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| 1 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 2 | Cu Partitioning Behavior and Its Effect on Microstructure and Mechanical Properties of 0.12C-1.33Mn-0.55Cu Q&P Steel显示文摘Cu, as an austenitic stable element, is added to steel in order to suppress the adverse effects of high content of C and Mn on welding. Based on C partitioning, Cu and Mn partitioning can further improve the stability of retained austenite in the intercritical annealing process. A sample of low carbon steel containing Cu was treated by the intercritical annealing, then quenching process(I&Q). Subsequently, another sample was treated by the intercritical annealing, subsequent austenitizing, then quenching and partitioning process(I&Q&P). The effects of element partitioning behavior in intercritical region on the microstructure and mechanical properties of the steel were studied. The results showed that after the I&Q process ferrite and martensite could be obtained, with C, Cu and Mn enriched in the martensite. When intercritically heated at 800 ℃, Cu and Mn were partitioned from ferrite to austenite, which was enhanced gradually as the heating time was increased. This partitioning effect was the most obvious when the sample was heated at 800 ℃ for 40 min. At the early stage of α→γ transformation, the formation of γ was controlled by the partitioning of carbon, while at the later stage, it was mainly affected by the partitioning of Cu and Mn. After the I&Q&P process, the partitioning effect of Cu and Mn element could be retained. C was assembled in retained austenite during the quenching and partitioning process. The strength and elongation of I&Q&P steel was increased by 5 305 MPa% compared with that subjected to Q&P process. The volume fraction of retained autensite was increased from 8.5% to 11.2%. Hence, the content of retained austenite could be improved significantly by Mn and Cu partitioning, which increased the elongation of steel. | 陈连生 HU Baojia XU Jinghui 田亚强 ZHENG Xiaoping SONG Jinying XU Yong | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，5： | 6 |
| 3 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 4 | Effect of ozone injection on the long-term performance and microbial community structure of a VOCs biofilter显示文摘For biofilters treating waste gases containing volatile organic compounds(VOCs), biomass accumulation is a common problem which will induce bed clogging and significant decrease in VOCs removal efficiency during long-term operation. In this study, ozone injection was developed as a biomass control strategy, and its effects on the biofilter performance and the microbial community structure were investigated in long-term operation. Two biofilters,identified as BF1 and BF2, were operated continuously for 160 days treating gaseous toluene under the same conditions, except that 200 mg/m3 ozone was continuously injected into BF1 during days 45–160. During the operation period, ozone injection did not change the toluene removal efficiency, while the pressure drop of BF1 with ozone injection was significantly lowered compared with BF2. The wet biomass accumulation rate of BF1 was 11 g/m^3/hr, which was only46% of that in BF2. According to the carbon balance result, ozone injection also increased the toluene mineralization rate from 83% to 91%, which could be an important reason for the low biomass accumulation. The PMA-q PCR result indicated that ozone injection increased the microbial viability of the biofilm. The high-throughput sequencing result also revealed that the dominant phyla and genera were not changed significantly by ozone injection, but some ozonetolerant genera such as Rhodanobacter, Dokdonella and Rhodococcus were enhanced by ozone exposure. All the results verified that ozone injection is capable of sustaining the long-term performance of biofilters by lowering the biomass accumulation, increasing the microbial viability and changing the microbial community structure. | Prakit Saingam Zenab Baig Yang Xu Jinying Xi | 2018 | Journal of Environmental Sciences2018，30，7： | 4 |
| 5 | Three-Phase Microstructure Topology Optimization of Two-Dimensional Phononic Bandgap Materials Using Genetic Algorithms显示文摘The bandgap,an important characteristic of the periodic structure,is dispersionrelated,which can be designed by tailoring the layout of materials within the periodic microstructures.A typical example of a periodic structure is phononic crystals (PnCs),which are traditionally fabricated from two-phase materials.Herein,we investigate the topologies of periodic three-phase PnCs.The microstructures of the three-phase PnCs are optimized using a two-stage genetic algorithm,and three case studies are proposed to obtain the following:(1)the maximum relative bandgap width,(2)the maximum absolute bandgap width,and (3)the max- imum bandgap at a specified frequency.More importantly,the three-phase material provides significant advantages compared to the typical two-phase materials,such as a low-frequency bandgap.This research is expected to contribute highly to vibration and noise isolation,elastic wave filters,and acoustic devices. | WeiKai Xu Jinying Ning Meng Zhang Wei Wang Tianzhi Yang | 2018 | Acta Mechanica Solida Sinica2018，31，6： | 4 |
