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| 1 | Synthesis, characterization and size control of zerovalent iron nanoparticles anchored on montmorillonite显示文摘Zerovalent iron nanoparticles have been successfully synthesized using sodium borohydride solution reduction of ferric trichloride hexahydrate in the presence of montmorillonite as an effective protective reagent and support as well. A combination of characterizations reveals that with high monodispersity these obtained iron nanoparticles are well dispersed on clay surface, virginal from boron related impurity, and oxidation resistant well with iron core-iron oxide shell structure. The shell thickness of 3 nm remains almost invariable under ambient conditions. The size control of these iron nanoparticles has been achieved by tailoring the amount of the ferric iron, which mainly depends on the protective action of montmorillonite. | FAN MingDe YUAN Peng CHEN TianHu HE HongPing YUAN AiHua CHEN KangMin ZHU JianXi LIU Dong | 2010 | Chinese Science Bulletin2010，55，11： | 15 |
| 2 | SNORD126 promotes HCC and CRC cell growth by activating the PI3K-AKT pathway through FGFR2显示文摘小核仁的 RNA (snoRNA ) 机能障碍与癌症开发被联系了。SNORD126 是在它的主机基因的 introns 5-6 以内被编码的孤儿 C/D 框 snoRNA, cyclin 交往 B1 蛋白质 1 (CCNB1IP1 ) 。SNORD126 触发的联系癌症的分子的机制充分没被理解。这里,我们证明 SNORD126 高度在 hepatocellular 癌(HCC ) 被表示, colorectal 癌症(CRC ) 病人取样。SNORD126 在裸体老鼠增加了 Huh-7 和 SW480 细胞生长和 tumorigenicity。SNORD126 击倒禁止的 HepG2 和 LS174T 房间生长。我们证实 SNORD126 没与 miRNA 活动被处理成小 RNA。而且, SNORD126 没在 HCC 样品与 CCNB1IP1 显示出重要表示关联或调整 CCNB1IP1 表示。我们的基因表示侧面分析显示了基因经常印射到 PI3K-AKT 小径的那 SNORD126-upregulated。SNORD126 overexpression 增加了 phosphorylated AKT, GSK-3,和 p70S6K 的层次并且提高了成纤维细胞生长因素受体 2 (FGFR2 ) 表示。在 SNORD126-overexpressing Huh-7 细胞的 FGFR2 的调停 siRNA 的击倒或调停 AZD4547 的 inactivation 禁止了 AKT phosphorylation 并且压制了细胞生长。这些调查结果在癌症为 SNORD126 显示一个 oncogenic 角色并且作为一个治疗学的目标建议它的潜力。 | Xianlong Fang Dongmei Yang Hongping Luo Shuai Wu Wenjie Dong Jing Xiao Sujing Yuan Aimin Ni Kang-Jian Zhang Xin-Yuan Liu Liang Chu | 2017 | Journal of Molecular Cell Biology2017，9，3： | 5 |
| 3 | Surgical treatment of hepato-pancreato-biliary disease in China:the Tongji experience显示文摘Hepato-pancreato-biliary(HPB) tumors are common in China. However, these tumors are often diagnosed at intermediate/advanced stages because of the lack of a systemic surveillance program in China. This situation creates many technical challenges for surgeons and increases the incidence of postoperative complications. Therefore, Dr. Xiao-Ping Chen has made many important technical improvements, such as Chen's hepatic portal occlusion method, the anterior approach for liver resection of large HCC tumors, the modified technique of Belghiti's liver-hanging maneuver, inserting biliary-enteric anastomosis technique, and invaginated pancreaticojujunostomy with transpancreatic U-sutures. These techniques are simple, practical, and easy to learn. Owing to these advantages, complicated surgical procedures can be simplified, and the curative effects are greatly improved. These improved techniques have been widely applied in China and will benefit many additional patients. In this review, we introduce our experience of surgically treating intermediate/advanced hepatocellular carcinoma(HCC), hilar cholangiocarcinoma(HC), and pancreatic carcinoma, mainly focusing on technical innovations established by Dr. Chen in HPB surgery. | binhao zhang wei dong hongping luo xuanru zhu lin chen changhai li wei zhang shuai xiang wanguang zhang zhiyong huang xiao-ping chen | 2016 | Science China(Life Sciences)2016，59，10： | 2 |
