|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alpha-helical cationic antimicrobial peptides: relationships of structure and function显示文摘Antimicrobial peptides(AMPs),with their extraordinary properties,such as broad-spectrum activity,rapid action and difficult development of resistance,have become promising molecules as new antibiotics.Despite their various mechanisms of action,the interaction of AMPs with the bacterial cell membrane is the key step for their mode of action.Moreover,it is generally accepted that the membrane is the primary target of most AMPs,and the interaction between AMPs and eukaryotic cell membranes(causing toxicity to host cells)limits their clinical application.Therefore,researchers are engaged in reforming or de novo designing AMPs as a‘singleedged sword’that contains high antimicrobial activity yet low cytotoxicity against eukaryotic cells.To improve the antimicrobial activity of AMPs,the relationship between the structure and function of AMPs has been rigorously pursued.In this review,we focus on the current knowledge of α-helical cationic antimicrobial peptides,one of the most common types of AMPs in nature. | Yibing Huang Jinfeng Huang Yuxin Chen | 2010 | Protein & Cell2010，1，2： | 22 |
| 2 | The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication显示文摘Coix is a grass crop domesticated as early as the Neolithic era.It is still widely cultivated for both highly nutritional food and medicinal use.However,the genetic study and breeding of this crop are hindered by the lack of a sequenced genome.Here,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding genes.Comparative genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in sorghum.We further constructed a genetic map and mapped several important traits,especially the strength of hull.Selection of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix domestication.The papery hull makes seed easier to process and germinate.Anatomic and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall biogenesis.We also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,respectively.The two QTLs were further fine mapped within intervals of 250 kb and 146 kb,respectively.These resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop. | Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo YawenYang-Hailan Liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou | 2020 | Molecular Plant2020，13，2： | 11 |
| 3 | A highly porous animal bone-derived char with a superiority of promoting nZVI for Cr(Ⅵ)sequestration in agricultural soils显示文摘Paddy soil and irrigation water are commonly contaminated with hexavalent chromium[Cr(Ⅵ)]near urban industrial areas,thereby threatening the safety of agricultural products and human health.In this study,we develop a porous and high specific area bone char(BC)to support nanoscale zero-valent iron(n ZVI)and apply it to remediate Cr(Ⅵ)pollution in water and paddy soil under anaerobic conditions.The batch experiments reveal that BC/n ZVI exhibits a higher removal capacity of 516.7 mg/(g·n ZVI)for Cr(Ⅵ)than n ZVI when normalized to the actual n ZVI content,which is 2.8 times that of n ZVI;moreover,the highest n ZVI utilization is the n ZVI loading of 15%(BC/n ZVI15).The Cr(Ⅵ)removal efficiency of BC/n ZVI15 decreases with increasing p H(4–10).Coexisting ions(phosphate and carbonate)and humic acid can inhibit the removal of Cr(Ⅵ)with BC/n ZVI15.Additionally,BC exhibits a strong advantage in promoting Cr(Ⅵ)removal by n ZVI compared to the widely used biochar and activated carbon.Our results demonstrate that reduction and coprecipitation are the dominant Cr(Ⅵ)removal mechanisms.Furthermore,BC/n ZVI15 shows a significantly higher reduction and removal efficiency as well as a strong anti-interference ability for Cr(Ⅵ)in paddy soil,as compared to n ZVI.These findings provide a new effective material for remediating Cr(Ⅵ)pollution from water and soil. | Kai Liu Fangbai Li Qingwen Tian Chengrong Nie Yibing Ma Zhenlong Zhu Liping Fang Yuanying Huang Siwen Liu | 2021 | Journal of Environmental Sciences2021，33，6： | 7 |
