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| 1 | Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern显示文摘Dear Editor,As of October,2021,SARS-CoV-2 has infected more than 230 million people;promoting roll-out vaccinations could help build herd immunity for the pandemic.However,the waning of antibody in magnitude and decreased protective efficacy in multiple types of vaccines have been reported. | Jingwen Ai Haocheng Zhang Qiran Zhang Yi Zhang Ke Lin Zhangfan Fu Jieyu Song Yuanhan Zhao Mingxiang Fan Hongyu Wang Chao Qiu Yang Zhou Wenhong Zhang | 2022 | Cell Research2022，32，1： | 19 |
| 2 | Clinical significance of gastrostomy for patients injury percutaneous endoscopic with severe craniocerebral显示文摘 | Tian Yong Du Hanggen Fan Chengpu Wang Cheng Zhang Guojun Chen Li Li Hongyu | 2014 | Chinese Journal of Traumatology2014，17，6： | 18 |
| 3 | Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation显示文摘Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods(AuNRs) were prepared with incorporation of paclitaxel(PTX). This therapeutic system was characterized by several features. First, the albumin modification enhanced the biocompatibility and colloidal stability. Second, the surface-coated albumin promoted cellular uptake via the albumin-binding protein pathway. Third, PTX was incorporated via hydrophobic interaction between PTX and the albumin lipophilic domain. Fourth, the system can be used for combined photothermo-chemotherapy for yielding synergistic effects. The antitumor activity of the system was evaluated both in vitro and in vivo using the HCT116 colon cancer cell and tumor model. The combination therapy was found with an enhanced treatment efficiency and no obvious side effect. Most importantly, the thermal effect was also discovered with the ability to modulate the tumor microenvironments and suppress the macrophages polarization towards the M2 pro-tumor phenotype. It could be a mechanism for photothermal immunotherapy. The combination strategy and the system provide a potential method for cancer therapy. | Dongdong Li Meng Zhang Fan Xu Yingzhi Chen Binfan Chen Ya Chang Huihai Zhong Hongyue Jin Yongzhuo Huang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 8 |
| 4 | Effects of adding bulking agents on the biodrying of kitchen waste and the odor emissions produced显示文摘The effects of adding a bulking agent on the performance and odor emissions(ammonia and eight sulfur-containing odorous compounds) when biodrying kitchen waste were investigated. Three treatments were considered: the addition of either cornstalks(CS) or wood peat(WP) to kitchen waste as a bulking agent before biodrying, and a control treatment(CK). The water-removal rates for CK, CS, and WP treatments were 0.35, 0.56, and0.43 kg/kg, respectively. Addition of bulking agents to kitchen waste produced less leachate,higher moisture-removal rates, and lower consumption of volatile solids. The CS treatment had the highest biodrying index(4.07), and those for the WP and CK treatments were 3.67 and 1.97, respectively. Adding cornstalks or wood peat decreased NH3 emissions by 55.8%and 71.7%, respectively. Total sulfur losses were 3.6%–21.6% after 21 days biodrying, and H2 S and Me2 SS were the main(> 95%) sulfur compounds released. The smallest amounts of sulfur-containing odorous compounds were emitted when cornstalks were added, and adding cornstalks and wood peat decreased total sulfur losses by 50.6%–64.8%. | Jing Yuan Yun Li Hongyu Zhang Difang Zhang David Chadwick Guoxue Li Guoying Wang Menghao Chi Fan Yang | 2018 | Journal of Environmental Sciences2018，30，5： | 7 |
