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| 1 | Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study显示文摘NF-κB pathway consists of canonical and non-canonical pathways.The canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory response.Meanwhile,the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily members.Since the activation of this pathway involves protein synthesis,the kinetics of non-canonical NF-κB activation is slow but persistent,in concordance with its biological functions in the development of immune cell and lymphoid organ,immune homeostasis and immune response.The activation of the canonical and non-canonical NF-κB pathway is tightly controlled,highlighting the vital roles of ubiquitination in these pathways.Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers,and NF-κB has been long proposed as the potential target for therapy of diseases.This review attempts to summarize our current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases. | Hui Yu Liangbin Lin Zhiqiang Zhang Huiyuan Zhang Hongbo Hu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 35 |
| 2 | Ubiquitin signaling in immune responses显示文摘 | Hongbo Hu Shao-Cong Sun | 2016 | Cell Research2016，26，4： | 27 |
| 3 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
| 4 | Nitrogen removal and simultaneous nitrification and denitrification in a fluidized bed step-feed process显示文摘For urban wastewater treatment,we conducted a novel four-stage step-feed wastewater treatment system combined with a fluidized bed laboratory experiment to investigate chemical oxygen demand(COD),NH4+-N,and total nitrogen(TN) removal performance.The removal rates of COD,NH4+-N and TN were 88.2%,95.7%,and 86.4% with e?uent concentrations of COD,NH4+-N and TN less than 50,8,and 10 mg/L,respectively.Biomass and bacterial activities were also measured,with results showing more nitrobacteria in the activated sludge than in the biofilm;however,bacterial activity of the biofilm biomass and the activated sludge were similar.Nitrogen concentrations during the process were also detected,with simultaneous nitrification and denitrification found to be obvious. | BingWang Wei Wang Hongjun Han Hongbo Hu Haifeng Zhuang | 2012 | Journal of Environmental Sciences2012，24，2： | 22 |
| 5 | Properties and characterization of Au^(3+)-adsorption by mycelial waste of Streptomyces aureofaciences显示文摘Mycelial waste of Streptomyces aureofaciences procured from the aureomycin fermentation industry is used as biosorbent for Au3+. The properties of Au3+ adsorption by the mycelial waste are studied. The results indicate that the optimum pH value of Au3+ adsorption is 3.5. The biosorption is a rapid and non-temperature-dependent process. The bio-sorptive capacity with 45.6 mg/g and efficiency with 91.2% are achieved under the conditions of pH 3.5 and 30℃ for 45 min, in which the ratio is 50 mg/g dry weight for the concentrations of initial Au3+ and the mycelial waste. The Au3+ ions adsorbed on the mycelial waste can be eluted. The observation in a transmission electron microscope shows that the Au3+ ions can be reduced to Au particles by the mycelial waste and the Au can become gold crystals with differentforms and sizes. X-ray photoelectron spectroscopy analysis further proves that the Au3+ can be reduced to Au0 by the mycelial waste. | LIU Yueying, FU Jinkun, HU Hongbo, TANG Dingliang, Nl Zimian & YU Xinsheng1. Department of Biology, 2. State Key Laboratory for Physical Chemistry of Solid Surface, 3. Center for Analysis & Testing, Xiamen University, Xiamen 361005, China | 2001 | Chinese Science Bulletin2001，46，20： | 15 |
| 6 | Kinematics and Dynamics Analysis of a Quadruped Walking Robot with Parallel Leg Mechanism显示文摘It is desired to require a walking robot for the elderly and the disabled to have large capacity,high stiffness,stability,etc.However,the existing walking robots cannot achieve these requirements because of the weight-payload ratio and simple function.Therefore,Improvement of enhancing capacity and functions of the walking robot is an important research issue.According to walking requirements and combining modularization and reconfigurable ideas,a quadruped/biped reconfigurable walking robot with parallel leg mechanism is proposed.The proposed robot can be used for both a biped and a quadruped walking robot.The kinematics and performance analysis of a 3-UPU parallel mechanism which