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| 1 | Ultrastructure of junction areas between neurons and astrocytes in rat supraoptic nuclei显示文摘AIM: To determine the ultrastructure of junction areas between neurons and astrocytes of supraoptic nuclei in rats orally administered 30 g/L NaCI solution for 5 days. METHODS: The anti-connexin (CX) 43 and anti-CX32 double immunoelectromicroscopic labeled method, and anti-Fos or anti-glial fibdllary acidic protein (GFAP) immunohistochemistry were used to detect changes in the junctional area between neurons and astrocytes in supraoptic nuclei of 5 rats after 30 g/L NaCL solution was given for 5days. RESULTS: A heterotypic connexin32/connexin43 gapjunction (HGJ) between neurons and astrocytes (AS) in rat supraoptic nuclei was observed, which was characterized by the thickening and dark staining of cytomembranes with a narrow cleft between them. The number of HGJs and Fos like immunoreactive (-LI) cells was significantly increased following hyperosmotic stimuli, that is, the rats were administered 30 g/L NaCI solution orally or 90 g/L NaCI solution intravenously. HGJs could be blocked with carbenoxolone (CBX), a gap junction blocker, and the number of Fos-LI neurons was significantly decreased compared with that in rats without CBX injection, while Fos-LI ASs were not affected. CONCLUSION: HGJ may be a rapid adaptive signal structure between neurons and ASs in response to stimulation. | LiDuan HuaYuan Chang-JunSu Ying-YingLiu Zhi-RenRao | 2004 | World Journal of Gastroenterology2004，10，1： | 16 |
| 2 | Polymorphisms of three gene-derived STS on pig chromosome 13q41 are associated with susceptibility to enterotoxigenic Escherichia coli F4ab/ac in pigs显示文摘Neonatal diarrhea caused by enterotoxigenic Escherichia coli(ETEC)F4 is a common and serious disease,resulting in significant economical loss in the pig industry.The locus encoding ETEC F4 receptor has been mapped to pig chromosome(SSC)13q41,and one of the most significantly linked markers is S0075.In this study,we selected three genes including SLC12A8,MYLK and KPNA1 from a chromosomal region flanking S0075 on SSC13 to develop pig specific sequence tagged sites(STS). Seven single nucleotide polymorphisms were identified in the three pig STS using DNA of four full-sib susceptible and resistant animals in a White Duroc×Erhualian intercross.All grandparents,parents and 755 offspring in the intercross were genotyped for three polymorphisms,including SLC12A8 g.159A>G,MYLK g.1673A>G and KPNA1 g.306A>G.Family-based transmission disequilibrium test(TDT) revealed that all polymorphisms and the corresponding haplotypes are significantly associated with ETEC F4ab/ac(especially F4ac)brush border adhesion phenotypes,indicating that these polymor- phism are in linkage disequlibrium with causal mutation(s)of the gene encoding ETEC F4ab/ac receptor. Our results strengthen the evidence for the involvement of SSC13q41 in high acquiring risk of ETEC F4ab/ac infection,and provide novel polymorphic markers for fine mapping of the ETEC F4ab/ac receptor locus. | HUANG Xiang 1 ,REN Jun 1 ,YAN XueMing 1,2 ,PENG QiuLing 1 ,TANG Huan 1 ,ZHANG Bo 1 ,JI HuaYuan 1 , YANG ShuJin1&HUANG LuSheng 1 1Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China,Jiangxi Agricultural University, Nanchang 330045,China 2Department of Biology,Nanchang University of Science and Technology,Nanchang 330038,China | 2008 | Science China(Life Sciences)2008，51，7： | 8 |
| 3 | Molecular mechanisms underlying the effects of acupuncture on neuropathic pain显示文摘Acupuncture has been used to treat neuropathic pain for a long time,but its mechanisms of action remain unknown.In this study,we observed the effects of electroacupuncture and manua acupuncture on neuropathic pain and on ephrin-B/EphB signaling in rats models of chronic constriction injury-induced neuropathic pain.The results showed that manual acupuncture and electroacupuncture significantly reduced mechanical hypersensitivity following chronic constriction injury,especially electroacupuncture treatment.Real-time PCR results revealed that ephrin-B1/B3and EphB1/B2 mRNA expression levels were significantly increased in the spinal dorsal horns