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| 1 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 2 | Permian High Ba-Sr Granitoids:Geochemistry,Age and Tectonic Implications of Erlangshan Pluton,Urad Zhongqi,Inner Mongolia显示文摘从 Urad Zhongqi 的 Erlangshan Pluton,中央内部蒙古,位于北方中国板的北边缘的中间的片断。岩石与片麻岩的结构主要由闪长岩组成。石油化学的特征表明闪长岩属于遇见了铝土的、高钾的计算碱的系列,与我类型花岗石的化学签名。他们被低 SiO 2内容描绘(56.63%58.53%)并且 A/CNK ( 0.90 0.96 ),高级艾尔 2 O 3内容(17.30%17.96%)并且 Na 2 O/K 2 O 比率( 1.20 1.70 ),在大离子亲石元素元素的丰富( LILE ,例如, Ba=556 915 ppm , Sr=463 595 ppm ),并且在高地力量元素的相对弄空( HFSE ,例如, Nb , Ta , Ti )在原始使披风正常化的蜘蛛克,和有稍微否定的 Eu 异例的衰退权利的稀土元素元素模式( δEu=0.72 0.90 )。他们有 Sr/Y 比率(20 25 ) 显然不到 Kebu Pluton (49 75 ) 到它的东方。微探查的 U-Pb 锆石标明日期闪长岩产出的敏感高分辨率离子 270 ± 8 妈的恼人的年龄。这导致我们断定 Erlangshan 闪长岩被在中间或更低的外壳导出岩浆和次要的导出披风的 mafic 岩浆之间混合形成,由部分结晶化列在后面,它在 post-collisional 设定是由外壳的扩展和差错活动的 trigged。 | LUO Hongling,WU Tairan~*,ZHAO Lei,HE Yuankai and JIN Xu The Key Laboratory of Orogenic Belts and Crustal Evolution,Ministry of Education,Beijing 100871, China School of Earth and Space Sciences,Peking University,Beijing 100871,China | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 9 |
| 3 | Construction and anti-tumor effects of recombinant fowlpox virus expressing Newcastle disease virus hemagglutinin-neuramidinase gene显示文摘Hemagglutinin-neuramidinase (HN ) ,纽卡斯尔疾病导出病毒的蛋白质,不是仅仅调停受体识别而且拥有 neuraminidase (NA ) 活动,劈开那些受体的一个部件的能力, N-acetylneuraminic 酸(NAcneu, sialic ) 。包括人,在哺乳动物的种类的这蛋白质有有趣的反肿瘤以及有免疫力的刺激性质,这被知道。在癌症基因治疗探索 HN 基因的使用,我们构造了表示 HN 蛋白质(vFV-HN ) 的一个 recombinant 家禽痘病毒并且在 vivo 并且在 vitro 把 recombinant 病毒的 theanti 肿瘤活动与野类型的家禽痘病毒(FPV ) 的作比较。这里,我们发现尽管 B16 房间对野类型的家禽痘病毒的基础细胞毒素的效果有点抵抗,有 vFV-HN 的感染引起了显著细胞毒素的效果并且,与 vFV-HN 使免疫的忍受肿瘤的老鼠的幸存显著地与独自与 FPV 使免疫的老鼠的幸存相比被增加。而且,有 vFV-HNelicited 的老鼠的免疫 B16 肿瘤特定的细胞毒素的 T 淋巴细胞(CTL ) 回答和在 vivo 的 bothCD4+ 和 CD8+ T 房间人口的同种细胞的扩大。另外,从老鼠的淋巴节点的 T 房间种牛痘, Th1 cytokine IL-2 和 IFN-v 高级的 vFV-HN 藏匿了,显示肿瘤房间的回归与 Th1 类型主导的有免疫力的回答有关。这些结果证明有 vFV-HN 的种痘可以是为癌症基因治疗的潜在的策略。 | LI Xiao JIN Ningyi LIAN Hai GUAN Goufang SUN Lili LI Xue mei ZHENG Hongling | 2006 | Chinese Science Bulletin2006，51，22： | 9 |
| 4 | N-Heterocyclic Carbene Organocatalysis: Activation Modes and Typical Reactive Intermediates显示文摘N-Heterocyclic carbene(NHC)organocatalysis has been developed as an important approach in modern organic synthesis.Versatile activation modes within NHC organocatalysis have been established with countless transformations being realized in both efficient and selective fashion.We would like to provide an overview on the key progresses achieved within this field in the past two decades.Since numerous excellent reviews have been documented within this area,we will mainly focus on the scientific development of this research field based on the basic reaction modes and typical reaction intermediates. | Xingkuan Chen Hongling Wang Zhichao Jin Yonggui Robin Chi | 2020 | Chinese Journal of Chemistry2020，38，10： | 5 |
| 5 | Controlled growth and photoconductive properties of hexagonal SnS2 nanoflakes with mesa-shaped atomic steps显示文摘We demonstrated the controlled growth of two-dimensional (2D) hexagonal tin disulfide (SnS2) nanoflakes with stacked monolayer atomic steps. The morphology was similar to flat-topped and step-sided mesa plateaus or step pyramids. The SnS2 nanoflakes were grown on mica substrates via an atmospheric-pressure chemical vapor deposition process using tin monosulfide and sulfur powder as precursors. Atomic force microscopy (AFM), electron microscopy, and Raman characterizations were performed to investigate the structural features, and a sequential layer-wise epitaxial growth mechanism was revealed. In addition, systematic Raman characterizations were performed on individual SnS2 nanoflakes with a wide range of thicknesses (1-100 nm), indicating that the A1g peak intensity and Raman shifts were closely related to the thickness of the SnS2 nanoflakes. Moreover, photoconductive AFM was performed on the monolayer-stepped SnS2 nanoflakes, revealing that the flat surface