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| 1 | A new method for detecting line spectrum of ship-radiated noise using Duffing oscillator显示文摘A detection scheme for line spectrum of ship-radiated noise is proposed using Duffing oscillator. The chaotic trajectory of Duffing oscillator is analyzed and the state equation of the system is improved to detect weak periodic signals in different frequencies. According to the simulation results, the phase transforms of Duffing oscillator are sensitive to periodic signals and immune to the random noise and the periodic interference signals which have larger angular frequency difference from the referential signal. By employing Lyapunov exponents in the field of detection as the criteria for chaos, the phase transforms of dynamic behaviors in quantity are successfully determined. Meanwhile, the threshold value in critical state has been evaluated more accurately. Based on the phase transforms of Duffing oscillator, a new method for detecting line spectrum of ship-radiated noise is given. Three types of ship-radiated noise signals are analyzed and the values of line spectrum are acquired successfully by this method. The experimental results show that this method has high sensitivity and high resolution. | ZHENG SiYi GUO HongXia LI YaAn WANG BingHe ZHANG PengYi | 2007 | Chinese Science Bulletin2007，52，14： | 21 |
| 2 | Crustal evolution of the Shiwandashan area in South China:Zircon U-Pb-Hf isotopic records from granulite enclaves in Indo-Sinian granites显示文摘标明日期的 U-Pb 在东南的 Guangxi 省从 Shiwandashan 区域在 Jiuzhou peraluminous 花岗石从 metasedimentary granulite 被外国领地包围的土地在锆石上结合了 Hf 同位素分析,华南在这份报纸被介绍。结果证明这些 granulite 被外国领地包围的土地的 protoliths 主要由有一座山峰的碎屑状的材料在 822 妈变老的 Neo-Mesoproterozoic (5641061 妈) 组成。这些材料可能从在 Rodinian Supercontinent 的 Neoproterozoic 决裂期间是 emplaced 的火的岩石被导出。辅助沉积包括 Paleoproterozoic (17782227 妈) ,有最旧的 U-Pb 的甚至 Meso-Paleoarchean 材料在 3551 | ZHAO Liang GUO Feng FAN WeiMing LI ChaoWen QIN XiaoFeng LI HongXia | 2010 | Chinese Science Bulletin2010，55，19： | 18 |
| 3 | Interlayer interactions in anisotropic atomically thin rhenium diselenide显示文摘在这个工作,我们学习夹层声子颤动模式, layer-numberdependent 原子地薄的金来 diselenide 的光 bandgap,和各向异性的光致发光(PL ) 系列(ReSe 2) 第一次。在 ReSe 2 的 ultralow 频率夹层拉曼系列和解决极化的高频率拉曼系列允许它的层数字和水晶取向的鉴定。而且, PL 大小显示出材料的各向异性的光排放紧张,它的 bandgap 在单层在体积从 1.26 eV 增加到 1.32 eV。拉曼模式和 PL 系列的层数字依赖的学习揭示相对弱的货车 der Waals 相互作用并且二维(2D ) 在原子地薄的 ReSe 2 的量监禁。在单层和多层的 ReSe 2 的吸引人的各向异性的夹层相互作用和悦耳的光转变的试验性的观察在在在红外线附近的光谱工作的各向异性的 optoelectronic 设备的发展为这材料的进一步的探索建立基础,它为在光通讯并且红外线的察觉到的许多应用是重要的。 | Huan Zhao Jiangbin Wu Hongxia Zhong Qiushi Guo Xiaomu Wang Fengnian Xia Li Yang Pingheng Tan Han Wang | 2015 | Nano Research2015，8，11： | 14 |
| 4 | The deep-lake deposit in the Upper Triassic Yanchang Formation in Ordos Basin, China and its significance for oil-gas accumulation显示文摘The deep-lake facies of the Yanchang Formation represents a large outflowing lake basin in the Ordos area. Its deposition can be divided into four stages: lake genetic and expanding stage, peak stage, inversion stage and dying stage. All the stages are obviously consistent with the evolution of depositional environment and the paleoclimate in the region. The study indicates that the lake basin has evolution fluctuations from highstand to lowstand for four times in its evolution history, and the deposition center of the lake has not obviously moved, staying along the Huachi-Yijun belt. The deep lake sedimentary system mainly consists of deep water deltas and turbidite fans during the entire evolution course of the lake basin in the Late Triassic. The former mainly developed on the slope of steep shore of the delta in the early period of the deep-water expansion and gradually experienced a big shift from deep-water deltas to shallow-water platform delta. And the latter appeared almost in all the above stages and had two types of turbidite fans, slope-moving turbidite fans and slump turbidite fans. The slope-moving turbidite fans have relatively complete facies belts overlapping one another vertically and consist of the slope channel of inter fans, the turbidite channel, inter turbidite channel and turbidite channel front of middle fans and outer fans (or lakebottom plain). However, the slide-moving turbidity fans are formed in the deep lake with their microfacies difficult to be distinguished, and only the center microfacies and edge microfacies can be determined. The two types of the turbidity fans are similarly distributing in the near-root-slope and far-root-slope regions. The deep-lake deposition governs the distribution of the hydrocarbon and reservoir, while the slope-moving turbidite fans are excellent reservoirs for oil-gas exploration due to their great thickness, widespread distribution and accumulation properties. | CHEN QuanHong LI WenHou GAO YongXiang GUO YanQin FENG JuanPing ZHANG DaoFeng CAO HongXia LIANG JiWei | 2007 | Science China Earth Sciences2007，50，z2： | 12 |
