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| 1 | High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa显示文摘It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-n Cov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas(TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression(FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. | Hao Xu Liang Zhong Jiaxin Deng Jiakuan Peng Hongxia Dan Xin Zeng Taiwen Li Qianming Chen | 2020 | International Journal of Oral Science2020，12，1： | 69 |
| 2 | Interlayer interactions in anisotropic atomically thin rhenium diselenide显示文摘在这个工作,我们学习夹层声子颤动模式, layer-numberdependent 原子地薄的金来 diselenide 的光 bandgap,和各向异性的光致发光(PL ) 系列(ReSe 2) 第一次。在 ReSe 2 的 ultralow 频率夹层拉曼系列和解决极化的高频率拉曼系列允许它的层数字和水晶取向的鉴定。而且, PL 大小显示出材料的各向异性的光排放紧张,它的 bandgap 在单层在体积从 1.26 eV 增加到 1.32 eV。拉曼模式和 PL 系列的层数字依赖的学习揭示相对弱的货车 der Waals 相互作用并且二维(2D ) 在原子地薄的 ReSe 2 的量监禁。在单层和多层的 ReSe 2 的吸引人的各向异性的夹层相互作用和悦耳的光转变的试验性的观察在在在红外线附近的光谱工作的各向异性的 optoelectronic 设备的发展为这材料的进一步的探索建立基础,它为在光通讯并且红外线的察觉到的许多应用是重要的。 | Huan Zhao Jiangbin Wu Hongxia Zhong Qiushi Guo Xiaomu Wang Fengnian Xia Li Yang Pingheng Tan Han Wang | 2015 | Nano Research2015，8，11： | 14 |
| 3 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 4 | A general powder dusting method for latent fingerprint development based on AIEgens显示文摘Powder dusting method is the most practically useful approach for latent fingerprint development in the crime scene. Herein, a general powder dusting method has been explored for latent fingerprint development based on aggregation-induced emission luminogens(AIEgens). A series of tetraphenylethene(TPE) derivatives with multiple diphenylamine(DPA), namely, TPE-DPA,TPE-2 DPA and TPE-4 DPA, were selected as candidates to dope with magnetic powders and applied for latent fingerprint development. After screening, the magnetic powder 3 doped with TPE-4 DPA proves to be the best, in terms of fluorescent intensity, resolution and adhesiveness. Afterwards, the magnetic powder 3 was applied for visualization of latent fingerprint on various smooth and porous substrates, including glass, stainless steel, leaf, ceram, plastic bag, lime wall, wood and paper money.Specific details, such as island, core, termination and bifurcation, can be clearly observed for the fluorescent fingerprint images. | Zijie Qiu Bin Hao Xinggui Gu Zhaoyu Wang Ni Xie Jacky W.Y.Lam Hongxia Hao Ben Zhong Tang | 2018 | Science China Chemistry2018，61，8： | 6 |
| 5 | MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer显示文摘 | Hongxia Deng Yanan Guo Haojun Song Bingxiu Xiao Weiliang Sun Zhong Liu Xiuchong Yu Tian Xia Long Cui Junming Guo | 2013 | Gene2013，，： | 5 |
| 6 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 7 | Kinetics, thermodynamics, and equilibrium of As(Ⅲ),Cd(Ⅱ), Cu(Ⅱ) and Pb(Ⅱ) adsorption using porous chitosan bead-supported MnFe_(2)O_(4) nanoparticles显示文摘A novel porous nanocomposite,cross-linked chitosan and polyethylene glycol(PEG) bead-supported MnFe_(2) O_(4) nanoparticles(CPM),was developed as an efficient adsorbent to remove metalloid(As(Ⅲ))and heavy metals(Cd(Ⅱ),Cu(Ⅱ),and Pb(Ⅱ)).The characteristics of CPM showed a porous structure,well dispersed MnFe_(2) O_(4),and several of hydroxyl and amino groups(-OH,-NH_(2)).Batch experiments demonstrated that the best adsorption property of As(Ⅲ),Cd(Ⅱ),Cu(Ⅱ),and Pb(Ⅱ) was achieved within 8 h with maximum adsorption capacities of 9.90,9.73,43.94,and 11.98 mg/g,respectively.Competitive and synergistic effects(particularly precipitation) were included in the co-adsorption mechanism of As(Ⅲ) and heavy metals.Thereinto,As(Ⅲ) was partly oxidized by MnFe_(2) O_(4) to As(V),and both were coordinated on MnFe_(2) O_(4) nanoparticles.Pb(Ⅱ) could also bind to MnFe_(2) O_(4) by ion exchange and electrostatic attraction.Furthermore,Cd(Ⅱ) and Cu(Ⅱ) tended to be coordinated on chitosan.Therefore,CPM can serve as a remediation material for water and soil co-contaminated with As(Ⅲ) and heavy metals. | Hongxia Li Hongbing Ji Xinglan Cui Xiaokui Che Qidong Zhang Juan Zhong Rongzhen Jin Lei Wang Yi Luo | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 8 | A mathematical modeling study of the HIV epidemics at two rural townships in the Liangshan Prefecture of the Sichuan Province of China显示文摘Background:As a response to a severe HIV epidemic in the Liangshan Prefecture,one of the worst in China,population based HIV interventions,including two population-wide HIV screening,have been carried out since 2005 at two townships in a remote mountainous region of Liangshan.The objective of our mathematical modeling study is to assess the temporal dynamics of the HIV epidemic in the two townships based on the data collected in the study area during the period 2005e2010.Methods:A mathematical model was set up to describe the population dynamics of HIV transmission in study area.The model was calibrated by fitting it to the HIV testing and treatment data from 2005 to 2008.Validation of the model was done by comparing its predicted value of HIV prevalence in 2010 to the