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| 1 | Randomized controlled trial of uncut Roux-en-Y vs Billroth Ⅱ reconstruction after distal gastrectomy for gastric cancer: Which technique is better for avoiding biliary reflux and gastritis?显示文摘AIM To identify which technique is better for avoiding biliary reflux and gastritis between uncut Roux-en-Y and Billroth Ⅱ reconstruction. METHODS A total of 158 patients who underwent laparoscopyassisted distal gastrectomy for gastric cancer at the First Hospital of Jilin University(Changchun, China) between February 2015 and February 2016 were randomized into two groups: uncut Roux-en-Y(group U) and Billroth II group(group B). Postoperative complications and relevant clinical data were compared between the two groups. RESULTS According to the randomization table, each group included 79 patients. There was no significant difference in postoperative complications between groups U and B(7.6% vs 10.1%, P = 0.576). During the postoperative period, group U stomach p H values were lower than 7 and group B p H values were higher than 7. After 1 year of follow-up, group B presented a higher incidence of biliary reflux and alkaline gastritis. However, histopathology did not show a significant difference in gastritis diagnosis(P = 0.278), and the amount of residual food and gain of weight between the groups were also not significantly different. At 3 mo there was no evidence of partial recanalization of uncut staple line, but at 1 year the incidence was 13%. CONCLUSION Compared with Billroth II reconstruction, uncut Rouxen-Y reconstruction is secure and feasible, and can effectively reduce the incidence of alkaline reflux, residual gastritis, and heartburn. Despite the incidence of recanalization, uncut Roux-en-Y should be widely applied. | Dong Yang Liang He Wei-Hua Tong Zhi-Fang Jia Tong-Rong Su Quan Wang | 2017 | World Journal of Gastroenterology2017，23，34： | 43 |
| 2 | Correlation of red cell distribution width with the severity of coronary artery disease: a large Chinese cohort study from a single center显示文摘 | MA Feng-lian LI Sha LI Xiao-lin LIU Jun QING Ping GUO Yuan-lin XU Rui-xia ZHU Cheng-gang JIA Yan-jun LIU Geng DONG Qian WU Na-qiong JIANG Li-xin LI Jian-jun | 2013 | Chinese Medical Journal2013，，6： | 32 |
| 3 | Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia显示文摘脉管的光滑的肌肉房间(VSMC ) 的增加的增长和移植是在动脉粥样硬化患者损害的开发的关键事件。Baicalin,导出植物的 flavonoid 混合物,以前被显示了通过多重小径在癌症房间导致 apoptosis 和生长抑制。然而,在 VSMC 增长和心血管的疾病的预防的规定的 baicalin 的潜在的角色仍然保持未经勘探。在这研究,我们证明有 baicalin 的那个预告的处理有一个剂量依赖者 PDGF-BB-stimulated VSMC 增长上的禁止的效果,与增殖的减小伴随了房间原子抗原(PCNA ) 表示。我们也证明导致 baicalin 的生长抑制在在 p27 的激活和增加在刺激 PDGF 的 VSMC 铺平的 cyclin E-CDK2 与减少被联系,它看起来是部分至少由 PDGF 受体尾的封锁调停了(PDGFR 尾) 发信号的细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 。另外, baicalin 也被发现禁止 PDGF-BB 在 VSMC 导致的粘附分子表达式和房间移植。而且,使用一根动物颈动脉动脉的汽球损害模型,我们发现 baicalin 显著地禁止了 neointimal 增生。一起拿,我们的结果在导致生长揭示 baicalin 的新奇功能在汽球损害以后刺激 PDGF 的 VSMC 和压制的 neointimal 增生逮捕,并且建议内在的机制经由 PDGFR 尾 - 的封锁包含在 p27 累积的 cyclin E-CDK2 激活和增加的抑制 ERK1/2 发信号串联。 | Li-Hua Dong Jin-Kun Wen Sui-Bing Miao Zhenhua Jia Hai-Juan Hu Rong-Hua Sun Yiling Wu Mei Han | 2010 | Cell Research2010，20，11： | 30 |
| 4 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 5 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 6 | Genetic diversity and construction of core collection in Chinese wheat genetic resources显示文摘Genetic diversity among 5029 accessions representing a proposed Chinese wheat core collection was analyzed using 78 pairs of fluorescent microsatellite (SSR) primers mapped to 21 chromosomes. A stepwise hierarchical sampling strategy with priority based on 4×105 SSR data-points was used to construct a core collection from the 23090 initial collections. The core collection consisted of 1160 accessions, including 762 landraces, 348 modern varieties and 50 introduced varieties. The core ac-counts for 23.1% of the 5029 candidate core accessions and 5% of the 23090 initial collections, but retains 94.9% of alleles from the candidate collections and captures 91.5% of the genetic