of chronic constriction injury rats.Electroacupuncture and manual acupuncture suppressed the high expression of ephrin-B1 mRNA,and elevated EphB3/B4 mRNA expression.Electroacupuncture significantly enhanced the mRNA expression of ephrin-B3 and EphB3/B6 in the dorsal horns of neuropathic pain rats.Western blot results revealed that electroacupuncture in particular,and manual acupuncture,significantly up-regulated ephrin-B3 protein levels in rat spinal dorsal horns The results of this study suggest that acupuncture could activate ephrin-B/EphB signaling in neuropathic pain rats and improve neurological function. | Ziyong Ju Huashun Cui Xiaohui Guo Huayuan Yang Jinsen He Ke Wang | 2013 | Neural Regeneration Research2013，8，25： | 8 |
| 4 | Easily manageable prognostic factors in 152 Chinese elderly acute myeloid leukemia patients:a single-center retrospective study显示文摘We retrospectively investigated the prognostic factors of acute myeloid leukemia(AML) in 152 Chinese patients with de novo AML who were older than 60 years of age and who received treatment at our hospital.Log-rank test showed that 6 parameters including older age,higher white blood cell(WBC) counts,lactate dehydrogenase(LDH)and bone marrow(BM) blasts at diagnosis,unfavorable risk cytogenetics,and non-mutated CEBPα were significant adverse prognostic factors of overall survival(OS) for elderly AML patients(P = 0.0013,0.0358,0.0132,0.0242,0.0236 and 0.0130,respectively).Moreover,older age and higher LDH were significant adverse predictors for relapse-free survival(RFS)(P = 0.0447 and 0.0470,respectively).Univariate analysis revealed similar results for OS to those of the log-rank test and only higher LDH at diagnosis was a significant adverse predictor for RFS(P = 0.028,HR:1.979,95%CI:1.075-3.644).In multivariate analysis,we identified 2 trends towards independent prognostic factors for OS,including BM blasts at diagnosis(P = 0.057,HR:1.676,95%CI:0.984-2.854)and mutation status of CEBPα(P = 0.064,HR:4.173,95%CI:0.918-18.966).Our data indicated that older age,gender and a previous history of hematologic diseases resulted in lower complete remission rate(P = 0.012,0.051 and 0.086,respectively).We further developed an easy scoring system for predicting prognosis and response to induction therapy in older AML patients.Patients who had lower scores showed significantly longer OS and RFS(P = 0.0006 and 0.1001,respectively) and higher CR rate(P = 0.014).Our research is limited by its retrospective nature and the results from our study need to be further validated by prospective randomized clinical trials. | Jiadai Xu Tingmei Chen Yun Liu Huayuan Zhu Wei Wu WenYi Shen Bei Xu Sixuan Qian Jianyong Li Peng Liu | 2014 | The Journal of Biomedical Research2014，28，5： | 7 |
| 5 | Highly sensitive flexible capacitive pressure sensor with a broad linear response range and finite element analysis of micro-array electrode显示文摘With the continuous development of wearable electronics,health care and smart terminals,highly performance flexible pressure sensors present a huge application prospect.In this study,by introducing the micro-array structured electrodes and dielectric layers with high dielectric constant,capacitive pressure sensor fabricated with a brand new preparation strategy and highly sensitive is proposed.The prepared micro-array structure is the basis for sensors with high sensitivity.Besides,the contact area between the two electrodes changes from linear to planar with the increased loading,which result in a wider linear responding range.In addition,by introducing ceramic dielectric material-barium titanate(BT)fillers into the dielectric layer to increase it’s the dielectric constant,the sensitivity of the sensor shows two-fold increase.Moreover,the sensitivity gradients can be tuned by changing the loading contents of BT particles.Hence,compared with parallel board capacitive sensors with ordinary dielectric layer,these sensors exhibit excellent performance as follow,high sensitivity(up to 4.9 kPa^(-1))under low pressure range(0-2500 Pa),low detection limit(<1.7 Pa),short response time(<50 ms),a stable response over 5000 loading-unloading cycles,bending stability and an adjustable sensitivity.Further,the flexible pressure sensor can detect the pressure of the water droplets and monitor human movement behavior.With the facile design and excellent comprehensive properties,the flexible pressure sensor provides a new approach to improve the sensitivity and shows a broad application prospects in the wearable electronics,health care and smart terminals. | Longquan Ma Xuecheng Yu Yuanyuan Yang Yougen Hu Xinyu Zhang Huayuan Li Xing Ouyang Pengli Zhu Rong Sun Ching-ping Wong | 2020 | Journal of Materiomics2020，6，2： | 4 |
