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| 1 | Avoiding the innovation island in infrastructure mega-project显示文摘Infrastructure mega-project(IMP) innovation is a complex process characterized by highly diverse innovators, a dynamic life-cycle, and stickiness of innovation knowledge. The IMP's innovation network can be easily broken due to the fact that the network involves many different innovators across different industries and different projects. Further reasons for the fragility of the IMP's innovation network are the dynamics of the IMP life-cycle, the diversity of the IMP's innovative entities, the uniqueness of each IMP, and the temporary nature of each IMP's organizations. The innovation island formed by the breaking of an IMP's innovation network can stifle and harm innovation performance. Drawing from the knowledge-based view as well as innovation network theory, our research identifies the heterogeneous characteristics of IMP innovation. We propose a framework to analyze the formation mechanism of the IMP innovation island from three dimensions—the horizontal innovation island, the vertical innovation island, and the longitudinal innovation island. We look at the Hong Kong-ZhuhaiMacao Bridge project to elaborate the innovation island concept that negatively impacts IMP innovation. We also offer theoretical implications regarding the broader question of how IMPs can manage their innovation in practice. | Hongquan CHEN Quanke SU Saixing ZENG Daxin SUN Jonathan Jingsheng SHI | 2018 | Frontiers of Engineering Management2018，5，1： | 10 |
| 2 | Cloning and bioinformatics analysis of a full-length cDNA of porcine CRl-like gene显示文摘 | Jing Cheng Junbing Jiang Junxing Zhao Zhirui Wang Yaogui Sun Haili Ma Kuohai Fan Wei Yin Na Sun Zhiwei Wang Xin Zhao Hongquan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 7 |
| 3 | Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice显示文摘Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using a mammary gland-specific promoter, mammary tumor virus(MMTV) long terminal repeat(LTR). Kindlin-2 was overexpressed in the epithelial cells of the transgenic mice. The mammary gland ductal trees were found to grow faster in MMTV-Kindlin-2 transgenic mice than in control mice during puberty. Kindlin-2 promoted mammary gland growth as indicated by more numerous duct branches and larger lumens, and more alveoli were formed in the mammary glands during pregnancy under Kindlin-2 overexpression. Importantly, mammary gland-specific expression of Kindlin-2 induced tumor formation at the age of 55 weeks on average. Additionally, the levels of estrogen receptor and progesterone receptor were decreased, whereas human epidermal growth factor receptor 2 and β-catenin were upregulated in the Kindlin-2-induced mammary tumors. These findings demonstrated that Kindlin-2 induces mammary tumor formation via activation of the Wnt signaling pathway. | Bing Li Xiaochun Chi Jiagui Song Yan Tang Juan Du Xiaokun He Xiaoran Sun Zhenwu Bi Yunling Wang Jun Zhan Hongquan Zhang | 2019 | Science China(Life Sciences)2019，62，2： | 6 |
| 4 | Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention显示文摘 | Yuhua Li Li Liu Yinbo Niu Juan Feng Yang Sun Xianghe Kong Yongchun Chen Xiaoyan Chen Hongquan Gan Shousong Cao Qibing Mei | 2012 | European Journal of Nutrition2012，，1： | 1 |
| 5 | Controllable synthesis and luminescent properties of three-dimensional nanostructured CaWO 4 :Tb 3+ microspheres显示文摘 | Yue Tian Baojiu Chen Hongquan Yu Ruinian Hua Xiangping Li Jiashi Sun Lihong Cheng Haiyang Zhong Jinsu Zhang Yanfeng Zheng Tingting Yu Libo Huang | 2011 | Journal of Colloid And Interface Science2011，，2： | 1 |
| 6 | Study on Environmental Multi-parameter Sensor Based on MEMS显示文摘A new membrane type Al_2O_3 micromachining material is used.We develop an environmental multi-parameter detection micro-system,which implements the detection to temperature,humidity,wind speed,and CO.The test results illustrate that the heat-release unit in micro-system intercross greatly affects other sensing units on the temperature.We study the method of etching process,which formed cavity to reduce the heat exchange efficiency and decrease temperature intercross effect. | Hongquan Zhang Tong Zhang Likai Sun Yunbo Shi Jianying Guo | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
| 7 | Chemo-and radioprotective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs显示文摘 | ZHANG Hongquan LIN Anping SUN Yun | 2001 | Acta Pharmacol Sin2001，22，12： | 1 |