variation in the initial collections. These data indicate that it is possible to maintain genetic diversity in a core collection while retaining fewer accessions than the accepted standard, i.e., 10% of the initial collections captured more than 70% of their genetic diversity. Estimated genetic representation of the core con-structed by preferred sampling (91.5%) is much higher than that by random sampling (79.8%). Both mean genetic richness and genetic diversity indices of the landraces were higher than those of the modern varieties in the core. Structure and principal coordinate analysis revealed that the landraces and the modern varieties were two relatively independent subpopulations. Strong genetic differentiation associated with ecological environments has occurred in the landraces, but was relatively weak in the modern cultivars. In addition, a mini-core collection was constructed, which consisted of 231 accessions with an estimated 70% representation of the genetic variation from the initial collections. The mini-core has been distributed to various research and breeding institutes for detailed phenotyping and breeding of genetic introgression lines. | HAO ChenYang DONG YuChen WANG LanFen YOU GuangXia ZHANG HongNa GE HongMei JIA JiZeng ZHANG XueYong | 2008 | Chinese Science Bulletin2008，53，10： | 27 |
| 7 | Practice guidelines for ultrasound-guided percutaneous microwave ablation for hepatic malignancy显示文摘Primary liver cancer and liver metastases are among the most frequent malignancies worldwide,with an increasing number of new cases and deaths every year.Traditional surgery is only suitable for a limited proportion of patients and imaging-guided percutaneous thermal ablation has achieved optimistic results for management of hepatic malignancy.This synopsis outlines the first clinical practice guidelines for ultrasoundguided percutaneous microwave ablation therapy for hepatic malignancy,which was created by a joint task force of the Society of Chinese Interventional Ultrasound.The guidelines aim at standardizing the microwave ablation procedure and therapeutic efficacy assessment,as well as proposing the criteria for the treatment candidates. | Ping Liang Jie Yu Ming-De Lu Bao-Wei Dong Xiao-Ling Yu Xiao-Dong Zhou Bing Hu Ming-Xing Xie Wen Cheng Wen He Jian-Wen Jia Guo-Rong Lu | 2013 | World Journal of Gastroenterology2013，19，33： | 26 |
| 8 | Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185^(c-erbB-2)显示文摘The c-erbB-2 proto-oncogene encodes a 185kDa protein p185, which belongs to epidermal growth factorreceptor family. Amplification of this gene has been shown to correlate with poor clinical prognosis forcertain cancer patients. The monoclonal antibody A21 which directed against p185 specifically inhibitsproliferation of tumor cells overexpressing p185, hence allows it to be a candidate for targeted therapy. Inorder to overcome several drawbacks of murine MAb, we cloned its VH and VL genes and constructed thesingle-chain Fv (scFv) through a peptide linker. The recombinant scFvA21 was expressed in Escherichiacoli and purified by the affinity column. Subsequently it was characterized by ELISA, Western blot, cellimmunohistochemistry and FACS. All these assays showed the binding activity to extracellular domain(ECD) of p185. Based on those properties of scFvA21, we further constructed the scFv-Fc fusion moleculewith a homodimer form and the recombinant product was expressed in mammalian cells. In a series ofsubsequent analysis this fusion protein showed identical antigen binding site and activity with the parentantibody. These anti-p185 engineered antibodies have promised to be further modified as a tumor targetingdrugs, with a view of application in the diagnosis and treatment of human breast cancer. | LIAN SHENG CHENG, AI PING LIU, JIA HONG YANG, YAN QIU DONG, LIANG WEI LI, JING WANG, CHAO CHEN WANG, JING LIUSchool of Life Science, University of Science and Technology of China, Hefei 230027, China | 2003 | Cell Research2003，13，1： | 24 |
