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| 1 | Gastric leptomeningeal carcinomatosis: Multi-center retrospective analysis of 54 cases显示文摘AIM: To identify the clinical features and outcomes of infrequently reported leptomeningeal carcinomatosis (LMC) of gastric cancer.METHODS: We analyzed 54 cases of cytologically confirmed gastric LMC at four institutions from 1994 to 2007.RESULTS: The male-to-female ratio was 32:22, and the patients ranged in age from 28 to 78 years (median,48.5 years). The majority of patients had advanced disease at initial diagnosis of gastric cancer. The clini-cal or pathologic tumor, node and metastasis stage ofthe primary gastric cancer wasin 38 patients (70%).The median interval from diagnosis of the primarymalignancy to the diagnosis of LMC was 6.3 mo, rang-ing between 0 and 73.1 mo. Of the initial endoscopic f indings for the 45 available patients, 23 (51%) of the patients were Bormann typeand 15 (33%) patientswere Bormann type. Pathologically, 94% of cases proved to be poorly differentiated adenocarcinomas. Signet ring cell component was also observed in 40% of patients. Headache (85%) and nausea/vomiting (58%) were the most common presenting symptoms of LMC. A gadolinium-enhanced magnetic resonance imaging was conducted in 51 patients. Leptomeningeal enhancement was noted in 45 cases (82%). Intrathecal (IT) chemotherapy was administered to 36 patients-primarily methotrexate alone (61%), but also in combi-nation with hydrocortisone/± Ara-C (39%). The median number of IT treatments was 7 (range, 1-18). Concomitant radiotherapy was administered to 18 patients, and concomitant chemotherapy to seven patients. Sev-enteen patients (46%) achieved cytological negative conversion. Median overall survival duration from the diagnosis of LMC was 6.7 wk (95% CI: 4.3-9.1 wk). In the univariate analysis of survival duration, hemoglobin, IT chemotherapy, and cytological negative conversion showed superior survival duration (P = 0.038, P = 0.010, and P = 0.002, respectively). However, in our multivariate analysis, only cytological negative conversion was predictive of relatively longer survival duration (3.6, 6.7 and 14.6 wk, P = 0.030, RR: 0.415, 95% CI: 0.188-0.918).CONCLUSION: Although these patients had a fatal clinical course, cytologic negative conversion by IT chemotherapy may improve survival. | Sung Yong Oh Su-Jin Lee Jeeyun Lee Suee Lee Sung-Hyun Kim Hyuk-Chan Kwon Gyeong-Won Lee Jung Hun Kang In Gyu Hwang Joung-Soon Jang Ho Yeong Lim Young Suk Park Won Ki Kang Hyo-Jin Kim | 2009 | World Journal of Gastroenterology2009，15，40： | 10 |
| 2 | Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive显示文摘AIM: To determine the changes of quantitative hepatitis B e antigen (HBeAg) that predicts early detection of non- response or breakthrough to long-term lamivudine (LAM) therapy.METHODS: Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 mo, we retrospectively analyzed 220 patients who had received LAM more than 24 mo. RESULTS: The mean duration of LAM therapy was 36 (range, 24-72) mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 (24.1%) patients. Viral breakthrough was observed in 105 (47.7%) patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg: decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non- response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 (92.5%) of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four (7.5%) had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 mo, 95.2% (negative predictive value) failed to achieve HBeAg seroconversion.CONCLUSION: Almost all patients who failed to showa continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough. | Jung Woo Shin Neung Hwa Park Seok Won Jung Byung Chul Kim Sung Ho Kwon Jae Serk Park In Du Jeong Sung-Jo Bang Do Ha Kim | 2006 | World Journal of Gastroenterology2006，12，41： | 7 |
