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| 1 | Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission显示文摘Dear Editor,The occurrence of concentrated pneumonia cases in Wuhan city,Hubei province of China was first reported on December 30,2019 by the Wuhan Municipal Health Commission(WHO,2020).The pneumonia cases were found to be linked to a large seafood and animal market in Wuhan,and measures for sanitation and disinfection were taken swiftly by the local government agency.The Centers for Disease Control and Prevention(CDC)and Chinese health authorities later determined and announced that a novel coronavirus(CoV),denoted as 2019-nCoV,had caused the pneumonia outbreak in Wuhan city(CDC,2020).Scientists from multiple groups had obtained the virus samples from hospitalized patients(Normile,2020).The isolated viruses were morphologically identical when observed under electron microscopy. | Xintian Xu Ping Chen Jingfang Wang Jiannan Feng Hui Zhou Xuan Li Wu Zhong Pei Hao | 2020 | Science China(Life Sciences)2020，63，3： | 737 |
| 2 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 3 | Drug-resistant gene based genotyping for Acinetobacter baumannii in tracing epidemiological events and for clinical treatment within nosocomial settings显示文摘背景 Acinetobacter baumannfi 在全世界作为与严重感染和医院的爆发有关的重要病原体出现了。经常使用的方法,然而,脉搏地胶化电气泳动(PFGE ) 和在 Acinetobacter baumannii genotyping 的放大碎片长度多型性(AFLP ) 缺乏药抵抗的直接分子的证明。这研究被进行基于药建立一个打字方法与在从2005年1月的医院的流行病或到2005年10月的 outbreak.Methods 的经期的传统的 PFGE 和 AFLP 相对照的抵抗基因鉴定,来自特别护理单位的 Acinetobacter 种类的 27 紧张,在 Ningbo 的第二所隶属于的医院被孤立,包括流行、分散的事件。危险性测试, PFGE, AFLP 和打字的药抵抗基因(DRGT ) 在外面是 carded 证实药抵抗并且分别地分析 genotyping。PFGE 被用作一本参考书评估 Acinetobacter 的 27 紧张显示了的 DRGT 和 AFLP.Results 的 typeability 多重抗菌素抵抗和药抵抗基因,和 -lactamase 基因在 85.2% 紧张被检测。尽管小差别存在, DRGT 的结果比得上在有不同的药抵抗的 Acinetobacter 紧张的 PFGE,并且甚至建议了不同药抵抗的紧张的一堂分子的进化功课。AFLP 显示出在紧张之间的大多型性并且在区分比作 AFLP 和 PFGE 的药 resistance.Conclusion 有弱能力, DRGT 是有用的分析医院的感染和爆发的局部性的分子的传染病学,它将有益于临床的诊断和治疗。 | JIN Hui XU Xiao-min MI Zu-huang MOU Yi LIU Pei | 2009 | Chinese Medical Journal2009，，3： | 18 |
| 4 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 5 | Chinese herbal medicine for subacute thyroiditis:a systematic review of randomized controlled trials显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Chinese herbal medicine(CHM) in the treatmentofsubacutethyroiditis.METHODS: Randomized controlled trials found in PubMed, Cochrane Library, and three Chinese databases were selected. RevMan 5.2 software was used to analyze the data with relative risk or mean difference, expressed with 95% of confidence interval. The quality of trials was assessed and gradedthe quality of evidence with GRADE profiler software.RESULTS: Twenty one studies were included. CHM was superior to Western Medicine(include prednisone and NSAIDs) in abating fever, relieving thyroid pain, recovering blood sedimentation, improving thyroid function, and preventing hypothyroidism(P<0.05), while no statistical differences were found in eliminating goiter and reducing relapse rate.CHM plusWestern Medicine were superior toWestern Medicine in abating fever, relieving thyroid pain, eliminating goiter, and reducing relapse rate,while no statistical differences(P>0.05) were found in recovering blood sedimentation and improving thyroid function. The incidence of adverse reactions in treatment group was lower than that in control group(relative risk was 0.12 and 95% confidence interval was 0.03-0.51). The methodological quality of trials is generally poor with a high risk of bias.CONCLUSION: CHM(particularly CHM combined withWestern Medicine) used to treat subacute thyroiditis may improve clinical symptoms and signs,reduce relapse rate, and alleviate the side effects of hormones. Due to poor methodological quality of included trials, further more high-quality studies are warranted to confirm the effectiveness and safety of CHM. | Hui Luo Meng Lü Xiaohua Pei Zhongyuan Xia | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 16 |
