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| 1 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 2 | An experimental study of the incipient bed shear stress partition in mobile bed channels filled with emergent rigid vegetation显示文摘This paper investigates the bed shear stress based on the condition of the incipient motion of sediment in a uniform-flow flume covered with emergent rigid vegetation,which is represented by arrays of circular cylinders arranged in a regular pattern.A total of 148 tests are performed to observe the influence of the vegetation density,bed slope,flow depth and sediment size on the bed shear stress.The tests reveal that when the sediment is in incipient motion,the resistances acting on the flow passing the rigid vegetation contain the vegetation resistance and the bed shear stress.This shear stress could be divided into two parts:the grain shear stress and the shear stress caused by sand dunes,which are the deformed bedform with the sediment incipient motion.An empirical relationship between the shear stress of the sand dune and vegetation density,the Froude number,the apparent vegetation layer velocity is developed. | WANG Hao TANG HongWu YUAN SaiYu LV ShengQi ZHAO XuanYu | 2014 | Science China(Technological Sciences)2014，57，6： | 10 |
| 3 | Biodegradation of nicosulfuron by a novel Alcaligenes faecalis strain ZWS11显示文摘A bacterial strain ZWS11 was isolated from sulfonylurea herbicide-contaminated farmland soil and identified as a potential nicosulfuron-degrading bacterium. Based on morphological and physicochemical characterization of the bacterium and phylogenetic analysis of the 16 S r RNA sequence, strain ZWS11 was identified as Alcaligenes faecalis. The effects of the initial concentration of nicosulfuron, inoculation volume, and medium p H on degradation of nicosulfuron were investigated. Strain ZWS11 could degrade 80.56% of the initial nicosulfuron supplemented at 500.0 mg/L under the conditions of p H 7.0, 180 r/min and30°C after incubation for 6 days. Strain ZWS11 was also capable of degrading rimsulfuron,tribenuron-methyl and thifensulfuron-methyl. Four metabolites from biodegradation of nicosulfuron were identified, which were 2-aminosulfonyl-N, N-dimethylnicotinamide(M1), 4, 6-dihydroxypyrimidine(M2), 2-amino-4, 6-dimethoxypyrimidine(M3) and2-(1-(4,6-dimethoxy-pyrimidin-2-yl)-ureido)-N,N-dimethyl-nicotinamide(M4). Among the metabolites detected, M2 was reported for the first time. Possible biodegradation pathways of nicosulfuron by strain ZWS11 were proposed. The degradation proceeded mainly via cleavage of the sulfonylurea bridge, O-dealkylation, and contraction of the sulfonylurea bridge by elimination of a sulfur dioxide group. The results provide valuable information for degradation of nicosulfuron in contaminated environments. | Weisong Zhao Chen Wang Li Xu Chunqing Zhao Hongwu Liang Lihong Qiu | 2015 | Journal of Environmental Sciences2015，27，9： | 9 |
| 4 | Gold nanoparticle/ZnO nanorod hybrids for enhanced reactive oxygen species generation and photodynamic therapy显示文摘金 nanoparticle (Au NP )@ ZnO nanorod (NR )(Au@ZnO ) 有各种各样的 ZnO 的混血儿: Au 臼齿的比率被开发在光力学的治疗(太平洋夏季时间) 提高反应的氧种类(ROS ) 的产生应用程序。介绍在 Au NP 和 ZnO NR 之间的一个金属 / 半导体 heterostructure 接口调制了电子转移在下面紫外(紫外) 照耀,它戏剧性地在 ZnO 压制了电子洞再结合并且同时在 Au NP 表面与高精力增加了激动的电子的数量。因此, nanohybrid 的 ROS 收益更加独自太古的 Au NP 或 ZnO NR 在那些上被改进并且表明了 1 + 1 > 2 效果。这改进随混血儿的 Au 的比例的增加被加强。结果证明有 ZnO 的 Au@ZnO nanohybrids : 因为他们有在 Au 和 ZnO 之间的最大的接口区域, 20:1 的 Au 比率产生了最高的 ROS 收益,它接着在太平洋夏季时间期间为 HeLa 和 C2C12 房间导致了最低房间生存能力。而且, ROS 产生和房间破坏断然与 nanohybrid 剂量被相关。Au@ZnO 混血儿(20:1, 100 g/mL ) 导致了为 2 min 象 28% 一样在紫外暴露以后低的 HeLa 房间生存能力,它显示了它的有希望的潜力改进太平洋夏季时间的治疗学的功效。 | Zhuo Kang Xiaoqin Yan Lanqing Zhao Qingliang Liao Kun Zhao Hongwu Du Xiaohui Zhang Xueji Zhang Yue Zhang | 2015 | Nano Research2015，8，6： | 7 |
