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| 1 | Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis显示文摘OBJECTIVE:To investigate the effectiveness of Banxia Xiexin decoction(BXD)in a rat model of chronic atrophic gastritis(CAG).METHODS:Sixty 6-week-old healthy Wistar rats(30 males,30 females)were used in the present study.A rat model of CAG was successfully established using the combined active immunization/ethanol/sodium deoxycholate method.BXD was prepared from a mixture of seven Chinese herbs,and was intragastrically administered to CAG rats at three different doses(6,12,and 24 g·kg^-1·d^-1).Af-ter 24 weeks,the rats were euthanized,and gastric tissue specimens were collected.Gastric mucosal specimens were stained with hematoxylin and eosin for histological examination to evaluate the degree of inflammation and morphological changes.Immunohistochemical staining was performed to examine the mucosal expression of proliferating cell nuclear antigen.Serum gastrin levels were measured using radioimmunoassay.The expression of Notch signaling-associated genes was examined by quantitative polymerase chain reaction and Western blot assay.RESULTS:BXD at all three doses significantly reversed the adverse effects generated by CAG in rats.Compared with control rats,the CAG rats who were administered BXD had an accelerated growth rate,reduced inflammatory cell infiltration,improved gastric mucosal morphology,augmented thickness of the gastric mucosa,increased number of gastric glands,enhanced mucosal expression of proliferating cell nuclear antigen,and elevated serum gastrin levels. | Bai Yu Chen Yongcan Chen Yu Yan Maoxiang Wei Hongquan Wang Hengcang Zeng Guoliang Yang Xiyin | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 14 |
| 2 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 3 | Fast Secret Key Generation Based on Dynamic Private Pilot from Static Wireless Channels显示文摘In static or quasi-static wireless channel environments, secret key generation(SKG) based on wireless channels is vulnerable to active attacks due to the openness and invariance of public pilot, especially man-inthe-middle(MITM) attacks, where attacker acts as a transparent relay to manipulate channel measurements and derive the generated keys. In order to fight against this attack, a dynamic private pilot is designed, where both private pilot and secret key are derived from the characteristics of wireless channels and private to third party. In static or quasi-static environments, we use singular value decomposition techniques to reconstitute the wireless channels to improve the randomness of the wireless channels. Private pilot can encrypt and authenticate the wireless channels, which can make channel state information intercepted by MITM attacker reduced to zero and the SKG rate close to that without attacks. Results of analysis and simulation show the proposed SKG scheme can withdraw the MITM attacks. | Yu Huang Liang Jin Hongquan Wei Zhou Zhong Shengjun Zhang | 2018 | China Communications2018，15，11： | 4 |
| 4 | The application of three-dimensional seismic spectral decomposition and semblance attribute to characterizing the deepwater channel depositional elements in the Taranaki Basin of New Zealand显示文摘In the past few years, three-dimensional(3-D) seismogram has become an essential tool for the interpretation of subsurface stratigraphy and depositional systems. Seismic stratigraphy in conjunction with seismic geomorphology has elevated the degree to which seismic data can facilitate geological interpretation, especially in a deepwater environment. Technologies such as time slicing and interval attribute analysis can enhance geomorphological interpretations, and, when integrated with stratigraphic analyses, can yield insights regarding distribution of seal and reservoir facies. Multiple attributes corendering can further bring out features of geological interest that other technologies may overlook. This method involves corender spectral decomposition components(SDC) with semblance attributes to describe the distribution of deepwater channel elements and the boundaries of deepwater sinuous channel. Applying this technology to four elements is observed:(1) point-bars,(2) migration of channel meander loops,(3) channel erosion/cut, and(4) avulsion. The planview expression of the deepwater channel ranges from low sinuosity to high sinuosity. Furthermore, this technology has enabled interpreters to visualize details of complex depositional elements and can be used to predict net-to-gross ratio in channel systems, which can be incorporated into borehole planning for exploration as well as development needs to improve risk management significantly. The technology is applied to the study area in an effort to illustrate the variety of interpretation technologies available to the geoscientist. | LI Quan WU Wei YU Shui KANG Hongquan TONG Liqing CAO Xiangyang LIU Xiaolong | 2017 | Acta Oceanologica Sinica2017，36，9： | 3 |