| 6 | Effect of dynamic hip screw on the treatment of femoral neck fracture in the elderly显示文摘ObjectiveTo 讨论指示,外科的过程,并且在在 elderly.MethodsA 的大腿骨的颈骨折的治疗的动态新潮的螺丝钉( DHS )的药品效果回顾的学习被进行分析在我们在2009年6月和2011年11月之间的部门与 DHS 为大腿骨的颈骨折被对待的 42 个老病人的临床的数据。与 68.5 年(范围 60-75 年) 的吝啬的年龄有 21 男性和 21 女性。根据花园分类,有类型 II,类型 III 的 21 个盒子和类型 IV 破裂的 2 个盒子的 19 个盒子。由 Singh 索引分类,有水平 2 的 3 个盒子,水平 4 破裂的水平 3 和 20 盒子的 19 个盒子。在手术以后的哈里斯标准,复杂并发症和功能恢复是在 42 个病人的 analysed.ResultsThe 一般水准住院时间是 11.2 天(范围 7-21 天) 。所有病人被跟随在上面为 12-26 月(平均数 18 月) 。没有肺感染,深静脉的血栓或另外的复杂并发症发生了。螺丝钉的部分支持外面在 2 种情况中被发现。内部固定设备在骨折愈合以后被撤退。内部固定切在 1 种情况中被发现,并且他在全部的新潮的关节造形术以后有好恢复。骨折愈合的时间从 3-6 月(一般水准 4.5 月)。根据哈里斯标准, 15 个盒子作为优秀被评估, 24 好, 2 交易会和 1 个穷人。哈里斯规模显著地从 30.52 被改进; ± ; 2.71 外科手术前地到 86.61 ; ± ; 2.53 在 6 个月手术后地( P ;< ; 0.05 ) .ConclusionDHS ,是最小的侵略,允许早活动并且忍受重量,为有大腿骨的颈骨折的老病人的治疗是明智的。另外,它能避免在人工的联合代替看见的复杂并发症。它对有温和骨质疏松症的病人特别合适。 | Zhao Wenbo Liu Lei Zhang Hui Fang Yue Pei Fuxing Yang Tianfu | 2014 | Chinese Journal of Traumatology2014，17，2： | 11 |
| 7 | Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease,2008-2013显示文摘Objective To investigate the serum total IgE(tlgE) and specific IgE(slgE) to common allergens among allergic patients in Guangzhou,China.Methods 7 085 patients were examined for tlgE and slgE to 15 allergens,based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.Results 3 758(53.04%) patients tested positive for tlgE,and 4 640(65.49%) for slgE.Der pteronyssinus,Der farinae,eggs,and cow's milk were the most common allergens leading to higher positive rates of slgE responses.Several peaks of sensitization were:Der pteronyssinus,Der farinae,and Blomia tropicalis at age 10-12;cow's milk at age below 3;eggs at age 4-6.The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens.Sensitization to Der pteronyssinus(OR,1.6;P<0.05),Der farinae(OR,1.5;P<0.05),Blomia tropicalis(OR,1.4;P<0.05),Blattella germanica(OR,1.5;P<0.05),cow's milk(OR,1.3;P<0.05),and soy beans(OR,2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.Conclusion The major allergens in Guangzhou include Der pteronyssinus,Der farinae,cow's milk,and eggs.Sensitization to these allergens appears to be predictors of allergy-related disorder. | SUN Bao Qing CHEN De Hui ZHENG Pei Yan HUANG Hui Min LUO Wen Ting ZENG Guang Qiao ZHANG Xiao Wen | 2014 | Biomedical and Environmental Sciences2014，27，7： | 11 |
| 8 | Dairy Consumption and Associations with Nutritional Status of Chinese Children and Adolescents显示文摘Objective This study aimed to describe frequency and quantity of total dairy consumption of Chinese children and adolescents and explore the associations between dairy consumption and nutrition status, including stunting, wasting, overweight, and obesity. Methods Participants included 28,250 children and adolescents aged 6-17 years old. A food frequency questionnaire(FFQ) including 100 kinds of food was used to collect information about frequency and quantity of dairy consumption. Determination of stunting was with a height cutoff value for age and gender, and determination for wasting, overweight, and obesity was with BMI for age and gender. Results Of the total sample, 36.1% of children aged 6-17 reported consuming dairy food more than once per day(≥ 1/day). The average total dairy intake of all the participants was 126.7 g/day. For boys, dairy consumption had an inverse correlation with stunting and wasting after controlling for confounders. For girls, dairy consumption was negatively associated with stunting and obesity after controlling for confounders as above. Conclusion Dairy consumption in Chinese children and adolescents was relatively lower than that in developed countries, and was negatively associated with stunting and wasting for boys and with stunting and obesity for girls. | XU Pei Pei YANG Ti Ti XU Juan LI Li CAO Wei GAN Qian HU Xiao Qi PAN Hui ZHAO Wen Hua ZHANG Qian | 2019 | Biomedical and Environmental Sciences2019，32，6： | 9 |