| 5 | Combination Patterns and Depositional Characteristics of Ordovician Carbonate Banks in the Western Tarim Basin,China显示文摘碳酸盐银行的联合模式和 depositional 特征在西方的 Tarim 盆基于奥陶纪的露头节,薄节,和碳同位素被调查,中国。四个碳酸盐银行联合模式在奥陶纪被扔,西方的 Tarim 盆,包括:礁石银行建筑群(RBC ) , Algae-Reef-Bank Interbed (ARBI ) ,厚层的蛋糕沉积银行(TLCAB ) ,和薄层的蛋糕逆行银行(TLCRB ) 。所有联合模式垂直地显示出清楚的时期。RBC 主要由礁石和 bioclastic 银行组成,并且 RBC 的尺寸取决于礁石的规模。Bioclastic 银行存款包围礁石。ARBI 的范围被水藻礁石,水藻 peloid 白云石 microfacies 和垂直地轮流出现的海藻的白云石 microfacies 沉积物的规模决定。当在周期叠并且与生气床上用品广泛地延长的层蛋糕发展了, TLCAB 和 TLCRB 被扔。TLCAB 和 TLCRB 的谷物是多样的并且多来源。与影响相对的海水平变化,生物发展和地形学, ARBI, TLCAB 或 TLCRB, RBC 连续地从更低的奥陶纪 Penglaiba 形成被开发到中间的奥陶纪 Yijianfang 形成。奥陶纪的 depositional 环境分析显示 RBC 和 ARBI 能形成有效的油和煤气的水库,并且 TLCAB 和 TLCRB 有潜力形成巨大的规模油和煤气的水库并且以后是为奥陶纪碳酸盐银行的探索的关键目标。 | HU Xiaolan FAN Tailiang GAO Zhiqian YU Bingsong CHEN Xiaozhi WANG Hongyu WANG Jianping LI Rangbin DING Meng LI Yifan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 7 |
| 6 | BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma显示文摘Background:Long non-codingRNAs(lncRNAs)have been found to be involved in the development of many cancers.In this study,we aimed to identify the molecular mechanisms of lncRNA BAALC antisense RNA 1(BAALC-AS1)in regulating the malignancy of esophageal squamous cell carcinoma(ESCC).Methods:The expression of BAALC-AS1 in cancer patients was analyzed using a tissue microarray.The protein and RNA levels of BAALC-AS1 were determined by Western blotting analysis and quantitative reverse transcription-PCR(RT-qPCR),respectively.The cell proliferation was determined by cell viability assays,bromodeoxyuridine incorporation,and flow cytometry.The relationships among BAALC-AS1,RasGAPSH3 domain-binding protein 2(G3BP2),and c-Myc were determined using RNA immunoprecipitation,RNA pull-down assays,and luciferase assays.Results:The expression of BAALC-AS1 was highly up-regulated and associated with malignant phenotypes in ESCC tissues and cell lines.In vivo and in vitro assays showed that BAALC-AS1 promoted ESCC cell proliferation,migration,and invasion.BAALC-AS1 directly interacted with G3BP2,and thereby inhibited the degradation of c-Myc RNA 3’-UTR by G3BP2,thus leading to the accumulation of c-Myc expression.Additionally,c-Myc acted as a transcription factor that can induce the expression of BAALC-AS1 by directly binding to its promoter region.Conclusions:BAALC-AS1/G3BP2/c-Myc feedback loop plays a critical role in the development of ESCC,which might provide a novel therapeutic target and facilitate the development of new therapeutic strategies for the treatment of ESCC. | Hongyue Zhang Yan Wang Weimin Zhang Qingnan Wu Jiawen Fan Qimin Zhan | 2021 | Cancer Communications2021，41，3： | 7 |
| 7 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 8 | Scalable synthesis of sub-lO0 nm hollow carbon nanospheres for energy storage applications显示文摘 | Hongyu Zhao Fan Zhang Shumeng Zhang Shengnan He Fei Shen Xiaogang Han Yadong Yin Chuanbo Gao | 2018 | Nano Research2018，11，4： | 4 |
| 9 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 10 | Orofacial inflammatory pain affects the expression of MT1 and NADPH-d in rat caudal spinal trigeminal nucleus and trigeminal ganglion显示文摘Very little is known about the role of melatonin in the trigeminal system,including the function of melatonin receptor 1.In the present study,adult rats were injected with formaldehyde into the right vibrissae pad to establish a model of orofacial inflammatory pain.The distribution of melatonin receptor 1 and nicotinamide adenine dinucleotide phosphate diaphorase in the caudal spinal trigeminal nucleus and trigeminal ganglion was determined with immunohistochemistry and histochemistry.The results show that there are significant differences in melatonin receptor 1 expression and nicotinamide adenine dinucleotide phosphate diaphorase expression in the trigeminal ganglia and caudal spinal nucleus during the early stage of orofacial inflammatory pain.Our findings suggest that when melatonin receptor 1 expression in the caudal spinal nucleus is significantly reduced,melatonin's regulatory effect on pain is attenuated. | Fang Huang Hongwen He Wenguo Fan Yongliang Liu Hongyu Zhou Bin Cheng | 2013 | Neural Regeneration Research2013，8，32： | 4 |