| 6 | Performance improvement approaches for optical fiber SPR sensors and their sensing applications显示文摘Optical fiber surface plasmon resonance(SPR) sensors point toward promising application potential in the fields of biomarker detection,food allergen screening,and environmental monitoring due to their unique advantages.This review outlines approaches in improving the fiber SPR sensing performance,e.g.,sensitivity,detection accuracy,reliability,cross-sensitivity,selectivity,convenience and efficiency,and corresponding sensing applications.The sensing principles of SPR sensors,especially the performance indicators and their influencing factors,have been introduced.Current technologies for improving the fiber SPR performance and their application scenarios are then reviewed from the aspects of fiber substrate,intrinsic layer(metal layer),and surface nanomaterial modification.Reasonable design of the substrate can strengthen the evanescent electromagnetic field and realize the multi-parameter sensing,and can introduce the in situ sensing self-compensation,which allows corrections for errors induced by temperature fluctuation,non-specific binding,and external disturbances.The change of the intrinsic layer can adjust the column number,the penetration depth,and the propagation distance of surface plasmon polaritons.This can thereby promote the capability of sensors to detect the large-size analytes and can reduce the full width at half-maximum of SPR curves.The modification of various-dimensionality nanomaterials on the sensor surfaces can heighten the overlap integral of the electromagnetic field intensity in the analyte region and can strengthen interactions between plasmons and excitons as well as interactions between analyte molecules and metal surfaces.Moreover,future directions of fiber SPR sensors are prospected based on the important and challenging problems in the development of fiber SPR sensors. | JIANYING JING KUN LIU JUNFENG JIANG TIANHUA XU SHUANG WANG JINYING MA ZHAO ZHANG WENLIN ZHANG TIEGEN LIU | 2022 | Photonics Research2022，10，1： | 3 |
| 7 | Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes显示文摘 | Qinyuan Xu Li Huang Juan Liu Liang Ma Tao Chen Jinying Chen Fei Peng Dong Cao Zhuang Yang Neng Qiu Jingxiang Qiu Guangcheng Wang Xiaolin Liang Aihua Peng Mingli Xiang Yuquan Wei Lijuan Chen | 2012 | European Journal of Medicinal Chemistry2012，，： | 1 |
| 8 | Development of a new simultaneous separation of cesium and strontium by extraction chromatograph utilization of a hybridized macroporous silica-based functional material 显示文摘 | Zhang Anyun Li Jinying Dai Ying Xu Lei | 2014 | Separation and Purification Technology2014，127，： | 1 |
| 9 | Photonic crystal slabs with maximal chiroptical response empowered by bound states in the continuum显示文摘To enhance the strength of chiral light–matter interaction for practical applications,the chirality and quality factors(Q-factors)of current methods need to be strengthened simultaneously.Here,we propose a design of photonic crystal slabs(Ph Cs)supporting chiral bound states in the continuum(BICs)of transverse electric(TE)and transverse magnetic(TM)modes,exhibiting maximal chiroptical responses with high Q-factors and near-unity circular dichroism(CD=0.98).Different from the past,the Ph Cs we employed only have reduced in-plane symmetry and can support simultaneously chiral quasi-BICs(q-BICs)of TE and TM mode with two-dimensional ultra-strong external and internal chirality.Based on the temporal coupled-mode theory,two analytical expressions of CD of chiral q-BICs response are revealed,which are consistent with the simulation results.Furthermore,we elucidate these results within the charge-current multipole expansion framework and demonstrate that the co-excitation of higher-order multipole electric/magnetic modes is responsible for near-perfect CD.Our results may provide more flexible opportunities for various applications requiring high Q-factors and chirality control,such as chiral lasing,chiral sensing,and enantiomer separation. | QILIN DUAN YALI ZENG YUHANG YIN JINYING XU ZHINING CHEN ZHANLEI HAO HUANYANG CHEN YINENG LIU | 2023 | Photonics Research2023，11，11： | 0 |
| 10 | Study on Infrared Spectra of Citrus grandis Peels from Guangxi Zhuang Autonomous Region显示文摘[Objective] This study aimed to establish the infrared (IR) spectra fingerprints for peels of Citrus grandis from Guangxi Zhuang Autonomous Region. [Method] The fingerprint was established by fourier transform infrared spectroscopy (FT-IR), and then were analyzed by Omic software. [Result] IR spectra fingerprint of C. grandis were successfully established. There were six common peaks in the characteristic spectra of 12 samples. [Conclusion] The specific, rapid and stable method can be applied to quality control of C. grandis. | Chenyan LIANG Xu FENG Hanshen ZHEN Jinying NIU Rui GUO | 2012 | Agricultural Biotechnology2012，1，4： | 0 |