| 9 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 10 | Effect of a Traditional Chinese Medicine combined therapy on adolescent idiopathic scoliosis:a randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness of a combined Traditional Chinese Medicine(TCM) therapy versus conventional treatment on adolescent idiopathic scoliosis.METHODS:One hundred twenty outpatients with mild and moderate adolescent idiopathic scoliosis were randomly divided into a TCM group(TCMG)and a brace group(CG).TCMG patients underwent Daoyin,Tuina,and acupotomology therapies.CG patients were treated with a Milwaukee brace.Each patient's Cobb angle was measured after 12 and 24 months of treatment,and pulmonary function was determined after 12 months of treatment.Average electromyogram(AEMG) ratio of the surface electromyogram was measured after 6 and 12 months of treatment and followed-up after 18 and 24 months.RESULTS:The Cobb angle significantly decreased in both groups after 12 months of treatment compared with before treatment(P< 0.05).The percentages of original Cobb angle in TCMG and CG were51.4%and 47.8%(P > 0.05) after 12 months and62.5%and 34.7%(P < 0.05) after 24 months,respectively.Pulmonary function significantly improved after 12 months in TCMG(P < 0.05) but significantly decreased in CG(P < 0.05).The AEMG ratio was significantly lower(P < 0.01) and tended to remain at1 after stopping treatment in TCMG,but increased in CG(P<0.05).CONCLUSION:TCM combined therapy can prevent the progression of scoliosis.The AEMG ratio is a promising index that could replace radiography in the evaluation of treatment effect and progression in scoliosis. | Wei Hui Xu Jinyuan Jiang Zhong Ye Shuliang Song Hongquan Ning Xitao Huang Huanmin Chen Wei Pei Jianwei Jiang Nengyi Chen Shao Du Honggen | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 9 |
| 11 | Production of conjugated linoleic acids by Lactobacillus plantarum strains isolated from naturally fermented Chinese pickles显示文摘Naturally fermented pickles harbour many lactic acid bacteria(LAB).Forty-three LAB strains with conjugated linoleic acid(CLA)-producing ability were isolated from three naturally fermented pickle brines.Of these isolates,lp15 identified as Lactobacillus plantarum by API 50 CHL system and full-length 16S rDNA sequence analysis exhibited the highest CLA-producing ability(26.1% conversion) at 48 h in de Man Rogosa Sharpe(MRS) broth in the presence of 100 μg/ml of linoleic acid(LA).Compared to other strains,L.plantarum strain lp15 showed the highest tolerance upon increased levels of LA in the medium,i.e.,up to 600 μg/ml.This strain converted about 25% of LA into CLA isomers [predominantly cis-9,trans-11 CLA(9-CLA) and trans-10,cis-12 CLA(10-CLA)],of which 75% was 9-CLA.Interestingly,though the conversion rate of LA into CLA by lp15 remained stable between 100 to 600 μg/ml LA levels in the medium,it dropped sharply at 1000 μg/ml.Taken together,the lp15 strain displayed relatively high LA tolerance with higher conversion rate,which implies that this strain is a valuable candidate for enhancing the CLA content in food-sources like pickles. | Pei LIU Sheng-rong SHEN Hui RUAN Qian ZHOU Liu-liu MA Guo-qing HE | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，11： | 8 |