| 4 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 5 | Comparison on effect of hydrophobicity on the antibacterial and antifungal activities of α-helical antimicrobial peptides显示文摘HPRP-A1, a 15-mer α-helical cationic peptide, was derived from N-terminus of ribosomal protein L1 (RpL1) of Helicobacter pylori. In this study, HPRP-A1 was used as a framework to obtain a series of peptide analogs with different hydrophobicity by single amino acid substitutions in the center of nonpolar face of the amphipathic helix in order to systematically study the effect of hydrophobicity on biological activities of -helical antimicrobial peptides. Hydrophobicity and net charge of peptides played key roles in the biological activities of these peptide analogs; HPRP-A1 and peptide analogs with relative higher hydrophobicity exerted broad spectrum antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and pathogenic fungi, but also showed stronger hemolytic activity; the change of hydrophobicity and net charge of peptides had similar effects with close trend and extent on antibacterial activities and antifungal activities. This indicated that there were certain correlations between the antibacterial mode of action and the antifungal mode of action of these peptides in this study. The peptides exhibited antimicrobial specificity for bacteria and fungi, which provided potentials to develop new antimicrobial drugs for clinical practices. | ZHAO LianJing HUANG YiBing GAO Song CUI Yan HE Dan WANG Li CHEN YuXin | 2013 | Science China Chemistry2013，56，9： | 3 |
| 6 | Role of helicity of a-helical antimicrobia peptides to improve specificity显示文摘 | Yibing Huang Liyan He Guirong Li Naicui Zhai Hongyu Jiang Yuxin Chen | 2014 | Protein & Cell2014，5，8： | 3 |
| 7 | Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer显示文摘Colorectal cancer is one of the leading causes of cancer death worldwide.According to global genomic status,colorectal cancer can be classified into two main types:microsatellite-stable and microsatellite-instable tumors.Moreover,the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular mechanisms.Recently,mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal cancer.However,the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer,which accounts for the majority of colorectal cancer,remain unclear.In this study,we systematically investigated the functional role of altered mitochondrial DNA copy number in the survival and metastasis of microsatellite-stable colorectal cancer cells.Moreover,the underlying molecular mechanisms were also explored.Our results demonstrated that increased mitochondrial DNA copy number by forced mitochondrial transcription factor A expression significantly facilitated cell proliferation and inhibited apoptosis of microsatellitestable colorectal cancer cells both in vitro and in vivo.Moreover,we demonstrated that increased mitochondrial DNA copy number enhanced the metastasis of microsatellite-stable colorectal cancer cells.Mechanistically,the survival advantage conferred by increased mitochondrial DNA copy number was caused in large part by elevated mitochondrial oxidative phosphorylation.Furthermore,treatment with oligomycin significantly suppressed the survival and metastasis of microsatellite-stable colorectal cancer cells with increased mitochondrial DNA copy number.Our study provides evidence supporting a possible tumor-promoting role for mitochondrial DNA and uncovers the underlying mechanism,which suggests a potential novel therapeutic target for microsatellite-stable colorectal cancer. | Xiacheng Sun Lei Zhan Yibing Chen Gang Wang Linjie He Qian Wang Feng Zhou Fang Yang Jin Wu Yousheng Wu Jinliang Xing Xianli He Qichao Huang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 8 | Can phosphate compounds be used to reduce the plant uptake of Pb and resist the Pb stress in Pb-contaminated soils?