| 6 | Effect of different twirling and rotating acupuncture manipulation techniques on the blood flow perfusion at acupoints显示文摘OBJECTIVE: To analyze the effect of different twirling and rotating acupuncture manipulation techniques on the blood flow perfusion at acupoints to provide a reference for the study of acupoint specificity and the quantification and effectiveness of acupuncture methods. METHODS: Twenty healthy male or female college students each received four different acupuncture manipulation techniques, including simple acupuncture, uniform reinforcing-reducing needling, twirling reinforcing needling, and twisting reducing needling. The self-control method was applied. Acupuncture was performed by an acupuncture manipulation simulator at Neiguan (PC 6) and Zusanli (ST 36). The process of twirling and rotating was divided into seven timepoints. The PeriCam Perfusion Speckle Imager (PSI) System was used to collect the blood flow perfusion data at each acupoint. The specificity of twirling and rotating acupuncture manipulation was analyzed based on changes in the curve, video, and numerical blood flow perfusion data at each timepoint. RESULTS: There were two peaks in the blood flow perfusion curve of twirling and rotating acupuncture manipulation;one appeared after 3 min of needle retention, and the other appeared 3 min after needle removal. The blood flow perfusion parameters showed that the greatest differences between the four manipulation techniques occurred after 5 and 10 min of needle retention. The specificity of various manipulation techniques was most obvious at these two timepoints. There were significant differences between the four manipulation groups in the blood flow perfusion and the relative change rates of blood flow perfusion at each timepoint. CONCLUSION: Laser speckle imaging enables the real-time, non-invasive, rapid, and accurate collection of blood flow perfusion data during acupuncture. This imaging technique enables the easy attainment of various parameters such as visual images, two-dimensional curves, and data tables. At various timepoints, the four groups significantly differed regarding changes in blood flow perfusion and relative change rates of blood flow perfusion, which facilitated the differentiation of the four acupuncture manipulation methods. Based on this, further analysis could be conducted to study spatial distribution characteristics such as the influence area and flare area. The frequency domain analysis of acupuncture manipulation curves is important in the study of the dose-effect relationship and specificity of acupuncture manipulation. | Xu Gang Xi Qianhui Tang Wenchao Liu Tangyi Gao Ming Li Shaoxiong Wen Junling Yang Huayuan | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 3 |
| 7 | Pretreatment of emulational manual acupuncture versus electroacupuncture against visceral traction pain in rats显示文摘BACKGROUND:Acupuncture and moxibustion against visceral noxious stimulation present different mechanisms in the peripheral and central nervous systems,involving release of neurotransmitter substance P,acetylcholine esterase,leucine-enkephalin,and c-Fos protein expression.However,there are few reports addressing changes in neurotransmitter expression following manual acupuncture and electroacupuncture against visceral traction pain.OBJECTIVE:To explore changes in neurotransmitter expression in the ileum and protein expression in the medullary visceral zone of visceral traction pain rats undergoing pretreatment of emulational manual acupuncture,and to investigate the differences between emulational manual acupuncture and electroacupuncture.DESIGN,TIME AND SETTING:The