| 8 | Effects of Bi^(3+) on down-/up-conversion luminescence,temperature sensing and optical transition properties of Bi^(3+)/Er^(3+)co-doped YNbO_(4) phosphors显示文摘A series of YNbO_(4):Bi^(3+) and YNbO_(4):Bi^(3+)/Er^(3+) phosphors were prepared by a conventional high temperature solid-state reaction method.The results of XRD and Rietveld refinement confirm that monoclinic phase YNbO_(4)samples are achieved.The down-/up-conversion luminescence of Er^(3+) ions was investigated under the excitation of ultraviolet light(327 nm)and near infrared light(980 nm).Under 327 nm excitation,broad visible emission band from Bi^(3+) ions and characteristic green emission peaks from Er^(3+) ions are simultaneously observed,while only strong green emissions from Er^(3+) ions are detected upon excitation of 980 nm.Remarkable emission enhancement is observed in down-/up-conversion luminescence processes by introducing Bi^(3+) ions into Er^(3+)-doped YNbO_(4)phosphors.Pumped current versus up-conversion emission intensity study shows that two-photon processes are responsible for both the green and the red up-conversion emissions of Er^(3+)ion.Through the study of the temperature sensing property of Er^(3+) ion,it is affirmed that the temperature sensitivity is sensitive to the doping concentration of Bi^(3+) ions.By comparing the experimental values of the radiative transition rate ratio of the two green emission levels of Er^(3+) ions and the theoretical values calculated by Judd-Ofelt(J-O)theory,it is concluded that the temperature sensing property of Er^(3+) ions is greatly affected by the energy level splitting. | Xin Wang Xiangping Li Hongquan Yu Sai Xu Jiashi Sun Lihong Cheng Xizhen Zhang Jinsu Zhang Yongze Cao Baojiu Chen | 2022 | Journal of Rare Earths2022，40，3： | 1 |
| 9 | The study on bivariate fractal interpolation functions and creation interpolation surfaces显示文摘 | Heping Xie Hongquan Sun | 1997 | Fractals1997，5，4： | 1 |
| 10 | Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs显示文摘 | Zhang HongQuan Lin AnPing Sun Yun | 2001 | Acta Pharmacol Sin2001，12，22： | 1 |
| 11 | Strigolactone/MAX2-Induced Degradation of Brassinosteroid Transcriptional Effector BES1 Regulates Shoot Branching显示文摘 | Yuan Wang Shiyong Sun Wenjiao Zhu Kunpeng Jia Hongquan Yang Xuelu Wang | 2013 | Developmental Cell2013，，6： | 1 |
| 12 | Acteoside protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell injury显示文摘 | Hongquan Wang Yuxia Xu Jie Yan Xiaoyan Zhao Xiaobo Sun Yanping Zhang Jingchun Guo Cuiqing Zhu | 2009 | Brain Research2009，，： | 1 |
| 13 | Study on generation of rock fracture surfaces by using fractal interpolation显示文摘 | Xie Heping Sun Hongquan Ju Yong | 2001 | International Journal of Solids and Structures2001，38，3233： | 1 |
| 14 | The concentration effect of upconversion luminescence properties in Er 3+ /Yb 3+ -codoped Y 2 (MoO 4 ) 3 phosphors显示文摘 | Weili Lu Lihong Cheng Jiashi Sun Haiyang Zhong Xiangping Li Yue Tian Jing Wan Yanfeng Zheng Libo Huang Tingting Yu Hongquan Yu Baojiu Chen | 2010 | Physica B: Physics of Condensed Matter2010，，16： | 1 |
| 15 | Microwave-assisted hydrothermal synthesis and temperature sensing application of Er 3+ /Yb 3+ doped NaY(WO 4 ) 2 microstructures显示文摘 | Hui Zheng Baojiu Chen Hongquan Yu Jinsu Zhang Jiashi Sun Xiangping Li Min Sun Bining Tian Shaobo Fu Hua Zhong Bin Dong Ruinian Hua Haiping Xia | 2014 | Journal of Colloid And Interface Science2014，，： | 1 |
| 16 | Doing a Good Job in Inspection and Maintenance of Facilities and Equipments in Bulk Curing Barn显示文摘Due to the limited management funds and insufficient management efforts,curing barns in traditional tobacco area are outdated and equipments are seriously damaged,which affects the normal operation and increases the maintenance cost of bulk curing barns,bringing adverse effects on tobacco leaf curing in the coming year and the sustainable development of tobacco industry in the future.To ensure the normal operation of curing barns and effectively prolong the service life of curing barns during tobacco leaf curing,we should do a good job in the publicity of management and maintenance,improve the system of management and maintenance,raise funds for management and maintenance,inspect facilities and equipments,carefully maintain equipments in curing barn and strictly perform examination and inspection. | Yonghua CHEN Hongquan SUN Pengzhen LONG Guoquan LIU Taiwei LIU Pengyu LU | 2022 | Plant Diseases and Pests2022，13，3： | 0 |