| 11 | Automatic segmentation of foveal avascular zone based on adaptive watershed algorithm in retinal optical coherence tomography angiography images显示文摘The size and shape of the foveal avascular zone(FAZ)have a strong positive correlation with several vision-threatening ret inovascular diseases.The identification,segmentation and analysis of FAZ are of great significance to clinical diagnosis and treatment.We presented an adaptive watershed algorithm to automatically extract F AZ from retinal optical coherence tomography angiography(OCTA)images.For the traditional watershed algorithm,'over-segmentation'is the most common problem.FAZ is often incorrectly divided into multiple regions by redundant'dams'.This paper analyzed the relationship between the'dams'length and the maximum inscribed circle radius of FAZ,and proposed an adaptive watershed algorithm to solve the problem of'over-segmentation'.Here,132 healthy retinal images and 50 diabetic retinopathy(DR)images were used to verify the accuracy and stability of the algorithm.Three ophthal-mologists were invited to make quan titative and qualitative evaluations on the segmentation results of this algorithm.The quantitative evaluation results show that the correlation coffi-cients between the automatic and manual segmentation results are 0.945(in healthy subjects)and 0.927(in DR patients),respectively.For qualitative evaluation,the percentages of'perfect segmentation'(score of 3)and'good segmentation'(score of 2)are 99.4%(in healthy subjects)and 98.7%(in DR patients),respectively.This work promotes the application of watershed algorithm in FAZ segmentation,making it a useful tool for analyzing and diagnosing eye diseases. | Jian Liu Shixin Yan Nan Lu Dongni Yang Chunhui Fan Hongyu Lv Shuanglian Wang in Zhu Yuqian Zhao Yi Wang Zhenhe Ma Yao Yu | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 3 |
| 12 | Principles of Trap Development and Characteristics of Hydrocarbon Accumulation in a Simple Slope Area of a Lacustrine Basin Margin:An Example from the Northern Section of the Western Slope of the Songliao Basin,China显示文摘The western slope of the Songliao Basin is a gently dipping monoclinal slope featured by stratum overlap, gradual change of stratum inclination and limited fault development, which formed during basin depression interrupted by a tectonic inversion stage. Structure, sedimentation and reservoir characteristics show that the development of the slope and its sand bodies' depositional genesis determined the types, distribution and evolution of traps. Up-dip wedge-out traps in distributary channels, lenticular traps in distal sand bars and sand sheets in the delta front are the main lithologic trap types and usually have thin reservoir beds, small areas, and are distributed in clusters and belts. The episode of tectonic inversion led to the formation of structural traps and combination traps. The combination traps are characterized by large numbers of thin oil-bearing beds occurring along fold belts. Matching axial directions of distributary channel sand bodies in delta fronts with channel morphology during the period between deposition of sand bodies and sealing by an unconformity above is the key to the search for large scale traps in a simple slope area. | Hongyu Wang Tailiang Fan Xuesong Fan | 2016 | Journal of Earth Science2016，27，6： | 2 |
| 13 | Delivery of pOXR1 through an injectable liposomal nanoparticle enhances spinal cord injury regeneration by alleviating oxidative stress显示文摘Oxidation resistance 1(OXR1)is regarded as a critical regulator of cellular homeostasis in response to oxidative stress.However,the role of OXR1 in the neuronal response to spinal cord injury(SCI)remains undefined.On the other hand,gene therapy for SCI has shown limited success to date due in part to the poor utility of conventional gene vectors.In this study,we evaluated the function of OXR1 in SCI and developed an available carrier for delivering the OXR1 plasmid(pOXR1).We found that OXR1 expression is remarkably increased after SCI and that this regulation is protective after SCI.Meanwhile,we assembled cationic nanoparticles with vitamin E succinate-graftedε-polylysine(VES-g-PLL)(Nps).The pOXR1 was precompressed with Nps and then encapsulated into cationic liposomes.The particle size of pOXR1 was compressed to 58 nm,which