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| 1 | A High-Density SNP Genotyping Array for Rice Biology and Molecular Breeding显示文摘一个高密度的单个核苷酸多型性(SNP ) 数组为遗传学者和分子的 breeders.With 是极其重要的 genomic 的巨大的数量的累积重新定序为精确 SNP 察觉的数据和可得到的技术,设计高密度、高质量的米饭 SNP 数组是可能的。这里,我们报导一个高密度的 riceSNP 数组和它的实用程序的开发。SNP 探针被屏蔽超过 10 设计从变化和一个数组说出 RiceSNP50 的 801 米饭的 re-sequencingdata 提取的 000 000 SNP loci 在 Illumina Infinium 站台上被生产。数组 contained51 478 个均匀地分布式的标记,其 68% 个在遗传因子的区域以内。有 parent/F1 relationshipswere 的几百米饭植物过去常为精确 SNP 打电话产生一个高质量的簇文件。应用程序测试证明这穿有的 highgenotyping 精确性,并且能被用于不同目的。例如,有好分辨率的精英米饭变化 wasclustered 的一个核心集合。染色体宽的协会研究(GWAS ) 分析正确地识别了描绘的 QTL.Further,这个数组成功地为变化确认和特点基因渗入被使用。作为一个精确 high-throughputgenotyping 工具, RiceSNP50 将在两功能的 genomics 学习和分子的 breeding.Key 词起一个重要作用: | Haodong Chen Weibo Xie Hang He Huihui Yu Wei Chen Jing Li Renbo Yu Yue Yao Wenhui Zhang Yuqing He Xiaoyan Tang Fasong Zhou Xing Wang Deng Qifa Zhang | 2014 | Molecular Plant2014，7，3： | 38 |
| 2 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 3 | Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats显示文摘Hyperlipidemia(HPL)characterized by metabolic disorder of lipids and cholesterol is one of the important risk factors for cardiovascular diseases.Proprotein convertase subtilsin/kexin type 9(PCSK9)is a potent circulating regulator of LDL through its ability to induce degradation of the low-density lipoprotein cholesterol receptor(LDLR)in the lysosome of hepatocytes.Aloe-emodin(AE)is one of potentially bioactive components of Chinese traditionalmedicine Daming capsule.In this study we evaluated the HPL-lowering efficacy of AE in both in vivo and in vitro HPL models.High-fat diet-induced rats were treated with AE(100 mg/kg per day,ig)for 6 weeks.We found that AE administration significantly decreased the levels of total cholesterol(TC)and LDL in the serum and liver tissues.Moreover,AE administration ameliorated HPL-induced hepaticlipid aggregation.But AE administration did not significantly inhibit HMG-CoA reductase activity in the liver of HPL rats.A cellular model of HPL was established in human hepatoma(HepG2)cells treated with cholesterol(20 μg/mL)and 25-hydroxycholesterol(2 μg/mL),which exhibited markedly elevated cholesterol levels.The increased cholesterol levels could be reversed by subsequent treatment with AE(30 μM).In both the in vivo and in vitro HPL models,we revealed that AE selectively suppressed the stero-regulatory element-binding protein-2(SREBP-2)and hepatocyte nuclear factor(HNF)1α-mediated PCSK9 signaling,which in turn upregulated LDL receptor(LDLR)and promoted LDL uptake.This study demonstrates that AE reduces cholesterol content in HPL rats by inhibiting the hepatic PCSK9/LDLR pathway. | Zhen-li Su Peng-zhou Hang Juan Hu Yu-yang Zheng Han-qi Sun Jing Guo Ke-yu Liu Zhi-min Du | 2020 | Acta Pharmacologica Sinica2020，41，8： | 14 |
| 4 | Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of ischemic stroke in Han Chinese of eastern China显示文摘Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene have been suggested to play an important role in the pathogenesis of atherosclerosis and ischemic stroke.This study was aimed to explore the association of ALOX5AP variants with ischemic stroke risk in Han Chinese of eastern China.A total of 690 ischemic stroke cases and 767 controls were recruited.The subjects were further subtyped according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria.On the basis of that,two polymorphisms of the ALOX5AP gene (rs10507391 and rs12429692) were determined by TaqMan genotyping assay.In addition,plasma leukotriene B4 (LTB4) levels were analyzed in these subjects.There was no evidence of association between the two variants of ALOX5AP and the risk of ischemic stroke or its TOAST-subtypes.Haplotype analysis and stratification analysis according to sex,age,body mass index,hypertension,and diabetes also showed negative association.Analysis of LTB4 levels in a subset of cases and controls revealed that LTB4 levels were significantly higher in ischemic stroke cases than in the controls (70.06±14.75 ng/L vs 57.34±10.93 ng/L;P=0.000) and carriers of the T allele of the rs10507391 variant were associated with higher plasma LTB4 levels (P=0.000).The present study suggests there is no association of the two polymorphisms in the ALOX5AP gene with ischemic stroke risk in Han Chinese of eastern China. | Gannan Wang Yao Wang Hao Sun Weijuan Cao Jing Zhang Hang Xiao Jinsong Zhang | 2011 | The Journal of Biomedical Research2011，25，5： | 12 |