| 9 | Multi-slice three-dimensional spiral CT cholangiography: a new technique for diagnosis of biliary diseases显示文摘Objective: To validate multi-slice three-dimensionalspiral CT cholangiography (3-D CTC) in clinical di-agnosis of biliary diseases.Methods: This study included 146 patients with bili-ary diseases, involving 73 cases of biliary tumor, 87cases of radioparent calculus, 12 cases of post cholan-gio-jejunostomy and one case of congenital choledo-chocyst. The data of thin-slice volumetric CT scanwere sent to the workstation (GE Advantage Win-dows 3. 1). Rational 3-D CTC including maximumintensity projection, minimum intensity projection,surface shaded display, CT virtual endoscopy andray sumption was performed. The diagnostic accura-cy of 3-D CTC was compared with that of conven-tional CT, ultrasonography and endoscopic retro-grade cholangiopancreaticography (ERCP).Results: Different biliary diseases showed distinct ima-ging manifestations on 3-D CTC, As a new techniquefor assessing the status of post cholangio-jejunosto-my, 3-D CTC was superior to conventional CT, ul-trasonography and ERCP in diagnosis of negative bil-iary calculus, extrahepatic cholangiocarcinoma,cancer embolus of the biliary duct, carcinoma of thepancreas head and periampullar carcinoma. It wasalso superior to conventional CT, ultrasonography orequal to ERCP in diagnosis of hilar cholangiocarcino-ma, but inferior to conventional CT and ultrasonog-raphy in diagnosis of gallbladder cancer.Conclusion: 3-D CTC as a non-invasive and sensitivetechnique for the diagnosis of biliary diseases withhigh diagnostic accuracy will greatly increase the de-tection rate of biliary diseases. | Ai-Min Xu Hong-Yan Cheng Wen-Bin Jiang Dong Chen Yu-Chen Jia Meng-Chao Wu the Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，4： | 22 |
| 10 | Emodin protects rat liver from CCl_4-induced fibrogenesis via inhibition of hepatic stellate cells activation显示文摘AIM:To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl4) in rats and to further explore the underlying mechanisms.METHODS: Rat models of experimental hepatic fibrosis were established by injection with CCl4; the treated rats received emodin via oral administration at a dosage of 20 mg/kg twice a week at the same time. Rats injected with olive oil served as a normal group. Histopathological changes were observed by hematoxylin and eosin staining. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and hepatic hydroxyproline content were assayed by biochemical analyses. The mRNA and protein relevant to hepatic stellate cell (HSC) activation in the liver were assessed using real-time reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, western blotting and enzyme-linked immunosorbent assay.RESULTS: The degree of hepatic fibrosis increased markedly in the CCl4 group compared to the normal group (P<0.01), and decreased markedly in the emodin group compared to the CCl4 group according to METAVIR scale (P<0.01) compared with those in the normal control group (51.02±10.64 IU/L and 132.28±18.14 IU/L). The activities of serum ALT and AST were significantly higher in rats injected with CCl4 (289.25±68.84 IU/L and 423.89±35.67 IU/L, both P<0.05). The activities of serum ALT and AST were significantly reduced by administration of emodin (176.34±47.29 IU/L and 226.1±44.52 IU/L, both P<0.05). Compared with the normal controls (54.53±13.46 mg/g), hepatic hydroxyproline content was significantly higher in rats injected with CCl4 (120.27±28.47 mg/g, P<0.05). Hepatic hydroxyproline content was significantly reduced in the rats treated with emodin at 20 mg/kg (71.25±17.02 mg/g, P<0.05). Emodin signif icantly protected the liver from injury by reducing serum AST and ALT activities and reducing hepatic hydroxyproline content. The mRNA levels of transforming growth factor-β1 (TGF-β1), Smad4 and α-SMA in liver tissues were significantly down-regulated in SD rats that received emodin treatment. Furthermore, significant down-regulation of serum TGF-β1 protein levels and protein expression of Smad4 and α-SMA in liver tissues was also observed in the rats. Emodin inhibited HSC activation by reducing the abundance of TGF-β1 and Smad4.CONCLUSION: Emodin protects the rat liver from CCl4-induced fibrogenesis by inhibiting HSC activation. Emodin might be a therapeutic antifibrotic agent for the treatment of hepatic fibrosis. | Miao-Xian Dong Yan Jia Ying-Bo Zhang Cheng-Chong Li Yu-Tao Geng Li Zhou Xue-Yan Li Ji-Cheng Liu Ying-Cai Niu | 2009 | World Journal of Gastroenterology2009，15，38： | 22 |
