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| 1 | Failure behavior of a rock-coal-rock combined body with a weak coal interlayer显示文摘Using an MTS 815 testing machine,the deformation and failure behavior of a rock-coal-rock combined body containing a weak coal interlayer has been investigated and described in this paper.Uniaxial loading leads to the appearance of mixed cracks in the coal body which induce instability and lead to bursts in coal.If the mixed crack propagates at a sufficiently high speed to carry enough energy to damage the roof rock,then coal and rock bursts may occur-this is the main mechanism whereby coal bumps or coal and rock bursts occur after excavation unloading.With increasing confining pressure,the failure strength of a rock-coal-rock combined body gradually increases,and the failure mechanism of the coal interlayer also changes,from mixed crack damage under low confining pressures,to parallel crack damage under medium confining pressures,and finally to single shear crack damage or integral mixed section damage under high confining pressures.In general,it is shown that a weak coal interlayer changes the form of overall coal damage in a rock-coal-rock combined body and reduces the overall stability of a coal body.Therefore,the whole failure behavior of a rock-coal-rock combined body in large cutting height working faces is controlled by these mechanisms. | Zuo Jianping Wang Zhaofeng Zhou Hongwei Pei Jianliang Liu Jianfeng | 2013 | International Journal of Mining Science and Technology2013，23，6： | 32 |
| 2 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 3 | QTG-Seq Accelerates QTL Fine Mapping through QTL Partitioning and Whole-Genome Sequencing of Bulked Segregant Samples显示文摘Deciphering the genetic mechanisms underlying agronomic traits is of great importance for crop improvement. Most of these traits are controlled by multiple quantitative trait loci (QTLs), and identifying the underlying genes by conventional QTL fine-mapping is time-consuming and labor-intensive. Here, we devised a new method, named quantitative trait gene sequencing (QTG-seq), to accelerate QTL fine-mapping. QTGseq combines QTL partitioning to convert a quantitative trait into a near-qualitative trait, sequencing of bulked segregant pools from a large segregating population, and the use of a robust new algorithm for identifying candidate genes. Using QTG-seq, we fine-mapped a plant-height QTL in maize (Zea mays L.), qPH7, to a 300-kb genomic interval and verified that a gene encoding an NF-YC transcription factor was the functional gene. Functional analysis suggested that qPH7-encoding protein might influence plant height by interacting with a CO-like protein and an AP2 domain-containing protein. Selection footprint ana卜 ysis indicated that qPH7 was subject to strong selection during maize improvement. In summary, QTG-seq provides an efficient method for QTL fine-mapping in the era of “big data'. | Hongwei Zhang Xi Wang Qingchun Pan Pei Li Yunjun Liu Xiaoduo Lu Wanshun Zhong Minqi Li Linqian Han Juan Li Pingxi Wang Dongdong Li Yan Liu Qing Li Fang Yang Yuan-Ming Zhang Guoying Wang Lin Li | 2019 | Molecular Plant2019，12，3： | 13 |
| 4 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 5 | Public Key Cryptography Based on Ergodic Matrices over Finite Field显示文摘A new public key encryption scheme is proposed in this paper, which is based on a hard problem over ergodic matrices. The security of this scheme is equal to the MQ-problem: multivariate quadratic equations over finite fields. This problem has been shown to be NP-complete and can’t be solved with polynomial time algorithm. | PEI Shihui ZHAO Hongwei ZHAO Yongzhe | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 8 |