| 12 | Interventional Bronchoscopic Therapy in Adult Patients with Tracheobronchial Mucoepidermoid Carcinoma显示文摘 | Hui Chen Jie Zhang Xiao-Jian Qiu Juan Wang Ying-Hua Pei Yu-Ling Wang | 2017 | Chinese Medical Journal2017，，20： | 8 |
| 13 | Effect of electroacupuncture on the mRNA and protein expression of Rho-A and Rho-associated kinase Ⅱ in spinal cord injury rats显示文摘Electroacupuncture is beneficial for the recovery of spinal cord injury, but the underlying mechanism is unclear. The Rho/Rho-associated kinase(ROCK) signaling pathway regulates the actin cytoskeleton by controlling the adhesive and migratory behaviors of cells that could inhibit neurite regrowth after neural injury and consequently hinder the recovery from spinal cord injury. Therefore, we hypothesized electroacupuncture could affect the Rho/ROCK signaling pathway to promote the recovery of spinal cord injury. In our experiments, the spinal cord injury in adult Sprague-Dawley rats was caused by an impact device. Those rats were subjected to electroacupuncture at Yaoyangguan(GV3), Dazhui(GV14), Zusanli(ST36) and Ciliao(BL32) and/or monosialoganglioside treatment. Behavioral scores revealed that the hindlimb motor functions improved with those treatments. Real-time quantitative polymerase chain reaction, fluorescence in situ hybridization and western blot assay showed that electroacupuncture suppressed the m RNA and protein expression of Rho-A and Rho-associated kinase Ⅱ(ROCKⅡ) of injured spinal cord. Although monosialoganglioside promoted the recovery of hindlimb motor function, monosialoganglioside did not affect the expression of Rho-A and ROCKⅡ. However, electroacupuncture combined with monosialoganglioside did not further improve the motor function or suppress the expression of Rho-A and ROCKⅡ. Our data suggested that the electroacupuncture could specifically inhibit the activation of the Rho/ROCK signaling pathway thus partially contributing to the repair of injured spinal cord. Monosialoganglioside could promote the motor function but did not suppress expression of Rho A and ROCKⅡ. There was no synergistic effect of electroacupuncture combined with monosialoganglioside. | You-jiang Min Li-li-qiang Ding Li-hong Cheng Wei-ping Xiao Xing-wei He Hui Zhang Zhi-yun Min Jia Pei | 2017 | Neural Regeneration Research2017，12，2： | 8 |
| 14 | Surface enhanced Raman spectroscopy signals of mixed pesticides and their identification显示文摘A rapid and sensitive method to identify and analyze mixed pesticides of tricyclazole,paraquat and flusilazole by surface-enhanced Raman scattering has been reported.Aqueous samples can be detected by SERS in low concentrations of 0.01 mg/L, 0.1 mg/L and 2.85 mg/L for individual tricyclazole,paraquat and flusilazole respectively.When mixing the three pesticides in the low concentrations,their characteristic peaks can still be identified from the SERS spectrum of the mixture. | Hui Rong Tang Qing Qing Li Yu Lan Ren Jin Pei Geng Peng Cao Tao Sui Xuan Wang Yi Ping Du | 2011 | Chinese Chemical Letters2011，22，12： | 7 |
| 15 | Advances in fungal-assisted phytoremediation of heavy metals:A review显示文摘Trace metals such as manganese(Mn),copper(Cu),zinc(Zn),and iron(Fe)are essential for many biological processes in plant life cycles.However,in excess,they can be toxic and disrupt plant growth processes,which is economically undesirable for crop production.For this reason,processes such as homeostasis and transport control of these trace metals are of constant interest to scientists studying heavily contaminated habitats.Phytoremediation is a promising cleanup technology for soils polluted with heavy metals.However,this technique has some disadvantages,such as the slow growth rate of metal-accumulating plant species,low bioavailability