| 4 | Calculus Bovis Sativus up-regulates hepatic protein 2(Mrp2) and Mrp4 in 17α-ethynylestradiol-induced cholestasis via a regulatory effect on ER signaling显示文摘OBJECTIVE:To investigate the pathway through which Calculus Bovis Sativus (CBS) up-regulates hepatic multidrug resistance-associated protein 2 (Mrp2) and Mrp4 in 17α-ethynylestradiol (EE)-induced cholestasis.METHODS:Five groups of rats were designed:control group,EE+ICI182780 group,EE group,EE+CBS 50 mg/kg group and EE + CBS 150 mg/kg group.CBS (50 and 150 mg.kg-1· d-1) was orally given to rats by gavage for five consecutive days in coadministration with EE.The levels of cholestasis biomarkers,alanine aminotransferase (ALT),aspartate aminotransferase (AST),alkaline phosphatase (ALP) and total bilirubin (TBIL) were determined by biochemical methods.The bile flow was measured.The histopathology of the liver tissue was evaluated.The expression of Mrp2,Mrp3,Mrp4,estrogen receptor α(ERα) and ERβ was determined by Western blotting.RESULTS:CBS markedly improved EE-induced cholestasis.EE exposure significantly reduced hepatic Mrp2 and Mrp4 expression compared with the control group.EE also dramatically up-regulated the expression of Mrp3.Compared to the EE group,CBS notably up-regulated hepatic Mrp2 and Mrp4 but failed to influence the Mrp3 level significantly.ICI182780,an ER antagonist,showed similar beneficial effects as CBS.Decreased expression of Mrp2 and Mrp4 caused by EE was also restored by IC1182780.Additionally,EE significantly induced hepatic ERα expression,which was reversed by ICI182780 or CBS (150 mg/kg) treatment,suggesting that CB5 exerted a moderate regulatory effect on ER signaling.CONCLUSION:CBS up-regulated hepatic Mrp2 and Mrp4 expression in EE-induced cholestasis,which might be associated with its regulation of ER signaling. | Wu Tao Liu Dong Song Hongping | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 2 |
| 5 | Gender Inequality in Rural Education and Poverty显示文摘 | Dong Qiang Li Xiaoyun Yang Hongping Zhang Keyun | | 0，，04： | 1 |
| 6 | Influences of thermal pretreatment temperature and solvent on the organosilane modification of Al 13 -intercalated/Al-pillared montmorillonite显示文摘 | Zonghua Qin Peng Yuan Jianxi Zhu Hongping He Dong Liu Shuqin Yang | 2010 | Applied Clay Science2010，，4： | 1 |
| 7 | Cell osteogenic bioactivity mediated precisely by varying scaled micro-pits on ordered micro/nano hierarchical structures of titanium显示文摘Hierarchical surface structures with micro–nano scale play a crucial role in regulation of cell proliferation and osteogenic differentiation.It has been proven that cells are extremely sensitive to the nanoscaled structure and show multifarious phenotypes.Though a vital function of microstructure on osseointegration has been confirmed,the cell performances response to different microscaled structure is needed to be further dissected and in depth understood.In this work,the ordered micro–nano hierarchical structures with varying micro-scaled pits were precisely fabricated on titanium successfully by the combination of electrochemical,chemical etching and anodization as well.In vitro systematical assessments indicated that the micro–nano multilevel structures on titanium exhibited excellent cells adhesion and spreading ability,as well as steerable proliferation and osteogenic differentiation behaviors.It is shown that smaller micro-pits and lower roughness of the hierarchical structures enabled faster cell propagation.Despite cell growth was delayed on micro–nano titanium with relatively larger cell-match-size micro-pits and roughness,osteogenic-specific genes were significantly elevated.Furthermore,the alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization of MC3T3-E1 on multiscaled titanium were suppressed by a large margin after adding IWP-2(an inhibitor of Wnt/b-catenin signal pathway),indicating this pathway played a crucial part in cell osteogenic differentiation modulated by micro–nano structures. | Yanmei Zhang Xiankuan Wang Yaxian Li Jianhe Liang Pinliang Jiang Qiaoling Huang Yun Yang Hongping Duan Xiang Dong Gang Rui Changjian Lin | 2022 | Regenerative Biomaterials2022，9，1： | 1 |
| 8 | Over‐expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial–mesenchymal transition in hepatocellular carcinoma cells显示文摘 | Minghua Hu Xiaobing Chen Jianmin Zhang Dong Wang Xiaosan Fang Xiaoming Wang Guannan Wang Guoyong Chen Xiaochun Jiang Hongping Xia Yongsheng Wang | 2013 | J Surg Oncol2013，，3： | 1 |
| 9 | Gender Inequality in Rural Education and Poverty显示文摘 | Dong Qiang Li Xiaoyun Yang Hongping Zhang Keyun | | 0，，04： | 1 |
| 10 | Existence of Separate Domains in Lysin PlyG for Recognizing Bacillus anthracis Spores and Vegetative Cells显示文摘 | Hang Yang Dian-Bing Wang Qiuhua Dong Zhiping Zhang Zongqiang Cui Jiaoyu Deng Junping Yu Xian-en Zhang Hongping Wei | 2012 | Antimicrobial Agents and Chemotherapy2012，，10： | 1 |