| 6 | Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection显示文摘The coronavirus disease 2019(COVID-19)pandemic is caused by infection with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is spread primary via respiratory droplets and infects the lungs.Currently widely used cell lines and animals are unable to accurately mimic human physiological conditions because of the abnormal status of cell lines(transformed or cancer cells)and species differences between animals and humans.Organoids are stem cell-derived selforganized three-dimensional culture in vitro and model the physiological conditions of natural organs.Here we showed that SARS-CoV-2 infected and extensively replicated in human embryonic stem cells(hESCs)-derived lung organoids,including airway and alveolar organoids which covered the complete infection and spread route for SARS-CoV-2 within lungs.The infected ceils were ciliated,club,and alveolar type 2(AT2)cells,which were sequentially located from the proximal to the distal airway and terminal alveoli,respectively.Additionally,RNA-seq revealed early cell response to virus infection including an unexpected downregulation of the metabolic processes,especially lipid metabolism,in addition to the well-known upregulation of immune response.Further,Remdesivir and a human neutralizing antibody potently inhibited SARS-CoV-2 replication in lung organoids.Therefore,human lung organoids can serve as a pathophysiological model to investigate the underlying mechanism of SARS-CoV-2 infection and to discover and test therapeutic drugs for COVID-19. | Rongjuan Pei Jianqi Feng Yecheng Zhang Hao Sun Lian Li Xuejie Yang Jiangping He Shuqi Xiao Jin Xiong Ying Lin Kun Wen Hongwei Zhou Jiekai Chen Zhili Rong Xinwen Chen | 2021 | Protein & Cell2021，12，9： | 7 |
| 7 | Expression and function of Delta-like ligand 4 in a rat model of retinopathy of prematurity显示文摘The Delta-like ligand 4/Notch signaling pathway was shown to participate in the process of retinal development and angiogenesis.However,the function of the Delta-like ligand 4/Notch signaling pathway in retinopathy of prematurity requires further study.Retinopathy of prematurity was induced in 5-day-old Sprague-Dawley rats exposed to hyperoxia for 7 days,and then returned to room air.Reverse transcription-PCR and western blot revealed that Delta-like ligand 4 levels decreased at postnatal day 12 and increased at postnatal day 17 in retinopathy of prematurity rats.Flat-mounted adenosine diphosphatase stained retina and hematoxylin-eosin stained retinal tissue slices showed that the clock hour scores and the nuclei counts in retinopathy of prematurity rats were significantly different compared to normal control rats.After retinopathy of prematurity rats were intravitreally injected with Delta-like ligand 4 monoclonal antibody to inhibit the Delta-like ligand 4/Notch signaling pathway,there was a significant increase in the severity of retinal neovascularization (clock hours) in the intravitreally injected eyes.The nuclei count was highly correlated with the clock hour score.These results suggest that Delta-like ligand 4/Notch signaling plays an essential role in the process of physiological and pathological angiogenesis in the retina. | Shaoyang Shi Xun Li You Li Cunwen Pei Hongwei Yang Xiaolong Chen | 2013 | Neural Regeneration Research2013，8，8： | 4 |
| 8 | Comparison of winter wheat yield sensitivity to climate variables under irrigated and rain-fed conditions显示文摘庄稼模拟模型提供决定庄稼产量的敏感到气候变化的其他、不太费时间、划算的工具。在这研究,二个动态机械学的模型,谷神星(庄稼环境资源合成)和 APSIM (农业生产系统模拟器),被用来在灌溉的井( CFG )下面模仿小麦( Triticum aestivum L.)的收益并且喂雨( YY )在北方中国平原( NCP )在与不同气候变量的关系调节。学习测试了冬季小麦收益敏感到温度,放射,降水,和大气的二氧化碳的不同层次(在在在 NCP 的 Luancheng Agro 生态系统试验性的车站的 CFG 和 YY 条件下面的公司 2) 集中。从 CERES 和 APSIM 小麦庄稼模型的结果大部分是一致的并且建议在气候变量的变化在 NCP 影响了小麦谷物产量。也在到在不同的水(CFG 和 YY ) 下面的气候变量的产量调节的冬季小麦的敏感有重要变化。当时 2 湩漠桴牥瀠潥汰 e 的温度增加? | Dengpan XIAO Yanjun SHEN He ZHANG Juana P. MOIWO Yongqing QI Rende WANG Hongwei PEI Yucui ZHANG Huitao SHEN | 2016 | Frontiers of Earth Science2016，10，3： | 4 |
| 9 | Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older显示文摘This study investigated whether high-normal thyrotropin(TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old.Clinical and metabolic factors were assessed in 2,356 subjects(40-77 years old) with TSH levels in the normal range(0.35-5.00 mU/L).Using 2.50 mU/L as the cut-off point of TSH level within the normal range,we divided subjects into the high-TSH(2.50-5.00 mU/L;n= 1,064) and low-TSH(0.35-2.50mU/L;n= 1,292) group.The results showed that the mean levels of body mass index(BMI),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),and fasting plasma glucose(FPG) were higher in the high-TSH group and TSH levels were significantly positively con-elated with BMI,LDL-C,TC,and FPG.The prevalence of central obesity,hypertriglyceridemia,low high density lipoprotein cholesterol(HDL-C),and high FPG(>5.60 mmol/L) was significantly higher in females and subjects with high-TSH levels.Metabolic syndrome was also more prevalent in the high-TSH group.People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of metabolic syndrome,compared with those with low-normal TSII levels,after adjusting for age and gender.In conclusion,high normal TSH is a risk factor for metabolic syndrome in people ≥40 years old. | Bojin Xu Hui Yang Zhixiao Wang Tao Yang Hongwei Guo Pei Cheng Wei He Min Sun Huanhuan Chen Yu Duan | 2016 | The Journal of Biomedical Research2016，30，6： | 4 |