| 5 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 6 | Normal blood D-dimer concentrations: do they exclude pulmonary embolism?显示文摘 | Guo Zhiguo Ma Qingbian Zheng Yaan Zhang Yumei Ge Hongxia | 2014 | Chinese Medical Journal2014，，1： | 9 |
| 7 | Ultrabithorax is a key regulator for the dimorphism of wings,a main cause for the outbreak of planthoppers in rice显示文摘Rice planthoppers,the most devastating rice pests,occur in two wing forms:the short-wing form for rapid population growth and long-wing form for long-distance migration,which together create the mechanism for outbreak.Here we show that Ultrabithorax(Ubx)is a key regulator for switching between the long-and short-wing forms of rice planthoppers.Ubx is expressed in both forewing and hindwing pads,which is different from the canonical model of Ubx expression.In brown planthoppers,expression of Ubx(Nl Ubx)is regulated by nutritional status of the rice host.High-quality young plants induce Nl Ubx expression leading to the short-wing form;low-quality ripe plants reduce Nl Ubx expression resulting in long-wing form.We also showed that Nl Ubx is regulated by the insulin receptors Nl In R1 and Nl In R2.The default expression of Nl In R1 inhibits Nl Ubx resulting in long-wings,while high-quality hosts induce Nl In R2 expression,which represses Nl In R1 thus promoting Nl Ubx expression to produce short-wings. | Fangzhou Liu Xiang Li Muhua Zhao Mengjian Guo Kehong Han Xinxin Dong Jing Zhao Wanlun Cai Qifa Zhang Hongxia Hua | 2020 | National Science Review2020，7，7： | 5 |
| 8 | Bitstream decoding and SEU-induced failure analysis in SRAM-based FPGAs显示文摘Reconfigurable SRAM-based FPGAs are highly susceptible to radiation induced single-event upsets (SEUs) in space applications.The bit flip in FPGAs configuration memory may alter user circuit permanently without proper bitstream reparation,which is a completely different phenomenon from upsets in traditional memory devices.It is important to find the relationship between a programmable resource and corresponding control bit in order to understand the impact of this effect.In this paper,a method is proposed to decode the bitstream of FPGAs from Xilinx Corporation,and then an analysis program is developed to parse the netlist of a specific design to get the configuration state of occupied programmable logic and routings.After that,an SEU propagation rule is established according to the resource type to identify critical logic nodes and paths,which could destroy the circuit topological structure.The decoded relationship is stored in a database.The database is queried to get the sensitive bits of a specific design.The result can be used to represent the vulnerability of the system and predict the on orbit system failure rate.The analysis tool was validated through fault injection and accelerator irradiation experiment. | WANG ZhongMing YAO ZhiBin GUO HongXia LV Min | 2012 | Science China(Information Sciences)2012，55，4： | 5 |
| 9 | MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer显示文摘 | Hongxia Deng Yanan Guo Haojun Song Bingxiu Xiao Weiliang Sun Zhong Liu Xiuchong Yu Tian Xia Long Cui Junming Guo | 2013 | Gene2013，，： | 5 |
| 10 | The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via targeting caveolin-1显示文摘Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer(NSCLC),and microRNA-1827(miR-1827)is closely correlated with NSCLC metastasis.In this study,we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC.The results showed that miR-1827 level was decreased in tumor tissues and cells and was correlated with tumor grade and lymph node(LN)metastasis.Overexpression of miR-1827 inhibited anchorage-independent growth and anoikis resistance in A549 cells.Bioinformatics and functional analysis identified that caveolin-1(CAV-1)is directly targeted by miR-1827.Restoration of CAV-1 significantly attenuated miR-1827’s effect on anoikis resistance in A549 cells.Our data identified a novel signaling axis of miR-1827/CAV-1 in regulating anoikis resistance,which might serve as a potential therapeutic target for metastatic NSCLC. | Xuedan Guo Zhi Wang Qing Sun Chunhua Sun Hongxia Hua Qing Huang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 5 |