| 17 | Dynamic optimization analysis of hydraulic pipeline system based on a developed response surface method显示文摘When designing a complex pipeline with long distance and multi-supports for offshore platform,it is necessary to analyze the vibration characteristics of the complex pipeline system to ensure that there is no harmful resonance in the working conditions.Therefore,the optimal layout of support is an effective method to reduce the vibration response of hydraulic pipeline system.In this paper,a developed dynamic optimization method for the complex pipeline is proposed to investigate the vibration characteristics of complex pipeline with multi-elastic supports.In this method,the Kriging response surface model between the support position and pipeline is established.The position of the clamp in the model is parameterized and the optimal solution of performance index is obtained by genetic algorithm.The number of clamps and the interval between clamps are considered as the constraints of layout optimization,and the optimization objective is the natural frequencies of pipeline.Taking a typical offshore pipeline as example to demonstrate the effectiveness of the proposed method,the results show that the vibration performance of the hydraulic pipeline system is distinctly improved by the optimization procedure,which can provide reasonable guidance for the design of complex hydraulic pipeline system. | Hongquan QU Jianlin SUN Xu YAN Yuanlin ZHANG Xuefeng LIU Tao YU HuaweiHAN Langjun XU | 2020 | Mechanical Engineering Science2020，2，2： | 0 |
| 18 | Traveling wave solutions for a discrete diffusive epidemic model with asymptomatic carriers显示文摘This paper mainly concerns about the traveling wave solution(TwS)for a discrete diffusive epidemic model with asymptomatic carriers.Analysis of the model shows that the minimum wave speed c*exists if a threshold is greater than one.With the help of sub-and super-solutions,we find that the condition for the existence of TWS is R>1 and wave speed c>c^(*).Further,we prove that the TwS connects two different boundary steady states.Through the arguments with Laplace transform,we show there is no TWS for the model if R>1 and o | Ran Zhang Dan Li Hongquan Sun | 2023 | International Journal of Biomathematics2023，16，2： | 0 |
| 19 | Comparison of Benefits of Different Tobacco Loading Methods and Matching Baking Processes in Intensive Curing Houses显示文摘[Objectives]To compare the benefits of different tobacco loading methods and supporting baking processes in intensive curing houses.[Methods]Flue-cured tobacco variety K326 was taken as material,and comparative experiment on baking effects of six tobacco loading methods(traditional hanging pole,loose leaf stacking,loose leaf binding and inserting,loose leaf inserting,loose leaf net basket,loose leaf grid)was conducted.[Results]Cost of dry tobacco loading equipment for hanging pole and loose leaf stacking was 0.01 and 0.1 yuan/kg,and cost of tobacco loading by loose leaf basket reached 0.36 yuan/kg.Labor cost for baking dry tobacco by direct stacking of loose leaves reached 2.02 yuan/kg,which was the lowest,while labor cost for binding and inserting loose leaves reached 2.44 yuan/kg,which was the highest.Energy consumption cost of dry tobacco baking with loose leaf grid was 1.06 yuan/kg,which was the lowest,while baking energy consumption cost of loose leaf stacking reached 1.23 yuan/kg,which was the highest.From the perspective of baking income,loose leaf inserting reached 21.36 yuan/kg,which was the lowest,while net basket reached 27.79 yuan/kg,which was the highest,followed by grid(23.46 yuan/kg)and loose leaf binding and inserting(22.5 yuan/kg).[Conclusions]It is worth popularizing the loose leaf binding and inserting and the loose leaf grid baking. | Yonghua CHEN Hongquan SUN Yongfeng AI Jinzhong SHI Pengzhen LONG Guoquan LIU Taiwei LIU | 2022 | Asian Agricultural Research2022，14，10： | 0 |
| 20 | Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the ninth most common human malignancy and the sixth leading cause of cancer-related death in China.AcK27-HOXB9 is a newly identified HOXB9 post-transcriptional modification that can predict the outcome in lung adenocarcinoma and colon cancer well.However,the role of AcK27-HOXB9 in PDAC is unclear.The present study aims to investigate the differential diagnostic role of patients with AcK27-HOXB9 PDAC.Tissue microarrays consisting of 162 pancreatic tumor tissue samples from patients with PDAC and paired normal subjects were used to examine HOXB9 and AcK27-HOXB9 levels and localizations by immunohistochemical analysis and Western blot assay,respectively.HOXB9 was upregulated(P<0.0001),and AcK27-HOXB9(P=0.0023)was downregulated in patients with PDAC.HOXB9 promoted(P=0.0115),while AcK27-HOXB9(P=0.0279)inhibited PDAC progression.AcK27-HOXB9 predicted favorable outcome in patients with PDAC(P=0.0412).AcK27-HOXB9 also suppressed PDAC cell migration in a cell migration assay.The results of this study showed that HOXB9 promoted and AcK27-HOXB9 suppressed PDAC progression.The determination of ratio between HOXB9 and AcK27-HOXB9 exhibited potential diagnostic value in patients with PDAC. | Xiaoran Sun Jiagui Song Jing Zhang Jun Zhan Weigang Fang Hongquan Zhang | 2020 | Frontiers of Medicine2020，14，1： | 0 |
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