| 11 | Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction显示文摘 | Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL | 2014 | Chinese Medical Journal2014，，4： | 23 |
| 12 | Real-time road traffic state prediction based on ARIMA and Kalman filter显示文摘道路交通流预测不仅可以为出行者提供实时有效的信息,而且可以帮助他们选择最佳路径,减少出行时间,实现道路交通路径诱导,缓解交通拥堵。本文提出了一种基于ARIMA模型和Kalman滤波算法的道路交通流预测方法。首先,基于道路交通历史数据建立时间序列的ARIMA模型。其次,结合ARIMA模型和Kalman滤波法构建道路交通预测算法,获取Kalman滤波的测量方程和更新方程。然后,基于历史道路交通数据进行算法的参数设定。最后,以北京的四条路段作为案例,对所提出的方法进行了分析。实验结果表明,基于ARIMA模型和Kalman滤波的实时道路交通状态预测方法是可行的,并且可以获得很高的精度。 | Dong-wei XU Yong-dong WANG Li-min JIA Yong QIN Hong-hui DONG | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，2： | 22 |
| 13 | Genotypic Difference in the Responses of Seedling Growth and Cd Toxicity in Rice(Oryza sativa L.)显示文摘The experiment was carried out to study the genotypic difference in the responses of seed germination, growth andphysiological characters of rice seedlings to Cd toxicity. The result showed that the germination was slightly stimulatedunder low Cd concentration (0.01-1.5 mM Cd), while severely depressed under higher Cd concentration (2.0 mM). Riceseedlings exposed to 0.01 mM Cd showed slight increases in plant height, root volume, biomass and chlorophyllconcentration. These parameters were significantly reduced when Cd level in the medium was increased to 0.5 mM, andmeanwhile corresponding increase in superoxide dismutase (SOD) and peroxidase (POD) activities, and MDA(malondialdehyde) content was observed. However, SOD and POD activities declined when plants were exposed to 1 mMCd when compared with those under 0.5 mM Cd. Cadmium addition lowered Fe, Cu and Mn concentrations in roots andshoots. There was significant genotypic difference in the response of these parameters to Cd stress. Under Cd stress,Xiushui 110 had the least inhibition of growth and increase in MDA content, higher shoot Cd concentration, and greatestincrease in POD and SOD activities, indicating its higher tolerance to Cd toxicity, while Bing 9914 had the greatestreduction of growth, and Zn, Cu, Fe, and Mn contents, but greatest increase in MDA content, and least increase inactivities of antioxidative enzymes, indicating its sensitivity to Cd toxicity. | WU Fei-bo DONG Jing JIA Guo-xia ZHENG Shan-jiu ZHANG Guo-ping | 2006 | Agricultural Sciences in China2006，5，1： | 20 |
| 14 | Genetic diversity in Chinese modern wheat varieties revealed by microsatellite markers显示文摘Genetic diversity of 1680 modern varieties in Chinese candidate core collections was analyzed at 78 SSR loci by fluorescence detection system. A total of 1336 alleles were detected, of which 1253 alleles could be annotated into 71 loci. For these 71 loci, the alleles ranged from 4 to 44 with an average of 17.6, and the PIC values changed from 0.19 to 0.89 with an average of 0.69. (1) In the three genomes of wheat, the average genetic richness was B>A>D, and the genetic diversity indexes were B>D>A. (2) Among the seven homoeologous groups, the average genetic richness was 2=7>3>4>6>5>1, and the genetic diversity indexes were 7>3>2>4>6>5>1. As a whole, group 7 possessed the highest genetic diversity, while groups 1 and 5 were the lowest. (3) In the 21 wheat chromosomes, 7A, 3B and 2D possessed much higher genetic diversity, while 2A, 1B, 4D, 5D and 1D were the lowest. (4) The highest average genetic diversity index existed in varieties bred in the 1950s, and then it declined continually. However, the change tendency of genetic diversity among decades was not greatly sharp. This was further illustrated by changes of the average genetic distance between varieties. In the 1950s it was the largest (0.731). Since the 1960s, it has decreased gradually (0.711, 0.706, 0.696, 0.695). The genetic base of modern varieties is becoming narrower and narrower. This should be given enough attention by breeders and policy makers. | HAO Chenyang, WANG Lanfen, ZHANG Xueyong, YOU Guangxia, DONG Yushen, JIA Jizeng, LIU Xu, SHANG Xunwu, LIU Sancai & CAO Yongsheng Key Laboratory of Crop Germplasm & Biotechnology, MOA, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China Agronomy College, Gansu Agricultural University, Lanzhou 730070, China | 2006 | Science China(Life Sciences)2006，49，3： | 19 |