and the edges of the SnS2 atomic steps had different electrical conductive properties and photoconductive behaviors. This is ascribed to the dangling bonds and defects at the atomic step edges, which caused a height difference of the Schottky barriers formed at the interfaces between the PtIr-coated AFM tip and the step edges or the flat surface of the SnS2 nanoflakes. The 2D SnS2 crystals with regular monolayer atomic steps and fast photoresponsivity are promising for novel applications in photodetectors and integrated optoelectronic circuits. | Yi Hu Tao Chen Xiaoqi Wang Lianbo Ma Renpeng Chen Hongfei Zhu Xin Yuan Changzeng Yan Guoyin Zhu Hongling Lv Jia Liang Zhong Jin Jie Liu | 2017 | Nano Research2017，10，4： | 5 |
| 6 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 7 | ClC-3 chloride channel in hippocampal neuronal apoptosis显示文摘Over-production of nitric oxide is pathogenic for neuronal apoptosis around the ischemic area following ischemic brain injury.In this study,an apoptotic model in rat hippocampal neurons was established by 0.5 mmol/L 3-morpholinosyndnomine(SIN-1),a nitric oxide donor.The models were then cultured with 0.1 mmol/L of 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid(DIDS;the chloride channel blocker) for 18 hours.Neuronal survival was detected using the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay,and apoptosis was assayed by Hoechst 33342-labeled neuronal DNA fluorescence staining.Western blot analysis and immunochemiluminescence staining were applied to determine the changes of activated caspase-3 and CIC-3 channel proteins.Real-time PCR was used to detect the mRNA expression of CIC-3.The results showed that SIN-1 reduced the neuronal survival rate,induced neuronal apoptosis,and promoted ClC-3 chloride channel protein and mRNA expression in the apoptotic neurons.DIDS reversed the effect of SIN-1.Our findings indicate that the increased activities of the ClC-3 chloride channel may be involved in hippocampal neuronal apoptosis induced by nitric oxide. | Lijuan Xu Shuling Zhang Hongling Fan Zhichao Zhong Xi Li Xiaoxiao Jin Quanzhong Chang | 2013 | Neural Regeneration Research2013，8，32： | 3 |
| 8 | Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice显示文摘 | Yanfei Wang Xia Zhao Hongfang Jin Hongling Wei Wei Li Dingfang Bu Xiuying Tang Yali Ren Chaoshu Tang Junbao Du | 2009 | Arteriosclerosis Thrombosis and Vascular Biology2009，，2： | 2 |
| 9 | Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice显示文摘 | Yanfei Wang Xia Zhao Hongfang Jin Hongling Wei Wei Li Dingfang Bu Xiuying Tang Yali Ren Chaoshu Tang Junbao Du | 2009 | Arteriosclerosis, Thrombosis, and Vascular Biology2009，，2： | 1 |
| 10 | Characteristics of high Al content AlGaN grown by pulsed atomic layer epitaxy显示文摘 | Xu Pan Xiaoliang Wang Hongling Xiao Cuimei Wang Cuibai Yang Wei Li Weiying Wang Peng Jin Zhanguo Wang | 2011 | Applied Surface Science2011，，20： | 1 |
| 11 | Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and Apoptin显示文摘 | Hai Lian Ningyi Jin Xiao Li Zhiqiang Mi Jingmin Zhang Lili Sun Xuemei Li Hongling Zheng Ping Li | 2007 | Cancer Immunology Immunotherapy2007，，2： | 1 |
| 12 | 显示文摘 | Zhang Jin Zou Hongling Qing Quan | 2003 | J Phys Chem B2003，107，16： | 1 |
| 13 | Transcriptome and metabolome analysis reveal that oral secretions from Helicoverpa armigera and Spodoptera litura influence wound-induced host response in cotton显示文摘Cotton(Gossypium hirsutum)is an important fiber crop worldwide.Insect attack causes cotton yield and quality losses.However,little is known about the mechanism of cotton response to insect attack.We simulated insect feeding by applying insect oral secretions(OS)to wounds,and combined transcriptome and metabolome analysis to investigate how OS from two major pest species(Helicoverpa armigera and Spodoptera litura)affect cotton defense responses.We found that respectively 12,668 and 13,379 genes were differentially expressed in comparison with wounding alone.On