| 11 | Dissipative particle dynamics thermostat: a novel thermostat for molecular dynamics simulation of liquid crystals with Gay–Berne potential显示文摘The Gay–Berne(GB) model has been proved to be highly successful in the simulation of liquid crystal phases via both molecular dynamics(MD) and nonequilibrium molecular dynamics(NEMD). However, the conventional thermostats used in the simulations of GB systems, such as Nosé–Hoover and Langevin thermostats, have serious shortcomings especially in NEMD simulations. Recently, dissipative particle dynamics(DPD) has established itself as a useful thermostat for soft matter simulations, whereas the application of DPD thermostat in(NE)MD simulations is limited to the spherically isotropic potential models, such as the Lennard–Jones model. Considering the virtues of the DPD thermostat, that is, local, momentum conserved, and Galilean invariant, we extend the DPD thermostat to the non-spherical GB model. It is interesting to find that the translational DPD and rotational DPD thermostats can be used in the GB system independently and both can achieve the thermostatting effects. Also, we compared the performance of the DPD thermostat with other commonly used thermostats in NEMD simulations by investigating the streaming velocity profiles and the dynamics of phase separation in a typical but simple binary GB mixture under shear field. It is revealed that the known virtues of DPD thermostats, such as Galilean invariant, shear velocity profile-unbiased, and unscreened hydrodynamic interactions, are still intact when applying to GB systems. Finally, the appropriate parameters for the DPD thermostat in the GB system are identified for future investigations. | Yuting Ouyang Liang Hao Yanping Ma Hongxia Guo | 2015 | Science China Chemistry2015，58，4： | 3 |
| 12 | Expression of nerve growth factor precursor, mature nerve growth factor and their receptors during cerebral ischemia-reperfusion injury显示文摘We investigated nerve growth factor precursor (proNGF) and mature NGF expression in ischemic and non-ischemic cortices after cerebral ischemia-reperfusion injury. In both ischemic and non-ischemic cortices, proNGF was found to be present in the extracellular space and cytoplasm. In addition, mature NGF was expressed in extracellular space, but with a very low signal. In ischemic cortex only, proNGF was significantly decreased, reaching a minimal level at 1 day. Mature NGF was increased at 4 hours, then reached a minimal level at 3 days. The p75 neurotrophin receptor (p75NTR) was significantly decreased after ischemia, and increased at 3 days after ischemia. These results confirmed that proNGF was the predominant form of NGF during the pathological process of cerebral ischemia-reperfusion injury. In addition, our findings suggest that ischemic injury may influence the conversion of proNGF to mature NGF, and that proNGF/p75NTR may be involved in reperfusion injury. | Guoqian He Jian Guo Jiachuan Duan Wenming Xu Ning Chen Hongxia Li Li He | 2011 | Neural Regeneration Research2011，6，22： | 3 |
| 13 | Establishment of a rhesus monkey model of middle cerebral artery ischemia and reperfusion using a microcatheter embolization method显示文摘Nonhuman primates are closest to humans in terms of lineage,and middle cerebral artery ischemia/reperfusion responses of nonhuman primates are most similar to ischemic stroke in humans.Therefore,nonhuman primates could be utilized to simulate the process of ischemic stroke in the human.Few studies,however,have reported the use of endovascular technology to establish a rhesus monkey stroke model.In the present study,seven adult,male,rhesus monkeys were selected and,following anesthesia,a microcatheter was inserted into one side of the middle cerebral artery via the femoral artery to block blood flow,thereby resulting in middle cerebral artery occlusion.After 2 hours,the microcatheter was withdrawn to restore the middle cerebral artery blood flow and to establish ischemia/reperfusion.Results from angiography and magnetic resonance angiography confirmed occlusion and reopening of the middle cerebral artery.Magnetic resonance imaging revealed the existence of ischemic brain lesions,and neurological examination showed sustained functional deficits following surgery.The rhesus monkey middle cerebral artery ischemia/reperfusion models established by microcatheter embolization had the advantage of non-craniotomy invasion and reproducibility.The scope and degree of ischemic damage using this model was controllable.Therefore,this nonhuman primate model is an ideal model for cerebral ischemia and reperfusion. | Jie Yang Jian Guo Hongbo Zheng Muke Zhou Li He Wenying Cao Li Xiao Jiachuan Duan Qiyong Gong Xiaoqi Huang Hongxia Li Li Wang Jingqiu Cheng | 2010 | Neural Regeneration Research2010，5，15： | 2 |
| 14 | β-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma显示文摘 | Shuang Yan Cuiqi Zhou Wei Zhang Guo Zhang Xuejian Zhao Shangbin Yang Yihua Wang Ning Lu Hongxia Zhu Ningzhi Xu | 2008 | Cancer Letters2008，，1： | 2 |