suggests that pOXR1 can be encapsulated inside liposomes with high encapsulation efficiency and stability to enhance the transfection efficiency.The agarose gel results indicated that Nps-pOXR1-Lip eliminated the degradation of DNA by DNase I and maintained its activity,and the cytotoxicity results indicated that pOXR1 was successfully transported into cells and exhibited lower cytotoxicity.Finally,Nps-pOXR1-Lip promoted functional recovery by alleviating neuronal apoptosis,attenuating oxidative stress and inhibiting inflammation.Therefore,our study provides considerable evidence that OXR1 is a beneficial factor in resistance to SCI and that Nps-Lip-pOXR1 exerts therapeutic effects in acute traumatic SCI. | Jing Zhang Yao Li Jun Xiong Helin Xu Guanghen Xiang Mingqiao Fan Kailiang Zhou Yutian Lin Xiangxiang Chen Lin Xie Hongyu Zhang Jian Wang Jian Xiao | 2021 | Bioactive Materials2021，6，10： | 2 |
| 14 | Research on the Antitumor Effect of Plumbagin by Inhibiting IL-6/STAT3 Pathway in Large Cell Lung Cancer显示文摘Background and Objective Lung cancer, which has become the leading cause of tumor mortality in many countries, appears to be one of the most dangerous malignant tumors that | Tao YU Yu FAN Li MA Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Qinghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 1 |
| 15 | Organotin Com- pounds Immobilized on Mesoporous Silicas as Heterogeneous Catalysts for Direct Synthesis of Dimethyl Carbonate from Methanol and Carbon Dioxide显示文摘 | Fan Binbin Li Hongyu Fan Weibin | 2010 | Appl Catal A2010，372，1： | 1 |
| 16 | Combination Patterns and Depositional Characteristics of Ordovician Carbonate Banks in the Western Tarim Basin, China显示文摘 | HU Xiaolan FAN Tailiang GAO Zhiqian YU Bingsong CHEN Xiaozhi WANG Hongyu WANG Jianping LI Rangbin DING Meng LI Yifan | 2012 | Acta Geologica Sinica ‐ English Edition2012，，4： | 1 |
| 17 | The subsurface structure and stratigraphic architecutre of rifit-related units in the Lishu Depre- ssion of the Songliao Basin, China 显示文摘 | Wang Hongyu Fan Tailiang Wu ~ue | 2015 | Journal of Asian Earth Sci- ences2015，99，： | 1 |
| 18 | Oxidation of cyclohexane over iron and copper salen complexes simultaneously encapsulated in zeolite Y显示文摘 | Fan Binbin Li Hongyu Fan Weibin | 2008 | Appl Catal A: Gen2008，340，1： | 1 |
| 19 | Identification of Perkinsus-like parasite in Manila clam, Ruditapes philippinarum using DNA molecular marker at ITS region显示文摘Genornic DNA was extracted from hypnospores of Perk ins us -like parasite of Manila clam Ruditapes philippinarum collected at the fishing grounds in Huanghai Sea coast Shicheng Island and East China Sea coast Ningbo, China. The internal transcribed spacer(ITS) in rDNA was PCR-amplified, cloned, sequenced, and compared with that of five Perkinsus species in GenBank. The fragment amplified from DNA of parasite of either Shicheng Island or Ningbo contained 649 bp, including partial ssrRNA(51 bp) and ITS(+5.8 S) (598 bp) regions. The ITS(+5.8S) sequences of Perkinsus-like parasite of both Shicheng Island and Ningbo were all 99% identical to those of Perkinsus atlantticus,and were not more than 95% identical to those of other four Perkinsus species including P. marinus, P. andrewsi, P. qugwadi and P. medienaneus.The ITS (+5.8S) sequence of Perkinsus-like parasite of Shicheng Island was 99% identical to that of Ningbo. These facts about nucleotide sequences suggested that the Perkinsus-like parasite in Manila clam, Ruditapes philippinarum collected from either the Huanghai Sea coast or the East China Sea coast was P. atlanticus, and might reflect P. atlanticus strains of distinct geographic distribution. | ZHANG Xichang LIANG Yubo FAN Jingfeng ZHANG We PU Hongyu LIANG Bin CHEN Hongxing SONG Lichao | 2005 | Acta Oceanologica Sinica2005，24，5： | 1 |
| 20 | Conversion of fruc- tose and glucose into 5-hydroxymethylfurfural catalyzed by a solid heteropolyacid salt 显示文摘 | Fan Chunyan Guan Hongyu Zhang Hang | 2011 | Biomass and Bioenergy2011，35，7： | 1 |
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