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| 1 | Meso-Cenozoic Evolution of Earth Surface System under the East Asian Tectonic Superconvergence显示文摘The East Asian geological setting has a long duration related to the superconvergence of the Paleo-Asian, Tethyan and Paleo-Pacific tectonic domains. The Triassic Indosinian Movement contributed to an unified passive continental margin in East Asia. The later ophiolites and I-type granites associated with subduction of the Paleo-Pacific Plate in the Late Triassic, suggest a transition from passive to active continental margins. With the presence of the ongoing westward migration of the Paleo-Pacific Subduction Zone, the sinistral transpressional stress field could play an important role in the intraplate deformation in East Asia during the Late Triassic to Middle Jurassic, being characterized by the transition from the E-W-trending structural system controlled by the Tethys and Paleo-Asian oceans to the NE-trending structural system caused by the Paleo-Pacific Ocean subduction. The continuously westward migration of the subduction zones resulted in the transpressional stress field in East Asia marked by the emergence of the Eastern North China Plateau and the formation of the Andean-type active continental margin from late Late Jurassic to Early Cretaceous(160-135 Ma), accompanied by the development of a small amount of adakites. In the Late Cretaceous(135-90 Ma), due to the eastward retreat of the Paleo-Pacific Subduction Zone, the regional stress field was replaced from sinistral transpression to transtension. Since a large amount of late-stage adakites and metamorphic core complexes developed, the Andean-type active continental margin was destroyed and the Eastern North China Plateau started to collapse. In the Late Cretaceous, the extension in East Asia gradually decreased the eastward retreat of the Paleo-Pacific subduction zones. Futhermore, a significant topographic inversion had taken place during the Cenozoic that resulted from a rapid uplift of the Tibet Plateau resulting from the India-Eurasian collision and the formation of the Bohai Bay Basin and other basins in the East Asian continental margin. The inversion caused a remarkable eastward migration of deformation, basin formation and magmatism. Meanwhile, the basins that mainly developed in the Paleogene resulted in a three-step topography which typically appears to drop eastward in altitude. In the Neogene, the basins underwent a rapid subsidence in some depressions after basin-controlled faulting, as well as the intracontinental extensional events in East Asia, and are likely to be a contribution to the uplift of the Tibetan Plateau. | DMITRIENKO Liudmila V. WANG Pengcheng LI Sanzhong CAO Xianzhi Ian SOMERVILLE ZHOU Zaizheng HU Mengying SUO Yanhui GUO Lingli WANG Yongming LI Xiyao LIU Xin YU Shengyao ZHU Junjiang | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 6 |
| 2 | miR-211 regulates the antioxidant function of lens epithelial cells affected by age-related cataracts显示文摘AIM: To investigate the effects and mechanism of miR-211 in mediating the antioxidant function of lens epithelial cells affected by age-related cataracts.METHODS: Real-time quantitative polymerase chain reaction(RT-q PCR) was used to detect miR-211 expression in the anterior lens capsules of healthy people, the anterior lens capsules of patients with age-related cataracts, and human epithelial cell line(SRA01/04) cells exposed to oxidative stress. A 2', 7'-dichloro-fluorescein diacetate(DCFH-DA) probe was used to measure the levels of endogenous reactive oxygen species(ROS) in human lens epithelial cells(h LECs) exposed to 400 μmol/L H_2O_2 for 1 h. SRA01/04 cells were transfected with either miR-211 mimics, mimic controls, miR-211 inhibitors or inhibitor controls. After 72 h, these cells were exposed to 400 μmol/L H_2O_2 for 1 h, then p53 and Bax m RNA expression were measured using RT-q PCR. p53 and Bax protein expression were also measured by Western blotting analysis. Finally, cell viability was assessed using an MTS assay.RESULTS: Compared to the control