randomized,controlled study was performed at the Biomedical Engineering Laboratory,Shanghai University of Traditional Chinese Medicine,Shanghai,China from August 2008 to July 2009.MATERIALS:G6805 electroacupuncture apparatus(Shanghai Medical Electronic Machine Factory,China) and ZSF-I acupuncture manipulation simulation therapeutic system(Chinese Medical Engineering Room,Shanghai University of Traditional Chinese Medicine,Shanghai China) were used in the present study.METHODS:A total of 40 male Sprague Dawley rats were equally and randomly assigned to sham surgery,model,emulational manual acupuncture and electroacupuncture groups.In the emulational manual acupuncture and electroacupuncture groups,emulational manual acupuncture and electroacupuncture were applied at bilateral Zusanli(ST 36) acupoints for 30 minutes,and models of visceral traction pain were established immediately.MAIN OUTCOME MEASURES:Substance P expression,c-Fos and glial fibrillary acidic protein expression were measured using immunohistochemistry.Acetylcholine esterase activity was examined utilizing a colorimetric method.Leucine-enkephalin content was detected using a radioimmune assay.Degree of pain in rats was assessed by pain score.RESULTS:Pain score,substance P expression in the ileum,acetylcholine esterase activity,expression of c-Fos protein and glial fibrillary acidic protein in the medullary visceral zone were significantly decreased following pretreatment of emulational manual acupuncture and electroacupuncture in rats with visceral traction pain(P < 0.05).Compared with the electroacupuncture group,the leucine-enkephalin content was significantly increased,and pain score was significantly diminished in the emulational manual acupuncture group(P < 0.05).CONCLUSION:Emulational manual acupuncture pretreatment decreases acetylcholine esterase activity,increases leucine-enkephalin release,downregulates expression of c-Fos protein and glial fibrillary acidic protein and ultimately inhibits visceral traction pain by reducing substance P release.The effectiveness in inhibiting visceral traction pain is greater when using emulational manual acupuncture compared with electroacupuncture.This is because emulational manual acupuncture effectively increases leucine-enkephalin release. | Huayuan Yang Tingting Guo Youjiang Min Tangyi Liu Ming Gao | 2010 | Neural Regeneration Research2010，5，10： | 2 |
| 8 | IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-N FATc3-Etv2 pathway显示文摘 | Yi-Jie Wang Jijun Huang Wenqiang Liu Xiaochen Kou Huayuan Tang Hong Wang Xiujian Yu Shaorong Gao Kunfu Ouyang Huang-Tian Yang | 2017 | Journal of Molecular Cell Biology2017，9，4： | 2 |
| 9 | Acupoint electrogymnastics therapy in stroke hemiplegia显示文摘BACKGROUND: Electrogymnastics can offer a range of proprioceptive, motor, and cutaneous sensation impulses to the central nerve system. The center receives perception of the paralyzed muscle through the aid of these impulses. During this process, functional reorganization of connecting network between segment and intersegment takes place. OBJECTIVE: To observe the therapeutic efficacy of acupoint electrogymnastics and traditional electroacupuncture on stroke hemiplegia. DESIGN, TIME AND SETTING: A multicenter, randomized, controlled, blinded, clinical study was performed at the College of Acu-moxibustion and Massage in Shanghai University of Traditional Chinese Medicine from May 2004 to September 2006. PARTICIPANTS: A total of 153 patients suffering from stroke hemiplegia, comprising 83 males and 70 females, aged 63-70 years, were admitted to outpatient and inpatient at LongHua Hospital Affiliated Shanghai University of Traditional Chinese medicine, Putuo District Traditional Chinese Medicine Hospital and Changqiao Street Community Health Service Center of Shanghai. METHODS: The patients were randomly divided into treatment (n = 77) and control (n = 76) groups. They were treated with acupoint electrogymnastics and traditional electroacupuncture, respectively. In the treatment group, two pairs of positive and negative JD-2008 type electrodes from a hemiplegia treatment apparatus were directly pasted on the Shousanli (LI 10) and Waiguan (SJ 5) acupoints