is the basic leg mechanism of a quadruped walking robot are conducted and the structural parameters are optimized.The results show that performance of the walking robot is optimal when the circumradius R,r of the upper and lower platform of leg mechanism are 161.7 mm,57.7 mm,respectively.Based on the optimal results,the kinematics and dynamics of the quadruped walking robot in the static walking mode are derived with the application of parallel mechanism and influence coefficient theory,and the optimal coordination distribution of the dynamic load for the quadruped walking robot with over-determinate inputs is analyzed,which solves dynamic load coupling caused by the branches' constraint of the robot in the walk process.Besides laying a theoretical foundation for development of the prototype,the kinematics and dynamics studies on the quadruped walking robot also boost the theoretical research of the quadruped walking and the practical applications of parallel mechanism. | WANG Hongbo SANG Lingfeng HU Xing ZHANG Dianfan YU Hongnian | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 12 |
| 7 | Characteristics of the lunar samples returned by the Chang'E-5 mission显示文摘Forty-five years after the Apollo and Luna missions returned lunar samples,China's Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon.Our study shows that 95%of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35μm,while 95%of the soils by mass are within the size range of 4.84-432.27μm.The bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm^(3),3.1952 g/cm^(3) and 0.56 m^(2)/g,respectively.Fragments from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also found.The minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and phosphorus.CE-5 soils have high FeO and low Mg index,which could represent a new class of basalt. | Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao Yonggang Yao Dingshuai Xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang | 2022 | National Science Review2022，9，2： | 12 |
| 8 | Molecular geochemical characteristics of gas source rocks from the Upper Triassic Xujiahe Formation indicate transgression events in the Sichuan Basin显示文摘The geochemical characteristics of saturated and aromatic hydrocarbons from different formations and lithologies provide ob-vious evidence for transgressions that occurred during Upper Triassic Xujiahe stage in Sichuan Basin with a great impact on the source input and depositional environment.A clear dual peak distribution for normal alkanes and obvious abundant com-pounds sourced from bacteria and algae in whole oil gas chromatogram indicates the abundance of lower organisms input.The ratio of Pr/Ph is low,ranging from 0.33 to 0.86 with an average of 0.60,quite different from Pr/Ph >2.0 for coal measures in swamp environment,representing source rocks from saline lake or marine facies.In the gas source rocks extracts,abundant β-carotane,-carotane,and their degradated series were detected in the whole oil chromatogram,indicating a reducing envi-ronment.The concentrations of methyl steranes and dinosteranes are high.The content of polycyclic aromatic sulfur heterocy-cles(PASH) is relatively higher in aromatic fraction and the assemblage of fluorene,dibenzofuran,and dibenzothiophene is different from the typical saline lake and the regular swamp facies source rocks,manifesting the transgression effects on gas source rocks. | ZHANG Min HUANG GuangHui LI HongBo HU GuoYi ZHANG ShuiChang | 2012 | Science China Earth Sciences2012，55，8： | 10 |
| 9 | Spatial and temporal distribution of Neolithic sites in coastal China:Sea level changes, geomorphic evolution and human adaption显示文摘The East China coastal plain is one of the most important Neolithic culture areas in China, where rich archaeological sites including those producing the earliest domesticated rice are observed. It is also a place where landscape has experienced dramatic evolution during the Holocene when both sea level and climate changed, such that it is an ideal place for studying human-environment interaction. This study investigated over 2000 sites of pre-history and Shang and Zhou Dynasties, with 655 of which being Neolithic ages, by using DEM and GIS methods. The results suggest that the spatial and temporal distribution of Neolithic sites has largely been controlled by landscape evolution(particularly changes in coastal line), which ultimately