of heavy metals,and long duration of remediation.Microbial-assisted phytoremediation is a promising strategy for hyperaccumulating,detoxifying,or remediating soil contaminants.Arbuscular mycorrhizal fungi(AMF)are found in association with almost all plants,contributing to their healthy performance and providing resistance against environmental stresses.They colonize plant roots and extend their hyphae to the rhizosphere region,assisting in mineral nutrient uptake and regulation of heavy metal acquisition.Endophytic fungi exist in every healthy plant tissue and provide enormous services to their host plants,including growth enhancement by nutrient acquisition,detoxification of heavy metals,secondary metabolite regulation,and enhancement of abiotic/biotic stress tolerance.The aim of the present work is to review the recent literature regarding the role of AMF and endophytic fungi in plant heavy metal tolerance in terms of its regulation in highly contaminated conditions. | Muhammad KHALID Saeed UR-RAHMAN Danial HASSANI Kashif HAYAT Pei ZHOU Nan HUI | 2021 | Pedosphere2021，31，3： | 6 |
| 16 | A New Chromone Derivative from Stellera chamaejasme L显示文摘A new chromone derivative, 3-[1- (2, 4, 6-trihydroxyphenyl) 3-di-(4-hydroxyphenyl) 1-propanone-2-yl] 5,7-dihydroxy-8-di(4-hydroxyphenyl)methyl-4H-1-benzopyran-4-one, named as isomohsenone was isolated from the roots of Stellera chamaejasme L. together with known chamaechromone. Its structure was determined by the analysis of MS and NMR data, especially 2D NMR spectra. | Bao Min FENG, Yue Hu PEI*, Hui Ming HUA School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016 | 2002 | Chinese Chemical Letters2002，13，8： | 6 |
| 17 | Anluohuaxianwan Alleviates Carbon Tetrachloride-Induced Hepatic Fibrosis in Rats through Upregulation of Peroxisome Proliferator-Activated Receptor-Gamma and Downregulation of Nuclear Factor-Kappa B/IκBα Signaling Pathway显示文摘Objective:The aim of this study was to investigate the effects of traditional Chinese medicine Anluohuaxianwan(ALHXW)on peroxisome proliferator-activated receptor-gamma(PPARγ)and nuclear factor-kappa B(NF-κB)signaling pathways using a rat model of carbon model groups were gavaged with saline for 6 weeks.Liver function was measured,and liver fibrosis and necroinflammation were assessed.Protein and messenger RNA expression levels of PPARγ,NF-κB,and Inhibitorαof NF-κB(IκBα)were analyzed by Western blot and reverse transcription–quantitative polymerase chain reaction.Results:ALHXW markedly alleviated liver injury compared with the model group,as indicated by the improvements in disease status,the morphology of liver and spleen,the liver and spleen indexes,and liver function.The extent of liver fibrosis was improved,hepatic stellate cell activation was inhibited,the expression of PPARγand IκBαwas significantly higher,and the expression of NF-κB was significantly lower in the treatment group as compared with the model group.Conclusions:ALHXW treatment can alleviate CCl4-induced liver fibrosis in rats, and the potential antifibrogenic mechanisms may occur through the upregulation of PPARγ expression and downregulation of NF-κB/IκBα signaling pathway. | Lin Wang Wei Lu Yu-Hua Gao Hai-Jiang Yan Fei Pei Xue-En Liu Hui Zhuang | 2019 | World Journal of Traditional Chinese Medicine2019，5，2： | 6 |
