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| 1 | Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer显示文摘AIM:To evaluate the depth of invasion of small,early colorectal cancers(ECCs)using conventional endoscopic features.METHODS:From January 2005 to September 2011,colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20mm underwent colonoscopy at the Yonsei University College of Medicine,Seoul,South Korea.Among them,8 patients were excluded due to incomplete medical records.Finally,a total of 64 ECCs with submucosa(SM)invasion and size less than 20 mm were included.One hundred fifty-two adenomas with size less than 20 mm were included as controls.Nine endoscopic features,including seven morphological findings(i.e.,loss of lobulation,excavation,demarcated and depressed areas,stalk swelling,fullness,fold convergence,and bleeding ulcers),pit patterns,and non-lifting signs,were evalu-ated retrospectively.All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology.RESULTS:Among the morphological findings,the size of deep submucosal cancers was bigger than that of superficial lesions(16.9 mm vs 12.3 mm,P<0.001).Also,demarcated depressed areas,stalk swelling,and fullness were more common in deep SM cancers than in superficial tumors(demarcated depressed areas:52.0%vs 15.7%,P<0.001;stalk swelling:100%vs4.2%,P<0.001;fullness:25.0%vs 0%,P=0.001).Among deep SM cancers,96%of polyps showed invasive pit patterns,whereas 19.4%of superficial tumors showed invasive pit patterns(P<0.001).A positive non-lifting sign was more common in deep SM cancers(85.0%vs 28.6%,P<0.001).Diagnostic accuracy of invasive morphology,invasive pit patterns,and nonlifting signs for deep SM cancers were 71%,82%,and75%,respectively.CONCLUSION:Conventional endoscopic findings were insufficient to discriminate small,deep SM cancers from superficial SM cancers by white light,standard colonoscopy. | Wan Park Bun Kim Soo Jung Park Jae Hee Cheon Tae Il Kim Won Ho Kim Sung Pil Hong | 2014 | World Journal of Gastroenterology2014，20，21： | 11 |
| 2 | Usefulness of CA 19–9 for pancreatic cancer screening in patients with new-onset diabetes显示文摘Background: Generally, carbohydrate antigen 19–9(CA 19–9) is not useful for screening pancreatic cancer in the asymptomatic general population. This study aimed to evaluate the utility of CA 19–9 level as a screening indicator of pancreatic cancer in asymptomatic patients with new-onset diabetes.Methods: We retrospectively reviewed the medical records of patients who visited our health promotion center for health check-ups without cancer related symptoms from January 2005 to January 2014, and were newly diagnosed with diabetes mellitus(DM) within 2 years before their visit.Results: Of the 5111 asymptomatic patients with new-onset DM(<2 years) selected for analyses, 87(1.7%) eventually developed pancreatic cancer after the health check-up. In the subgroup of 322 patients with high total bilirubin levels(>1.7 mg/d L) at the screening time, 42(73.7%) of 57 patients with high CA19–9 levels(>37 IU/m L) had been diagnosed as pancreatic cancer during follow-up period and 12(4.5%)of 265 patients with normal CA 19–9 levels had finally developed pancreatic cancer(OR = 16.3). In the subgroup of 4789 patients with normal bilirubin levels, pancreatic cancer had been detected in 20(3.8%)of 522 patients with high CA 19–9 level, while only 13(0.3%) in 4267 patients with normal CA 19–9 levels(OR = 12.6), respectively.Conclusion: CA 19–9 levels after a diagnosis of new-onset DM could be a useful biomarker of pancreatic cancer, especially in patients with high serum bilirubin. | Jung Wan Choe Hyo Jung Kim Jae Seon Kim Jaehyung Cha Moon Kyung Joo Beom Jae Lee Jong-Jae Park Young-Tae Bak | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，3： | 6 |