governed by sea level changes. During early Holocene, Neolithic sites sparsely distributed in the intermountain basins of east Zhejiang Province, far from the influence of ocean. Over the period of 9–7 ka, the coastal plain(including the shelf) was largely submerged,only the feet of low hills to the south and southwest of the study area, and islands protruding the estuary, cradled limited number of settlements with characteristic 'maritime components'. At about 7 ka, sea level rise decelerated prominently, while sediments supply in the drainage remained high value, the combination of which led to land formation and propagation. Vast space during this period facilitated the growth of settlements in both size and number. In the mean time, however, the coastal plain was vulnerable to extreme environmental events such as storms and flooding owning to its geomorphic nature, which exerted great influence on the rise and fall of Neolithic culture. | ZHENG HongBo ZHOU YouSheng YANG Qing HU ZhuJun LING GuangJiu ZHANG JuZhong GU ChunGuang WANG YingYing CAO YeTing HUANG XianRong CHENG Yue ZHANG XiaoYu WU WenXiang | 2018 | Science China Earth Sciences2018，61，2： | 7 |
| 10 | A lentiviral vector-based therapeutic vaccine encoding Ag85B-Rv3425 potently increases resistance to acute tuberculosis infection in mice显示文摘为 multidrug 抵抗的肺结核(TB ) 和到为 TB 的新奇治疗学的途径的发展的广泛地药抵抗的 TB 电话注意的很少处理选择。因为他们能导致抗原特定的细胞的有免疫力的回答,治疗学的疫苗正在答应候选人,它在 Mycobacterium 肺结核(鱼雷快艇) 的消除起一个重要作用。在这研究,新奇 lentiviral 向量为交付鱼雷快艇特定的熔化蛋白质 Ag85B-Rv3425 的治疗学的疫苗被构造。结果证明这支 recombinant lentivirus 疫苗单个注射的能在老鼠触发抗原特定的 Th1 类型有免疫力的回答。更重要地,有急性感染的老鼠在肺和脾由显著地减少的鱼雷快艇负担从这支疫苗的一个单个剂量的政府有益于很多以及与未经治疗的老鼠相比在肺稀释了损害。这些结果为 TB 的免疫疗法显示了这支新奇疫苗的好前景。 | Enzhuo Yang Feifei Wang Ying Xu Honghai Wang Yong Hu Hongbo Shen Zheng W. Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 6 |
| 11 | Effect of Dahuang Zhechong pills on long non-coding RNA growth arrest specific 5 in rat models of hepatic fibrosis显示文摘OBJECTIVE: To investigate the involvement of growth arrest specific 5(GAS5), a long non-coding RNA, in the anti-hepatic fibrosis process induced by Dahuang Zhechong pill(DHZCP) in rats.METHODS: Thirty adult rats were divided into three groups, including a control group, a CCl4-induced fibrosis group and a DHZCP-treated fibrosis group. Hematoxylin-eosin and Masson staining were used for histopathological study. Serum enzymes, cytokines and cell proliferation were assayed using commercially available kits. A GAS5 lenti-virus vector was constructed to further investigate the role of GAS5 in the anti-hepatic fibrosis effect of DHZCP in rats.RESULTS: Our results revealed that the proliferation of hepatic stellate cells cultured in serum derived from rats treated with DHZCP was significantly decreased, compared with cells treated with serum from the untreated rats. DHZCP alleviated the CCl4-induced hepatic fibrosis. Additionally, DHZCP can restore the expression of GAS5,which was significantly decreased in the CCl4-induced group, and markedly suppress the expression of p-p38 and p-Erk induced by CCl4, but not p-Jnk. Cell proliferation was significantly arrested when cells overexpressed GAS5. Thus,DHZCP can inhibit the expression of p-p38 and p-Erk, while GAS5 can only inhibit the expression of p-Erk.CONCLUSIONS: DHZCP can alleviate hepatic fibrosis by increasing the expression of GAS5 to suppress p-Erk and regulating other factors to inhibit p-p38. | Gong Zhenghua Deng Chaowen Xiang Tianxin Tao Lili Xiao Hongbo Peng Yanzhong Zheng Jie Hu Guoxin | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 6 |
| 12 | CDP1, a novel component of chloroplast division site positioning system in Arabidopsis显示文摘叶绿体是从 endosymbiotic cyanobacteria 演变的植物特定的细胞器。他们通过二进制分裂划分。叶绿体部门地点的选择为对称的叶绿体部门是枢轴的。在 E。coli,在房间的中点部门地点放被 Min 系统的动态摆动调整,它包括 MinC,头脑和矿。在植物的头脑和矿的相当或相同的事物涉及叶绿体分割。MinC 的相当或相同的事物仍然没在更高的植物被识别。然而,象 FtsZ 一样蛋白质, ARC3,被发现地点放涉及叶绿体分割。这里,我们报导放 1 的那个叶绿体部门地点(AtCDP1 ) 是在 Arabidopsis 涉及叶绿体部门地点放置的新奇叶绿体部门蛋白质。AtCDP1 被与房间部门显型为殖民地在细菌屏蔽一个 Arabidopsis cDNA 表示图书馆发现。AtCDP1 只在 Arabidopsis 在年轻绿纸巾被表示。有多重部门地点的伸长的叶绿体在 loss-of-function cdp1 异种被观察。AtCDP1 的 Overexpression 也引起了一个叶绿体部门显型。蛋白质相互作用试金建议 AtCDP1 可以调停通过和 ARC3 的相互作用放的叶绿体部门地点。总的来说,我们的结果显示 AtCDP1 是放系统,和这个系统的工作机制的叶绿体部门地点的一个新奇部件与在原核生物的房间的传统的 MinCDE 系统的不同。 | Min Zhang Yong Hu Jingjing Jia Dapeng Li Runjie Zhang Hongbo Gao Yikun He | 2009 | Cell Research2009，19，7： | 5 |