addition of OS,the jasmonic acid signaling pathway was rapidly and strongly induced,whereas genes involved in salicylic acid biosynthesis were downregulated.On constructing a coexpression gene network,we identified a hub gene encoding a leucine-rich repeat receptor kinase that may play an important role in early signal recognition and transduction.OS from the two insect species altered the abundance of flavonoid-related compounds in different patterns.Gossypol remained in lower concentration after OS application than after wounding alone,suggesting a suppressive effect of OS on cotton defense response.This study illustrated transcriptional and metabolic changes of cotton in responding to OS from two chewing insect species,identified potential key response genes,and revealed evidence for OS inhibition of wounding-induced cotton defense response. | Huan Si Hongling Liu Yiwen Sun Zhongping Xu Sijia Liang Bo Li Xiao Ding Jianying Li Qiongqiong Wang Lin Sun Xianlong Zhang Shuangxia Jin | 2020 | The Crop Journal2020，8，6： | 1 |
| 14 | A batch of road traffic injury on pre hospital and in-hospital emergency to explore nursing mode 显示文摘 | Xu Yan Wang Hongling Jin Rui | 2012 | Chemists ( Second Half )2012，9，27： | 1 |
| 15 | New Sixth-Order Compact Schemes for Poisson/Helmholtz Equations显示文摘Some new sixth-order compact finite difference schemes for Poisson/Helmholtz equations on rectangular domains in both two-and three-dimensions are developed and analyzed.Different from a few sixth-order compact finite difference schemes in the literature,the finite difference and weight coefficients of the new methods have analytic simple expressions.One of the new ideas is to use a weighted combination of the source term at staggered grid points which is important for grid points near the boundary and avoids partial derivatives of the source term.Furthermore,the new compact schemes are exact for 2D and 3D Poisson equations if the solution is a polynomial less than or equal to 6.The coefficient matrices of the new schemes are M-matrices for Helmholtz equations with wave number K≤0,which guarantee the discrete maximum principle and lead to the convergence of the new sixth-order compact schemes.Numerical examples in both 2D and 3D are presented to verify the effectiveness of the proposed schemes. | Kejia Pan Kang Fu Jin Li Hongling Hu Zhilin Li | 2023 | Numerical Mathematics(Theory,Methods and Applications)2023，16，2： | 0 |
| 16 | The complete and fully-phased diploid genome of a male Han Chinese显示文摘Since the release of the complete human genome,the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity.Here,we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual(CN1),in which the assemblies of both haploids achieve the telomere-to-telomere(T2T)level.Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere.Outside the centromere,we discovered 11,413 structural variations,including numerous novel ones.We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population.Further,we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references.Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling,with nearly 2 million rare SNPs miss-called with different reference genomes.Finally,applying the CN1 as a reference,we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan,respectively,including many East Asian specific ones undetected using CHM13 as the reference.Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies.This complete genome will serve as an alternative reference for future genomic studies on the East Asian population. | Chentao Yang Yang Zhou Yanni Song Dongya Wu Yan Zeng Lei Nie Panhong Liu Shilong Zhang Guangji Chen Jinjin Xu Hongling Zhou Long Zhou Xiaobo Qian Chenlu Liu Shangjin Tan Chengran Zhou Wei Dai Mengyang Xu Yanwei Qi Xiaobo Wang Lidong Guo Guangyi Fan Aijun Wang Yuan Deng Yong Zhang Jiazheng Jin Yunqiu He Chunxue Guo Guoji Guo Qing Zhou Xun Xu Huanming Yang Jian Wang Shuhua Xu Yafei Mao Xin Jin Jue Ruan Guojie Zhang | 2023 | Cell Research2023，33，10： | 0 |