| 11 | Computational analysis of di - peptides correlated with the optimal temperature in G/11 xylanase显示文摘 | Liangwei Liu Hongping Dong Suya Wang | 2006 | Process Biochemistry2006，41，2： | 1 |
| 12 | Decolorization of methylene blue by heterogeneous Fenton reaction using Fe 3? x Ti x O 4 (0<ce:hsp sp='0.25'/>≤<ce:hsp sp='0.25'/> x <ce:hsp sp='0.25'/>≤<ce:hsp sp='0.25'/>0.78) at neutral pH values显示文摘 | Shijian Yang Hongping He Daqing Wu Dong Chen Xiaoliang Liang Zonghua Qin Mingde Fan Jianxi Zhu Peng Yuan | 2009 | Applied Catalysis B Environmental2009，，3： | 1 |
| 13 | The influence of alkyl chain length on surfactant distribution within organo-montmorillonites and their thermal stability显示文摘 | Jianxi Zhu Wei Shen Yuehong Ma Lingya Ma Qing Zhou Peng Yuan Dong Liu Hongping He | 2012 | Journal of Thermal Analysis and Calorimetry2012，，1： | 1 |
| 14 | 2013~2017年中国空气质量改善与早产疾病负担改变显示文摘Preterm birth(PTB)is a leading cause of perinatal mortality and morbidity worldwide[1].Since maternal and fetal health protection has been included in the United Nations Sustainable Development Goals,identification of modifiable risk factors for PTB is particularly crucial.The Global Burden of Disease(GBD)Study 2019 recognized fine particulate matter(PM2.5)pollution as a risk factor for decreased gestational age and low birth weight. | Yixuan Jiang Yuan He Shenpeng Wu Renjie Chen Ying Yang Jihong Xu Ya Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Zuoqi Peng Xudong Dong Hongping Zhang Lifang Jiang Huichu Li Yixiang Zhu Cong Liu Weidong Wang Xia Meng Tao Pei Ci Song Aaron Cohen Xu Ma Jing Cai Haidong Kan | 2022 | Science Bulletin2022，67，9： | 1 |
| 15 | Physical activation of diatomite-templated carbons and its effect on the adsorption of methylene blue (MB)显示文摘 | Dong Liu Weiwei Yuan Peng Yuan Wenbin Yu Daoyong Tan Hongmei Liu Hongping He | 2013 | Applied Surface Science2013，，： | 1 |
| 16 | No-reference image quality assessment in curvelet domain 显示文摘 | Liu Lixiong Dong Hongping Hua Huang | 2014 | Signal Pro- cessing : Image Communication2014，29，： | 1 |
| 17 | Flavivirus RNA cap methyltransferase:structure,function,and inhibition显示文摘Many flaviviruses are significant human pathogens.The plus-strand RNA genome of a flavivirus contains a 5′terminal cap 1 structure(m7GpppAmG).The flavivirus encodes one methyltransferase(MTase),located at the Nterminal portion of the NS5 RNA-dependent RNA polymerase(RdRp).Here we review recent advances in our understanding of flaviviral capping machinery and the implications for drug development.The NS5 MTase catalyzes both guanine N7 and ribose 2'-OH methylations during viral cap formation.Representative flavivirus MTases,from dengue,yellow fever,and West Nile virus(WNV),sequentially generate GpppA!m7GpppA!m7GpppAm.Despite the existence of two distinct methylation activities,the crystal structures of flavivirus MTases showed a single binding site for S-adenosyl-L-methionine(SAM),the methyl donor.This finding indicates that the substrate GpppA-RNA must be repositioned to accept the N7 and 2'-O methyl groups from SAM during the sequential reactions.Further studies demonstrated that distinct RNA elements are required for the methylations of guanine N7 on the cap and of ribose 2'-OH on the first transcribed nucleotide.Mutant enzymes with different methylation defects can trans complement one another in vitro,demonstrating that separate molecules of the enzyme can independently catalyze the two cap methylations in vitro.In the context of the infectious virus,defects in both methylations,or a defect in the N7 methylation alone,are lethal to WNV.However,viruses defective solely in 2'-O methylation are attenuated and can protect mice from later wild-typeWNV challenge.The results demonstrate that the N7 methylation activity is essential for the WNV life cycle and,thus,methyltransferase represents a novel and promising target for flavivirus therapy. | Lihui LIU Hongping DONG Hui CHEN Jing ZHANG Hua LING Zhong LI Pei-Yong SHI Hongmin LI | 2010 | Frontiers in Biology2010，5，4： | 0 |