| 5 | Platelet count combined with right liver volume and spleen volume measured by magnetic resonance imaging for identifying cirrhosis and esophageal varices显示文摘AIM: To determine whether the combination of platelet count(PLT) with spleen volume parameters and right liver volume(RV) measured by magnetic resonance imaging(MRI) could predict the Child-Pugh class of liver cirrhosis and esophageal varices(EV).METHODS: Two hundred and five cirrhotic patients with hepatitis B and 40 healthy volunteers underwent abdominal triphasic-enhancement MRI and laboratory examination of PLT in 109/L. Cirrhotic patients underwent endoscopy for detecting EV. Spleen maximal width(W), thickness(T) and length(L) in mm together with spleen volume(SV) and RV in mm3 were measured by MRI, and spleen volume index(SI) in mm3 was obtained by W × T × L. SV/PLT, SI/PLT and RV × PLT/SV(RVPS) were calculated and statistically analyzed to assess cirrhosis and EV.RESULTS: SV/PLT(r = 0.676) and SI/PLT(r = 0.707) increased, and PLT(r =-0.626) and RVPS(r =-0.802) decreased with the progress of Child-Pugh class(P < 0.001 for all). All parameters could determine the presence of cirrhosis, distinguish between each class of Child-Pugh class, and identify the presence of EV [the areas under the curve(AUCs) = 0.661-0.973]. A m o n g p a ra m e t e r s, R V P S c o u l d b e s t d e t e r m i n e presence and each class of cirrhosis with AUCs of 0.973 and 0.740-0.853, respectively; and SV/PLT could best identify EV with an AUC of 0.782.CONCLUSION: The combination of PLT with SV and RV could predict Child-Pugh class of liver cirrhosis and identify the presence of esophageal varices. | Xiao-Li Chen Tian-Wu Chen Xiao-Ming Zhang Zhen-Lin Li Nan-Lin Zeng Ping Zhou Hang Li Jing Ren Guo-Hui Xu Jia-Ni Hu | 2015 | World Journal of Gastroenterology2015，21，35： | 10 |
| 6 | Partial Iterative Decode of Turbo Codes for On-Board Processing Satellite Platform显示文摘There is a contradiction between high processing complexity and limited processing resources when turbo codes are used on the on-board processing(OBP)satellite platform.To solve this problem,this paper proposes a partial iterative decode method for on-board application,in which satellite only carries out limited number of iteration according to the on-board processing resource limitation and the throughput capacity requirements.In this method,the soft information of parity bits,which is not obtained individually in conventional turbo decoder,is encoded and forwarded along with those of information bits.To save downlink transmit power,the soft information is limited and normalized before forwarding.The iteration number and limiter parameters are optimized with the help of EXIT chart and numerical analysis,respectively.Simulation results show that the proposed method can effectively decrease the complexity of onboard processing while achieve most of the decoding gain.. | LI Hang GAO Zhen ZHAO Ming WANG Jing | 2015 | China Communications2015，12，11： | 8 |
| 7 | China's treatment regimen for fulminant myocarditis is bringing wonderful achievement to the world显示文摘Fulminant myocarditis is characterized by acute and severe inflammation with injury of myocardium globally. It has a fulminant course and high in-hospital mortality rate of up to50%-70%. It onsets rapidly after viral infection and progresses to hypotension. | Jing Zhang Weijian Hang Rutai Hui Qiong Zhao Shashank S.Desai | 2019 | Science China(Life Sciences)2019，62，2： | 8 |
| 8 | Kinetics simulation and experimental observation of fine microstructure of 9%Ni cryogenic steel processed by QLT heat treatment显示文摘Thermo-Calc and Dictra commercial calculation software programs have been used to simulate the formation of fine microstructure of 9%Ni cryogenic steel processed by quench–lamellarize–temper(QLT)heat treatment.The calculations show many compositional fluctuations in each single-martensite lath after QLT treatment;the peak concentrations of carbon and nickel reach about 0.40%and 18%,respectively.The width of the C or Ni element-enriched zone increases when the critical lamellarizing temperature decreases or the temper temperature increases.Extending the temper time has a similar effect on the element profiles.The simulation results are in accordance with the observed fine microstructures. | Tao Pan Jing Zhu Caifu Yang Hang Su | 2014 | Chinese Science Bulletin2014，59，15： | 8 |