| 3 | Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression显示文摘AIM: To evaluate the effects of butein on inflammatory cytokines, matrix metalloproteinase-9(MMP-9), andcolitis in interleukin(IL)-10-/- mice.METHODS: To synchronize colitis, 8- to 10-wk-old IL-10-/- mice were fed pellet-chow containing piroxicam for 2 wk. Subsequently, phosphate-buffered saline or butein(1 mg/kg per day, ip) was injected for 4 wk. Histologic scores, inflammatory cytokines, MMP-9 and phosphorylated signal transducer and activator of transcription 3(p STAT3) expressions were analyzed in IL-10-/- mice and in Colo 205 cells.RESULTS: Butein reduced the colonic inflammatory score by > 50%. Expression levels of IL-6, IL-1β, interferon(IFN)-γ and MMP-9 were decreased in the colons of mice exposed to butein, whereas other inflammatory cytokines(IL-17 A, IL-21 and IL-22) were unchanged. Immunohistochemical staining for p STAT3 and MMP-9 was significantly decreased in the buteintreated groups compared with the controls. Butein inhibited IL-6-induced activation of STAT3 in Colo 205 cells.CONCLUSION: Butein ameliorated colitis in IL-10-/-mice by regulating IL-6/STAT3 and MMP-9 activation. | Sehe Dong Lee Jung Wan Choe Beom Jae Lee Myoung Hee Kang Moon Kyung Joo Ji Hoon Kim Jong Eun Yeon Jong-Jae Park Jae Seon Kim Young-Tae Bak | 2015 | World Journal of Gastroenterology2015，21，2： | 3 |
| 4 | Endoscopic submucosal dissection of a large colonic lipoma:Report of two cases显示文摘A colonic lipoma is a very rare benign tumor that is usually asymptomatic and is found incidentally by colonoscopy.Patients with a large colonic lipoma may present with symptoms such as abdominal pain,bleeding,and colonic obstruction or intussusceptions.We report two patients with large colonic lipomas and symptoms.Standard endoscopic submucosal dissection(ESD) was performed to remove the lipomas instead of conventional surgical bowel resection.No complications were observed during or after the procedure.The tumors were resected en bloc,and the patients were discharged 2 d after ESD with a regular diet.The results indicate that ESD can be applied as safe and effective treatment for a large colonic lipoma. | Jae Min Lee Jeong Ho Kim Myungsung Kim Jun Hyoung Kim Young Bae Lee Jae Hyuk Lee Che Wan Lim | 2015 | World Journal of Gastroenterology2015，21，10： | 2 |
| 5 | Evaluation of SWAT sub-daily runoff estimation at small agricultural watershed in Korea显示文摘A study was undertaken for the prediction of runoff flow from 0.8 ha field-sized agricultural watershed in South Korea using Soil and Water Assessment Tool (SWAT) sub-daily. The SWAT model with sub-daily configuration predicted flow from the watershed within the range of acceptable accuracy. The SWAT sub-daily simulations were carried out for a total of 18 rainfall events, 9 each for calibration and validation. Overall trend and extent of matching simulated flow for the rainfall events in 2007-2008 with measured data during the calibration process were coefficient of determination (R2) value of 0.88 and Nash and Sutcliffe Efficiency (ENs) value of 0.88. For validation, R2 and ENs values were 0.9 and 0.84, respectively. Whereas R2 and ENs values for simulation results