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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens显示文摘Naturally,resistant crop germplasms are important resources for managing the issues of agricultural product safety and environment deterioration.We found a spontaneous mutant of‘Newhall’navel orange(Citrus sinensis Osbeck)(MT)with broad-spectrum protections against fungal pathogens in the orchard,postharvest-storage,and artificial inoculation conditions.To understand the defense mechanism of MT fruit,we constructed a genome-scale metabolic network that integrated metabolome and transcriptome datasets.The coordinated transcriptomic and metabolic data were enriched in two sub-networks,showing the decrease in very long chain fatty acid(by 41.53%)and cuticular wax synthesis(by 81.34%),and increase in the synthesis of jasmonic acid(JA)(by 95.23%)and JA-induced metabolites such as 5-dimethylnobietin(by 28.37%)in MT.Furthermore,cytological and biochemical analyses confirmed that the response to fungal infection in MT was independent of wax deficiency and was correlated with the levels of jasmonates,and the expression of plant defensin gene PDF1.2.Results of exogenous application of MeJA and JA inhibitors such as propyl gallate proved that JA-mediated defense contributes to the strong tolerance against pathogens in MT.Our results indicated that jasmonate biosynthesis and signaling are stimulated by the fatty acid redirection of MT,and participate in the tolerance of pathogenic fungi. | Yizhong He Jingwen Han Runsheng Liu Yuduan Ding Jinqiu Wang Li Sun Xiaoming Yang Yunliu Zeng Weiwei Wen Juan Xu Hongming Zhang Xiang Yan Zhaoxing Chen Zuliang Gu Hong Chen Huanqing Tang Xiuxin Deng Yunjiang Cheng | 2018 | Horticulture Research2018，5，1： | 8 |
| 3 | Effects of Subtotal Gastrectomy and Roux-en-Y Gastrojejunostomy on the Clinical Outcome of Type 2 Diabetes Mellitus显示文摘 | Juntao Yang Chunxue Li Hongming Liu Hongguang Gu Ping Chen Baohua Liu | 2010 | Journal of Surgical Research2010，，1： | 1 |
| 4 | Open and close-ended CoMoS_(3) nanotubes for hydrogen evolution in acidic and basic conditions显示文摘Electrochemical hydrogen evolution reaction(HER) is a promising route to harvest high-purity hydrogen(H_(2)).Efficient and selective energy transformations rely on the development of novel catalytic materials in terms of compositions and structures that survive under harsh conditions.This study focuses on a unique nanostructured CoMoS_(3) catalyst for HER under strong acidic and basic electrolyte.The morphologies of the catalysts are fine-tuned by altering reaction times in a hydrothermal reaction.Limited reaction time generates twisted thin-sheet CoMoS_(3)(12 h),which spins into a nanotube with an extended synthetic time(16 h).As the reaction time increases to 20 h,the CoMoS_(3) composite creates open-ended nanotubes,facilitating reactants to penetrate and react actively in the inner space of the nanotubes.Further,prolonged reaction time(24 h) results in the formation of the close-ended CoMoS_(3) nanotubes.We find out that the open-ended structure plays an important role in achieving fast kinetics as well as creating more active sites in HER reaction.The catalyst delivers a profound performance under both acidic and basic conditions,with overpotentials of 93 mV and 115 mV(at a current density of 10 mA/cm^(2)) in the acidic and basic electrolytes,respectively.Moreover,it shows superior long-term durability in both solutions.This work will provide a great foundation for understanding the morphology effect with the same composited catalyst towards energy conversion reactions,not limited to HER. | Yuan Li Xuewei Hou Jing Gu Veronika Mikhaylova Kangli Chen Hongming Zhang Shumin Han | 2021 | Journal of Energy Chemistry2021，30，6： | 0 |