| 9 | Research on the carbon isotopic composition of organic matter from Lake Chenghai and Caohai Lake sediments显示文摘The carbon isotopic composition of organic matter from lake sediments has been extensively used to infer variations in productivity. In this paper, based on the study of the contents and δ13C values of organic matter in different types of lakes, it has been found that δ13C values of organic matter have different responses to lake productivity in different lakes. As to the lakes dominated by aqutic macrophytes such as Lake Caohai, organic matter becomes enriched in 13C with increasing productivity. As to the lakes dominated by aquatic algae such as Lake Chenghai, δ13C values of organic matter decrease with increasing productivity, and the degradation of aquatic algae is the main factor leading to the decrease of δ13C values of organic matter with increasing productivity. Therefore, we should be cautious to use the carbon isotopic composition of organic matter to deduce lake productivity. | ZHU Zhengjie CHEN Jing'an ZENG Yan LI Hang YAN Hui REN Shicong | 2011 | Chinese Journal Of Geochemistry2011，30，1： | 7 |
| 10 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 11 | Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver显示文摘Dear Editor,RNA knockdown in vivo carries significant potential for dis-ease modeling and therapies.Despite the emerging approaches of CRISPR/Cas9-mediated permanent knock out of targeted genes,strategies targeting RNA for disruption are advantageous in the treatment of acquired metabolic disorders when permanent modification of genome DNA is not appropriate,and RNA virus infection diseases when pathogenic DNA is not available(such as SARS-Cov-2 and MERS infections). | Bingbing He Wenbo Peng Jia Huang Hang Zhang Yingsi Zhou Xiali Yang Jing Liu Zhijle Li Chunlong Xu Mingxing Xue Hui Yang Pengyu Huang | 2020 | Protein & Cell2020，11，7： | 7 |
| 12 | The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging:An in vivo study显示文摘The application of medical devices to repair skin damage is clinically accepted and natural polymer enjoys an important role in this field,such as collagen or hyaluronic acid,etc.However,the biosafety and efficacy of these implants are still challenged.In this study,a skin damage animal model was prepared by UV-photoaging and recombinant humanized type Ⅲ collagen(rhCol Ⅲ)was applied as a bioactive material to implant in vivo to study its biological effect,comparing with saline and uncrosslinked hyaluronic acid(HA).Animal skin conditions were non-invasively and dynamically monitored during the 8 weeks experiment.Histological observation,specific gene expression and other molecular biological methods were applied by the end of the animal experiment.The results indicated that rhCol Ⅲ could alleviate the skin photoaging caused by UV radiation,including reduce the thickening of epidermis and dermis,increase the secretion of Collagen Ⅰ(Col Ⅰ)and Collagen Ⅲ(Col Ⅲ)and remodel of extracellular matrix(ECM).Although the cell-material interaction and mechanism need more investigation,the effect of rhCol Ⅲ on damaged skin was discussed from influence on cells,reconstruction of ECM,and stimulus of small biological molecules based on current results.In conclusion,our findings provided rigorous biosafety information of rhCol Ⅲ and approved its potential in skin repair and regeneration.Although enormous efforts still need to be made to achieve successful translation from bench to clinic,the recombinant humanized collagen showed superiorities from both safety and efficacy aspects. | Jing Wang He Qiu Yang Xu Yongli Gao Peijie Tan Rui Zhao Zhanhong Liu Yajun Tang Xiangdong Zhu Chongyun Bao Hang Wang Hai Lin Xingdong Zhang | 2022 | Bioactive Materials2022，7，5： | 7 |
