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| 1 | Time range of Mesozoic tectonic regime inversion in eastern North China Block显示文摘An important tectonic inversion took place in eastern North China Block(NCB) during Mesozoic, which caused a great lithosphere thinning, reconstruction of basin-range series, powerful interaction between mantle and crust, a vast granitic intrusion and volcanism, and large-scale metallogenic explosion. The time range of the Mesozoic tectonic regime inversion in the eastern North China Block is one of the key issues to understand mechanism of tectonic regime inversion. Our updated results for recognizing the time range are mainly obtained from the following aspects: structural analyses along northern and southern margins of the NCB and within the NCB for revealing tectonic inversion from compression to extension and structural striking from ~EW to NNE; geothermic analyses of the eastern sedimental basins for a great change of thermal history and regime; basin analysis for basin inversion from compression to extension and basin migration from ~EW to NNE; petrological and geochemical studies of volcanic rocks and lowermost crust xenoliths for recognizing peak period of mantle upwelling and intense interaction between mantle and crust, and main metallogenic epoch. All the studies of the above give the same time range from~150-140 Ma to ~110-100Ma, peaking at ~120 Ma. | ZHAI Mingguo ZHU Rixiang LIU Jianming MENG Qingren HOU Quanlin HU Shengbiao LIU Wei LI Zhong ZHANG Hongfu ZHANG Huafeng | 2004 | Science China Earth Sciences2004，47，2： | 89 |
| 2 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 3 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 4 | Deep-learning-based extraction of the animal migration patterns from weather radar images显示文摘Continental coverage and year-round operation of the weather radar networks provide an unprecedented opportunity for studying large-scale airborne migration.The broad and local-scale airborne information collected by these infrastructures can answer many ecological questions.However,extracting and interpreting the biological information from such massive weather radar data remains an intractable problem.Recently,many big-data problems have been solved using the deep learning technology.In this study,the biological information in the weather radar data is identified using the advanced deep learning method.The proposed method consists of two main parts,i.e.,a rendering and casting procedure and an image segmentation procedure based on a convolutional neural network.The biological data are automatically extracted by rendering and mapping,image segmentation,and result masking.By analyzing the typical radar data from single and multiple stations,we partly reveal the intensity and speed of the migration pattern.We present the first feasibility study of the extraction of local and large-scale biological phenomena from the Chinese weather radar network data. | Kai CUI Cheng HU Rui WANG Yi SUI Huafeng MAO Huayu LI | 2020 | Science China(Information Sciences)2020，63，4： | 11 |
| 5 | Rapid drift of the Tethyan Himalaya terrane before two-stage India-Asia collision显示文摘The India-Asia collision is an outstanding smoking gun in the study of continental collision dynamics.How and when the continental collision occurred remains a long-standing controversy.Here we present two new paleomagnetic data sets from rocks deposited on the distal part of the Indian passive margin,which indicate that the Tethyan Himalaya terrane was situated at a paleolatitude of∼19.4°S at∼75 Ma and moved rapidly northward to reach a paleolatitude of∼13.7°N at∼61 Ma.This implies that the Tethyan Himalaya terrane rifted from India after∼75 Ma,generating the North India Sea.We document a new two-stage continental collision,first at∼61 Ma between the Lhasa and Tethyan Himalaya terranes,and subsequently at∼53−48 Ma between the Tethyan Himalaya terrane and India,diachronously closing the North India Sea from west to east.Our scenario matches the history of India-Asia convergence rates and reconciles multiple lines of geologic evidence for the collision. | Jie Yuan Zhenyu Yang Chenglong Deng Wout Krijgsman Xiumian Hu Shihu Li Zhongshan Shen Huafeng Qin Wei An Huaiyu He Lin Ding Zhengtang Guo Rixiang Zhu | 2021 | National Science Review2021，8，7： | 7 |
| 6 | Petrologic indicators of prograde metamorphism in Paleoproterozoic garnet mafic granulites from the Huai'an complex, North China Craton显示文摘Reconstruction of pressure-temperature-time(P-T-t)paths and thermal regimes are essential for inferring tectono-metamorphic processes involved in the formation of metamorphic terranes.However,the P-T information,especially the prograde evolution is generally preserved incompletely due to the fast intra-or inter-grains diffusion under high-temperatures.It may result | Jialin Wu Mingguo Zhai Huafeng Zhang Jinghui Guo Haozheng Wang Wenqiang Yang Hong Zhang Bo Hu | 2018 | Science Bulletin2018，63，2： | 2 |
