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| 1 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 2 | Geology, Geochemistry, and Geochronology of the Fenghuangshan Skarn-type Copper Deposit in the Tongling Ore Cluster, Anhui Province, East China显示文摘The Fenghuangshan skarn-type Cu deposit, Tongling Ore Cluster, Anhui Province, is an important component in the Middle-Lower Yangtze River ore-forming belt. To better understand magmatism and its relationship to mineralization, we investigated geochemical features, ore-forming fluids, and geochronology of the Xinwuli intrusion and the related Fenghuangshan Cu deposit. Lithogeochemical characteristics show that the Xinwuli quartz monzodiorite is formed by mixing magma derived from upper mantle alkaline basalt that has been contaminated by crust materials. C, H and O isotopes indicate that ore-forming fluids mainly come from the magma, with minor amounts of meteoric fluids involved at the late stage. S and Pb isotopic components indicate that ore-forming materials are derived from the mantle. Molybdenite Re-Os isotopic dating yields Re-Os model ages ranging from 139.1±2.4 Ma to 142.0±2.2 Ma, with an isochronal age of 141.1±1.4 Ma, which is consistent with sensitive, high-resolution ion microprobe (SHRIMP) zircon U-Pb ages of quartz monzodiorite and granodiorite in the mining area. Dating analysis yields ages from 136.0±2.0 Ma to 143.0±2.4 Ma for the quartz monzodiorite (a weighted average of 139.4±1.2 Ma) and ages from 136.7±2.0 Ma to 145.3±2.4 Ma for granodiorite (a weighted average of 141.0±1.1 Ma). | QU Hongying PEI Rongfu FEI Hongcai LI Jinwen WANG Yonglei WANG Haolin YAO Lei | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 3 |
| 3 | New Recognized Intellect for Prospecting Large-superlarge Mineral Deposits显示文摘Based on the data base of 1285 mineral deposits of 22 commodities in 121 countries of 6 continents of the world, the authors use the linear trend analysis for their reserves to determine the cut-off limited order of reserves to select 36 exceptional superlarge (as peak mineral), 95 superlarge and 314 large deposits as new recognized intellect for their quantitative change. We have projected above 445 large-superlarge deposits on (1:5 M) global tectonic background map and divided 4 metallogenic domains, 21 metallogenic belts. Global metallogeny of large-superlarge deposits are: unity by endogenic, exogenic metamorphic and epigenetic in origin; speciality in different metallogenic domains and belts; preferentiality to ore-forming elements of Cu, Au, Fe, Ag, Cr, Mn, Zn, Pb, Sb, Hg, to continental margins or plate convergent belts, to Intra-continental tectono-magmatic complex belts and Large ductile shear zones; abnormality by the global oxyatmversion (excess oxygen atmospheric event) in Archean, redoxyatmversion (lack oxygen atmospheric event) in Proterozoic-Paleozoic, and tectonosphere thermal erosion (great amount of tectonic magmatic event) in Mesozoic-Cenozoic. | PEI Rongfu MEI Yanxiong WANG Haolin QU Hongying | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 3 |
| 4 | Ectopic expression of antifreeze protein gene from Ammopiptanthus nanus confers chilling tolerance in maize显示文摘Improved chilling tolerance is important for maize production. Previous efforts in transgenics and marker-assisted breeding have not achieved practical results. In this study, the antifreeze protein(AnAFP) from the super-xerophyte Ammopiptanthus nanus was aligned to KnS-type dehydrins.Phosphorylation in vitro and subcellular localization showed that AnAFP was phosphorylated by maize casein kinase II and translocated from nucleus to cytoplasm under chilling stress. AnAFP also increased lactate dehydrogenase activity. A parent line of commercial maize hybrids was transformed with the AnAFP gene. Based on thermal asymmetric interlaced PCR, one hemizygous and two homozygous integration sites were identified in one T_(1) line. Ectopic expression of AnAFP in transgenic lines was confirmed by quantitative real-time PCR, RNA-seq, and Western blotting. After chilling treatment, the transgenic lines showed significantly improved phenotype, higher kernel production, survival rate and biomass, and lower relative electrolyte leakage and superoxide dismutation than the untransformed line. Thus, ectopic expression of AnAFP gene improved chilling tolerance in the transgenic lines, which could be used to apply for further safety assessment for commercial breeding. | Yuanyuan Zhang Yang Cao Hongying Zheng Wenqi Feng Jingtao Qu Fengling Fu Wanchen Li Haoqiang Yu | 2021 | The Crop Journal2021，9，4： | 2 |