| 13 | Non-suicidal self-harm is linked to suicidal thoughts in Chinese adolescents with mood disorders:a cross-sectional report显示文摘Non-suicidal self-injury (NS SI) refers to any intentional,self-inflicted behavior that causes direct damage to body tissues (Kerr et al.,2010),and has emerged as a challenging public health issue worldwide,especially among adolescents.The most common presentations of NSSI include skin-cutting,severe scratching,and burning (Whitlock et al,2006). | Yixin WANG Jianbo LAI Chanchan HU Hongbo MENG Duo LYU Shaohua HU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 5 |
| 14 | Experimental research on rotating detonation with liquid hypergolic propellants显示文摘This paper describes experimental research into the initiation and propagation of rotating detonation for liquid Nitrogen TetrOxide(NTO) and liquid MonoMethylHydrazine(MMH).An annular rocket-type combustor without nozzle was designed to investigate detonation combustion. The propellants were injected through unlike impingement injectors. The combustion flame fronts and pressure waves were detected using optical diagnostics and dynamic pressure sensors,respectively. The propagation of rotating detonation was established spontaneously by increasing the mass flow rate of propellants. The velocity of propagation of the flame fronts and pressure waves was nearly equal and reaches supersonic speed. Two different detonation combustion patterns are present, single wave mode and double waves mode. And in double waves mode, the two detonation waves are always counter-rotating. The possibility of rotating detonation initiation in a combustor with nozzle was also checked. Stable rotating detonation can be initialized and sustained at similar operating conditions. | Shuaijie XUE Hongjun LIU Lixin ZHOU Weidong YANG Hongbo HU Yu YAN | 2018 | Chinese Journal of Aeronautics2018，31，12： | 5 |
| 15 | Toward reverse engineering on secret S-boxes in block ciphers显示文摘It has been widely accepted that the security cryptosystems should be only dependent on the security of their secret keys.However,there are still secret ciphers with unknown components in their commercial applications due to various reasons.The existing reverse engineering analyzes are developed for analyzing specific ciphers,and cannot cope with secret algorithms with diferent structures.By looking into the common characteristics of the secret algorithms of ciphers implemented with unknown S-boxes,we proposed a novel reverse engineering analysis approach referred to as Signed Reverse Engineering based on Diferential Power Analysis(SREDPA).It is a generic reverse engineering analysis and can recover the parameters of the secret S-boxes of the block ciphers in typical structures such as SPN,Feistel,and XFeistel(eXtended Feistel).By identifying the bias of the diferential power analysis(DPA)traces,we build the theoretical model of SREDPA and prove its efectiveness.Experiments are performed on secret algorithms in diferent structures and further validate our SREDPA experimentally.The complexity of SREDPA only relies on the size of S-boxes and the reverse engineering analysis is efcient.As shown in the theoretical analysis and the conducted experiments,our SREDPA approach is readily to be extended for analyzing other secret ciphers with unknown S-boxes.This renders a new challenge on the design and implementation of secret ciphers. | TANG Ming QIU ZhenLong PENG HongBo HU XiaoBo YI Mu ZHANG HuanGuo | 2014 | Science China(Information Sciences)2014，57，3： | 4 |
| 16 | Individual particle analysis of aerosols collected at Lhasa City in the Tibetan Plateau显示文摘To understand the composition and major sources of aerosol particles in Lhasa City on the Tibetan Plateau(TP), individual particles were collected from 2 February to 8 March, 2013 in Tibet University. The mean concentrations of both PM2.5and PM10 during the sampling were25.7 ± 21.7 and 57.2 ± 46.7 μg/m3, respectively, much lower than those of other cities in East and South Asia, but higher than those in the remote region in TP like Nam Co, indicating minor urban pollution. Combining the observations with the meteorological parameters and back trajectory analysis, it was concluded that local sources controlled the pollution during the sampling. Transmission electron microscopy(TEM) combined with energydispersive X-ray spectra(EDS) was used to study 408 particles sampled on four days. Based on the EDS analysis, a total of 8 different