| 7 | A high-sensitivity MEMS gravimeter with a largedynamic range显示文摘Precise measurement of variations in the local gravitational acceleration is valuable for natural hazard forecasting,prospecting,and geophysical studies.Common issues of the present gravimetry technologies include their high cost,high mass,and large volume,which can potentially be solved by micro-electromechanical-system(MEMS)technology.However,the reported MEMS gravimeter does not have a high sensitivity and a large dynamic range comparable with those of the present commercial gravimeters,lowering its practicability and ruling out worldwide deployment.In this paper,we introduce a more practical MEMS gravimeter that has a higher sensitivity of 8μGal/√Hz and a larger dynamic range of 8000 mGal by using an advanced suspension design and a customized optical displacement transducer.The proposed MEMS gravimeter has performed the co-site earth tides measurement with a commercial superconducting gravimeter GWR iGrav with the results showing a correlation coefficient of 0.91. | Shihao Tang Huafeng Liu Shitao Yan Xiaochao Xu Wenjie Wu Ji Fan Jinquan Liu Chenyuan Hu Liangcheng Tu | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 8 | Structural iMoSIFT for Human Action Recognition显示文摘Classic local space-time features are successful representations for action recognition in videos. However, these features always confuse object motions with camera motions, which seriously affect the accuracy of action recognition. In this paper, we propose improved motion scale-inviriant feature transform(iMoSIFT) algorithm to eliminate the negative effects caused by camera motions. Based on iMoSIFT, we consider the spatial-temporal structure relationship among iMoSIFT interest points, and adopt locally weighted word context descriptors to code this relationship. Then, we use two-layer BOW representation for every video clip. The proposed approach is evaluated on available datasets, namely Weizemann, KTH and UCF sports. The experimental results clearly demonstrate the effectiveness of the proposed approach. | CHEN Huafeng CHEN Jun HU Ruimin | 2016 | Wuhan University Journal of Natural Sciences2016，21，3： | 2 |
| 9 | A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma显示文摘Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28 immune modulatory genefamily. Although PD-1H has been shown to function as a coinhibitory receptor on T cells to limit naive T-cellactivation and proliferation, its role in the regulation of the T-cell response to allergens is unknown. We report herethat genetic ablation or blockade of PD-1H drastically promotes pulmonary inflammation with massive accumulationof eosinophils in a mouse model of experimental asthma, indicating a suppressive function of PD-1H in allergicinflammation. The loss of PD-1H led to elevated production of both innate cytokines (IL-6, MCP-1 and TNFα) andTh2 cytokines (IL-5 and IL-13) in the lung, indicating a critical role of PD-1H in suppressing the production ofairway inflammatory cytokines. In addition, the loss of PD-1H also impaired the expansion of systemic andpulmonary regulatory T cells during asthma induction. These findings support a critical role of intrinsic PD-1H inthe regulation of inflammatory responses to allergens. Finally, we showed that treatment with a PD-1H agonisticmonoclonal antibody reduced the severity of asthma, which was accompanied by suppressed lung inflammation.Our findings support PD-1H as a potential target and suggest a possible strategy for the treatment of allergicasthma in humans. | Huafeng Liu Xin Li Li Hu Min Zhu Bailin He Liqun Luo Lieping Chen | 2018 | Cellular & Molecular Immunology2018，15，9： | 1 |
| 10 | Action Recognition with Temporal Scale-Invariant Deep Learning Framework显示文摘Recognizing actions according to video features is an important problem in a wide scope of applications. In this paper, we propose a temporal scale.invariant deep learning framework for action recognition, which is robust to the change of action speed. Specifically, a video is firstly split into several sub.action clips and a keyframe is selected from each sub.action clip. The spatial and motion features of the keyframe are extracted separately by two Convolutional Neural Networks(CNN) and combined in the convolutional fusion layer for learning the relationship between the features. Then, Long Short Term Memory(LSTM) networks are applied to the fused features to formulate long.term temporal clues. Finally, the action prediction scores of the LSTM network are combined by linear weighted summation. Extensive experiments are conducted on two popular and challenging benchmarks, namely, the UCF.101 and the HMDB51 Human Actions. On both benchmarks, our framework achieves superior results over the state.of.the.art methods by 93.7% on UCF.101 and 69.5% on HMDB51, respectively. | Huafeng Chen Jun Chen Ruimin Hu Chen Chen Zhongyuan Wang | 2017 | China Communications2017，14，2： | 1 |
| 11 | Applications of knitted mesh fabrication techniques to scaffolds for tissue engineering and regenerative medicine显示文摘 | Xingang Wang Chunmao Han Xinlei Hu Huafeng Sun Chuangang You Changyou Gao Yang Haiyang | 2011 | Journal of the Mechanical Behavior of Biomedical Materials2011，，7： | 1 |