using daily rainfall data were 0.79 and -0.01, respectively, that were observed to be out of acceptable limits for the model simulation. The importance of higher time resolution (hourly) precipitation records for flow simulation were evaluated by comparing Ra and ENs with 15 min, 2 h, 6 h and 12 h precipitation data, which resulted in lower statistics with increases in time resolution of precipitation data. The SWAT sub-daily sensitivity analysis was performed with the consideration of hydraulic parameter and was found as in the rank order of CN2 (curve number), ESCO (soil evaporation compensation factor), GW_DELAY (ground water delay time), ALPHA BF (base flow alpha factor), GWQMN (a threshold-minimum depth of water in the shallow aquifer required for return flow to occur), REVAPMN (minimum depth of water in shallow aquifer for re-evaporation to occur), LAT TIME (lateral flow travel time) respectively. These sensit]-ve parameters were evaluated at 10% higher and lower values of the parameters, corresponding to 70.5% higher and 23.2% lower in simulated flow out from the SWAT model. From the results obtained in this study, hourly precipitation record for SWAT sub-daily with Green-Ampt infiltration method was proven to be efficient for runoff estimation at field sized watershed with higher accuracies that could be efficiently used to develop site- specific Best Management Practices (BMPs) considering rainfall intensity, rather than simply using daily rainfall data. | Ganga Ram Maharjan Youn Shik Park Nam Won Kim Dong Seok Shin Jae Wan Choi Geun Woo Hyun Ji-Hong Jeon Yong Sik Ok Kyoung Jae Lim | 2013 | Frontiers of Environmental Science & Engineering2013，7，1： | 2 |
| 6 | Survival improvement and prognostic factors in recent management of extrahepatic cholangiocarcinoma:A single-center study显示文摘Background:Cholangiocarcinoma was considered as a dismal disease with very poor prognosis until re-cently.Cholangiocarcinoma is increasingly found due to increased life expectancy.Although surgical and medical management were advanced recently,data on the prognosis,especially extrahepatic cholangio-carcinoma(ECC),were limited.This study aimed to identify clinicopathologic features and prognosis of patients with ECC.Methods:Patients followed up and diagnosed with ECC between January 2014 and December 2016 at a tertiary hospital were included,whereas those with intrahepatic cholangiocarcinoma,gallbladder cancer,and ampullary cancer were excluded.Results:A total of 83 patients were followed after the treatment(49 men and 34 women;median age 73.3 years).Cancer location was classified as distal common bile duct(25 patients),proximal com-mon bile duct(24 patients),common hepatic duct(20 patients),and hilar(14 patients).About 14.5%of patients had history of another malignant neoplasm,and 24.1%patients had chronic illness.Surgi-cal resection was performed in 54 patients(65%)and dysplasia was combined in 63%(34/54).Adjuvant chemotherapy was performed in 54%(29/54),but only 7 underwent palliative chemotherapy in 29 non-surgical patients.The median overall survival in all patients was 30.9 months.In analyzing the treatment modality,median survival of adjuvant chemotherapy,surgery only,palliative chemotherapy,and support-ive care groups were 42.9,30.9,12.0,and 8.9 months,respectively(P<0.05).In the Cox regression analy-sis of survival,age,surgical resection,chemotherapy,and comorbidity were significant prognostic factors,and the comorbidity was the only significant prognostic