| 5 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 6 | HGF percutaneous endocardial injection induces cardiomyocyte proliferation and rescues cardiac function in pigs显示文摘Objective:To investigate the effect of cardiomyocyte proliferation induced by human hepatocyte growth factor(HGF)in pigs with chronic myocardial infarction(CMI).Methods:A steerable,deflectable 7F catheter incorporating a 27-guage needle was advanced percutaneously to the left ventricular myocardium of 18 pigs with CMI.Pigs were randomized(1:1:1)to receive adenoviral vector HGF(total dose,1×1010 genome copies),which was administered as five injections into the infarcted myocardium(total,1.0 mL),or saline,or Ad-null(control groups).Injections were guided by Ensite NavX left ventricular electroanatomical mapping.HGF and cyclin proteins were detected by western blot and immunoprecipitation analysis.Histological and immunohistochemical analysis determined proliferating cardiomyocytes.Myocardial perfusion and cardiac function were estimated by Gated-Single Photon Emission Computed Tomography(G-SPECT).Results:Western blot analyses showed that HGF were predominantly expressed in the infarct core and border in the myocardium of the infarcted heart.G-SPECT analysis indicated that the HGF group had better cardiac function and myocardial perfusion four weeks after the injection of Ad-HGF than before the injection of Ad-HGF.After treatment there were more proliferating cardiomyocytes in the HGF group compared to either of the control groups.Furthermore,the HGF group myocardial samples expressed higher levels of p-Akt,cyclin A,cyclin E,cyclin D1,cdk2,cdk4 than those in the control groups.Conclusion:The over-expression of HGF activates pro-survival pathways,induces cardiomyocyte proliferation,and improves the perfusion and function of the porcine CMI heart. | Zhengxian Tao Bo Chen Yingming Zhao Hongwu Chen Liansheng Wang Yonghong Yong Kejiang Cao Qifeng Yu Danian Ke` Hua Wang Zuze Wu Zhijian Yang | 2010 | The Journal of Biomedical Research2010，24，3： | 3 |
| 7 | Numerical Modeling of Friction Stir Welding Process by Using Rate-dependent Constitutive Model显示文摘率依赖者组成的模型被用来在 materialbehaviors 上模仿粘性系数和过程参数的磨擦 stirwelding process.The 效果,在大头针附近的压力分布是 studied.Results 显示大头针的 stressin 前面在在大头针前面的 theradial/circumferential 应力之间的 pin.The 差别后面比那大并且当 thematerial 接近最高的 surface.This 差别增加 wi 时。 | Hongwu ZHANG Zhao ZHANG | 2007 | Journal of Materials Science & Technology2007，23，1： | 3 |
| 8 | Particle size distribution of bed materials in the sandy river bed of alluvial rivers显示文摘The particle size distribution of bed materials in the sandy river bed of alluvial rivers is important in the study of topics such as friction, river bed evolution, erosion, and siltation. It also can reflect the dependency relation between river bed sediment and flow intensity. In this paper, the critical pattern of sediment movement in the near-wall region of a sandy river bed was analyzed. According to the principle of momentum balance, the critical settling-rising condition of bed material in a sandy river bed was found to be instantaneous turbulent velocity equal to 2.7 times the sediment settling velocity in quiescent water. Based on a vertical instantaneous turbulent velocity with a Gaussian distribution, a theoretical relation for calculating the particle size distribution of bed materials in a sandy river bed without pre-known characteristic grain sizes was developed by solving a stochastic equation. The formula is verified using measured data, and the results show that the proposed formula was in accordance with the measured data. This study has theoretical significance and practical value for determining the bed material particle size distribution of the sandy bed of alluvial rivers. | Luohao Zhang Hongwu Zhang Hongwu Tang Chensu Zhao | 2017 | International Journal of Sediment Research2017，32，3： | 2 |