| 18 | Relationship between iNOS expression and apoptosis in cerebral tissue, and the effect of Sini injection in endotoxin shock rats显示文摘OBJECTIVE: To investigate the dynamic changes and relationship of inducible nitric oxide synthase (iNOS) and apoptosis in endotoxin shock rats, as well as the effects of Sini injection. METHODS: In total, 102 Sprague-Dawley (SD) rats were randomly divided into a normal group (n=6, NG), sham operation group (n=24, OG), model group (n=24, MG), dexamethasone group (n=24, DG), and Sini group (n=24, SG). The endotoxin shock model was induced by an intravenous injection of lipopolysaccharide (LPS) (8 mg/kg). Rats in the OG, MG, DG, and SG groups were further divided into 4 groups: 1, 2, 3 and 6 h after shock groups (n=6 per group). iNOS expression was detected by immunohistochemistry. Terminal Deoxynucleotidyl Transferase Mediated Deoxyuridine Triphosphate-biotin Nick End Labeling was employed to measure apoptosis. RESULTS: No iNOS expression was found in the OG group. Compared with the OG group, iNOS expres-sion in the MG group was markedly elevated, reached a peak at 1 h (P<0.01), decreased at 2 and 3 h, and rebounded at 6 h. Compared with the MG group, iNOS expression decreased significantly in both the DG (P<0.05) and SG (P<0.01) groups at 6 h. Thenumberofapoptoticcellsin the MG group was markedly increased than that in the NG and OG (P<0.01) groups, and reached a peak at 6 h. The number of apoptotic cells in the DG group at 1 and 2 h (P<0.01) and SG group at 2, 3 and 6 h (P<0.01) decreased when compared with the MG group. CONCLUSION: Sini injection can significantly inhibit NO generation, which decreases apoptosis and subsequently protects the brain from endotoxic shock. | Hui Pei Yuzhong Zhang Haiyan Wu Liwei Ren Xu Jia Yinzhu Zhang Ming Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 5 |
| 19 | Clinical Experience in Treatment of Alzheimer’s Disease with Jiannao Yizhi Formula (健脑益智方) and Routine Western Medicine显示文摘Objective:To investigate the long-term therapeutic effects of the Chinese medicine Jiannao Yizhi Formula(健脑益智方,JYF)in the treatment of Alzheimer’s disease(AD).Methods:Sixty mild-to-moderate AD participants were recruited and randomly allocated to the treatment(30 with JYF)and the control groups(30 with donepezil)for 6 months with the random numbers.The primary outcomes were scores of Alzheimer’s Disease Rating Scale-Cognitive(ADAS-Cog)and Chinese Medicine Symptom Scale(CM-SS).The secondary outcomes were scores of Mini Mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),and Activities of Daily Living(ADL).Safety assessments were conducted at baseline and the 6 th month of treatment.Serum levels of acetylcholine(Ach),amyloid-β protein 42(Aβ42),and the microtubule-associated protein tau(Tau)were also determined by enzyme-liked immunosorbent assay.Results:Fifty-one participants were included in the final analyses(JYF n=27;donepezil n=24).Compared with baseline,both JYF and donepezil increased the MoCA and MMSE scores and decreased the ADAS-Cog and CM-SS scores(P<0.05 or P<0.01).Both drugs increased the serum levels of Ach and decreased the serum levels of Aβ42 and Tau(all P<0.05).There was no significant difference in these variables between the two groups,which showed that JYF was not inferior to donepezil.No obviously significant changes were observed in the ADL.No severe adverse events were observed in both groups.Conclusion:The effect and safety of JYF for the treatment of AD were not inferior to those of donepezil. | WANG Hui-chan LIU Nan-yang ZHANG Shuai YANG Yang WANG Zhi-Yong WEI Yun LIU Jian-Gang PEI Hui LI Hao | 2020 | Chinese Journal of Integrative Medicine2020，26，3： | 5 |
| 20 | A new cytotoxic caged polyprenylated xanthone from the resin of Garcinia hanburyi显示文摘新将关入笼中的 polyprenylated 氧杂蒽酮, gambogic 醛(1 ) ,从 Garcinia hanburyi 的树脂被孤立。它的结构被阐明根据光谱数据包括 1D 和 2D NMR 数据。另外,化合物 1 的 antiproliferative 能力在老鼠白血病 P388 和 P388/ADR 房间被决定。 | Li Li Wang Zhan Lin Li Yong Peng Xu Xiao Qiu Liu Yue Hu Pei Yong Kui Jing Hui Ming Hua | 2008 | Chinese Chemical Letters2008，19，10： | 5 |
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