| 12 | Author Correction:A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma显示文摘In the Acknowledgement section of this article,NIH grants numbered P50 CA196530 and P30 CA016359 were incorrectly attributed to author Lieping Chen and should not have been cited.The original article has been corrected. | Huafeng Liu Xin Li Li Hu Min Zhu Bailin He Liqun Luo Lieping Chen | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 13 | 肿瘤再生细胞通过犬尿氨酸转移以及芳香烃受体激活诱导CD8^+T细胞表达PD-1显示文摘文章简介肿瘤免疫治疗是当前肿瘤研究的热点领域之一,通过利用免疫细胞、免疫分子直接或间接杀伤肿瘤细胞,以控制或清除肿瘤,被认为是人类战胜癌症的希望所在。肿瘤免疫治疗主要依赖活化的T细胞杀伤肿瘤细胞. | 刘玉英 梁晓雨 董文茜 Yi Fang Jiadi Lv Tianzhen Zhang Roland Fiskesund Jing Xie Jinyan Liu Xiaonan Yin Xun Jin Degao Chen Ke Tang Jingwei Ma Huafeng Zhang Jing Yu Jun Yan Huaping Liang Siqi Mo Feiran Cheng Yabo Zhou Haizeng Zhang Jing Wang Jingnan Li Yang Chen Bing Cui Zhuo-Wei Hu Xuetao Cao F. Xiao-Feng Qin 黄波 | 2019 | 科学新闻2019，0，2： | 0 |
| 14 | Efficient Ship:A Hybrid Deep Learning Framework for Ship Detection in the River显示文摘Optical image-based ship detection can ensure the safety of ships and promote the orderly management of ships in offshore waters.Current deep learning researches on optical image-based ship detection mainly focus on improving one-stage detectors for real-time ship detection but sacrifices the accuracy of detection.To solve this problem,we present a hybrid ship detection framework which is named EfficientShip in this paper.The core parts of the EfficientShip are DLA-backboned object location(DBOL)and CascadeRCNN-guided object classification(CROC).The DBOL is responsible for finding potential ship objects,and the CROC is used to categorize the potential ship objects.We also design a pixel-spatial-level data augmentation(PSDA)to reduce the risk of detection model overfitting.We compare the proposed EfficientShip with state-of-the-art(SOTA)literature on a ship detection dataset called Seaships.Experiments show our ship detection framework achieves a result of 99.63%(mAP)at 45 fps,which is much better than 8 SOTA approaches on detection accuracy and can also meet the requirements of real-time application scenarios. | Huafeng Chen Junxing Xue Hanyun Wen Yurong Hu Yudong Zhang | 2024 | Computer Modeling in Engineering & Sciences2024，138，1： | 0 |
| 15 | Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target显示文摘Amyotrophic lateral sclerosis(ALS)is the most common motor neuron disease.At present,no definite ALS biomarkers are available.In this study,exosomes from the plasma of patients with ALS and healthy controls were extracted,and differentially expressed exosomal proteins were compared.Among them,the expression of exosomal coronin-1a(CORO1A)was 5.3-fold higher than that in the controls.CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice.CORO1A was also overexpressed in NSC-34 motor neuron-like cells,and apoptosis,oxidative stress,and autophagic protein expression were evaluated.CORO1A overexpression resulted in increased apoptosis and oxidative stress,overactivated autophagy,and hindered the formation of autolysosomes.Moreover,CORO1A activated Ca^(2+)-dependent phosphatase calcineurin,thereby blocking the fusion of autophagosomes and lysosomes.The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes.In conclusion,the role of CORO1A in ALS pathogenesis was discovered,potentially affecting the disease onset and progression by blocking autophagic flux.Therefore,CORO1A might be a potential biomarker and therapeutic target for ALS. | Qinming Zhou Lu He Jin Hu Yining Gao Dingding Shen You Ni Yuening Qin Huafeng Liang Jun Liu Weidong Le Sheng Chen | 2022 | Frontiers of Medicine2022，16，5： | 0 |
| 16 | Kinematic synthesis and simulation of a vegetable pot seedling transplanting mechanism with four exact task poses显示文摘To obtain a picking and planting integrated transplanting mechanism(PITM)with ideal trajectory shape,reasonable operating attitude,and compact structure for vegetable pot seedling transplanting,a symmetrical structural PITM composed of two planetary carriers and driven by a cam-noncircular gear combination mechanism was proposed in this paper.In accordance with the requirements of transplanting agronomy,the shape of the motion trajectory and the attitude of the end tip of the clamping claw at several specific positions(the starting and end points of picking seedling,the starting point of pushing seedling,and a special point on the return segment)were planned.To make the clamping claws of PITM pass through a set of prescribed positions,the mechanism was simplified to an open-chain 3R mechanism.An accurate four-position-based method for solving the open-chain mechanism model was adopted to obtain the curves of its fixed hinge point(central point)and dynamic hinge point(circle point).The ratio of adjacent bars’lengths was analyzed to determine the feasible interval of the central and circle point curves and the reasonable link length.A desired closed transplanting trajectory that goes through the given points and the corresponding transmission ratio model of the open-chain mechanism was established.After the transmission ratio of each stage of gear and cam pairs was calculated and distributed,the prototype of PITM was designed and manufactured.Lastly,the effectiveness and feasibility of the design were verified through a preliminary experiment of the prototype. | Liang Sun Haocong Xu Yuzhu Zhou Jiahao Shen Gaohong Yu Huafeng Hu Yuejun Miao | 2023 | International Journal of Agricultural and Biological Engineering2023，16，2： | 0 |
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