| 18 | Methane Adsorption on Montmorillonite, Kaolinite and Illite at High Pressures显示文摘Shale gas, which is derived from organic matters in shale and stored in shale deposits, is an important unconventional gas resource and attracts attention due to its significant requirement in the hydrocarbon production. Methane (CH4) is the dominant component of shale gas, and adsorbed gas is an important reservoir form. Many studies have investigated the adsorption capacities and adsorption mechanisms of CH4 in shale. Organic matters and clay minerals have been proposed to be the two major components for CH4 adsorption. Adsorption of CH4 in organic matters, such as the adsorption capacity and effects of characteristics of the organic matters, has been well investigated. However, studies on CH4 adsorption on clay minerals have mainly focused on evaluating the adsorption capacity, and very little information about the adsorption mechanism has been provided. For example, the adsorption sites and factors influencing CH4 adsorption on clay minerals remain unclear. Three main reasons account for this: (1) the co-existence of organic matters in samples affects the evaluation of CH4 adsorption on clay minerals; (2) the pressures used during adsorption are not representative of actual reservoir pressures; and (3) the clay minerals selected have low swelling capacity and a smaller interlayer distances than a CH4 size, resulting in the misunderstanding of the CH4 adsorption sites. | LIU Dong YUAN Peng LIU Hongmei TAN Daoyong YUAN Weiwei ZHOU Xiang HE Hongping | 2013 | 矿物学报2013，33，S1： | 0 |
| 19 | Physically Activated Diatomite-templated Carbon with High Porosity for the Adsorption of Methylene Blue显示文摘Porous carbons are extensively applied in gas separation, water purification, catalytic reaction, and electrochemical processing, attributing to their high specific surface area, large pore volume, chemical inertness, and good mechanical and thermal stability. The templating method is widely used to synthesize porous carbons with the controlled pore structure. Among them, preparation of diatomite-templated carbons attracts increasing attention because the obtained carbon has unique developed macropores and exhibits the promising application in adsorption and support of large-sized molecules. Macroporous diatomite-templated carbons are prepared by using additive or inherent solid acid sites of diatomite as the catalyst. The obtained carbons showed tubular and pillared macroporous structures, and had a few mesopores and micropores. However, the carbons possessed the small specific surface area and micropore volume, and thus showed the low adsorption capacity of small-sized molecules, such as methylene blue (MB). In this case, enhancement of porosity, especially microporosity, is necessary. | LIU Dong YUAN Weiwei YUAN Peng YU Wenbin TAN Daoyong LIU Hongmei HE Hongping | 2013 | 矿物学报2013，33，S1： | 0 |
| 20 | Role of the Interlayer Space of Montmorillonite in Hydrocarbon Generation: A Combined Study by TG-FTIR and High Temperature-Pressure Pyrolysis显示文摘The interlayer clay-organic complex is an important clay-organic association in sedimentary environments. The interlayer region of clay minerals not only provides storage space for organic matter, but also possesses solid acid sites; and these acid sites were proposed to be involved with the transformation of organic matter into liquid and gaseous hydrocarbons. However, the effect of the organic matter storage in the interlayer space of clay minerals on the hydrocarbons generation has not been made clear. In this study, the interlayer complex of 12-aminolauric acid (ALA) and Na+-montmorillonite (Na+-Mt), labeled as ALAinter-Mt (Na), was synthesized to investigate the role of the interlayer space of montmorillonite in hydrocarbon generation. Simply mixed ALA-Mt complex [ALA-Mt (Na)] was also prepared for comparison. The pyrolysis of ALA and ALA-Mt complexes was studied using thermogravimetry coupled with Fourier transform infrared spectroscopy (TG-FTIR) and a high temperature-pressure system (a confined gold capsule-autoclave system). | LIU Hongmei YUAN Peng LIU Dong ZHOU Xiang HE Hongping ZHU Jianxi | 2013 | 矿物学报2013，33，S1： | 0 |
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