| 3 | A gastrointestinal stromal tumor of the duodenum masquerading as a pancreatic head tumor显示文摘Gastrointestinal stromal tumor (GIST) represents the most common kind of mesenchymal tumor that arises from the alimentary tract. GIST is currently defined as a gastrointestinal tract mesenchymal tumor showing CD117 (c-kit protein) positivity at immunohistochemistry. Throughout the whole length of the gastrointestinal tract, GIST arises most commonly from the stomach followed by the small intestine, the colorectum, and the esophagus. Only 3%-5% of GISTs occur in the duodenum, and especially, if GIST arises from the C loop of the duodenum, it can be difficult to differentiate from the pancreas head mass because of its anatomical proximity. Here, we report a case of duodenal GIST, which was assessed as a pancreatic head tumor preoperatively. | Sung Ho Kwon Hee Jeong Cha Seok Won Jung Byung Chul Kim Jae Serk Park In Du Jeong Jong Hwa Lee Yang Won Nah Sung Jo Bang Jung Woo Shin Neung Hwa Park Do Ha Kim | 2007 | World Journal of Gastroenterology2007，13，24： | 4 |
| 4 | Effect of external beam radiotherapy on patency of uncovered metallic stents in patients with inoperable bile duct cancer显示文摘BACKGROUND: Although biliary decompression with metallic stenting is the preferred treatment for inoperable bile duct cancer(BDC), maintenance of patency is still unsatisfactory.We tried to assess the effectiveness and safety of external beam radiotherapy(EBRT) for prolonging stent patency in patients having uncovered metallic stents.METHOD: We retrospectively reviewed 50 patients who received endoscopic stenting, of whom 18 received EBRT(RT group) and 32 did not(non-RT group).RESULTS: No difference was found in baseline characteristics between the two groups. Although stent patency was longer in the RT group than that in the non-RT group(140.7±51.3 vs136.4±34.9 days, P=0.94), the difference was not statistically significant. There were a lower rate of stent occlusion(27.8% vs50.0% of patients, P=0.12) and a longer overall survival(420.1 ±73.2 vs 269.1±41.7 days, P=0.11) in the RT group than in the non-RT group, and the difference again was not statistically significant. The development of adverse reactions did not differ(55.6% vs 53.1% of patients, P=0.91). There was no serious adverse reaction in both groups(P=0.99).CONCLUSIONS: EBRT did not significantly improve stent patency in patients with inoperable BDC having uncovered metallic stents. However, EBRT was safe. Future trials withrefined protocols for better efficacy are expected. | Jun Kyu Lee Won Kwon Kwack Sang Hyub Lee Jin Hee Jung Jae Hyun Kwon In Woong Han Jin Ho Lee | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 3 |
| 5 | Bevacizumab as a second- or later-line of treatment for metastatic colorectal cancer显示文摘AIM: To determine the efficacy of bevacizumab in patients with metastatic colorectal cancer (MCRC) who have failed prior chemotherapy without bevacizumab. METHODS: Between March 2002 and June 2010, 40 patients in South Korea with MCRC who were treated with bevacizumab plus chemotherapy as a second or later-line treatment were analyzed retrospectively for their overall response rate (ORR), overall survival (OS), and progression-free survival (PFS). The tumor responses were assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) guidelines. RESULTS: All of the patients had progressed under prior chemotherapy without bevacizumab. Three patients (7.5%) exhibited an ORR, twenty one patients (52.5%) exhibited stable disease (SD), and fifteen patients (37.5%) exhibited disease progression. The median duration of the OS and PFS were 14.0 and 6.13 mo respectively. The median OSs were 16.60, 14.07 and 13.00 mo for second-line, third-line and fourth- or later-line treatments, respectively. The median PFSs were 7.23, 7.30 and 3.87 mo for the second-line, third-line and fourth- or later-line treatments, respectively. CONCLUSION: In patients with MCRC, bevacizumab combined chemotherapy may be beneficial during second- or later-line treatment. | Lee Chun Park Ho Sup Lee Seong Hoon Shin Seun Ja Park Moo In Park Sung Yong Oh Hyuk Chan Kwon Jin ho Baek Young Jin Choi Myoung Joo Kang Yang Soo Kim | 2012 | World Journal of Gastroenterology2012，18，10： | 3 |