group, expression of miR-211 in the anterior lens capsules of age-related cataract patients and in SRA01/04 cells exposed to oxidative stress was significantly increased(P<0.001). Levels of endogenous ROS were significantly elevated in h LECs exposed to oxidative stress(P<0.001). Compared to the mimic control group, the h LECs in the miR-211 mimic group expressed significantly higher levels of p53 and Bax m RNA and protein while cell viability was significantly reduced(P<0.001). Conversely, p53 and Bax m RNA and protein expression were significantly reduced in the miR-211 inhibitor group as compared to the control group, while the cells in this group had much higher levels of cell viability(P<0.001).CONCLUSION: miR-211 is upregulated in the anterior lens capsules of age-related cataract patients. miR-211 decreased the antioxidative stress capacity of lens epithelial cells by upregulating p53 and Bax, while inhibiting cell proliferation and repair. This finding suggests that miR-211 may play a key role in the development of age-related cataracts. | Bo Lu Ian T. Christensen Li-Wei Ma Tao Yu Ling-Feng Jiang Chun-Xia Wang Li Feng Jin-Song Zhang Qi-Chang Yan Xin-Ling Wang | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 4 |
| 3 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 4 | Operational optimization of a building-level integrated energy system considering additional potential benefits of energy storage显示文摘As a key component of an integrated energy system(IES),energy storage can effectively alleviate the problem of the times between energy production and consumption.Exploiting the benefits of energy storage can improve the competitiveness of multi-energy systems.This paper proposes a method for day-ahead operation optimization of a building-level integrated energy system(BIES)considering additional potential benefits of energy storage.Based on the characteristics of peak-shaving and valley-filling of energy storage,and further consideration of the changes in the system’s load and real-time electricity price,a model of additional potential benefits of energy storage is developed.Aiming at the lowest total operating cost,a bi-level optimal operational model for day-ahead operation of BIES is developed.A case analysis of different dispatch strategies verifies that the addition of the proposed battery scheduling strategy improves economic operation.The results demonstrate that the model can exploit energy storage’s potential,further optimize the power output of BIES and reduce the economic cost. | Sai Liu Cheng Zhou Haomin Guo Qingxin Shi Tiancheng E.Song Ian Schomer Yu Liu | 2021 | Protection and Control of Modern Power Systems2021，6，1： | 3 |
| 5 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 6 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 7 | Outcome of nephrostomy balloon dilation for vesicourethral anastomotic strictures following radical prostatectomy: a retrospective study显示文摘为开发了跟随激进的前列腺切除术的 vesicourethral anastomotic 苛评(管) 的病人评估 nephrostomy 汽球膨胀(NBD ) 的功效。NBD 在开发了管后面的激进的前列腺切除术的病人被执行。生活(QoL ) 的质量,国际前列腺症状分数(IPSS ) 和最大的尿流动率(Qmax ) 被评估。463 个前列腺癌症病人经历了激进的 retropubic 前列腺切除术(RRP ) ,并且 86 经历了 laparoscopic 激进分子前列腺切除术(LRP ) 。大多数病人(90.3%) 有 T2 或 T3 前列腺癌症和 ≤ 的一个病理学的格利森分数;7。45 (8.2%) 并且四(4.7%) 病人们分别地由于基或 LRP 开发了管。四十(89%) 病人们经历了 NBD,包括重复膨胀的三个盒子。中部的 Qmax 是 4 ml s −1(interquartile 范围(IQR ) , 2.3-5.6 ) 在膨胀前并且改善了到 16 ml s −1(IQR, 15-19 ) 并且 19 ml s −1(IQR, 18-21 ) 在 1 月、 12 月的后续,分别地(P <0.01 ) 。十五(37.5%) 病人们在膨胀以前有尿不能自制,而仅仅三(7.5%) 病人们有不能自制 12 月后面的膨胀(P <0.01 ) 。中部的 IPSS 分数从 19 改善了( IQR , 17-24 )在到 7 的膨胀前( IQR , 6-8 )在 12 月后面的膨胀,和 QoL , 20 从 5 改善了( IQR , 4-6 )在到 2 的膨胀前( IQR , 2-3 )在 12 月后面的膨胀( P < ;0.01 在两个) 。管发生在跟随激进的前列腺切除术的病人的一个小却重要的比例。NBD 为管提供有效疗法。 | Chong-Yu Zhang Yu Zhur Kin Li Laphong Ian Sonfat HOe Waihong Pun Hiofai Lao Vitalino Carvalho Ding-Yi Liu Zhou-Jun Shen | 2014 | Asian Journal of Andrology2014，16，1： | 2 |