prevalence data obtained in the 2010 population wide HIV testing.The validated model was used to produce estimation of HIV incidence,prevalence and death.Results:Our model estimations show that population-based HIV interventions have significantly slowed down the rise of the HIV epidemic in the two townships.Over the five-year period from 2005 to 2010,the year-over-year rate of increase in HIV incidence,prevalence,and death has declined by 91.5%,28.7%,and 52.3%,respectively.Conclusion:Mathematical models,when integrated with epidemiological and surveillance data,can be an effective tool for predicting the temporal dynamics of HIV and assessing the impacts of HIV interventions. | Zhimin Su Caiting Dong Ping Li Hongxia Deng Yuhan Gong Shiyong Zhong Min Wu Yuhua Ruan Guangming Qin Wen Yang Yiming Shao Michael Li | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 9 | Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis显示文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis. | Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen | 2022 | International Journal of Oral Science2022，14，2： | 2 |
| 10 | ESTIMATION OF ACTIVATED ENERGY OF DESORPTION OF n-HEXANE ON ACTIVATED CARBONS BY TPD TECHNIQUE显示文摘In this paper, six kinds of activated carbons such as Ag+-activated carbon, Cu2+- activated carbon, Fe3+- activated carbon, activated carbon, Ba2+- activated carbon and Ca2+- activated carbon were prepared. The model for estimating activated energy of desorption was established. Temperature-programmed desorption (TPD) experiments were conducted to measure the TPD curves of n-hexanol and then estimate the activation energy for desorption of n-hexanol on the activated carbons. Results showed that the activation energy for the desorption of n-hexanol on the Ag+- activated carbon, the Cu2+- activated carbon and the Fe3+- activated carbon were higher than those of n-hexanol on the activated carbon, the Ca2+- activated carbon and the Ba2+- activated carbon. | LI Zhong WANG Hongjuan XI Hongxia XU Kefeng WEN Jun Research Institute of Chemical Engineering, South China University of Technology, Guangzhou, 510640 | 2001 | Chinese Journal of Reactive Polymers2001，10，2： | 2 |
| 11 | Determination of mixed-mode interfacial fracture toughness for thermal barrier coatings显示文摘In this work,a test method was developed to determine the interfacial fracture toughness of the air plasma sprayed (APS) thermal barrier coatings (TBCs) over a wide range of mode mixities.For this mixed-mode test method,the analytical expressions for the energy release rate and stress intensity factors were derived based on the energy theory and the concept of 'equivalence'.The fidelity of these expressions was affirmed by selected finite element analysis.The experimental results showed that the critical energy release rate increased with the increase of the positive mode mixity,which was mainly due to the increase in contact/friction effect and plastic work dissipation with increasing shear mode loading.Furthermore,an elliptical interfacial failure criterion in terms of the stress intensity factors was proposed.The agreement between the experimental results in the literature and those in our work indicated that our test method and the corresponding analytical solutions can well determine the interfacial fracture toughness of the TBCs over a wide range of mode mixities. | DENG HongXia SHI HuiJi YU HuiChen ZHONG Bin | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 2 |
| 12 | Effects of ultrasound on adsorption equilibrium of phenol on polymeric adsorption resin 显示文摘 | LI Zhong LI Xiangbin XI Hongxia | 2002 | Chemical Engineering Journal2002，86，3： | 1 |
| 13 | 显示文摘 | Li Zhong Wang Hongjuan Xi Hongxia | 2003 | Adsorption Science and Technology2003，21，2： | 1 |
| 14 | 显示文摘 | Xi Hongxia Li Zhong Zhang Haibing | 2003 | Separation and Purification Technology2003，31，1： | 1 |
| 15 | Estimation of activation energy for desorption of low-volatility dioxins on zeolites by TPD technique显示文摘 | Xi Hongxia Li Zhong Zhang Haibing | 2003 | Separation and Purification Technology2003，31，1： | 1 |
| 16 | 显示文摘 | Li Zhong Li Xiangbin Xi Hongxia | 2002 | Chemical Engineering Journal2002，86，： | 1 |
| 17 | Activation Energy of Desorption of Dibenzothiophene on Modified Activated Carbon by Loading Metal Ions 显示文摘 | Moxin YU Zhong LI Hongxia XI | 2007 | Chemical Engineering Journal2007，132，： | 1 |
| 18 | Effects of ultrasound on adsorption quilibrium of phenol on polymeric adsorption resin显示文摘 | Zhong Li Xiangbin Li Hongxia Xi | 2002 | Chemical Engineering Journal2002，86，： | 1 |
| 19 | Estimation of activation ener- gy for desorption of low-volatility dioxins on zeolites by TPD technique 显示文摘 | Xi Hongxia Li Zhong | 2003 | Separation and Purification Technology2003，1，1： | 1 |
| 20 | Activation energy of desorption of dibenzothiopbene on modified activated carbon by loading metal ions显示文摘 | Yu Moxin Li Zhong Xi Hongxia | 2007 | Chemical Engineering Journal2007，132，： | 1 |
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