| 11 | Multi-omics for COVID-19:driving development of therapeutics and vaccines显示文摘The ongoing COVID-19 pandemic caused by SARS-CoV-2 has raised global concern for public health and economy.The development of therapeutics and vaccines to combat this virus is continuously progressing.Multi-omics approaches,including genomics,transcriptomics,proteomics,metabolomics,epigenomics and metallomics,have helped understand the structural and molecular features of the virus,thereby assisting in the design of potential therapeutics and accelerating vaccine development for COVID-19.Here,we provide an up-to-date overview of the latest applications of multi-omics technologies in strategies addressing COVID-19,in order to provide suggestions towards the development of highly effective knowledge-based therapeutics and vaccines. | Mengyu Guo Muya Xiong Jinying Peng Tong Guan Haixia Su Yanyi Huang Cai-Guang Yang Yang Li Diana Boraschi Thanigaimalai Pillaiyar Guanbo Wang Chengqi Yi Yechun Xu Chunying Chen | 2023 | National Science Review2023，10，9： | 0 |
| 12 | Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has become a global public health threat.Here we use a TRACE-seq-based metatranscriptomic analysis to compare host responses and vaginal microbiome of postmenopausal female patients with underlying severe COVID-19 disease with those of healthy females,thereby providing insights into the changes in the microenvironment of women's reproductive system. | Meng Xiao Bo Lu Rui Ding Xia Liu Xian Wu Yaqian Li Xudong Liu Lin Qiu Zhibo Zhang Jing Xie Yu Chen Dong Zhang Liting Dong Meiling Zhang Jinying Peng Hua Yang Timothy Kudihna Yingchun Xu Taisheng Li Chengqi Yi Lan Zhu | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 13 | A novel gene R049 identified in uropathogenic Escherichia coli provides partial protection in mice from colonization显示文摘Uropathogenic Escherichia coli(UPEC) is the most common causative organism of human urinary tract infection(UTI).Several UPEC virulence factors have been identified,but more are yet to be found.We previously identified a novel 789-bp-long DNA fragment(named R049) in UPEC strain 132 using a suppressive subtractive hybridization technique.In the present study,we used genome walking to elongate the sequence of this fragment to obtain the whole gene sequence and examined the role of this gene product in generating protective immunity.Through bioinformatic analysis,we predicted that this gene is a 1311-bp open reading frame(ORF),which we designated ORFR049(GenBank accession No.:EF488001).We further constructed a prokaryotic expression system to express full recombinant R049 protein and isolated and purified the protein through IPTG induction and nickel affinity chromatography.Using mouse immunosera generated by the purified protein,we confirmed the natural expression and outer membrane localization of the protein in wild-type strain UPEC132 by Western blotting.To test the potential of this protein as a vaccine candidate,we immunized mice with the recombinant protein before challenging them with UPEC132 through the urinary tract.The results showed significantly reduced bacterial colonization in the urine and kidneys of the immunization group compared with the control group.However,the degree of renal pathological damage was not significantly improved in the immunized mice.Our study has identified a novel gene of UPEC which can generate protective immunity against UTI.This novel gene provides a promising new vaccine candidate. | CHEN JinYing GE Xin ZHANG YuMei LIN Xu ZHANG Wei YANG Xi | 2011 | Chinese Science Bulletin2011，56，8： | 0 |
| 14 | Direct measurement of the Raman enhancement factor of rhodamine 6G on graphene under resonant excitation显示文摘 | Shibin Deng Weigao Xu Jinying Wang Xi Ling Juanxia Wu Liming Xie Jing Kong Mildred S. Dresselhaus Jin Zhang | 2014 | Nano Research2014，7，9： | 0 |
| 15 | Recent Advances and Perspective of Photonic Bound States in the Continuum显示文摘Recent advancements in photonic bound states in the continuum(BICs)have opened up exciting new possibilities for the design of optoelectronic devices with improved performance.In this perspective article,we provide an overview of recent progress in photonic BICs based on metamaterials and photonic crystals,focusing on both the underlying physics and their practical applications.The first part of this article introduces 2 different interpretations of BICs,based on far-field interference of multipoles and near-field analysis of topological charges.We then discuss recent research on manipulating the far-field radiation properties of BICs through engineering topological charges.The second part of the article summarizes recent developments in the applications of BICs,including chiral light and vortex beam generation,nonlinear optical frequency conversion,sensors,and nanolasers.Finally,we conclude with a discussion of the potential of photonic BICs to advance terahertz applications in areas such as generation and detection,modulation,sensing,and isolation.Webelieve that continued researchinthis area will lead to exciting new advancements in optoelectronics,particularly in the field of terahertz devices. | Guizhen Xu Hongyang Xing Zhanqiang Xue Dan Lu Jinying Fan Junxing Fan Perry Ping Shum Longqing Cong | 2023 | Ultrafast Science2023，3，5： | 0 |