of the upper limb, as well as the Zusanli (S 36) and Yanglingquan (GB 34) acupoints of the lower limb, respectively. In the control group, needles were consecutively inserted into the above acupoints. Using the method of lifting-inserting and twisting-rotating, the needle was manipulated with small amplitude of 5-7 mm and a fast frequency of 80-120 times/min when the needle was inserted to a suitable depth. When the sensation of needling was attained, the two pairs of positive and negative electrodes of type G6805-II electro-acupuncture apparatus were connected to the Shousanli (LI 10) and Waiguan (SJ 5) acupoints of the upper limb, as well as the Zusanli (S 36) and Yanglingquan(GB 34) acupoints of the lower limb, respectively. MAIN OUTCOME MEASURES: The Fugl-Meyer evaluation method was used to assess upper limb movement, lower limb movement, sensory stimulation of all limbs, balance, and joint range of motion. RESULTS: Upper-lower limb motor function, limb sensory function, balance, and joint range of motion were significantly ameliorated following treatment, compared with pre-treatment (P < 0.01). There was no significant difference in various indexes between the two groups after treatment (P > 0.05). CONCLUSION: Acupoint electrogymnastics and traditional electroacupuncture exhibited similar curative effects in the treatment of stroke hemiplegia, | Huayuan Yang Tangyi Liu Yanhong Wang Shengguo Ying Chaoying Zheng Le Kuai MingGao Youjiang Min | 2008 | Neural Regeneration Research2008，3，10： | 1 |
| 10 | Laser Quenching and Ion Sulphidizing Complex Surface Treat Technology for Diesel Engine Cylinder显示文摘In order to solve the problem of wear-out-failure of diesel engine cylinder, the laser-quenching and low temperature ion sulfurizing complex surface treatment technology was operated on the surface of 42MnCr52 steel. And the tribological properties of the complex layer were investigated. The experimental results indicated that the complex layer was composed of soft surface sulphide layer and sub-surface laser-quenching harden layer, and showed excellent friction-reduction and wear-resistance performance at high temperature. The synergistic effect of the complex layer resulted in 20% increase in hardness, 10% reduction in friction coefficient and 50% reduction in wear weight loss, respectively, compared with those of the standard samples. The bench-test further demonstrated that this technology can improve the lubricating condition between cylinder and piston ring, and reduce both abnormity wear when the lubricating oil is deficiency at the time of start-up and sticking wear at high temperature during the operating period, and then prolong the service life of engine. | 谢兆钱 ZENG Qingqiang HUANG Huayuan Cai Zhihai ZHAO Yuqiang | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，6： | 1 |
| 11 | Effects of Acupuncture on Mitochondria of Muscle Cell in Rats of Acute Swimming Exercise显示文摘 | Ming Gao Huayuan Yang Tangyi Liu | 2008 | IFMBE Proceedings2008，，19： | 1 |
| 12 | Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection 显示文摘 | HENG D U TONG L I HUAYUAN ZHANG | 2007 | Liver Int2007，27，2： | 1 |
| 13 | Genetic Analysis of Multiple Paternity in an Endangered Ovoviviparous Lizard Shinisaurus crocodilurus显示文摘The crocodile lizard(Shinisaurus crocodilurus) is an ovoviviparous lizard belonging to a monotypic family that originated during the end of the quaternary ice age. A rare species in the wild, the crocodile lizard was listed in CITES Appendix II. Knowledge of the reproductive biology and mating system of this species is important for designing conservation strategies and improving genetic variation. To investigate the paternity of the crocodile lizards and to interpret their reproductive behaviour, we collected saliva from females, potential fathers and offspring in a seminatural enclosure experiment and analyzed the paternity of the crocodile lizard using 12 microsatellite genetic loci. The overall observed incidence of multiple paternity was 42.9%(6 of 14 clutches) and Fis was 0.089 ± 0.056. These results indicate that the primary mating mode of the crocodile lizard is that males are polygynous while with females are polyandrous, and there is multiple paternity among offspring of the same mother. | Huayuan HUANG Dan LUO Cong Guo Zhuo TANG Zhengjun WU Jinping CHEN | 2015 | Asian Herpetological Research2015，6，2： | 1 |