显示文摘The effects of different phosphate-amendments on lead(Pb) uptake,the activities of superoxide dismutase(SOD) and the level of malondialdehyde(MDA) in cauliflower(Brassica oleracea L.) in contaminated soils with 2500,or 5000 mg P2O5/kg soil of hydroxyapatite(HA),phosphate rock(PR),single-superphosphate(SSP) and the mix of HA/SSP(HASSP) were evaluated in pot experiments.Results showed that the Pb concentrations in shoots and roots decreased by 18.3%-51.6% and 16.8%-57.3% among the treatments respectively compared to the control samples.The effciency order of these phosphate-amendments in reducing Pb uptake was as follows:HASSP≈ HA > SSP ≈ PR.With the addition of SSP,HA and the mix of HA/SSP,the SOD activity in shoot was reduced markedly(P < 0.05) compared with that in the control group.For example,the SOD activities in shoot by the treatments of HASSP,SSP,and HA in 5000 mg P2O5/kg were found to be only 51.3%,56.2%,and 56.7%,respectively.Similar effects were also observed on the level of MDA in the shoots with a decrease in 24.5%-56.3%.The results verified the inference that phosphate compounds could be used to reduce the plant uptake of Pb and resist the Pb stress in the plant vegetated in Pb-contaminated soils. | CHEN Shibao CHEN Li MA Yibing HUANG Yizong | 2009 | Journal of Environmental Sciences2009，21，3： | 3 |
| 9 | The Langmuir Probe onboard CSES: data inversion analysis method and first results显示文摘The Langmuir Probe(LAP), onboard the China Seismo-Electromagnetic Satellite(CSES), has been designed for in situ measurements of bulk parameters of the ionosphere plasma, the first Chinese application of in-situ measurement technology in the field of space exploration. The two main parameters measured by LAP are electron density and temperature. In this paper, a brief description of the LAP and its work mode are provided. Based on characteristics of the LAP, and assuming an ideal plasma environment, we introduce in detail a method used to invert the I-V curve; the data products that can be accessed by users are shown. Based on the LAP data available, this paper reports that events such as earthquakes and magnetic storms are preceded and followed by obvious abnormal changes. We suggest that LAP could provide a valuable data set for studies of space weather, seismic events, and the ionospheric environment. | Rui Yan YiBing Guan XuHui Shen JianPing Huang XueMin Zhang Chao Liu DaPeng Liu | 2018 | Earth and Planetary Physics2018，2，6： | 2 |
| 10 | Combination therapy of thiamine,vitamin C and hydrocortisone in treating patients with sepsis and septic shock:a meta-analysis and trial sequential analysis显示文摘Background:The objective of this study was to evaluate the clinical efficacy of thiamine and vitamin C with or without hydrocortisone coadministration on the treatment of sepsis and septic shock.Methods:MEDLINE,EMBASE and CENTRAL databases were searched for randomized controlled trials(RCTs)that made a comparative study between the combination therapy of vitamin C and thiamine with or without hydrocortisone and the administration of placebo in patients with sepsis or septic shock.Two reviewers independently performed study selection,data extraction and quality assessment.Both short-term mortality and change in the sequential organ failure assessment(SOFA)score from baseline(delta SOFA)were set as the primary outcomes.Secondary endpoints included intensive care unit(ICU)mortality,new onset of acute kidney injury,total adverse events,ICU and hospital length of stay,duration of vasopressor usage and ventilator-free days.Meanwhile,trial sequential analysis was conducted for primary outcomes.Results:Eight RCTs with 1428 patients were included in the current study.The results showed no significant reduction of short-term mortality in sepsis and septic shock patients who received combination therapy of vitamin C and thiamine with or without hydrocortisone compared to those with placebo{risk ratio(RR),1.02[95%confidence interval(CI),0.87 to 1.20],p=0.81,I2=0%;risk difference(RD),0[95%CI,−0.04 to 0.05]}.Nevertheless,the combination therapy was associated with significant reduction in SOFA score[mean difference(MD),−0.63,(95%CI,−0.96 to−0.29,p<0.001,I^(2)=0%]and vasopressors duration(MD,−22.11[95%CI,−30.46 to−13.77],p<0.001,I2=6%).Additionally,there were no statistical differences in the pooled estimate for other outcomes.Conclusions:In the current meta-analysis,the combination therapy of vitamin C and thiamine,with or without hydrocortisone had no impact on short-term mortality when compared with placebo,but was associated with significant reduction in SOFA score among patients with sepsis and septic shock. | Renqi Yao Yibing Zhu Yue Yu Zhixuan Li Lixue Wang Liyu Zheng Jingyan Li Huibin Huang Guosheng Wu Feng Zhu Zhaofan Xia Chao Ren Yongming Yao | 2021 | Burns & Trauma2021，9，1： | 2 |