factor in the multivariable analysis(hazard ratio[HR]=2.80;95%CI:1.32–5.95;P=0.007).In a subgroup analysis of surgical patients,the presence of dysplasia was a favorable prognostic factor in the multivariable analysis(HR=0.29;95%CI:0.09–0.91;P=0.033).Conclusions:The overall survival of patients with ECC was quite high and increased with chemotherapy.Absence of comorbidity,and presence of dysplasia were good prognostic factors. | Jung Wan Choe Hyo Jung Kim Jae Seon Kim | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 2 |
| 7 | 每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性比较显示文摘通过一项为期12周的多中心、随机、开放、平行组试验,比较每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性。按需服用乌地那非200mg能够改善勃起功能障碍的161名患者,被随机分为200mg按需治疗组(n=80)和50mg每日一次组仰=81),两组分别接受相应治疗8周,8周后停药并随访4周,这些患者均通过性活动日志中Q2(插入成功率)和Q3(性交中保持勃起至完成性交的成功率)进行评估。主要的疗效指标是国际勃起功能问卷.勃起功能分级(IIEF.EFD)评分的变化。次要的疗效指标包括性活动日志02、Q3,国际勃起功能问卷的Q3、Q4及其他部分,全球评估问卷,以及正常率(EFD_〉26)的变化。我们也对血管内皮细胞标志物进行了检测。经过8周的治疗,两组的IIEF.EFD评分都得到改善fP〈O.0001),且两组之间没有显著的统计学差异。但这种改善并没有维持到无治疗随访期之后。次要的疗效指标也有类似的结果。在血管内皮标志物方面,两组之间无显著差异。患者对每日一次乌地那非具有更好的耐受性,且两组之间药物不良反应以及不良事件方面无显著性差异。其中脸红和头痛是最常见的不良反应。这两种方案都能改善糖尿病患者的勃起功能障碍,且均有良好的患者耐受性。乌地那非每日给药对糖尿病患者勃起功能障碍的治疗作用值得进一步研究。 | Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon Ah Sung Tae Hwa Kim Jae Min Lee Kang Seo Park | 2015 | Asian Journal of Andrology2015，17，1： | 2 |
| 8 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 9 | EMR for early gastric cancer in Korea: a multicenter retrospective study显示文摘 | Jae J. Kim Jun Haeng Lee Hwoon-Yong Jung Gin Hyug Lee Joo Yong Cho Chang Beom Ryu Hoon Jai Chun Jong Jae Park Wan Sik Lee Hyun Soo Kim Moon Gi Chung Jeong Seop Moon Seok Reyol Choi Geun Am Song Hyun Yong Jeong Sam Ryong Jee Sang Yong Seol Yong Bum Yoon | 2007 | Gastrointestinal Endoscopy2007，，4： | 2 |
| 10 | Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study显示文摘BACKGROUND Ampullary adenoma is a rare premalignant lesion,but its incidence is increasing.Endoscopic papillectomy has become the first treatment of choice for ampullary adenomas due to its safety and effectiveness,thereby replacing surgical resection.However,recurrence rates and adverse events after endoscopic papillectomy were reported in up to 30%of cases.AIM To review the long-term outcomes of endoscopic papillectomy and investigate the factors that affect these outcomes.METHODS We retrospectively analyzed the data of patients who underwent endoscopic papillectomy for ampullary adenoma at five tertiary hospitals between 2013 and 2020.We evaluated clinical outcomes and their risk factors.The definitions of outcomes were as follow:(1)curative resection:complete endoscopic resection without recurrence;(2)endoscopic success:treatment of ampullary adenoma with endoscopy without surgical intervention;(3)early recurrence:reconfirmed adenoma at the first endoscopic surveillance;and(4)late recurrence:reconfirmed adenoma after the first endoscopic surveillance.RESULTS A total of 106 patients were included for analysis.Of the included patients,81(76.4%)underwent curative resection,99(93.4%)had endoscopic success,showing that most patients with noncurative resection were successfully managed with endoscopy.Sixteen patients(15.1%)had piecemeal resection,22 patients(20.8%)had shown positive/uncertain resection margin,11 patients(16.1%)had an early recurrence,13 patients(10.4%)had a late recurrence,and 6 patients(5.7%)had a re-recurrence.In multivariate analysis,a positive/uncertain margin[Odds ratio(OR)=4.023,P=0.048]and piecemeal