| 5 | The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis显示文摘PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor progression.Inhibition of DNA methyltransferases(DNMTs)leads to elevated hyaluronan levels;however,whether DNMT inhibitors control PH20 remains unclear.Here,we report that the DNMT1 inhibitor,decitabine,suppresses PH20 expression by activating the long non-coding RNA PHACTR2-AS1(PAS1).PAS1 forms a tripartite complex with the RNA-binding protein vigilin and histone methyltransferase SUV39H1.The interaction between PAS1 and vigilin maintains the stability of PAS1.Meanwhile,PAS1 recruits SUV39H1 to trigger the H3K9 methylation of PH20,resulting in its silencing.Functionally,PAS1 inhibits breast cancer growth and metastasis,at least partially,by suppressing PH20.Combination therapy of decitabine and PAS1-30nt-RNA,which directly binds to SUV39H1,effectively blocked breast cancer growth and metastasis in mice.Taken together,DNMT1,PAS1,and PH20 comprise a regulatory axis to control breast cancer growth and metastasis.These findings reveal that the DNMT1-PAS1-PH20 axis is a potential therapeutic target for breast cancer. | Yenan Fu Xi Zhang Xiao Liu Peng Wang Wenhui Chu Wei Zhao Yunling Wang Guangbiao Zhou Yu Yu Hongquan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 6 | Impact of gravitation on gaseous pollutant source identification显示文摘It is necessary to identify a gaseous pollutant source rapidly so that prompt actions can be taken, but this is one of the difficulties in the inverse problem areas. In this paper, an approach to identifying a sudden continuous emission pollutant source based on single sensor information is developed to locate a source in an enclosed space with a steady velocity field. Because the gravity has a very important influence on the gaseous pollutant transport and the source identification, its influence is analyzed theoretically and a conclusion is drawn that the velocity of fluid is a key factor to effectively help weaken the gravitational influence. Further studies for a given 2-D case by using the computational fluid dynamics (CFD) method show that when the velocity of inlet is less than one certain value, the influence of gravity on the pollutant transport is very significant, which will change the velocity field obviously. In order to quantitatively judge the practical applicability of identification approach, a synergy degree of the velocity fields before and after a source appearing is proposed as a condition for considering the influence of gravity. An experimental device simulating pollutant transmission was set up and some experiments were conducted to verify the practical application of the above studies in the actual gravitational environment. The results show that the proposed approach can successfully locate the sudden constant source when the experimental situations meet the identified conditions. | Pang Liping Zhang Yu Qu Hongquan Hu Tao Zhao Jingquan | 2013 | Chinese Journal of Aeronautics2013，26，2： | 2 |
| 7 | Electrospinning preparation and characterization of polyoxometalate fibers显示文摘Poly(vinyl alcohol)/K7[SiW11O39Co(H3P2- O7)] hybrid fine fiber mats (PVA/SiW11Co-P2O7) were prepared through electrospinning technique. After calcinations of PVA/SiW11Co-P2O7 at 500℃ for 8 h, pure SiW11Co-P2O7 fine fibers were obtained with the Keggin structure keeping unchanged. The fiber mats were characterized by IR, ESR, PXRD and scanning electron microscopy (SEM) methods. The average diameter of the fibers is about 250 nm. The SiW11Co- P2O7 fibers showed color change when absorbing and desorbing moisture. | YU Hongquan PENG Jun GUAN Hongyu XIN Zhifeng PAN Yan GONG Jian SHAO Changlu DONG Baoxia | 2006 | Chinese Science Bulletin2006，51，8： | 2 |
| 8 | Controllable synthesis and luminescent properties of three-dimensional nanostructured CaWO 4 :Tb 3+ microspheres显示文摘 | Yue Tian Baojiu Chen Hongquan Yu Ruinian Hua Xiangping Li Jiashi Sun Lihong Cheng Haiyang Zhong Jinsu Zhang Yanfeng Zheng Tingting Yu Libo Huang | 2011 | Journal of Colloid And Interface Science2011，，2： | 1 |
| 9 | Study on Temperature Modulation Techniques for Micro Gas Sensors显示文摘The sensitivity and selectivity of gas sensors are related with not only sensing material,but also their operating temperatures.Applying this property,temperature modulation technique has been proposed to improve the selectivity of gas sensors.With a newly developed alumina based micro gas sensor,the sensitivity to CO and CH_4 at different operating temperatures was investigated.By modulating the temperature of the sensor at pulse and sine wave modes with different frequencies and amplitudes,the dynamic responses of the sensor were measured and processed.Results show that the modulating waveshape plays an important role in the improvement of selectivity,while the influence of frequency is small at the suitable sampling frequency in the range of 25 mHz~200 mHz. | Guangfen Wei Zhenan Tang Hongquan Zhang Yanbing Xue Jun Yu | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