| 14 | Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia显示文摘 | Huayuan Zhu Wei Wu Yuan Fu Wenyi Shen Kourong Miao Min Hong Wei Xu Ken H. Young Peng Liu Jianyong Li | 2014 | Annals of Hematology2014，，3： | 1 |
| 15 | VvBBX44 and VvMYBA1 form a regulatory feedback loop to balance anthocyanin biosynthesis in grape显示文摘Anthocyanins are essential for the quality of perennial horticultural crops,such as grapes.In grapes,ELONGATED HYPOCOTYL 5(HY5)and MYBA1 are two critical transcription factors that regulate anthocyanin biosynthesis.Our previous work has shown that Vitis vinifera B-box protein 44(VvBBX44)inhibits anthocyanin synthesis and represses VvHY5 expression in grape calli.However,the regulatory mechanism underlying this regulation was unclear.In this study,we found that loss of VvBBX44 function resulted in increased anthocyanin accumulation in grapevine callus.VvBBX44 directly represses VvMYBA1,which activates VvBBX44.VvMYBA1,but not VvBBX44,directly modulates the expression of grape UDP flavonoid 3-O-glucosyltransferase(VvUFGT).We demonstrated that VvBBX44 represses the transcriptional activation of VvUFGT and VvBBX44 induced by VvMYBA1.However,VvBBX44 and VvMYBA1 did not physically interact in yeast.The application of exogenous anthocyanin stimulated VvBBX44 expression in grapevine suspension cells and tobacco leaves.These findings suggest that VvBBX44 and VvMYBA1 form a transcriptional feedback loop to prevent overaccumulation of anthocyanin and reduce metabolic costs.Our work sheds light on the complex regulatory network that controls anthocyanin biosynthesis in grapevine. | Wenwen Liu Huayuan Mu Ling Yuan Yang Li Yuting Li Shenchang Li Chong Ren Wei Duan Peige Fan Zhanwu Dai Yongfeng Zhou Zhenchang Liang Shaohua Li Lijun Wang | 2023 | Horticulture Research2023，10，10： | 0 |
| 16 | The class B heat shock factor HSFB1 regulates heat tolerance in grapevine显示文摘Grape is a widely cultivated crop with high economic value.Most cultivars derived from mild or cooler climates may not withstand increasing heat stress.Therefore,dissecting the mechanisms of heat tolerance in grapes is of particular significance.Here,we performed comparative transcriptome analysis of Vitis davidii‘Tangwei’(heat tolerant)and Vitis vinifera‘Jingxiu’(heat sensitive)grapevines after exposure to 25°C,40°C,or 45°C for 2 h.More differentially expressed genes(DEGs)were detected in‘Tangwei’than in‘Jingxiu’in response to heat stress,and the number of DEGs increased with increasing treatment temperatures.We identified a class B Heat Shock Factor,HSFB1,which was significantly upregulated in‘Tangwei’,but not in‘Jingxiu’,at high temperature.VdHSFB1 from‘Tangwei’and VvHSFB1 from‘Jingxiu’differ in only one amino acid,and both showed similar transcriptional repression activities.Overexpression and RNA interference of HSFB1 in grape indicated that HSFB1 positively regulates the heat tolerance.Moreover,the heat tolerance of HSFB1-overexpressing plants was positively correlated to HSFB1 expression level.The activity of the VdHSFB1 promoter is higher than that of VvHSFB1 under both normal and high temperatures.Promoter analysis showed that more TATA-box and AT∼TATA-box cis-elements are present in the VdHSFB1 promoter than the VvHSFB1 promoter.The promoter sequence variations between VdHSFB1 and VvHSFB1 likely determine the HSFB1 expression levels that inf luence heat tolerance of the two grape germplasms with contrasting thermotolerance.Collectively,we validated the role of HSFB1 in heat tolerance,and the knowledge gained will advance our ability to breed heat-tolerant grape cultivars. | Haiyang Chen Xinna Liu Shenchang Li Ling Yuan Huayuan Mu Yi Wang Yang Li Wei Duan Peige Fan Zhenchang Liang Lijun Wang | 2023 | Horticulture Research2023，10，3： | 0 |
