizu Noboru Mitsuhashi Masayuki Ohtsuka Hiroshi Ito Fumio Kimura Satoshi Ambiru Akira Togawa Hiroyuki Yoshidome Atsushi Kato Masaru Miyazaki | 2005 | World Journal of Gastroenterology2005，11，46： | 17 |
| 3 | Surgical Resection after Downsizing Chemotherapy for Initially Unresectable Locally Advanced Biliary Tract Cancer: A Retrospective Single-center Study显示文摘 | Atsushi Kato Hiroaki Shimizu Masayuki Ohtsuka Hiroyuki Yoshidome Hideyuki Yoshitomi Katsunori Furukawa Dan Takeuchi Tsukasa Takayashiki Fumio Kimura Masaru Miyazaki | 2013 | Annals of Surgical Oncology2013，，1： | 1 |
| 4 | Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate显示文摘 | Nozomi Sugimoto Kenichiro Watanabe Kazuyo Watanabe Shinichi Ogata Ryo Shimoda Hiroyuki Sakata Yuichiro Eguchi Toshihiko Mizuta Seiji Tsunada Ryuichi Iwakiri Junichi Nojiri Masanobu Mizuguchi Sho Kudo Kohji Miyazaki Kazuma Fujimoto | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 5 | Transposon tagging in rice显示文摘 | Takeshi Izawa Tohru Ohnishi Toshitsugu Nakano Nobuhiro Ishida Hiroyuki Enoki Hisako Hashimoto Kimiko Itoh Rie Terada Chuanyn Wu Chikara Miyazaki Tomoko Endo Shigeru Iida Ko Shimamoto | 1997 | Plant Molecular Biology (-)1997，，1： | 1 |
| 6 | Continuous hyperthermic peritoneal perfusion for the prevention of peritoneal recurrence of gastric cancer: Randomized controlled study显示文摘 | Takashi Fujimura Yutaka Yonemura Keiichi Muraoka Hiroyuki Takamura Yasuo Hirono Hiroyuki Sahara Itasu Ninomiya Hisashi Matsumoto Kouichiro Tsugawa Gen-ichi Nishimura Kazuo Sugiyama Kouichi Miwa Itsuo Miyazaki | 1994 | World Journal of Surgery1994，，1： | 1 |
| 7 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato-Biliary-Pancreatic Surgery2007，，5： | 1 |
| 8 | Benefits and limits of hepatic resection for gastric metastases显示文摘 | Satoshi Ambiru Masaru Miyazaki Hiroshi Ito Koji Nakagawa Hiroaki Shimizu Hiroyuki Yoshidome Yoshiaki Shimizu Nobuyuki Nakajima | 2001 | The American Journal of Surgery2001，，3： | 1 |
| 9 | Significant correlation between expression of heat shock proteins27,70 and lymphocyte infiltration in esophageal squamous cell carcinoma显示文摘 | Masanobu Nakajima Hiroyuki Kuwano Tatsuya Miyazaki | 2002 | Cancer Lett2002，178，： | 1 |
| 10 | Circulating oxidized low-density lipoprotein is an independent predictor for cardiac event in patients with coronary artery disease显示文摘 | Kazunori Shimada Hiroshi Mokuno Eriko Matsunaga Tetsuro Miyazaki Katsuhiko Sumiyoshi Katsumi Miyauchi Hiroyuki Daida | 2004 | Atherosclerosis2004，，2： | 1 |
| 11 | Factors Associated with the Development of Reflux Esophagitis After Helicobacter pylori Eradication显示文摘 | Katsuhiko Tsukada MD Hiroyuki Katoh MD Tatsuya Miyazaki MD Minoru Fukuchi MD Hiroyuki Kuwano MD Hitoshi Kimura MD Yasuyuki Fukai MD Takanori Inose MD Teiji Motojima MD Naotaka Toda MD Shuji Yamada MD | 2006 | Digestive Diseases and Sciences2006，，3： | 1 |
| 12 | Combined vascular resection in operative resection for hilar cholangiocarcinoma: Does it work or not?显示文摘 | Masaru Miyazaki Atsushi Kato Hiroshi Ito Fumio Kimura Hiroaki Shimizu Masayuki Ohtsuka Hiroyuki Yoshidome Hideyuki Yoshitomi Katsunori Furukawa Satoshi Nozawa | 2007 | Surgery2007，，5： | 1 |
| 13 | gene transfer into muscle by electroporation in vivo显示文摘 | Hiroyuki Aihara Jun-ichi Miyazaki | 1998 | Nature Biotechnology1998，16，： | 1 |
| 14 | Predictive value of blood flow in the gastric tube in anastomotic insufficiency after thoracic esophagectomy显示文摘 | Tatsuya Miyazaki M.D. Hiroyuki Kuwano M.D. Ph.D. Hiroyuki Kato M.D. Ph.D. Minako Yoshikawa M.D. Hitoshi Ojima M.D. Ph.D. Katsuhiko Tsukada M.D. Ph.D | 2002 | World Journal of Surgery2002，，11： | 1 |
| 15 | Interval Period Tumor Progression: Does Delayed Hepatectomy Detect Occult Metastases in Synchronous Colorectal Liver Metastases?显示文摘 | Hiroyuki Yoshidome Fumio Kimura Hiroaki Shimizu Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Ayako Iida Masaru Miyazaki | 2008 | Journal of Gastrointestinal Surgery2008，，： | 1 |
| 16 | Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma 显示文摘 | TATSUYA MIYAZAKI HIROYUKI KATO YOSHINORI SHITARA | 2000 | Cancer2000，89，5： | 1 |
| 17 | Surgical strategy for mucin-producing bile duct tumor显示文摘 | Masayuki Ohtsuka Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Atsushi Kato Hideyuki Yoshitomi Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Tsukasa Takayashiki Kosuke Suda Masaru Miyazaki | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，3： | 1 |
| 18 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，5： | 1 |
| 19 | Preoperative immunonutrition decreases postoperative complications by modulating prostaglandin E2 production and T cell differentiation in patients undergoing pancreaticoduodenectomy显示文摘 | Toshiaki Aida Katsunori Furukawa Daisuke Suzuki Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Masaru Miyazaki | 2013 | Surgery2013，，： | 1 |
| 20 | Genetic Alterations in Esophageal Cancer显示文摘 | Hiroyuki Kuwano Hiroyuki Kato Tatsuya Miyazaki Minoru Fukuchi Norihiro Masuda Masanobu Nakajima Yasuyuki Fukai Makoto Sohda Hitoshi Kimura Ahmad Faried | 2005 | Surgery Today2005，，1： | 1 |
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