| 10 | New Supercritical Fluid Extraction Treatment Method for Determination of Tripterine in Tripterygium wilfordii Hook. F显示文摘 | Hongru Li Shufen Li Yu Zhang Hongquan Duan | 2008 | Journal of Liquid Chromatography & Related Technologies2008，，10： | 1 |
| 11 | Electrospinning Preparation, Structure, and Photoluminescence Properties of YBO3: Eu^3+ Nanotubes and Nanowires 显示文摘 | Song Hongwei Yu Hongquan Pan Guohui | 2008 | Chemistry of Materials2008，20，14： | 1 |
| 12 | Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family显示文摘 | Yu Yu Junzhou Wu Lizhao Guan Lihua Qi Yan Tang Bo Ma Jun Zhan Yunling Wang Weigang Fang Hongquan Zhang | 2013 | Int J Cancer2013，，6： | 1 |
| 13 | Kindlin-2 promotes genome instability in breast cancer cells显示文摘 | Ting Zhao Lizhao Guan Yu Yu Xuelian Pei Jun Zhan Ling Han Yan Tang Feng Li Weigang Fang Hongquan Zhang | 2012 | Cancer Letters2012，，： | 1 |
| 14 | Effects of Bi^(3+) on down-/up-conversion luminescence,temperature sensing and optical transition properties of Bi^(3+)/Er^(3+)co-doped YNbO_(4) phosphors显示文摘A series of YNbO_(4):Bi^(3+) and YNbO_(4):Bi^(3+)/Er^(3+) phosphors were prepared by a conventional high temperature solid-state reaction method.The results of XRD and Rietveld refinement confirm that monoclinic phase YNbO_(4)samples are achieved.The down-/up-conversion luminescence of Er^(3+) ions was investigated under the excitation of ultraviolet light(327 nm)and near infrared light(980 nm).Under 327 nm excitation,broad visible emission band from Bi^(3+) ions and characteristic green emission peaks from Er^(3+) ions are simultaneously observed,while only strong green emissions from Er^(3+) ions are detected upon excitation of 980 nm.Remarkable emission enhancement is observed in down-/up-conversion luminescence processes by introducing Bi^(3+) ions into Er^(3+)-doped YNbO_(4)phosphors.Pumped current versus up-conversion emission intensity study shows that two-photon processes are responsible for both the green and the red up-conversion emissions of Er^(3+)ion.Through the study of the temperature sensing property of Er^(3+) ion,it is affirmed that the temperature sensitivity is sensitive to the doping concentration of Bi^(3+) ions.By comparing the experimental values of the radiative transition rate ratio of the two green emission levels of Er^(3+) ions and the theoretical values calculated by Judd-Ofelt(J-O)theory,it is concluded that the temperature sensing property of Er^(3+) ions is greatly affected by the energy level splitting. | Xin Wang Xiangping Li Hongquan Yu Sai Xu Jiashi Sun Lihong Cheng Xizhen Zhang Jinsu Zhang Yongze Cao Baojiu Chen | 2022 | Journal of Rare Earths2022，40，3： | 1 |
| 15 | Preparation and luminescent properties of europium-doped yttria fibers by electrospinning显示文摘 | YU Hongquan SONG Hongwei PAN Guohui | 2007 | Journal of Luminescence2007，124，1： | 1 |
| 16 | A competitive chemiluminescence enzyme immunoassay for rapid and sensitive determination of enrofloxacin显示文摘 | Fei Yu Yongjun Wu Songcheng Yu Huili Zhang Hongquan Zhang Lingbo Qu Peter de B. Harrington | 2012 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2012，，： | 1 |
| 17 | Ring- opening polymerization of epichlorohydrin and its copolymeriza- tion with other alkylene oxides by quaternary catalyst system 显示文摘 | Xie Hongquan Guo Junshi Yu Guangquan | 2001 | Journal of Applied Polymer Selene2001，80，13： | 1 |
| 18 | Depletion of Kindlin-2 induces cardiac dysfunction in mice显示文摘Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy(HCM) or dilated cardiomyopathy(DCM). Our previous investigation showed that Kindlin-2 is mainly localized at the Z-disc and depletion of Kindlin-2 disrupts the structure of the Z-Disc. Here, we reported that depletion of Kindlin-2 leads to the disordered myocardial fibers, fractured and vacuolar degeneration in myocardial fibers. Interestingly, depletion of Kindlin-2 in mice induced cardiac myocyte hypertrophy and increased the heart weight. Furthermore, decreased expression of Kindlin-2 led to cardiac dysfunction and also markedly impairs systolic function. Our data indicated that Kindlin-2 not only maintains the cardiac structure but also is required for cardiac function. | Lihua Qi Yu Yu Xiaochun Chi Danyu Lu Yao Song Youyi Zhang Hongquan Zhang | 2016 | Science China(Life Sciences)2016，59，11： | 1 |
| 19 | Adult stages of hypospa- dias operation显示文摘 | Sheng Xujun Geng Hongquan Wu Yu | 2013 | Chinese Journal of andrology2013，19，12： | 1 |
| 20 | The concentration effect of upconversion luminescence properties in Er 3+ /Yb 3+ -codoped Y 2 (MoO 4 ) 3 phosphors显示文摘 | Weili Lu Lihong Cheng Jiashi Sun Haiyang Zhong Xiangping Li Yue Tian Jing Wan Yanfeng Zheng Libo Huang Tingting Yu Hongquan Yu Baojiu Chen | 2010 | Physica B: Physics of Condensed Matter2010，，16： | 1 |
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