particle categories were classified for all 408 particles, including Si-rich, Ca-rich, soot, K-rich, Fe-rich, Pb-rich, Al-rich and other particles.The dominant elements were Si, Al and Ca, which were mainly attributed to mineral dust in the earth's crust such as feldspar and clay. Fe-, Pb-, K-, Al-rich particles and soot mainly originated from anthropogenic sources like firework combustion and biomass burning during the sampling. During the sampling, the pollution mainly came from mineral dust,while the celebration ceremony and religious ritual produced a large quantity of anthropogenic metal-bearing particles on 9 and 25 February 2013. Cement particles also had a minor influence. The data obtained in this study can be useful for developing pollution control strategies. | Bu Duo Yunchen Zhang Lingdong Kong Hongbo Fu Yunjie Hu Jianmin Chen Lin Li A.Qiong | 2015 | Journal of Environmental Sciences2015，27，3： | 4 |
| 17 | 晚期转移性膀胱癌患者血清CA125检测的临床意义(英文)显示文摘Objective: To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma. Methods: Electrochemiluminescence technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer. 30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group. Results: Serum CA125 level in 39 (67.2%) out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL (mean 498.3 U/mL), being higher than normal (< 35 U/mL). Serum CA125 level of metastatic bladder cancer patients was 324.5 U/mL, significantly higher than that in control group (P < 0.001). Serum CA125 level of 10 patients after transure- thral resection operation was significantly lower than that before operation (P < 0.05). Serum CA125 level of 16 patients who refused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL (P = 0.041) 3 months after discharge from the hospital. Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL (P < 0.001) after bilateral iliac-arterial embolism treatment. Conclusion: CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer. | Jinyi Yang Wei Wei Jianguang Liu Xiaoqi Hu Lin Ye Jie Zhou Hongbo Jiang Xingjin Jiang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，8： | 3 |
| 18 | Comprehensive profiling of EBV gene expression in nasopharyn- geal carcinoma through paired-end transcriptome sequencing显示文摘在鼻咽的癌(NPC ) 的 Epstein-Barr 病毒(EBV ) 基因的潜伏的表示模式广泛地被调查了,并且在 NPC 的几 lysin 的基因的表示被报导了。然而,通过在 NPC 的 EBV transcriptome 分析的全面信息是有限的。我们执行了对结束 RNA-seq 到系统地并且包括地在 NPC 织物和 C666-1 NPC 房间线描绘 EBV 基因的表示,它一致地带 EBV。除了限制打 II 潜伏感染,类型 III 潜伏 EBNA3s 基因和lysin 的基因的一个实质的数字的抄本,例如 BZLF1 , BRLF1 ,和 BMRF1 ,通过 RNA-seq 被检测并且进一步通过也执行的实时 PCR.We 在 C666-1 房间和 NPC 织物被验证聚类分析以 EBV 基因表示分类 NPC 耐心的组,它介绍了 NPC 样品的二种子类型。结果在 NPC 病人揭示了 EBV 基因表示的有趣的模式。这个聚类与 heterotrimeric G 蛋白质发信号有关与许多发信号的小径被相关,例如那些,发炎由 chemokine 并且 cytokine 发信号调停了,核糖体,蛋白质新陈代谢,流行性感冒感染,和 ECM 受体相互作用。我们的联合调查结果建议在 NPC 的 EBV 基因的表示被限制不仅打 II 潜伏基因而且打 III 潜伏和 lysin 的基因。这研究在 NPC 的发展提供了进一步的卓见进 EBV 的潜在的角色。 | Lijuan Hu Zhirui Lin YanhengWu Juqin Dong Bo Zhao Yanbing Cheng Peiyu Huang Lihua Xu Tianliang Xia Dan Xiong Hongbo Wang Manzhi Li Ling Guo Elliott Kieff YixinZeng | 2016 | Frontiers of Medicine2016，10，1： | 3 |
| 19 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 20 | A Summary of Chinese Expert Consensus on Fetal Growth Restriction (An Update on the 2019 Version)显示文摘Fetal growth restriction(FGR)is a common complication of pregnancy associated with higher rates of perinatal mortality and morbidity,as well as a variety of long-term adverse outcomes.To standardize the clinical practice for the management of FGR in China,Fetal Medicine Subgroup,Chinese Society of Perinatal Medicine,Chinese Medical Association and Maternal-Fetal Medicine Committee,Chinese Society of Obstetrics and Gynecology,Chinese Medical Association organized an expert committee to provide official consensus-based recommendations on FGR.We evaluated the evidence provided by relevant high-quality literature,performed a three-round Delphi study and organized face-to-face meetings with experts from multidisciplinary backgrounds.The consensus includes the definition,prenatal screening,prevention,diagnosis,monitoring and management of FGR. | Fetal Medicine Subgroup,Chinese Society of Perinatal Medicine,Chinese Medical Association Maternal-Fetal Medicine Committee,Chinese Society of Obstetrics and Gynecology,Chinese Medical Association Luming Sun Yali Hu Hongbo Qi | 2022 | Maternal-Fetal Medicine2022，4，3： | 2 |
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