| 11 | Rice(Oryza sativa L.)seedlings enriched with zinc or manganese:Their impacts on cadmium accumulation and expression of related genes显示文摘Cadmium(Cd)contamination in paddy soils means that the rice produced there may be unsafe for human consumption.A hydroponic study was conducted to enrich rice seedlings with zinc(Zn)or manganese(Mn),and the uptake and transport characteristics of Cd in these Zn-and Mn-rich seedlings were subsequently investigated using a greenhouse pot trial.The results showed that hydroponic cultivation in 10-50μmol L^(-1) Zn(ZnSO_(4)·7 H_(2)O)or50-250μmol L^(-1) Mn(MnSO_(4)·H_(2)O)for 30 d had no significant impact on rice growth,while the accumulation of Zn and Mn was 7.31-18.5 and 25.4-47.7 times higher,respectively,than in the control(no Zn or Mn addition).The accumulation of Cd in the Zn-and Mn-rich rice plants was 26.3%-38.6% and 34.4%-44.5% lower than that in the control,respectively,and the translocation factors of Cd from roots to shoots also decreased by 23.3%-41.3% and 25.3%-37.0%,respectively,after transplanting to Cd-contaminated soils.Furthermore,the relative expression levels of OsIRT1(Oryza sativa iron-regulated transporter 1)were downregulated by 40.1%-59.3% and 16.0%-25.9%,respectively,in the Zn-and Mn-rich seedling roots.This downregulation may indicate a possible mechanism contributing to the reductions in Cd absorption.Field experiments confirmed that the Zn-and Mn-rich seedlings produced brown rice(unpolished rice grains)with significantly decreased concentrations of Cd(34.2%-44.4%).This study provides an innovative method for reducing the food safety risks from rice grown on slightly to moderately Cd-contaminated paddy soils. | Gaoxiang HUANG Changfeng DING Yibing MA Yurong WANG Zhigao ZHOU Shun'an ZHENG Xingxiang WANG | 2021 | Pedosphere2021，31，6： | 2 |
| 12 | Gelcasting of alumina ceramics in the mixed acrylamide and polyacrylamide systems显示文摘 | Jingtao Ma Zhipeng Xie Hezhuo Miao Yong Huang Yibing Cheng Weiyou Yang | 2003 | Journal of the European Ceramic Society2003，，13： | 1 |
| 13 | The influence of soil solution properties on phytotoxicity of soil soluble copper in a wide range of soils显示文摘 | Xiaoqing Zhang Xuedong Wang Dongpu Wei Bo Li Yibing Ma Zhanbin Huang | 2013 | Geoderma2013，，： | 1 |
| 14 | Preparation and properties studies of halogen-free flame retardant form-stable phase change materials based on paraffin/high density polyethylene composites显示文摘 | Cai Yibing Wei Qufu Huang Fenglin | 2008 | Appl Energy2008，85，： | 1 |
| 15 | Mesoporous anatase TiOz beads with high surface areas and controllable pore sizes: a superior candidate for high-performance dye-sensitized solar cells显示文摘 | Chen Dehong Huang Fuzhi Cheng Yibing Caruso Rachel A | 2009 | Advanced Materials2009，21，21： | 1 |
| 16 | Formation of sil- icon nitride binded silicon carbide by aqueous geleasting 显示文摘 | Xie Zhipeng Cheng Yibing Huang Yong | 2003 | Materials and Engineering2003，349，： | 1 |
| 17 | 显示文摘 | Huang Fuzhi Zhou Meifang Cheng Yibing | 2006 | Chem Mater2006，18，： | 1 |
| 18 | Mesoporous anatase TiO2 beads with high surface areas and controllable pore sizes: a superior candidate for high-performance dye-sensitized solar ceils 显示文摘 | CHEN Dehong HUANG Fuzhi CHENG Yibing | 2009 | Adv Mater2009，21，21： | 1 |
| 19 | Dual-function scattering layer of submicrometer-sized mesoporous TiO2 beads for high-efficiency dye-sensitized solar cells显示文摘 | Huang Fuzhi Chen Dehong Cheng Yibing | 2010 | Advanced Functional Materials2010，20，8： | 1 |
| 20 | Preparation and properties studies of halogen-free flame retardant form-stable phase change materials based on paraffin/high density polyethylene composites 显示文摘 | Cai Yibing Wei Qufu Huang Fonglin | 2008 | Applied Energy2008，85，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员