| 5 | Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115显示文摘 | Min Wu Qi Shen Yong Yang Sheng Zhang Wen Qu Jing Chen Hongying Sun Shuqing Chen | 2013 | Journal of Industrial Microbiology & Biotechnology2013，，6： | 1 |
| 6 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 7 | Prognostic value of cancer stem cell marker CD133 expression in non-small cell lung cancer:a systematic review 显示文摘 | Hongying Qu Rong Li Zhiyue Liu Junyi Zhang Rongcheng Luo | 2013 | Int J Clin Exp Pathol2013，6，11： | 1 |
| 8 | Formable porous biochar loaded with La-Fe(hydr)oxides/montmorillonite for efficient removal of phosphorus in wastewater:process and mechanisms显示文摘The development of biochar-based granule-like adsorbents suitable for scaled-up application has been attracting increasing attention in the field of water treatment.Herein,a new formable porous granulated biochar loaded with La-Fe(hydr)oxides/montmorillonite(LaFe/MB)was fabricated via a granulation and pyrolysis process for enhanced phosphorus(P)removal from wastewater.Montmorillonite acted as a binder that increased the size of the granulated biochar,while the use of Fe promoted the surface charge and facilitated the dispersion of La,which was responsible for selective phosphate removal.LaFe/MB exhibited rapid phosphate adsorption kinetics and a high maximum adsorption capacity(Langmuir model,52.12 mg P g^(−1)),which were better than those of many existing granulated materials.The desorption and recyclability experiments showed that LaFe/MB could be regenerated,and maintained 76.7%of its initial phosphate adsorption capacity after four adsorption cycles.The high hydraulic endurance strength retention rate of the developed material(91.6%)suggested high practical applicability in actual wastewater.Electro-static attraction,surface precipitation,and inner-sphere complexation via ligand exchange were found to be involved in selective P removal over a wide pH range of 3-9.The thermodynamic parameters were determined,which revealed the feasibility and spontaneity of adsorption.Based on approximate site energy distribution analyses,high distribution frequency contributed to efficient P removal.The research results provide a new insight that LaFe/MB shows great application prospects for advanced phosphate removal from wastewater. | Enhui Sun Yanyang Zhang Qingbo Xiao Huayong Li Ping Qu Cheng Yong Bingyu Wang Yanfang Feng Hongying Huang Linzhang Yang Charles Hunter | 2022 | Biochar2022，4，1： | 1 |
| 9 | Comparative analysis of mitochondrial fragments transferred to the nucleus in vertebrate显示文摘Mitochondrial DNA sequences transferred to the nucleus give rise to the so-called nuclear mitochondrial DNA (numt). In the GenBank database, 244 numts have been found in six orders of birds (Anseriformes, Columbiformes, Falconiformes, Charadriiformes, Galliformes and Passeriformes). Sequences alignment (NCBI-BLASTN) was carried out with mitochondrial and corresponding nuclear genome sequences in nine vertebrate species. The sequences with high homology were considered as numts. The number of numts ranged from 15 in chicken to 159 in chimpanzee. The sequences of numts in macaque, chimpanzee, and human spanned 100% of the entire mammalian mitochondrial genome. The reconstructed frequency of the mitochondrial gene transferred to the nucleus demonstrated that the rRNA genes had high frequencies than other mitochondrial genes. Using the RepeatMasker program, the transposable elements were detected in the flanking regions of each numt. The results showed that less than 5% of the flanking sequences were made up of repetitive elements in chicken. The GC content of 5′- and 3′-flanking regions of numts in nine species was less than 44%. The analysis of the flanking sequences provided a valuable understanding for future study on mechanism of mitochondrial gene transfer to the nucleus and the site of numt integration. | Hongying Qu Fei Ma Qingwei Li | 2008 | Journal of Genetics and Genomics2008，35，8： | 0 |
| 10 | Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),theseventh coronavirus known to jump from intermediate hosts to humans,has resulted in a worldwide pandemic and caused immense economicdamage(Tan et al.,2020;Zhu et al.,2020).It is believed that coronavirus spillover may occur again in the future.Human exposure to a bat coro-navirus has been serologically confimed in a rural area of China,indi-cating that the coronavirus spillover occurred,although the origin andfrequency of spillovers are unclear(Wang et al.,2018). | Yabin Hu Jun Chen Jing Yang Zhanpeng Liu Xiaoyue Zhang Qian Wu Lulu Liu Shishan Teng Rongzhang He Bo Liu Xingyu Zheng Rui Lu Dong Pan You Wang Liting Peng Hongying chen Yi-Ping Li Wenpei Liu Xiaowang Qu | 2024 | Virologica Sinica2024，39，1： | 0 |
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