resection(OR=6.610,P=0.005)were significant risk factors for early and late recurrence,respectively.Piecemeal resection was also a significant risk factor for non-curative resection(OR=5.424,P=0.007).Twenty-six patients experienced adverse events(24.5%).CONCLUSION Endoscopic papillectomy is a safe and effective treatment for ampullary adenomas.Careful selection and follow-up of patients is mandatory,particularly in cases with positive/uncertain margin and piecemeal resection. | Seong Ji Choi Hong Sik Lee Jiyeong Kim Jung Wan Choe Jae Min Lee Jong Jin Hyun Jai Hoon Yoon Hyo Jung Kim Jae Seon Kim Ho Soon Choi | 2022 | World Journal of Gastroenterology2022，28，17： | 2 |
| 11 | 微波辐射辅助柠檬酸络合法制备的Ho^(3+)/Tm^(3+)/Yb^(3+)共掺杂CaWO_4的白光性能(英文)显示文摘采用微波辐射辅助柠檬酸络合法制备Ho3+/Tm3+/Yb3+共掺杂CaWO4纳米晶升频转换荧光粉。将柠檬酸络合物前驱体在300~700°C热处理3 h。Ho3+/Tm3+/Yb3+共掺杂CaWO4C在400°C时开始结晶,在600°C时结晶完成。经600°C热处理的Ho3+/Tm3+/Yb3+共掺杂CaWO4主要呈球形,且形态均匀。在980 nm的激光激发下,Ho3+/Tm3+/Yb3+共掺杂CaWO4纳米晶出现肉眼可见的明亮的白色升频转换发射,这种现象来自Tm3+的475 nm蓝光发射以及Ho3+的543 nm绿光和651 nm红光发射。通过调整Tm3+和Ho3+的浓度可以控制Ho3+/Tm3+/Yb3+共掺杂CaWO4的CIE色度图从冷到暖白色之间变化。讨论了Tm3+和Ho3+浓度对升频转换光性能的影响以及与激光泵功率相关的影响机制。 | Hyun CHO Seok Min HWANG Jae Bin LEE Dong Hyun KA Tae Wan KIM Bo Seul LEE Ji Young LEE Jung-Il LEE Jeong Ho RYU | 2014 | Transactions of Nonferrous Metals Society of China2014，24，S1： | 2 |
| 12 | Effect of ultrasound ondisperse dye particle size 显示文摘 | LEE Keun Wan KIM Jae Pil | 2001 | Textile TechnologyOverseas2001，71，5： | 1 |
| 13 | Long-Term Outcomes of Mechanical Valve Replacement in Patients With Atrial Fibrillation: Impact of the Maze Procedure显示文摘 | Joon Bum Kim Joon Suk Moon Sung-Cheol Yun Wan Kee Kim Sung-Ho Jung Suk Jung Choo Hyun Song Cheol Hyun Chung Jae Won Lee | 2012 | Circulation2012，，17： | 1 |
| 14 | EMR for early gastric cancer in Korea: a multicenter retrospective study显示文摘 | Jae J. Kim Jun Haeng Lee Hwoon-Yong Jung Gin Hyug Lee Joo Yong Cho Chang Beom Ryu Hoon Jai Chun Jong Jae Park Wan Sik Lee Hyun Soo Kim Moon Gi Chung Jeong Seop Moon Seok Reyol Choi Geun Am Song Hyun Yong Jeong Sam Ryong Jee Sang Yong Seol Yong Bum Yoon | 2007 | Gastrointestinal Endoscopy2007，，4： | 1 |
| 15 | Evaluation of Individual Symptoms Cannot Predict Presence of Gastric Hypersensitivity in Functional Dyspepsia显示文摘 | Poong-Lyul Rhee Young-Ho Kim Hee Jung Son Jae J. Kim Kwang Cheul Koh Seung Woon Paik Jong Chul Rhee Kyoo Wan Choi | 2000 | Digestive Diseases and Sciences2000，，8： | 1 |
| 16 | Clinicopathological Analysis and Survival outcome of Duodenal Adenocarcinoma显示文摘 | Myung Jin Kim Sae Byeol Choi Hyung Joon Han Pyoung Jae Park Wan Bae Kim Tae Jin Song Sung Ock Suh Sang Yong Choi | 2013 | Kaohsiung Journal of Medical Sciences2013，，： | 1 |
| 17 | A compact system for simuitaneous measurement of line- ar and angular displacements of nano-stages显示文摘 | Jae Wan Kim Chu Shik Kang Jong Ahn Kim | 2007 | Opti- cal Express2007，15，15： | 1 |
| 18 | Phase Noise Model of Single Loop Frequency Synthesizer显示文摘 | Young Wan Kim Jae Du Yu | 2008 | IEEE Trans on Broadcasting2008，54，1： | 1 |
| 19 | Effect of Ultrasound on Disperse Dye Particle Size显示文摘 | Keun Wan Lee Jae Pil Kim | 2001 | Textile Research Journal2001，71，5： | 1 |
| 20 | Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflamination and Improves Memory Deficit in Mice Fed a High-Fat Diet显示文摘 | Jeon Byeong Tak Jeong Eun Ae Shin Hyun Joo Lee Younghyurk Lee Dong Hoon Kim Hyun Joon Kang Sang Soo Cho Gyeong Jae Choi Wan Sung Roh Gu Seob | 2012 | EN2012，，6： | 1 |
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