| 5 | Modulation bandwidth enhancement in monolithic integrated two-section DFB lasers based on the detuned loading effect显示文摘Modulation bandwidth enhancement in a directly modulated two-section distributed feedback(TS-DFB)laser based on a detuned loading effect is investigated and experimentally demonstrated.The results show that the 3-dB bandwidth of the TS-DFB laser is increased to 17.6 GHz and that chirp parameter can be reduced to 2.24.Compared to the absence of a detuned loading effect,there is a 4.6 GHz increase and a 2.45 reduction,respectively.After transmitting a 10 Gb/s non-return-to-zero(NRZ)signal through a 5-km fiber,the modulation eye diagram still achieves a large opening.Eight-channel laser arrays with precise wavelength spacing are fabricated.Each TS-DFB laser in the array has side mode suppression ratios(SMSR)>49.093 dB and the maximum wavelength residual<0.316 nm. | Yunshan Zhang Yifan Xu Shijian Guan Jilin Zheng Hongming Gu Lianyan Li Rulei Xiao Tao Fang Hui Zou Xiangfei Chen | 2023 | Journal of Semiconductors2023，44，11： | 0 |
| 6 | 评估帕博利珠单抗在中国晚期黑色素瘤患者中的应用:基于KEYNOTE-151研究的3年随访数据显示文摘中国肢端和黏膜黑色素瘤的发病率较高,但治疗选择有限,晚期黑色素瘤患者的生存率普遍较低。对Ib期KEYNOTE-151研究的初步分析显示,帕博利珠单抗在作为二线药物治疗中国晚期黑色素瘤患者中,表现出了良好的耐受性和优异的临床抗肿瘤活性。本研究分析了3年随访的研究数据,纳入一线治疗后进展的不可切除的III/IV期中国黑色素瘤患者,给予帕博利珠单抗2 mg/kg治疗,每3周1次,最长使用35剂。主要终点为安全性和客观缓解率(objective response rate,ORR);次要终点包括疗效维持时间(duration of response,DOR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。根据RECIST v1.1标准,采用独立中心盲法评估患者疗效。此外,根据黑色素瘤亚型,以及BRAF突变状态和PD-L1表达状态(仅肢端黑色素瘤)进行亚组分析。本研究共纳入103例患者,中位随访时间[从首次用药到数据截止时间(2020年7月13日)]为44.6个月[四分位距(interquartile range,IQR):39.1–46.2]。85.4%的患者发生了任一级别的治疗相关不良事件(treatment-related adverse events,TRAEs),12.6%的患者发生了3/4级的TRAEs,无5级TRAE发生。3例患者因TRAEs(免疫相关肝炎、肺炎和关节炎)停药。免疫相关AEs和输液反应发生比例为34.0%(3/4级,2.9%)。ORR为17.6%(95%CI:10.8–26.4;1例完全缓解/17例部分缓解),中位DOR为13.8个月(范围:2.7–37.4+)。中位PFS为2.8个月(95%CI:2.7–3.5),36个月的PFS率为5.0%。中位OS为13.2个月(95%CI:10.4–16.5),36个月的OS率为22.3%。肢端黑色素瘤中位OS为14.8个月,非肢端皮肤黑色素瘤为13.5个月,黏膜黑色素瘤为7.4个月。在肢端黑色素瘤亚组中,程序性死亡配体-1(programmed death ligand-1,PD-L1)阳性的中位OS为22.8个月,PD-L1阴性的中位OS为8.4个月,BRAF野生型的中位OS为18.5个月,BRAF突变型的中位OS为5.8个月。综上,本研究对3年随访数据分析结果表明,帕博利珠单抗作为二线治疗在中国晚期黑色素瘤患者中的安全性可控,且达到了具有临床意义的抗肿瘤活性,使部分患者获得持久缓解。亚组分析表明PD-L1阳性和BRAF野生型的肢端黑色素瘤患者从该治疗中获益较大,但由于亚组样本量较小,该研究结论仍需进一步验证。 | Lu Si Xiaoshi Zhang Yongqian Shu Hongming Pan Di Wu Jiwei Liu Lili Mao Xuan Wang Xizhi Wen Yanhong Gu Lingjun Zhu Shijie Lan Xin Cai Scott J.Diede Haiyan Dai Cuizhen Niu Jianfeng Li Jun Guo 李雯钰(翻译校对) 斯璐(点评) | 2023 | 癌症2023，42，8： | 0 |
| 7 | Steel Fiber Toughening Mullite-SiC Castables for Coke Dry Quenching Furnace Corbel Pillar显示文摘The mullite-SiC castables for coke dry quenching(CDQ)furnace corbel pillar were prepared by taking mullite and silicon carbide as aggregates,silicon carbide powder,fused silica powder,α-Al_2O_3powder and silica fume as matrix,calcium aluminate cement as binding system,and extra-adding steel fibers to extend the CDQ furnace refractory life.The effects of steel fiber types(melt pumping meniscus,cut straight,wavy indentation,cold-drawn hook)and steel fiber extra-additions(0,1%,2%,3%by volume)on the properties of mullite-SiC castables were investigated.Then the toughening mechanism of steel fiber in the castables was analyzed according to the load-displacement curves.The results show that:(1)the toughening effects of the melt pumping meniscus steel fiber with rough surface and colddrawn hook steel fiber with strong anchoring effect with the matrix are better than those of cut straight steel fiber and wavy indentation steel fiber;(2)the suitable amount of steel fiber(less than 2%)in mullite-SiC castables not only significantly improves the mechanical properties,thermal shock resistance and wearing resistance,but also improves the fracture energy by 49.0%and slows the crack growth;(3)the bond strength and mechanical anchoring force between steel fiber and castable interface are key elements of steel fiber reinforced castables. | NI Kangxiang ZHANG Meijie GU Huazhi HUANG Ao LI Hongming SHAO Zhijun | 2017 | China's Refractories2017，26，1： | 0 |
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