| 13 | Synthesis of fluorescent carbon quantum dots from aqua mesophase pitch and their photocatalytic degradation activity of organic dyes显示文摘A synthesis strategy of fluorescent carbon quantum dots(CQDs) with high quantum yield(QY) using aqua mesophase pitch(AMP) as the carbon source has been developed via the hydrothermal method in this study. The hydrothermal temperature and soaking time have important effects on the morphology and QY of CQDs. As-prepared CQDs at 120℃ holding for 24 h(CQDs-120-24) have the uniform size of about 2.8 nm, and the QY can reach 27.6%. The obtained CQDs are successfully modified with ammonia and thionyl chloride, respectively, and they exhibit an excellent photocatalytic performance on degrading rhodamine B(Rh B), methyl blue(MB) and indigo carmine(IC). Importantly, the degradation percentage of N-CQDs on Rh B under natural light for 4 h reaches 97% with the degradation rate constant of 0.02463 min^(-1) and it can maintain 93% after repetitively used 5 times. The results indicate that these as-prepared CQDs have the potential application in degrading organic dyes. | Youliang Cheng Mengsha Bai Jian Su Changqing Fang Hang Li Jing Chen Jieming Jiao | 2019 | Journal of Materials Science & Technology2019，35，8： | 6 |
| 14 | Clinical factors in patients with ischemic versus hemorrhagic stroke in East China显示文摘 | Jing Zhang Yao Wang Gan-nan Wang Hao Sun Tao Sun Jian-quan Shi Hang Xiao Jin-song Zhang | 2011 | World Journal of Emergency Medicine2011，2，1： | 6 |
| 15 | MicroRNA-99b-3p promotes angiotensin II-induced cardiac fibrosis in mice by targeting GSK-3β显示文摘Cardiac fibrosis is a typical pathological change in various cardiovascular diseases. Although it has been recognized as a crucial risk factor responsible for heart failure, there is still a lack of effective treatment. Recent evidence shows that microRNAs (miRNAs) play an important role in the development of cardiac fibrosis and represent novel therapeutic targets. In this study we tried to identify the cardiac fibrosis-associated miRNA and elucidate its regulatory mechanisms in mice. Cardiac fibrosis was induced by infusion of angiotensin II (Ang II, 2 mg·kg^(−1)·d^(−1)) for 2 weeks via osmotic pumps. We showed that Ang II infusion induced cardiac disfunction and fibrosis accompanied by markedly increased expression level of miR-99b-3p in heart tissues. Upregulation of miR-99b-3p and fibrotic responses were also observed in cultured rat cardiac fibroblasts (CFs) treated with Ang II (100 nM) in vitro. Transfection with miR-99b-3p mimic resulted in the overproduction of fibronectin, collagen I, vimentin and α-SMA, and facilitated the proliferation and migration of CFs. On the contrary, transfection with specific miR-99b-3p inhibitor attenuated Ang II-induced fibrotic responses. Similarly, intravenous injection of specific miR-99b-3p antagomir could prevent Ang II-infused mice from cardiac dysfunction and fibrosis. We identified glycogen synthase kinase-3 beta (GSK-3β) as a direct target of miR-99b-3p. In CFs, miR-99b-3p mimic significantly reduced the expression of GSK-3β, leading to activation of its downstream profibrotic effector Smad3, whereas miR-99b-3p inhibitor caused anti-fibrotic effects. GSK-3β knockdown ameliorated the anti-fibrotic role of miR-99b-3p inhibitor. These results suggest that miR-99b-3p contributes to Ang II-induced cardiac fibrosis at least partially through GSK-3β. The modulation of miR-99b-3p may provide a new approach for tackling fibrosis-related cardiomyopathy. | You-hui Yu Yu-hong Zhang Yan-qing Ding Xue-ying Bi Jing Yuan Hang Zhou Pan-xia Wang Li-li Zhang Jian-tao Ye | 2021 | Acta Pharmacologica Sinica2021，42，5： | 5 |
| 16 | A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice显示文摘Dear Editor,Since the beginning of this century,humanity has been struck three times by the coronavirus outbreak.The most recent one is caused by the SARS-CoV-2 virus,which was first reported in January 2020 and spread rapidly worldwide,developing into a global coronavirus disease pandemic coded COVID-19.1 By July 28,2020,SARS-CoV-2 has caused over sixteen million COVID-19 cases worldwide and 650,805 deaths.2 Such a grave situation has made the development of a COVID-19 vaccine imperative and urgent. | Jing Lu Guoliang Lu Shudan Tan Jia Xia Hualong Xiong Xiaofei Yu Qingqing Qi Xiang Yu Li Li Hang Yu Ningshao Xia Tianying Zhang Yingjie Xu Jinzhong Lin | 2020 | Cell Research2020，30，10： | 5 |