| 17 | Phase Ⅰ study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients显示文摘Anti-CD 19 chimeric antigen receptor(CAR)T cell therapy has shown impressive efficacy in treating B-cell malignancies.A single-center phase I dose-escalation study was conducted to evaluate the safety and efficacy of T cells transduced with CBM.CD19 CAR,a second-generation anti-CD19 CAR bearing 4-1BB costimulatory molecule,for the treatment of patients with refractory diffuse large B-cell lymphoma(DLBCL).Ten heavily treated patients with refractory DLBCL were given CBM.CD19 CAR-T cell(C-CAR011)treatment.The overall response rate was 20%and 50%at 4 and 12 weeks after the infusion of C-CAR011,respectively,and the disease control rate was 60%at 12 weeks after infusion.Treatment-emergent adverse events occurred in all patients.The incidence of cytokine release syndrome in all grades and grade^3 was 90%and 0,respectively,which is consistent with the safety profile of axicabtagene ciloleucel and tisagenlecleucel.Neurotoxicity or other dose-limiting toxicides was not observed in any dose cohort of C-CAR011 therapy.Antitumor efficacy was apparent across dose cohorts.Therefore,C-CAR011 is a safe and effective therapeutic option for Chinese patients with refractory DLBCL,and further large-scale clinical trials are warranted. | Lei Fan Li Wang Lei Cao Huayuan Zhu Wei Xu Jianyong Li | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 18 | The changes of NOS positive cells and astrocyte in the memorydeficits rat induced by β-amyloid peptide fragmant 25~35显示文摘 | YanwuLing HuaYuan PeichunLi BingpuChen | 2004 | 中国组织化学与细胞化学杂志2004，13，3： | 0 |
| 19 | Waldenstrom's macroglobulinemia associated with Hodgkin's lymphoma:a case report显示文摘Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma(WM/LPL) is a low-grade B-cell nonHodgkin's lymphoma with an indolent clinical course.Higher-grade non-Hodgkin lymphoma(NHL) and therapyrelated myelodysplasia/acute leukemia(t-MDS/AML) have been reported in patients with WM/LPL in previous studies.However,only two cases with WM/LPL were reported to develop to Hodgkin lymphoma(HL).Here,we report the first case of WM/LPL who developed classical HL simultaneously 3 years after initial nucleoside analog-based chemotherapy. | Yuan Fu Huayuan Zhu Peng Liu | 2015 | The Journal of Biomedical Research2015，29，6： | 0 |
| 20 | Overexpression of c-Myc-dependent heterogeneous nuclear ribonucleoprotein A1 promotes proliferation and inhibits apoptosis in NOTCH1-mutated chronic lymphocytic leukemia cells显示文摘Background: NOTCH1 mutation is an essential molecular biologic aberration in chronic lymphocytic leukemia (CLL). CLL patients withNOTCH1 mutation have shown an unfavorable survival and a poor response to chemoimmunotherapy. This study aims to present the mechanisms of adverse prognosis caused byNOTCH1 mutation from the perspective of the splicing factor heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1).Methods: The microarray data in Gene Expression Omnibus datasets were analyzed by bioinformatics and the function of hnRNPA1 was checked by testing the proliferation and apoptosis of CLL-like cell lines. Afterward, quantitative reverse transcription-polymerase chain reaction and Western blotting were applied to explore the relationship among NOTCH1, c-Myc, and hnRNPA1.Results: RNA splicing was found to play a vital part inNOTCH1-mutated CLL cells;hence, hnRNPA1 was selected as the focus of this study. Higher expression of hnRNPA1 validated in primaryNOTCH1-mutated CLL samples could promote proliferation and inhibit apoptosis in CLL. The expression of hnRNPA1 increased when NOTCH1 signaling was activated by transfection with NOTCH1 intracellular domain (NICD)-overexpressed adenovirus vector and declined after NOTCH1 signaling was inhibited by NOTCH1-shRNA. Higher expression of c-Myc was observed in NICD-overexpressed cells and hnRNPA1 expression was downregulated after applying c-Myc inhibitor 10058-F4. Moreover, in NICD-overexpressed cells, hnRNPA1 expression decreased through c-Myc inhibition.Conclusion: Overexpression of c-Myc-dependent hnRNPA1 could promote proliferation and inhibit apoptosis inNOTCH1- mutated CLL cells, which might partly account for the poor prognosis of patients withNOTCH1 mutation. | Yixin Zou Hanning Tang Yi Miao Huayuan Zhu Li Wang Lei Fan Jianxin Fu Wei Xu Jianyong Li Yi Xia | 2022 | Chinese Medical Journal2022，，8： | 0 |
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