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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | Impact of mobile health and medical applications on clinical practice in gastroenterology显示文摘Mobile health apps (MHAs) and medical apps (MAs) are becoming increasinglypopular as digital interventions in a wide range of health-related applications inalmost all sectors of healthcare. The surge in demand for digital medical solutionshas been accelerated by the need for new diagnostic and therapeutic methods inthe current coronavirus disease 2019 pandemic. This also applies to clinicalpractice in gastroenterology, which has, in many respects, undergone a recentdigital transformation with numerous consequences that will impact patients andhealth care professionals in the near future. MHAs and MAs are considered tohave great potential, especially for chronic diseases, as they can support the selfmanagementof patients in many ways. Despite the great potential associated withthe application of MHAs and MAs in gastroenterology and health care in general,there are numerous challenges to be met in the future, including both the ethicaland legal aspects of applying this technology. The aim of this article is to providean overview of the current status of MHA and MA use in the field ofgastroenterology, describe the future perspectives in this field and point out someof the challenges that need to be addressed. | Sven Kernebeck Theresa S Busse Maximilian D Bottcher Jurgen Weitz Jan Ehlers Ulrich Bork Didactics Educational Research in Health | 2020 | World Journal of Gastroenterology2020，26，29： | 2 |
| 3 | Operation of homogeneous azeotropic distillation column sequences显示文摘 | Jan Ulrich Manfred Morari | 2003 | Ind Eng Chem Res2003，42，： | 1 |
| 4 | 2-Year Follow-Up of Patients Undergoing Transcatheter Aortic Valve Implantation Using a Self-Expanding Valve Prosthesis显示文摘 | Lutz Buellesfeld Ulrich Gerckens Gerhard Schuler Raoul Bonan Jan Kovac Patrick W. Serruys Marino Labinaz Peter den Heijer Michael Mullen Wayne Tymchak Stephan Windecker Ralf Mueller Eberhard Grube | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 5 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 6 | Flow simulation studies in coronary arteries—Impact of side-branches显示文摘 | Ernst Wellnhofer Jan Osman Ulrich Kertzscher Klaus Affeld Eckart Fleck Leonid Goubergrits | 2010 | Atherosclerosis2010，，2： | 1 |
| 7 | Detection of cytomegalovirus (CMV) by real-time PCR in fecal samples for the non-invasive diagnosis of CMV intestinal disease显示文摘 | Tina Ganzenmueller Jeanette Kluba Jan Ulrich Becker Oliver Bachmann Albert Heim | 2014 | Journal of Clinical Virology2014，，： | 1 |
| 8 | Reduced expression of Ca^(2+)-regulating proteins in the upper gastrointestinal tract of patients with achalasia显示文摘AIM: To compare expression of Ca2+-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS: Sarcoplasmic reticulum Ca2+ ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats, rabbits, and humans. Furthermore, expression profi les of these proteins in biopsies of lower esophageal sphincter and esophagus from patients with achalasia and healthy volunteers were analyzed. RESULTS: SERCA 2a protein expression was much higher in human heart (cardiac ventricle) compared to esophagus. However, SERCA 2b was expressed predominantly in the esophagus. The highest CRT expression was noted in the human esophagus, while PLB, although highly expressed in the heart, was below our detection limit in upper GI tissue. Compared to healthy controls, CSQ and CRT expression in lower esophageal sphincter and distal esophageal body were signif icantly reduced in patients with achalasia (P < 0.05). CONCLUSION: PLB in the human esophagus mightbe of lesser importance for