| 6 | The Relationship Between Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia and the Number of Components of Metabolic Syndrome显示文摘 | Yeon Won Park Sung Bin Kim Hanna Kwon Hee Cheol Kang Kyunghee Cho Kung In Lee Yung Jung Kim Jun Ho Lee | 2013 | Urology2013，，3： | 2 |
| 7 | Association between psoriasis and cardiovascular risk factors in Korean patients显示文摘 | Woo Jin Choi Eun Joo Park In Ho Kwon | 2010 | Ann Dermatol2010，22，3： | 1 |
| 8 | A Phytochemically Characterized Extract of Cordyceps militaris and Cordycepin Protect Hippocampal Neurons from Ischemic Injury in Gerbils显示文摘 | In Hwang Soon Lim Ki-Yeon Yoo Yeon Lee Ho Kim Il-Jun Kang Hyung Kwon Jinseu Park Soo Choi Moo-Ho Won | 2008 | Planta Med2008，，02： | 1 |
| 9 | Usefulness of colonic tattooing using indocyanine green in patients with colorectal tumors显示文摘AIM To prove that tattooing using indocyanine green(ICG) is feasible in laparoscopic surgery for a colon tumor.METHODS From January 2012 to December 2016, all patients who underwent laparoscopic colonic surgery were retrospectively screened, and 1010 patients with colorectal neoplasms were included. Their lesions were tattooed with ICG the day before the operation. The tattooed group(TG) included 114 patients, and the non-tattooed group(NTG) was selected by propensity score matching of subjects based on age, sex, tumor staging, and operation method(n = 228). In total, 342 patients were enrolled. Between the groups, the changes in [Delta(Δ), preoperative-postoperative] the hemoglobin and albumin levels, operation time, hospital stay, oral ingestion period, transfusion, and perioperative complications were compared. RESULTS Preoperative TG had a shorter operation time(174.76 ± 51.6 min vs 192.63 ± 59.9 min, P < 0.01), hospital stay(9.55 ± 3.36 d vs 11.42 ± 8.23 d, P < 0.01), and postoperative oral ingestion period(1.58 ± 0.96 d vs 2.81 ± 1.90 d, P < 0.01). The Δ hemoglobin(0.78 ± 0.76 g/dL vs 2.2 ± 1.18 g/dL, P < 0.01) and Δ albumin(0.41 ± 0.44 g/dL vs 1.08 ± 0.39 g/dL, P < 0.01) levels were lower in the TG. On comparison of patients in the 'N0' and 'N1 or N2' groups, the N0 colon cancer group had a better operation time, length of hospital stay, oral ingestion period, Δ hemoglobin, and Δ albumin results than those of the N1 or N2 group. The operation methods affected the results, and laparoscopic anterior resection(LAR) showed similar results. However, for left and right hemicolectomy, both groups showed no difference in operation time or hospital stay.CONCLUSION Preoperative tattooing with ICG is useful for laparoscopic colectomy, especially in the N0 colon cancer group and LAR. | Jae Ho Park Hee Seok Moon In Sun Kwon Gee Young Yun Seo Hee Lee Dae Hwa Park Ju Seok Kim Sun Hyung Kang Eaum Seok Lee Seok Hyun Kim Jae Kyu Sung Byung Seok Lee Hyun Yong Jeong | 2018 | World Journal of Clinical Cases2018，6，13： | 1 |
| 10 | Can we apply the same indication of endoscopic submucosal dissection for primary gastric cancer to remnant gastric cancer?显示文摘 | Yoon Young Choi In Gyu Kwon Sang Kil Lee Hyun Ki Kim Ji Yeong An Hyoung Il Kim Jae Ho Cheong Richard Thomas Mliwa Sung Kwan Shin Yong Chan Lee Woo Jin Hyung Sung Hoon Noh | 2014 | Gastric Cancer2014，，2： | 1 |
| 11 | Identification of hepatitis c virus core domain inducing suppression of allostimulatory capacity of dendritic cells显示文摘 | Ho Sang Kim Jae Kwon Lee In Ho Yang Jeong Keun Ann Yoon-I Oh Chul Joong Kim Young Sang Kim Chong-Kil Lee | 2002 | Archives of Pharmacal Research2002，，3： | 1 |
| 12 | 4-1BB-based Isolation and Expansion of CD8+ T Cells Specific for Self-Tumor and Non–Self-Tumor Antigens for Adoptive T-cell Therapy显示文摘 | Beom K. Choi Sang C. Lee Myoung J. Lee Young H. Kim Young-Woo Kim Keun-Won Ryu Jun-Ho Lee Su M. Shin Sang-Ho Lee Susumu Suzuki Ho S. Oh Chang H. Kim Don G. Lee Sun H. Hwang Eun-Mi Yu In O. Lee Byoung S. Kwon | 2014 | Journal of Immunotherapy2014，，4： | 1 |
| 13 | Vibration Control of Bridges Under Moving Loads 显示文摘 | Ho - Chul Kwon Man - Cfeol Kim In - Won Lee | 1998 | Computer & Structures1998，166，4： | 1 |