| 8 | Biodegradable magnesium alloys for orthopaedic applications显示文摘There is increasing interest in the development of bone repair materials for biomedical applications.Magnesium(Mg)-based alloys have a natural ability to biodegrade because they corrode in aqueous media;they are thus promising materials for orthopaedic device applications in that the need for a secondary surgical operation to remove the implant can be eliminated.Notably,Mg has superior biocompatibility because Mg is found in the human body in abundance.Moreover,Mg alloys have a low elastic modulus,close to that of natural bone,which limits stress shielding.However,there are still some challenges for Mg-based fracture fixation.The degradation of Mg alloys in biological fluids can be too rapid,resulting in a loss of mechanical integrity before complete healing of the bone fracture.In order to achieve an appropriate combination of bio-corrosion and mechanical performance,the microstructure needs to be tailored properly by appropriate alloy design,as well as the use of strengthening processes and manufacturing techniques.This review covers the evolution,current strategies and future perspectives of Mg-based orthopaedic implants. | Yu Lu Subodh Deshmukh Ian Jones Yu-Lung Chiu | 2021 | Biomaterials Translational2021，2，3： | 2 |
| 9 | Recent developments in the chemistry of halogen - free flame retardant polymers 显示文摘 | Shui -Yu Lu Ian Hamerton | 2002 | Prog Polym Sci2002，27，： | 1 |
| 10 | Production of submieron diameter silk fibers under benign processing conditions by two-fluid electrospinning显示文摘 | Wang Mao Yu J ian H Kaplan D L | 2006 | Macromolecules2006，39，3： | 1 |
| 11 | Structural and Functional Analysis of the Globular Head Domain of p115 Provides Insight into Membrane Tethering显示文摘 | Yu An Christine Y. Chen Bryan Moyer Piotr Rotkiewicz Marc-André Elsliger Adam Godzik Ian A. Wilson William E. Balch | 2009 | Journal of Molecular Biology2009，，1： | 1 |
| 12 | Studies on the structure–activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents显示文摘 | Ben Li Eric Dale Jones Enkun Zhou Li Chen Dean Cameron Baylis Shanghai Yu Miao Wang Xing He Jonathan Alan Victor Coates David Ian Rhodes Gang Pei John Joseph Deadman Xin Xie Dawei Ma | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，17： | 1 |
| 13 | Zircon Ce4+/Ce3+ ratios and ages for Yulong ore-bearing porphyries in eastern Tibet显示文摘 | Hua-Ying Liang Ian H. Campbell Charlotte Allen Wei-Dong Sun Cong-Qiang Liu Heng-Xiang Yu Ying-Wen Xie Yu-Qiang Zhang | 2006 | Mineralium Deposita2006，，2： | 1 |
| 14 | In vitro multiplication of statice plantlets using sugar-free media 显示文摘 | XIAO YU IAN KOZAI T | 2006 | Scientia Horticulturae2006，109，： | 1 |
| 15 | Effects of acetylsalicylic acid on kiwifruit ethylene biosynthesis and signaling components显示文摘 | Xue-ren Yin Yu Zhang Bo Zhang Shao-lan Yang Yan-na Shi Ian B. Ferguson Kun-song Chen | 2013 | Postharvest Biology and Technology2013，，： | 1 |
| 16 | Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit?显示文摘 | Man Yu Alberto Ocana Ian F. Tannock | 2013 | Cancer and Metastasis Reviews2013，，： | 1 |
| 17 | Zircon Ce4+/Ce3+ ratios and ages for Yulong ore-bearing porphyries in eastern Tibet显示文摘 | Hua-Ying Liang Ian H. Campbell Charlotte Allen Wei-Dong Sun Cong-Qiang Liu Heng-Xiang Yu Ying-Wen Xie Yu-Qiang Zhang | 2006 | Mineralium Deposita2006，，2： | 1 |
| 18 | The Tarim picrite–basalt–rhyolite suite, a Permian flood basalt from northwest China with contrasting rhyolites produced by fractional crystallization and anatexis显示文摘 | Wei Tian Ian H. Campbell Charlotte M. Allen Ping Guan Wenqing Pan Mimi Chen Hongjiao Yu Wenping Zhu | 2010 | Contributions to Mineralogy and Petrology2010，，3： | 1 |
| 19 | Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: A randomized phase III trial显示文摘 | Masatoshi Kudo Guohong Han Richard S. Finn Ronnie T.P. Poon Jean‐Frederic Blanc Lunan Yan Jijin Yang Ligong Lu Won‐Young Tak Xiaoping Yu Joon‐Hyeok Lee Shi‐Ming Lin Changping Wu Tawesak Tanwandee Guoliang Shao Ian B. Walters Christine Dela Cruz Valerie Po | 2014 | Hepatology2014，，5： | 1 |
| 20 | 显示文摘 | Yu - An Huang Ian Phau Chad Lin Consumer ani-mosity economic hardship and normative influence:How do they affect consumers' purchase intention | 2010 | European Journal of Marketing2010，44，78： | 1 |
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