| 10 | Tuning the properties of Ni-based catalyst via La incorporation for efficient hydrogenation of petroleum resin显示文摘The hydrogenation of petroleum resin(PR)is an effective process to prepare high value-added hydrogenated PR(HPR).However,the preparation of non-noble metal-based catalysts with high catalytic activity for PR hydrogenation still remains a challenge.Herein,a La promoted Ni-based catalyst is reported through the thermal reduction of quaternary Ni La Mg Al-layered double hydroxides(Ni La Mg Al-LDHs).The incorporation of La is beneficial to the reduction and stability of Ni particles with reduced particle size,and the increased alkalinity effectively mitigates the breakage of molecular chains of PR.As a result,the La promoted Ni-based catalyst exhibits high catalytic activity and excellent stability for PR hydrogenation.A hydrogenation degree of 95.4%and 96.1%can be achieved for HC_(5)PR and HC_(9) PR with less reduced softening point,respectively.Notably,the hydrogenation degree still maintains at 92.7%even after 100 hours’reaction,much better than that without La incorporation or prepared using conventional impregnation method. | Qunhong Liu Jiangtao Yang Hongwei Zhang Hongming Sun Shuzheng Wu Bingqing Ge Rong Wang Pei Yuan | 2022 | Chinese Journal of Chemical Engineering2022，35，5： | 2 |
| 11 | Dasatinib inhibits proliferation of liver cancer cells,but activation of Akt/mTOR compromises dasatinib as a cancer drug显示文摘Dasatinib is a multi-target protein tyrosine kinase inhibitor.Due to its potent inhibition of Src,Abl,the platelet-derived growth factor receptor(PDGFR)family kinases,and other oncogenic kinases,it has been investigated as a targeted therapy for a broad spectrum of cancer types.However,its efficacy has not been significantly extended beyond leukemia.The mechanism of resistance to dasatinib in a wide array of cancers is not clear.In the present study,we investigated the effect of dasatinib on hepatocellular carcinoma cell growth and explored the underlying mechanisms.Our results showed that dasatinib potently inhibited the proliferation of SNU-449 cells,but not that of other cell lines,such as SK-Hep-1,even though it inhibited the phosphorylation of Src on both negative and positive regulation sites in all these cells.Dasatinib activated the phosphoinositide-dependent protein kinase1(PDK1)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway in SK-Hep-1 cells,but not in SNU-449 cells.Blocking the Akt/mTOR signaling pathway strongly promoted the efficacy of dasatinib in SK-Hep-1 cells.In SNU-449 cells,dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7,induced cell cycle arrest in the G1 phase,and inhibited the expression of Cyclin-dependent kinase(CDK4)/6/CyclinD1 complex.These findings demonstrate that dasatinib exerts its anti-proliferative effect on hepatocellular cell proliferation by blocking the Src family kinases;however,it causes Akt activation,which compromises dasatinib as an anti-cancer drug. | Chang Liu Xiaoxia Zhu Yuqi Jia Fenqing Chi Keru Qin Jinhong Pei Chan Zhang Xiuli Mu Hongwei Zhang Xiushan Dong Jun Xu Baofeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 12 | Effect of Mn on the formation of Mg-based spherical icosahedral quasicrystal phase 显示文摘 | Zhang Jinshan Du Hongwei Pei Li-xia | 2007 | J Alloys Compounds2007，427，： | 1 |