| 15 | Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B显示文摘AIM: To investigate the combined diagnostic accuracy of acoustic radiation force impulse(ARFI), aspartate aminotransferase to platelet ratio index(APRI) and Forns index for a non-invasive assessment of liver fibrosis in patients with chronic hepatitis B(CHB). METHODS: In this prospective study, 206 patients had CHB with liver fibrosis stages F0-F4 classified by METAVIR and 40 were healthy volunteers were measured by ARFI, APRI and Forns index separately or combined as indicated. RESULTS: ARFI, APRI or Forns index demonstrated a significant correlation with the histological stage(all P < 0.001). According to the AUROC of ARFI and APRI for evaluating fibrotic stages more than F2, ARFI showed an enhanced diagnostic accuracy than APRI(P < 0.05). The combined measurement of ARFI and APRI exhibited better accuracy than ARFI alone when evaluating ≥ F2 fibrotic stage(Z = 2.77, P = 0.006). Combination of ARFI, APRI and Forns index did not obviously improve the diagnostic accuracy compared to the combination of ARFI and APRI(Z = 0.958, P = 0.338). CONCLUSION: ARFI + APRI showed enhanced diagnostic accuracy than ARFI or APRI alone for significant liver fibrosis and ARFI + APRI + Forns index shows the same effect with ARFI + APRI. | Chang-Feng Dong Jia Xiao Ling-Bo Shan Han-Ying Li Yong-Jia Xiong Gui-Lin Yang Jing Liu Si-Min Yao Sha-Xi Li Xiao-Hua Le Jing Yuan Bo-Ping Zhou George L Tipoe Ying-Xia Liu | 2016 | World Journal of Hepatology2016，8，14： | 18 |
| 16 | Marine Geohazards: Review and Future Perspective显示文摘With offshore resource exploration moving to the deep water, marine geohazards have been attracting attention from the academic and industry. Research achievements of marine geohazards were reviewed in this paper. We analyzed and discussed typical issues among marine geohazards, including coastal erosion, submarine slope failure, turbidity current and special hazards induced by gas hydrate dissociation, in terms of their definition, distribution, characteristics and case studies. Major international projects on marine geohazards headed by the United States, Europe, Japan and other international organizations are introduced as well. Three marine geohazard survey methods, including geophysical survey, geotechnical exploration and in-situ observation, were summarized with a brief description of each approach, respectively. Especially, the history of marine geohazard researches in China is briefly reviewed, showing the disparity between China and developed countries in the study of marine geohazards narrows gradually. The potential research tendency in future was suggested. | JIA Yonggang ZHU Chaoqi LIU Liping WANG Dong | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 18 |
| 17 | Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure显示文摘长期的心失败(CHF ) ,源于各种各样的心血管的疾病(CVD ) 的后果的临床的症候群,逐渐地正在成为病态和死亡的一个全球原因。我们更早证明了洗旅行的一个 4 天的森林能在病人上向附属治疗学的影响提供 CHF。为了进一步调查影响和森林洗澡的最佳的频率的持续时间,与 CHF 在病人摔倒,我们招募了经历了在 4 个星期以后再洗旅行的第一个森林并且也就是,随机把他们分成了二个组的那些对象城市的控制组(城市)和洗组(森林)的森林。在洗旅行的第二个 4 天的森林以后,我们象氧化应力一样在大脑 natriuretic 肽层次,心失败的 biomarker,和稀释煽动性的回答观察了稳定的衰落。因此,这探索研究表明了添加剂好处两次,森林洗澡与 CHF 在老病人摔倒,它能进一步为在 CVD 分析如此的干预的效果铺平道路。 | MAO Gen Xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，2： | 18 |