| 15 | Heavy ion micro-beam study of single-event transient(SET) in Si Ge heterjunction bipolar transistor显示文摘Silicon-germainum heterojunction bipolar transistor(Si Ge HBT)has been demonstrated to be suitable in extreme environment because of its superior temperature characteristics which can operate from 43 K to 400 K[1].In addition,outstanding hardness to both total ionizing dose(TID)radiation and displacement damage make Si Ge HBT technology particularly attractive for | Jinxin ZHANG Hongxia GUO Fengqi ZHANG Chaohui HE Pei LI Yunyi YAN Hui WANG Linxia ZHANG | 2017 | Science China(Information Sciences)2017，60，12： | 2 |
| 16 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 17 | Effects of water stress on quality and sugar metabolism in'Gala'apple fruit显示文摘Sugar plays an important role in apple fruit development,appearance and quality as well as contributing to a plant’s water stress response.Trehalose and the trehalose biosynthetic metabolic pathways are part of the sugar signaling system in plants,which are important regulator of water stress response in apple.The effect of water stress treatments applied to apple trees and the corresponding effects of ABA on developmental fruit quality were examined for indicators of fruit quality during fruit development.The results indicated that the severe water stress treatment(W2)occurring after the last stage of fruit cell division caused a decrease in the color and size of fruit.The moderate water stress(W1)occurring after the last stage of fruit cell enlargement(S2)caused an increase in the content of fructose and sorbitol while the apple fruit shape was not affected.These changes in sugar are related to the activity of sugar metabolic enzymes.While the enzymatic activity of vacuolar acid invertase(vAINV)was higher,that of sucrose-phosphate synthase(SPS)was lower in water stress treated fruit throughout the developmental period.This indicates that enhanced sucrose degradation and reduced sucrose synthesis leads to an overall reduced sucrose content during times of drought.Thus,water stress reduced sucrose content.Whereas the content of endogenous trehalose and ABA were the highest in water stress treated fruit.A moderate water stress(W1)imposed on apple trees via water restriction(60%–65%of field capacity)after the fruit cell enlargement phase of fruit development yielded sweeter fruit of higher economic value. | Hongxia Tao Hanqing Sun Yufei Wang Xin Wang Yanping Guo | 2023 | Horticultural Plant Journal2023，9，1： | 2 |
| 18 | The NPU Multi-case Chinese 3D Face Database and Information Processing显示文摘 | ZHANG Yanning GUO Zhe LIN Zenggang ZHANG Hongxia ZHANG Chao | 2012 | Chinese Journal of Electronics2012，21，2： | 2 |
| 19 | TiO2-incorporated polyelectrolyte composite membrane with transformable hydrophilicity/hydrophobicity for nanofiltration separation显示文摘The wettability of the membrane surface has shown obvious influent on the separation performance of the membrane.In this work,a hydrophilic PDA-[PDDA/TiO2]+Cl-membrane was prepared by a one-step codeposition of poly(diallyldimethylammonium chloride)(PDDA)polyelectrolyte solution containing positively charged TiO2@PDDA nanoparticles with the assistance of dopamine(DA).Such positively charged membrane can be transformed into a hydrophobic membrane PDA-[PDDA/TiO2]+PFO-via the counterion exchange between Cl-and PFO-(perfluorooctanoate).The transformation between hydrophilicity and hydrophobicity is reversible.For both hydrophilic and hydrophobic membranes,the nanofiltration performances were respectively investigated by the aqueous solution and ethanol solution of dyes including methyl blue(MB),Congo red(CR)and Evans blue(EB),and as well metal salt aqueous solution.The consecutive running stability and anti-fouling performance of both hydrophilic and hydrophobic membranes were explored.The results revealed that both membranes showed high nanofiltration performances for retention of dyes in(non)aqueous solution.For the hydrophilic membrane,the rejection of salts in a sequence is MgSO4>Na2SO4>MgCl2>NaCl.Moreover,both of the hydrophilic and hydrophobic membranes showed high stability and antifouling property. | Yahua Lu Zhenping Qin Naixin Wang Hongxia Guo Quanfu An Yucang Liang | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 2 |
| 20 | Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers显示文摘 | Long Cui Yanru Lou Xinjun Zhang Hui Zhou Hongxia Deng Haojun Song Xiuchong Yu Bingxiu Xiao Weihua Wang Junming Guo | 2011 | Clinical Biochemistry2011，，13： | 2 |
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