| 13 | Self-twisting for macrochirality from an achiral asterisk molecule with fluorescence-phosphorescence dual emission显示文摘Understanding of the role of supramolecular chirality for tuning material optoelectronic properties has been restricted by the limited number of cases. A particular challenge is to impose supramolecular chirality onto multicolor luminescent systems that can emit in aggregation state. Here we present a selfassembly strategy from a well-selected asterisk molecule for generating supramolecular chirality with fluorescence-phosphorescence dual emission. The work takes advantages of(1) achiral chemical structure dependent peculiar self-assembly that can spontaneously undergo symmetry breaking to produce macrochirality, and(2) the assembly process can be monitored by time which due to the crystallization-driven self-assembly by self-twisting, allowing a self-progressing chiral amplification. A multicolor luminescence induced by the fluorescence-phosphorescence dual emission along with such a self-assembly behavior was also observed at a single solution system versus the time. The self-twisting chiral self-assembly fashion provides new prospects for understanding the establishment of nanochirality from achiral molecular building blocks. | Hongwei Wua Bin Wu Xiyuan Yu Pei Zhao Wenbo Chen Liangliang Zhu | 2017 | Chinese Chemical Letters2017，28，11： | 1 |
| 14 | Estimating groundwater recharge using deep vadose zone data under typical irrigated cropland in the piedmont region of the North China Plain显示文摘 | Min Leilei Shen Yanjun Pei Hongwei | 2015 | Journal of Hydrology2015，527，： | 1 |
| 15 | Sentiment classification of online reviews: using sentence-based lan- guage mode显示文摘 | WANG Hongwei YIN Pei ZHENG Lijian | 2014 | Journal of Experimental Theoretical Artificial Intelligence2014，26，1： | 1 |
| 16 | Sentiment classification of online reviews: using sentence-based language model 显示文摘 | Wang Hongwei Yin Pei Zheng Lijuan | 2014 | Journal of Experimental & Theoretical Artificial Intelligence2014，26，1： | 1 |
| 17 | Printed hole-conductor-free mesoscopic perovskite solar cells with excellent long-term stability using PEAI as an additive显示文摘Phenethylamine(PEA) was successfully introduced into hole-conductor-free, fully printable mesoscopic MAPbI3 perovskite solar cells(MPSCs) with a carbon electrode by mixing phenethylammonium iodide with MAPbI3 perovskite solution. PEA-MAPbI3 films show better pore filling into TiO2 scaffold that forms better contact, and induce longer exciton lifetime and higher quantum efficiency of photoinduced charge separation. As a result, the power conversion efficiency of PEA-MAPbI3 MPSCs is 37% higher than that of MAPbI3 MPSCs. And PEA-MAPbI3 MPSCs show excellent long-term stability that could keep 90% of origin power conversion efficiency for over 80 days in the air. | Cong Xua Zheling Zhang Yue Hu Yusong Sheng Pei Jiang Hongwei Han Jian Zhang | 2018 | Journal of Energy Chemistry2018，27，3： | 1 |
| 18 | Effect of Mg-based spherical quasi-crystals on microstructure and mechanical properties of AZ91 alloy 显示文摘 | Zhang Jinshan Pei Lixia Du Hongwei | 2008 | J Alloys Compounds2008，453，： | 1 |
| 19 | Impacts of varying agricultural intensification on crop yield and groundwater resources:Comparison of the North China Plain and US High Plains显示文摘 | Pei Hongwei Scanlon B R Shen Yanjun | 2015 | Environmental Research Letters2015，10，04： | 1 |
| 20 | Crystal structure of the phosphorylated Arabidopsis MKK5 reveals activation mechanism of MAPK kinases显示文摘The mitogen-activated protein kinase(MAPK)signaling pathways are highly conserved in eukaryotes,regulating various cellular processes.The MAPK kinases(MKKs)are dual specificity kinases,serving as convergence and divergence points of the tripartite MAPK cascades.Here,we investigate the biochemical characteristics and three-dimensional structure of MKK5 in Arabidopsis(AtMKK5).The recombinant full-length AtMKK5 is phosphorylated and can activate its physiological substrate AtMPK6.There is a conserved kinase interacting motif(KIM)at the N-terminus of AtMKK5,indispensable for specific recognition of AtMPK6.The kinase domain of AtMKK5 adopts active conformation,of which the extended activation segment is stabilized by the phosphorylated Ser221 and Thr215 residues.In line with sequence divergence from other MKKs,theαD andαK helices are missing in AtMKK5,suggesting that the AtMKK5 may adopt distinct modes of upstream kinase/substrate binding.Our data shed lights on the molecular mechanisms of MKK activation and substrate recognition,which may help design specific inhibitors targeting human and plant MKKs. | Chao-Jun Pei Qing-Xia He Zhipu Luo Hongwei Yao Zhi-Xin Wang Jia-Wei Wu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 0 |
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