| 17 | Natural vegetation restoration of Liaodong oak(Quercus liaotungensis Koidz.) forests rapidly increased the content and ratio of inert carbon in soil macroaggregates显示文摘The lack of clarity of how natural vegetation restoration influences soil organic carbon(SOC) content and SOC components in soil aggregate fractions limits the understanding of SOC sequestration and turnover in forest ecosystems.The aim of this study was to explore how natural vegetation restoration affects the SOC content and ratio of SOC components in soil macroaggregates(>250 μm), microaggregates(53–250 μm), and silt and clay(<53 μm) fractions in 30-, 60-, 90-and 120-year-old Liaodong oak(Quercus liaotungensis Koidz.) forests, Shaanxi, China in 2015.And the associated effects of biomasses of leaf litter and different sizes of roots(0–0.5, 0.5–1.0, 1.0–2.0 and >2.0 mm diameter) on SOC components were studied too.Results showed that the contents of high activated carbon(HAC), activated carbon(AC) and inert carbon(IC) in the macroaggregates, microaggregates and silt and clay fractions increased with restoration ages.Moreover, IC content in the microaggregates in topsoil(0–20 cm) rapidly increased;peaking in the 90-year-old restored forest, and was 5.74 times higher than AC content.In deep soil(20–80 cm), IC content was 3.58 times that of AC content.Biomasses of 0.5–1.0 mm diameter roots and leaf litter affected the content of aggregate fractions in topsoil, while the biomass of >2.0 mm diameter roots affected the content of aggregate fractions in deep soil.Across the soil profiles, macroaggregates had the highest capacity for HAC sequestration.The effects of restoration ages on soil aggregate fractions and SOC content were less in deep soil than in topsoil.In conclusion, natural vegetation restoration of Liaodong oak forests improved the contents of SOC, especially IC within topsoil and deep soil.The influence of IC on aggregate stability was greater than the other SOC components, and the aggregate stability was significantly affected by the biomasses of litter, 0.5–1.0 mm diameter roots in topsoil and >2.0 mm diameter roots in deep soil.Natural vegetation restoration of Liaodong oak forests promoted SOC sequestration by soil macroaggregates. | SUN Lipeng HE Lirong WANG Guoliang JING Hang LIU Guobin | 2019 | Journal of Arid Land2019，11，6： | 5 |
| 18 | Association between genetic variants of the leukotriene biosynthesis pathway and the risk of stroke: a case-control study in the Chinese Han population显示文摘 | SUN Hao ZHANG Jing WANG Jun SUN Tao XIAO Hang ZHANG Jin-song | 2013 | Chinese Medical Journal2013，，2： | 4 |
| 19 | Aggregate binding agents improve soil aggregate stability in Robinia pseudoacacia forests along a climatic gradient on the Loess Plateau,China显示文摘The distribution of binding agents(i.e.,soil organic carbon(SOC)and glomalin-related soil protein(GRSP))in soil aggregates was influenced by many factors,such as plant characteristics and soil properties.However,how these factors affect binding agents and soil aggregate stability along a climatic gradient remained unclear.We selected the Robinia pseudoacacia L.forests from semi-arid to semi-humid of the Loess Plateau,China to analyze the plant biomass,soil physical-chemical properties,SOC and GRSP distribution in different sized soil aggregates.We found that from semi-arid to semi-humid forests:(1)the proportion of macro-aggregates(>0.250 mm)significantly increased(P<0.05),whereas those of micro-aggregates(0.250–0.053 mm)and fine materials(<0.053 mm)decreased and soil aggregate stability was increased;(2)the contents of SOC and GRSP in macro-aggregates and micro-aggregates significantly increased,and those in fine materials decreased;(3)the contribution of SOC to soil aggregate stability was greater than those of total GRSP and easily extractable GRSP;(4)soil properties had greater influence on binding agents than plant biomass;and(5)soil aggregate stability was enhanced by increasing the contents of SOC and GRSP in macro-aggregates and soil property was the important part during this process.Climate change from semi-arid to semi-humid forests is important factor for soil structure formation because of its positive effect on soil aggregates. | JING Hang MENG Min WANG Guoliang LIU Guobin | 2021 | Journal of Arid Land2021，13，2： | 4 |
| 20 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
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