| 9 | Dual stability enhancement mechanisms of axial-slot casing treatment in a high-speed mixed-flow compressor with various tip clearances显示文摘The influence of Axial-Slot Casing Treatment(ASCT)on the performance and stability enhancement mechanisms of ASCT were experimentally and numerically investigated in a highspeed mixed-flow compressor under three different tip clearances.Unsteady simulations showed the compressor stalled through end-wall stall route,i.e.the spike stall inception originating from rotor tip region,which was validated by dynamical measurements.When the ASCT was applied,greater than 20%of Stall Margin Improvement(SMI)could be achieved for the compressor under each tip clearance size.The streamwise velocity contours and flow structures in the tip region and axial slots were deeply analyzed to explore how the so called‘‘suction and injection effects'generated by the ASCT manipulate tip clearance flow and enhance the stability of compressor under different tip clearances.It was found that the dominant stability enhancement mechanisms of ASCT varies with tip clearance size for the mixed-flow compressor.(A)For the small tip clearance,the dominant mechanism of stability enhancement is the blockage reduction generated in the blade passage by the suction effect of ASCT.(B)For the large tip clearance,the injection effect of the ASCT is the dominant mechanism of stability enhancement with ASCT,which plays the leading role in delaying the spillage of incoming/tip leakage flow interface at the rotor Leading Edge(LE)plane. | Qianfeng ZHANG Juan DU Jichao LI Ming ZHAO Hongwu ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，4： | 2 |
| 10 | Effect of Traverse/Rotational Speed on Material Deformations and Temperature Distributions in Friction Stir Welding显示文摘A fully coupled thermo-mechanical model was developed to study the temperature fields and the plastic deformations of alloy AL6061-T6 under different process parameters during the friction stir welding (FSW) process.Three-dimensional results under different process parameters were presented.Results indicate that the maximum temperature is lower than the melting point of the welding material.The higher temperature gradient occurs in the leading side of the workpiece.The calculated temperature field can be fitted well with the one from the experimental test.A lower plastic strain region can be found near the welding tool in the trailing side on the bottom surface,which is formed by the specific material flow patterns in FSW.The maximum temperature can be increased with increasing the welding speed and the angular velocity in the current numerical modelling. | Zhao ZHANG Jun BIE Yali LIU Hongwu ZHANG | 2008 | Journal of Materials Science & Technology2008，24，6： | 2 |
| 11 | A Differential Game Based Approach Against Objective Function Attack in Cognitive Networks显示文摘We study the problem of defense strategy against Objective function attack(OFA) in Cognitive networks(CNs), where the network can be operated at the optimal state by adapting the parameters of its objective function. An OFA attacker can disrupt the parameter adaptation by interfering measures, which results in some operating parameters of the objective function deviating from their optimal settings. We first model the interactive process between the OFA attacker and defense system using differential game theory, and propose a defense strategy by introducing a new metric, namely, threat factor. Then,we obtain the optimal defense strategy by proving the existence of the saddle point of the proposed model. Moreover,this defense strategy is scale-free such that it can conquer a large number of OFAs in a decentralized way. Finally, we conduct extensive simulations to show that the proposed approach is effective. | FENG Guangsheng LIN Junyu ZHAO Qian WANG Huiqiang LYU Hongwu ZHAO Xiaoyu HAN Jizhong LI Bingyang | 2018 | Chinese Journal of Electronics2018，27，4： | 2 |