| 16 | Blockchain-based smart contract for smart payment in construction: A focus on the payment freezing and disbursement cycle显示文摘Late payment,and indeed no payment,is a rampant and chronic problem that has plagued the global construction industry for too long.Recent development in blockchain technology,particularly its smart contract,seems to provide a new opportunity to improve this old problem.However,this opportunity is largely unexploited.This study aims to develop a blockchain-based smart contract(BBSC)system for smart payment in the construction industry by focusing on the fundamental cycle of payment freezing(sometimes also synonymously called payment guarantees)and disbursement application.Firstly,a BBSC framework,containing three processes of(a)initiation and configuration,(b)payment freezing,and(c)disbursement application,is developed.Next,based on the framework,the system architecture of the BBSC system,containing three layers of(1)Infrastructure as a Service(IaaS),(2)Blockchain as a Service(BaaS),and(3)Software as a Service(SaaS)is proposed and elaborated.Finally,based on the system architecture,a BBSC prototype system is developed using a real-life modular construction project as a case study.It was found that the prototype system can improve the certainty and efficiency of the progress payment,thereby enabling smart payment in construction transactions.Without advocating radical changes(e.g.,the contractual relationships or the intermediate role of banks in modem construction projects),the prototype can be developed into a real-life BBSC system that can work compatibly with current advancements in the field.Future works are recommended to fine-tune the findings and translate and implement them in real-life applications. | Liupengfei WU Weisheng LU Jinying XU | 2022 | Frontiers of Engineering Management2022，9，2： | 0 |
| 17 | Support vector machine regression(SVR)-based nonlinear modeling of radiometric transforming relation for the coarse-resolution data-referenced relative radiometric normalization(RRN)显示文摘Radiometric normalization,as an essential step for multi-source and multi-temporal data processing,has received critical attention.Relative Radiometric Normalization(RRN)method has been primarily used for eliminating the radiometric inconsistency.The radiometric trans-forming relation between the subject image and the reference image is an essential aspect of RRN.Aimed at accurate radiometric transforming relation modeling,the learning-based nonlinear regression method,Support Vector machine Regression(SVR)is used for fitting the complicated radiometric transforming relation for the coarse-resolution data-referenced RRN.To evaluate the effectiveness of the proposed method,a series of experiments are performed,including two synthetic data experiments and one real data experiment.And the proposed method is compared with other methods that use linear regression,Artificial Neural Network(ANN)or Random Forest(RF)for radiometric transforming relation modeling.The results show that the proposed method performs well on fitting the radiometric transforming relation and could enhance the RRN performance. | Jing Geng Wenxia Gan Jinying Xu Ruqin Yang Shuliang Wang | 2020 | Geo-Spatial Information Science2020，23，3： | 0 |
| 18 | Magnetic-field modulation of topological electronic state and emergent magneto-transport in a magnetic Weyl semimetal显示文摘The modulation of topological electronic state by an external magnetic field is highly desired for condensed-matter physics.Schemes to achieve this have been proposed theoretically,but few can be realized experimentally.Here,combining transverse transport,theoretical calculations,and scanning tunneling microscopy/spectroscopy(STM/S)investigations,we provide an observation that the topological electronic state,accompanied by an emergent magneto-transport phenomenon,was modulated by applying magnetic field through induced non-collinear magnetism in the magnetic Weyl semimetal EuB6.A giant unconventional anomalous Hall effect(UAHE)is found during the magnetization re-orientation from easy axes to hard ones in magnetic field,with a UAHE peak around the low field of 5 kOe. | Jianlei Shen Jiacheng Gao Changjiang Yi Meng Li Shen Zhang Jinying Yang Binbin Wang Min Zhou Rongjin Huang Hongxiang Wei Haitao Yang Youguo Shi Xiaohong Xu Hong-Jun Gao Baogen Shen Geng Li Zhijun Wang Enke Liu | 2023 | The Innovation2023，4，2： | 0 |
| 19 | Thread Private Variable Access Optimization Technique for Sunway High-Performance Multi-core Processors显示文摘The primary way to achieve thread-level parallelism on the Sunwayhigh-performance multicore processor is to use the OpenMP programming technique.To address the problem of low parallelism efficiency caused by slow accessto thread private variables in the compilation of Sunway OpenMP programs, thispaper proposes a thread private variable access technique based on privilegedinstructions. The privileged instruction-based thread-private variable access techniquecentralizes the implementation of thread-private variables at the compilerlevel, eliminating the model switching overhead of invoking OS core processingand improving the speed of accessing thread-private variables. On the Sunway1621 server platform, NPB3.3-OMP and SPEC OMP2012 achieved 6.2% and6.8% running efficiency gains, respectively. The results show that the techniquesproposed in this paper can provide technical support for giving full play to theadvantages of Sunway’s high-performance multi-core processors. | Jinying Kong Kai Nie Qinglei Zhou Jinlong Xu Lin Han | 2021 | 国际计算机前沿大会会议论文集2021，，1： | 0 |
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