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| 1 | Brazilian biosafety law and the new breeding technologies显示文摘Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two decades.Although this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to country.In recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food security.In Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and management.However,most of new breeding technologies did not exist at that time and were not considered in this law.In2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation system.Briefly,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk assessment.If the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing procedures.Currently,152 GM products are commercially approved in Brazil.In 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six products.It is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops. | Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 5 |
| 2 | E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer显示文摘 | Giovanni Corso Corrado Pedrazzani Hugo Pinheiro Eduardo Fernandes Daniele Marrelli Andrea Rinnovati Valeria Pascale Raquel Seruca Carla Oliveira Franco Roviello | 2010 | European Journal of Cancer2010，，4： | 1 |
| 3 | E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions显示文摘 | Patrícia Carneiro Maria Sofia Fernandes Joana Figueiredo Joana Caldeira Joana Carvalho Hugo Pinheiro Marina Leite Soraia Melo Patrícia Oliveira Joana Sim?es-Correia Maria José Oliveira Fátima Carneiro Céu Figueiredo Joana Paredes Carla Oliveira Raquel Ser | 2012 | FEBS Letters2012，，18： | 1 |
| 4 | Numerical modelling of the cyclic behaviour of RC elements built with plain reinforcing bars显示文摘 | José Melo Catarina Fernandes Humberto Varum Hugo Rodrigues Aníbal Costa António Arêde | 2010 | Engineering Structures2010，，2： | 1 |
| 5 | Osteoinductive ceramics as a synthetic alternative to autologous bone grafting 显示文摘 | Huipin Yuana Hugo Fernandes Pamela Habibovicb | 2010 | Proc Natl Acad Sci USA2010，107，13： | 1 |
| 6 | Numerical modelling of the cyclic behaviour of RC elements built with plain reinforcing bars显示文摘 | José Melo Catarina Fernandes Humberto Varum Hugo Rodrigues Aníbal Costa António Arêde | 2010 | Engineering Structures2010，，2： | 1 |
| 7 | Effect of Al 2 O 3 and K 2 O content on structure, properties and devitrification of glasses in the Li 2 O–SiO 2 system显示文摘 | Hugo R. Fernandes Dilshat U. Tulyaganov Ashutosh Goel Manuel J. Ribeiro Maria J. Pascual José M.F. Ferreira | 2010 | Journal of the European Ceramic Society2010，，10： | 1 |
| 8 | Extramedullary Hematopoiesis Mimicking a Neoplasm in a Goeldi's Monkey (Callimico goeldii)显示文摘 | Rute Marina Noiva Hugo Pissarra Teresa Fernandes Rui Bernardino Luis Madeira de Carvalh~ Femando Alves Afonso Maria Conceicao Peleteiro | 2013 | Journal of Life Sciences2013，7，12： | 0 |
| 9 | Growth inhibitory effects of Phyllanthus niruri extracts in combination with cisplatin on cancer cell lines显示文摘AIM:To investigate the cytotoxic effects of spray-dried extracts of Phyllanthus niruri in combination with cisplatin on two cancer cell lines.METHODS:Colorectal carcinoma(HT29) and human hepatocellular carcinoma(HepG2) cells were treated with spray-dried extracts of Phyllanthus niruri(SDEPN) either alone or in combination with cisplatin at different concentrations(0.5 mg/mL and 1 mg/mL) for 4 h and 24 h.To verify and quantify cancer cells treated with these products as well as identify the cell cycle stage and cell viability,we stained the cells with propidium iodide and assessed them by flow cytometry.The percentage of cells in different cell cycle phases was quantified and data were expressed as histograms.Significant differences between groups were determined using analysis of variance and Bonferroni's test,as indicated.A value of P < 0.05 was considered to be statistically significant.RESULTS:SDEPN had significantly different cytotoxic effects on HT29(2.81 ± 0.11 vs 3.51 ± 1.13,P > 0.05) and HepG2(5.07 ± 0.3 vs 15.9 ± 1.04,P < 0.001) cells when compared to control cells for 4 h.SDEPN also had significantly different cytotoxic effects on HT29(1.91 ± 0.57 vs 4.53 ± 1.22,P > 0.05) and HepG2(14.56 ± 1.6 vs 35.67 ± 3.94,P < 0.001) cells when compared to control cells for 24 h.Both cell lines were killed by cisplatin in a dose-dependent manner compared to control cells(HepG2 cells for 4 h:10.78 ± 1.58 vs 53.89 ± 1.53,P < 0.001;24 h:8.9 ± 1.43 vs 62.78 ± 1.87,P < 0.001 and HT29 cells for 4 h:9.52 ± 0.913 vs 49.86 ± 2.89,P < 0.001;24 h:11.78 ± 1.05 vs 53.34 ± 2.65,P < 0.001).In HT29 cells,pretreatment with SDEPN and subsequent treatment with cis-platin resulted in a greater number of cells being killed(12.78 ± 1.01 vs 93.76 ± 1.6,P < 0.001).HepG2 cells showed significant cell killing with treatment with SDEPN when combined with cisplatin(12.87 ± 2.78 vs 78.8 ± 3.02,P < 0.001).CONCLUSION:SDEPN is selectively toxic against two cancer cell lines.Moreover,SDEPN in combination with cisplatin induces a synergistic increase in the cell death of both HT29 and HepG2 cells. | Raimundo Fernandes de Araújo Júnior Luiz Alberto Lira Soares Cínthia Raquel da Costa Porto Ranniere Gurgel Furtado de Aquino Hugo Gon alo Guedes Pedro Ros Petrovick Tatiane Pereira de Souza Aurigena Antunes de Araújo Gerlane Coelho Bernardo Guerra | 2012 | World Journal of Gastroenterology2012，18，31： | 0 |
| 10 | Superconductor Substrate with Critical Temperature at 212 K for Planar Antenna显示文摘 | Humberto Cesar Chaves Fernandes Hugo Michel Camara Azevedo Maia | 2010 | 材料科学与工程(中英文版)2010，4，7： | 0 |
| 11 | 波尔图Fraunhofer新总部显示文摘设计师应邀来设计位于波尔图技术大学校园内的新总部。他们通过传达一个简单而积极的动态信息,将弗劳恩霍夫的创新哲学纳入了设计考量的范畴。弗劳恩霍夫办公创新中心位于斯图加特.其创新工作室布局及组织元素为弗劳恩霍夫的设计理念增添了一个新的层次。 | Hugo Ramos Rita Pais Jette Fyhn Dina Castro Andr Gois Fernandes Ricardo Sousa. Bruno Almeida Rita a Joana Coimbra JCT with GATFNGRL Astratec with Prolicht Lighting BENE Empatias Joo Morgado Pauline Pan | 2012 | 设计家2012，，2： | 0 |
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