regulation of SERCA than in heart. Lower expression of Ca2+ storage proteins (CSQ and CRT) might contribute to increased lower esophageal sphincter pressure in achalasia, possibly by increasing free intracellular Ca2+. | Harald Fischer Judith Fischer Peter Boknik Ulrich Gergs Wilhelm Schmitz Wolfram Domschke Jan W Konturek Joachim Neumann | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 9 | Holocene ITCZ and Indian monsoon dynamics recorded in stalagmites from Oman and Yemen (Socotra)显示文摘 | Dominik Fleitmann Stephen J. Burns Augusto Mangini Manfred Mudelsee Jan Kramers Igor Villa Ulrich Neff Abdulkarim A. Al-Subbary Annett Buettner Dorothea Hippler Albert Matter | 2006 | Quaternary Science Reviews2006，，1： | 1 |
| 10 | Validation of the RANS Simulation of Laminar Separation Bubbles on Airfoils 显示文摘 | Windte Jan Scholz Ulrich Radespiel Rolf | 2006 | Aerospace Science and Technology2006，10，： | 1 |
| 11 | Cytotoxic T Lymphocyte Antigen–4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis显示文摘 | Nicole M. F. Gerven Ynto S. Boer Antonie Zwiers Bart Hoek Karel J. Erpecum Ulrich Beuers Henk R. Buuren Joost P. H. Drenth Jannie W. den Ouden Robert C. Verdonk Ger H. Koek Johannes T. Brouwer Maureen M. J. Guichelaar Jan M. Vrolijk G. Kraal Chris J. J. M | 2013 | Liver Int2013，，7： | 1 |
| 12 | Transmission Phase S hift of a Quantum Dot with Kondo Correlations显示文摘 | Jan von Delft Costi T A | 2000 | Phys Rev Lett2000，84，： | 1 |
| 13 | Particle- based multidimensional muhispecies biofilm model 显示文摘 | Cristian Picioreanu Jan - Ulrich Kreft Mark C M | 2004 | Applied and Environmental Microbiology2004，70，5： | 1 |
| 14 | Study of Health in Pomerania (SHIP): A health examination survey in an east German region: Objectives and design显示文摘 | Prof. Dr. Ulrich John Elke Hensel Jan Lüdemann Marion Piek Sybille Sauer Christiane Adam Gabriele Born Dietrich Alte Eberhard Greiser Ursula Haertel Hans-Werner Hense Johannes Haerting Stefan Willich Christof Kessler | 2001 | Sozial - und Pr?ventivmedizin SPM2001，，3： | 1 |
| 15 | Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury显示文摘 | Andreas Linkermann Jan Hinrich Br?sen Maurice Darding Mi Kyung Jin Ana B. Sanz Jan-Ole Heller Federica De Zen Ricardo Weinlich Alberto Ortiz Henning Walczak Joel M. Weinberg Douglas R. Green Ulrich Kunzendorf Stefan Krautwald | 2013 | Proceedings of the National Academy of Sciences2013，，29： | 1 |
| 16 | Management of health,safety and environment in process industry显示文摘 | Nijs Jan Duijm Cecile Fievez Marko Gerbec Ulrich Hauptmanns Myrto Konstandinidou | 2008 | Safety Science2008，，46： | 1 |
| 17 | Albumin dialysis in airrhosis with superimposed acute liver injury:A prospective,controlled study显示文摘 | Heemann Ulrich Trejchel Jan Loock | 2002 | Hepatology2002，36，： | 1 |
| 18 | Study of Health in Pomerania (SHIP): A health examination survey in an east German region: Objectives and design显示文摘 | Prof. Dr. Ulrich John Elke Hensel Jan Lüdemann Marion Piek Sybille Sauer Christiane Adam Gabriele Born Dietrich Alte Eberhard Greiser Ursula Haertel Hans-Werner Hense Johannes Haerting Stefan Willich Christof Kessler | 2001 | Sozial - und Pr?ventivmedizin SPM2001，，3： | 1 |
| 19 | Effect of rare earth elements on the microstructure and texture development in magnesium–manganese alloys during extrusion显示文摘 | Jan Bohlen Sangbong Yi Dietmar Letzig Karl Ulrich Kainer | 2010 | Materials Science & Engineering A2010，，： | 1 |
| 20 | Evaluation of a Pharmacology-Driven Dosing Algorithm of 3-Weekly Paclitaxel Using Therapeutic Drug Monitoring显示文摘 | Markus Joerger Stefanie Kraff Alwin D. R. Huitema Gary Feiss Berta Moritz Jan H. M. Schellens Jos H. Beijnen Ulrich Jaehde | 2012 | Clinical Pharmacokinetics2012，，： | 1 |
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