| 12 | High-resolution optical coherence tomography over a large depth range with an axieon lens显示文摘 | Ding Zhihua Ren Hongwu Zhao Yonghua | 2002 | Opt Lett2002，27，4： | 1 |
| 13 | Dynamic cavitations in incompressible hyperelastic pre-strained circular sheets显示文摘A class of dynamic cavitations is examined for an isotropic incompressible hyperelastic circular sheet under a pre-strained state caused by an initially applied finite radial tension.The solutions that describe the radially symmetric motion of the pre-strained sheet are obtained.The conditions of cavitated bifurcation that describe cavity formation and motion with time at the axial line of the pre-strained sheet are proposed,that is to say,a circular cavity will form if the suddenly applied radial tensile load exceeds a certain critical value;dynamically,it is proved that the formed cavity will present a nonlinearly periodic oscillation,which is essentially different from the singular periodic oscillation of the formed cavity in an incompressible hyperelastic solid sphere.Numerical simulations show the effects of prescribed radial tension,material parameter and tensile load on critical ten-sile load describing cavity formation and periodic oscillation of the pre-strained circular sheet. | YUAN XueGang ZHANG HongWu ZHANG WenZheng ZHAO Wei Dong Bin | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 1 |
| 14 | Asymmetric Synthesis of Novel Axially Chiral 2,2'-Bipyridine N,N'-Dioxides Bearing α-Amino Acid Residues and Their Applications in Enantioselective Allylation of Aromatic Aldehydes with Allyltrichlorosilane显示文摘当 chiral 采购原料,一系列新奇向轴的方向 chiral 2,2-bipyridine N, N 二氧化物适用 C1 或 C2 对称被 enantiopure 氨基酸的使用综合了。这些 organocatalysts 的轴的 chirality 的绝对立体化学清楚地和文学协议借助于 CD 大小被分配了。这些 organocatalysts 的反应和 enantioselectivities 与 allyltrichlorosilane 在芳香的醛的反应被检验了,因此向需要的产品提供中等收益和 enantioselectivies。 | Hongwu Zhao Yuanyuan Yue Hailong Li Zhihui Sheng Zhao Yang Wei Meng | 2013 | Chinese Journal of Chemistry2013，31，4： | 1 |
| 15 | Loess erosion change modeling during heavy rainfall显示文摘A typical gully sub-basin with a complex geomorphological form is used to do a model test of gravity erosion of loess by considering the sequence of slopes in a prototype gully creating a sequence of underlying surface forms in the upper reaches.The results show that the runoff from heavy rainfall is the main external force for the erosion of loess,and also is an important influencing factor to stimulate and intensify the development of gravity erosion.The soil structure and the height of the critical surface have a direct impact on the possibility of gravity erosion.Spatially,the upper section of the drainage channel mainly experiences undercutting and headcut erosion,the middle section mainly experiences lateral erosion and gravity erosion,and the lower section alternately experiences sedimentation or alluvial erosion.Rainfall splash erosion produces a large amount of sand to yield high concentration mud flows in the middle and lower sections of the channel.Because of the mud flows the flood flow is obviously larger than the runoff volume formed by rainfall in a small watershed.The flood formed by high-intensity rainfall brings a large amount of sediment into the downstream rivers along the channel,indicating that under