| 18 | Differential responses of short-term soil respiration dynamics to the experimental addition of nitrogen and water in the temperate semi-arid steppe of Inner Mongolia, China显示文摘We examined the effects of simulated rainfall and increasing N supply of different levels on CO2 pulse emission from typical Inner Mongolian steppe soil using the static opaque chamber technique, respectively in a dry June and a rainy August. The treatments included NH4NO3 additions at rates of 0, 5, 10, and 20 g N/(m2·year) with or without water. Immediately after the experimental simulated rainfall events, the CO2 effluxes in the watering plots without N addition(WCK) increased greatly and reached the maximum value at 2 hr. However, the efflux level reverted to the background level within 48 hr. The cumulative CO2 effluxes in the soil ranged from 5.60 to 6.49 g C/m2over 48 hr after a single water application, thus showing an increase of approximately 148.64% and 48.36% in the effluxes during both observation periods. By contrast, the addition of different N levels without water addition did not result in a significant change in soil respiration in the short term. Two-way ANOVA showed that the effects of the interaction between water and N addition were insignificant in short-term soil CO2 effluxes in the soil. The cumulative soil CO2fluxes of different treatments over 48 hr accounted for approximately 5.34% to 6.91% and 2.36% to 2.93% of annual C emission in both experimental periods. These results stress the need for improving the sampling frequency after rainfall in future studies to ensure more accurate evaluation of the grassland C emission contribution. | Yuchun Qi Xinchao Liu Yunshe Dong Qin Peng Yating He Liangjie Sun Junqiang Jia Congcong Cao | 2014 | Journal of Environmental Sciences2014，26，4： | 17 |
| 19 | Cerebrolysin improves sciatic nerve dysfunction in a mouse model of diabetic peripheral neuropathy显示文摘To examine the effects of Cerebrolysin on the treatment of diabetic peripheral neuropathy, we first established a mouse model of type 2 diabetes mellitus by administering a high-glucose, high-fat diet and a single intraperitoneal injection of streptozotocin. Mice defined as diabetic in this model were then treated with 1.80, 5.39 or 8.98 m L/kg of Cerebrolysin via intraperitoneal injections for 10 consecutive days. Our results demonstrated that the number, diameter and area of myelinated nerve fibers increased in the sciatic nerves of these mice after administration of Cerebrolysin. The results of several behavioral tests showed that Cerebrolysin dose-dependently increased the slope angle in the inclined plane test(indicating an improved ability to maintain body position), prolonged tail-flick latency and foot-licking time(indicating enhanced sensitivity to thermal and chemical pain, respectively, and reduced pain thresholds), and increased an index of sciatic nerve function in diabetic mice compared with those behavioral results in untreated diabetic mice. Taken together, the anatomical and functional results suggest that Cerebrolysin ameliorated peripheral neuropathy in a mouse model of type 2 diabetes mellitus. | Han-yu Dong Xin-mei Jiang Chun-bo Niu Lin Du Jun-yan Feng Fei-yong Jia | 2016 | Neural Regeneration Research2016，11，1： | 17 |
| 20 | Three-dimensional Evolutionary Models of the Qiongxi Structures,Southwestern Sichuan Basin,China:Evidence from Seismic Interpretation and Geomorphology显示文摘褶层结束是在有压缩性的差错相关的褶层的学习的特色。如此的结束能由于戳差错上的排水量的损失或 / 并且形成一个侧面或倾斜的斜面。因此,高质量的地震数据将明白地帮助定义哪个机制应该为给定的差错相关的褶层的结束负责。在四川盆的 Qiongxi 和 Qiongxinan 结构,中国是拥有在他们之间的北结束和结构的僵绳的自然差错繁殖褶层的例子。合拢 / 指责几何学和沿着罢工排水量变化被工业 3-D 抑制地震体积。我们解释北结束和结构的僵绳附近的褶层的 plunge 由于排水量的损失罢工。与北结束联系的差错几何学变化从一在 Qiongxinan 结构的冠扁平斜面在排水量最大的地方,到简单地 Qiongxi 结构的北尖端附近的一个斜面,没有形成一个侧面或倾斜的斜面。在这研究,我们也使用排水模式,在沿着一个差错的排水量与推进为 Qiongxinan 的侧面的繁殖建议一个模型的持续时间成正比的 Qiongxinan 结构和假设的冠保存的胚胎的结构和 Qiongxi 结构。明确地,我们建议结构首先在易碎的单位以内作为一个孤立的差错斜面开始了。与弄短增加,差错变得以更弱的页岩单位与更低的分队连接创造 hybridized 差错繁殖褶层。我们的模型为 Qiongxinan 和 Qiongxi 结构的侧面的繁殖历史建议可能的解释,并且也提供一条其他的途径给在迟了的新生代在西南的四川盆证实以前的 Pingluoba 结构的活动。 | JIA Qiupeng JIA Dong LUO Liang CHEN Zhuxin LI Yiquan DENG Fei SUN Shengsi LI Haibin | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 17 |
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