| 17 | Paleo-polyploidization in Lycophytes显示文摘Lycophytes and seed plants constitute the typical vascular plants.Lycophytes have been thought to have no paleo-polyploidization although the event is known to be critical for the fast expansion of seed plants.Here,genomic analyses including the homologous gene dot plot analysis detected multiple paleo-polyploidization events,with one occurring approximately 13–15 million years ago(MYA)and another about 125–142 MYA,during the evolution of the genome of Selaginella moellendorffii,a model lycophyte.In addition,comparative analysis of reconstructed ancestral genomes of lycophytes and angiosperms suggested that lycophytes were affected by more paleopolyploidization events than seed plants.Results from the present genomic analyses indicate that paleo-polyploidization has contributed to the successful establishment of both lineages—lycophytes and seed plants—of vascular plants. | Jinpeng Wang Jigao Yu Pengchuan Sun Chao Li Xiaoming Song Tianyu Lei Yuxian Li Jiaqing Yuan Sangrong Sun Hongling Ding Xueqian Duan Shaoqi Shen Yanshuang Shen Jing Li Fanbo Meng Yangqin Xie Jianyu Wang Yue Hou Jin Zhang Xianchun Zhang Xiu-Qing Li Andrew HPaterson Xiyin Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 0 |
| 18 | Investigation of the pin-roller metering device and tube effect for wheat seeds and granular fertilizers based on DEM显示文摘The metering device is the central part of the seeder discharging granular fertilizers or seeds from the hopper to the colter passing through the tube.Depending on the metering device design,the batches of particles are discharged or discharged evenly.This research analyzes existing metering devices,and a new pin-roller metering device is recommended to discharge evenly high doses of granular fertilizers and wheat seeds at low rotation speeds.The objective was to adapt the metering device to precision agriculture so that a little electric motor containing gearbox drives every metering device.Therefore,the pin-roller metering device parameters were investigated to apply high doses of granular fertilizers and wheat seeds evenly.The optimal pin positions were determined according to response surface methods(RSM)by simulating the granular fertilizers and wheat seeds'behavior on DEM.The coefficient of variation(CV)and the slip rate(SR)of the particles between the pins were chosen as indicators for evaluating the pin-roller.The shape of the pin was specified,and then the number of lines,the number of pins in a line,and the pin height were chosen to optimize.The analysis of the simulation results shows the optimal parameters:the number of pins in a line is four,and the number of lines is sixteen.The SR of granular fertilizers and wheat seeds were 8%and 2%,respectively.The pin-roller metering device is compared with the six-grooved and twelve-grooved metering devices.The comparison results show that the pin-roller metering device distributes twice more uniformly than other metering devices.The CV of the granular fertilizer distribution for six-grooved,twelve-grooved,and pin-roller metering devices was 111.13%,80.74%,and 37%,respectively.The CV of the wheat seed distribution for twelve-grooved and pin-roller metering devices was 96%,and 37%,respectively.As long as the particles interact with the tube,leaving the metering device,the effect of tube type and position is investigated.As a result,it was determined that the tube has minimal effect on the pin-roller metering device while positively impacting the six-grooved and twelve-grooved metering devices,improving the CV of the particle distribution into the soil. | Sugirbay Adilet Kaiyuan Zhao Guangyao Liu Nukeshev Sayakhat Jun Chen Guangrui Hu Lingxin Bu Yu Chen Hongling Jin Shuo Zhang Zagainov Nikolay Muratkhan Marat | 2023 | International Journal of Agricultural and Biological Engineering2023，16，2： | 0 |
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