| 14 | Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study显示文摘 | Sung Yong Oh Won Seog Kim Jin Seok Kim Seok Jin Kim Suee Lee Dae Ho Lee Jong-Ho Won In Gyu Hwang Min Kyoung Kim Soon Il Lee Yee Soo Chae Deok-Hwan Yang Hye Jin Kang Chul Won Choi Jinny Park Hyo Jung Kim Jung Hye Kwon Ho Sup Lee Gyeong-Won Lee Hyeon Seok E | 2010 | International Journal of Hematology2010，，3： | 1 |
| 15 | Vibration Control of Bridges Under Moving Loads显示文摘 | Ho Chul Kwon Man Cfeol Kim In Won Lee | 1998 | Computer & Structures1998，66，4： | 1 |
| 16 | Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta‐analysis显示文摘 | Yoon Young Choi Jung Min Bae Ji Yeong An In Gyu Kwon In Cho Hyun Beak Shin Tanaka Eiji Mohammad Aburahmah Hyung‐Il Kim Jae‐Ho Cheong Woo Jin Hyung Sung Hoon Noh | 2014 | J. Surg. Oncol2014，，2： | 1 |
| 17 | Arthroscopic Hybrid Fixation of a Tibial Eminence Fracture in Children显示文摘 | Jong In Kim Jae Ho Kwon Dong Hyun Seo Shaishav M. Soni Michael Mu?oz Kyung Wook Nha | 2013 | Arthroscopy Techniques2013，，： | 1 |
| 18 | Pain,Catastrophizing,and Depression in Chronic Prostatitis/ Chronic Pelvic Pain Syndrome显示文摘 | Jong Kyou Kwon In Ho Chang | 2013 | IntNeurourol J2013，17，： | 1 |
| 19 | Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation ofβ-catenin显示文摘Vestibular schwannoma(VS),one of characteristic tumors of neurofibromatosis type 2(NF2),is an intracranial tumor that arises from Schwann cells of the vestibular nerve.VS results in hearing loss,tinnitus,dizziness,and even death,but there are currently no FDA-approved drugs for treatment.In this study,we established a high-throughput screening to discover effective compounds that could inhibit the viability of VS cells.Among 1019 natural products from the Korea Chemical Bank screened,we found that celastrol,a pentacyclic triterpene derived from a Tripterygium Wilfordi plant,exerted potent inhibitory effect on the viability of VS cells with an IC50 value of 0.5µM.Celastrol(0.5,1µM)dose-dependently inhibited the proliferation of primary VS cells derived from VS patients.Celastrol also inhibited the growth,and induced apoptosis of two other VS cell lines(HEI-193 and SC4).Aberrant activation of Wnt/β-catenin signaling has been found in VS isolated from clinically defined NF2 patients.In HEI-193 and SC4 cells,we demonstrated that celastrol(0.1,0.5μM)dose-dependently inhibited TOPFlash reporter activity and protein expression ofβ-catenin,but not mRNA level ofβ-catenin.Furthermore,celastrol accelerated the degradation ofβ-catenin by promoting the formation of theβ-catenin destruction complex.In nude mice bearing VS cell line SC4 allografts,administration of celastrol(1.25 mg·kg^(−1)·d^(−1),i.p.once every 3 days for 2 weeks)significantly suppressed the tumor growth without showing toxicity.Collectively,this study demonstrates that celastrol can inhibit Wnt/β-catenin signaling by promoting the degradation ofβ-catenin,consequently inhibiting the growth of VS. | Na Hui Kim Minji Kwon Jiwoo Jung Hyo Byeong Chae Jiwoo Lee Yeo-Jun Yoon In Seok Moon Ho KLee Wan Namkung Konstantina M.Stankovic Se A.Lee Jong Dae Lee Sin-Aye Park | 2022 | Acta Pharmacologica Sinica2022，43，11： | 0 |
| 20 | Duodenal obstruction after successful embolization for duodenal diverticular hemorrhage: A case report显示文摘We present a 69-year-old woman with a duodenal obstruction after successful selective transcatheter arterial embolization (TAE) for a duodenal diverticular hemorrhage. Two weeks after TAE, the patient showed abrupt symptoms of duodenal obstruction. Resolving hematomas after successful selective transcatheter arterial embolization should be thoroughly observed because they might result in duodenal fibrotic encasement featuring inflammatory duodenal wall thickening, duodenal deformity, dysmotility, and fi nally obstruction. | Yu Jin Kwon Ji Hun Kim Seung Hyoung Kim Bong Soo Kim Heung Up Kim Eun Kwang Choi In Ho Jeong | 2009 | World Journal of Gastroenterology2009，15，30： | 0 |
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