the condition that high-intensity rainfall on the Loess Plateau,lots sediment will enter the Yellow River,and the erosion deformation occurs on all slopes.Further the steep slope drainage flow causes undercutting and lateral erosion,and the soil body moves down along the slope under the action of gravity.The gully in the middle section still experience sediment washing in both depth and width,and the downstream gully continues to experiences sedimentation due to the reduction of the gradient,reflecting the adaptive adjustment of water flow and the boundary.Headcut erosion occurred on almost all slopes during different periods of rainfall,while gravity erosion mostly occurred on steep slope sections during periods of high-intensity rainfall. | Hongwu Zhang Guangquan Liu Chensu Zhao Luohao Zhang Qiang Zhang Heng Fu Shuai Cao | 2023 | International Journal of Sediment Research2023，38，1： | 1 |
| 16 | Organocatalytic Stereoselective Synthesis of 3-Alkyl-3-hydroxy-2-oxindoles Catalyzed by Novel Water-compatible Axially Unfixed Biaryl-based Bifunctional Organocatalysts显示文摘In this work,six novel axially unfixed biaryl-based water-compatible bifunctional organocatalysts were de-signed and synthesized for the organocatalytic access to a variety of 3-alkyl-3-hydroxy-2-oxindole derivatives via aldol reactions in water.Organocatalyzed by 5a,the direct aldol reactions of isatins with enolisable ketones under-went readily in water,furnishing the structurally diverse 3-alkyl-3-hydroxy-2-oxindoles in various stereoselectivi-ties(up to>99%dr and>99%ee).Moreover,a plausible transition state of the conducted aldol reactions was hy-pothesized to shed light on the observed stereoselectivities of the obtained 3-alkyl-3-hydroxy-2-oxindoles. | Hongwu Zhao Wei Meng Zhao Yang Ting Tian Zhihui Sheng Hailong Li Xiuqing Song Yutong Zhang Sen Yang Bo Li | 2014 | Chinese Journal of Chemistry2014，32，5： | 1 |
| 17 | 三氧化二砷逆转人胃癌细胞SGC7901/ADR耐药性的作用机制(英文)显示文摘Objective: To investigate the reversal effect of arsenic trioxide (As2O3) on the multidrug resistance of human gas-tric tumor SGC7901/ADR cell line to adriamycin (ADM) and its reversal mechanisms. Methods: The non-cytotoxic concentra-tion of As2O3 and the sensitivity of SGC7901/ADR cells to ADM were detected by MTT assay. The drug concentration and P-gp function of SGC7901/ADR cells were measured with flow cytometry (FCM), and the impacts of As2O3 on the GST-π and Topo II expressions of SGC7901/ADR cells were analyzed by immunohistochemical method. Results: As2O3 at 0.4 to 0.8 μmol/L concentrations were not significantly cytotoxic to SGC7901/ADR cells. As2O3 at 0.8 μmol/L could improve the sensitivity of SGC7901/ADR cells to ADM via inhibiting P-gp function, down-regulating GST-π expression and increasing the intracellular accumulation of ADM in SGC7901/ADR cells. Conclusion: As2O3 can reverse partly the drug-resistance of SGC7901/ADR cells to ADM, which may be related with inhibiting the P-gp function and down-regulating GST-π expression. | Hongwu Yang Dan Chen Hongwei Guan Chao Zhao | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，5： | 1 |
| 18 | Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression显示文摘 | Hongwu Zhu Xiong Chen Bin Chen Bei Chen Jianyong Fan Weibing Song Ziying Xie Dan Jiang Qiuqiong Li Meihua Zhou Dayong Sun Yagang Zhao | 2014 | Cancer Letters2014，，1： | 1 |
| 19 | Numerical investigations of size effects on residual states of friction stir weld显示文摘 | Zhang Zhengwei Zhang Zhao Zhang Hongwu | 2014 | Proceedings of the Institution of Mechanical Engi2014，，： | 1 |
| 20 | Active control of wall acoustic impedance显示文摘 | ZHAO Hongwu SUN Xiaofeng | 1999 | AIAA Journal1999，37，7： | 1 |
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