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| 1 | 体力活动、久坐、身体素质与1型和2型糖尿病年轻患者健康预后的关系:对流行病学文献的综述(英文)显示文摘Diabetes is a leading chronic disease of childhood and adolescence.In addition to the well-known auto-immune,insulin-dependent diabetes mellitus(type 1 diabetes(T1D)),the past two decades have witnessed the emergence of type 2 diabetes(T2D) in children and adolescents,which previously was only seen in middle-aged or older adults.One of the key components of diabetes management is physical activity(PA).The beneficial effects of increased PA and decreased sedentary behavior are extremely important in youth with diabetes because of the markedly increased long-term risk of cardiovascular disease in this population compared to persons without diabetes.This review aims to comprehensively summarize the epidemiologic,observational research published and listed in PubMed between 1970 and 2012 on PA and sedentary behaviors,as well as physical fitness in children and adolescents with TID and T2D.Additionally,we describe briefly the state of knowledge on perceived barriers of PA in persons with diabetes,with a focus on hypoglycemia.Finally,we provide an overview of the epidemiological literature pertaining to health benefits of increased PA in youth with TID and T2D and briefly discuss the topic of exercise-related hypoglycemia. | Angela D. Liese Xiaoguang Ma David M. Maahs Jennifer L. Trilk | 2013 | Journal of Sport and Health Science2013，2，1： | 12 |
| 2 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 3 | HPV Infection among Uygur Women in a Rural Area of Hetian Prefecture,Xinjiang Uygur Autonomous Region, China显示文摘It is not clear how HPV infection is prevalent among Uygur women in Xinjiang Uygur Autonomous Region,China and whether the distribution of HPV infection is related with cervical intraepithelial neoplasia (CIN) incidence among them.A study including 883 Uygur women were conducted from 2006 to 2007 in Hetian Prefecture,Xinjiang Uygur Autonomous Region,China.Exfoliated cells were collected from the cervix for HPV DNA testing.Cervical samples were | Sulaiya HUSAIYIN Mayinuer NIYAZI WANG Li hong WANG Jun Jie WANG Jian Bing Ayeti SIMAYI WANG Lin Zumurelaiti AINIWAER MA Chun Hua Jennifer S.SMITH | 2013 | Biomedical and Environmental Sciences2013，26，11： | 8 |
| 4 | RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis显示文摘Histone ubiquitination 调整为许多生物过程是重要的染色质结构。最近, histones 的 ubiquitination 在 DNA 损坏反应(DDR ) 期间被观察,并且这修正被确实有趣的新基因(戒指) 控制领域 E3 ligase, RNF8。和结合酶 UBC13 的 E2, RNF8 在 DDR 期间催化 histones H2A 和 H2AX 的 ubiquitination,因此便于 DDR 因素的下游的招募,例如 p53 绑定蛋白质 1 (53BP1 ) 并且乳癌类型 1 危险性蛋白质(BRCA1 ) ,到损坏地点。因此, RNF8 猛烈鼠标显示与没有通过的 DDR 联系的显型,包括到电离的超敏性放射, V (D) J 再结合缺乏,和倾向到癌症。除了 DDR 显型, RNF8 猛烈老鼠没能在精子发生期间产生成熟精子,导致男绝育。RNF8 猛烈老鼠也在睾丸在 histone ubiquitination 有激烈的减小。这些调查结果显示 histone ubiquitination 的角色能被 RNF8 依赖的机制在染色质在二个不同生物事件改变期间连接。这里,我们在 DDR 和精子发生两个都考察 RNF8 依赖的 histone ubiquitination 的分子的机制。 | Teng Ma Jennifer A. Keller Xiaochun Yu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 6 |
| 5 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 6 | Engaging HIV-infected patients in antiretroviral therapy services: CD4 cell count testing after HIV diagnosis from 2005 to 2009 in Yunnan and Guangxi, China显示文摘中国的国家免费 antiretroviral 治疗节目的开始和扩大导致了的背景在它的参加者之中的幸存的重要改进。在加强 HIV 屏蔽和照顾的有效连接之上的在治疗范围休息上面的进一步的可伸缩的成功。及时 CD4 房间计数在 HIV 诊断以后测试是必要的决定一个病人是否为 antiretroviral 治疗满足标准,并且代表一个关键连接使 感染HIV 的病人参加适当照顾,它没在 China.Methods 被评估我们评估了所有病人 16 年在云南和 Guangxi.Multivariate 逻辑回归模型测试了从 2005~2009 积极的 HIV 的人,被使用房间计数在 H 以后在 6 个月以内测试识别与 CD4 的缺乏联系的因素在学习经期上, 30 (37%) 635 在 6 月收到 HIV 诊断以内题目收到了一个 CD4 房间计数。CD4 房间计数在 6 月 HIV 诊断以内测试的率在 2009 在 2005 ~ 62% 从 7% 显著地增加了。除 HIV 诊断的更早的年以外,为 CD4 房间计数在 multivariate 分析测试的否定预言者包括了老年,没结婚或不清楚的婚姻地位,下狱,在性播送疾病诊所的诊断,作为与人性交的人分类的 HIV 传播的模式,静脉内的药用户或传播线路不清楚少数种族,高中或高等教育的收据,在自愿的建议,并且有 HIV 的诊断和严峻的诊所积极 pa 然而, HIV 积极病人的一个相当大的比例仍然在 6 月诊断以内缺乏 CD4testing。特别地在有识别风险因素的病人之中,测试的改善 CD4 是必要的与艺术服务连接病人并且优化治疗范围。 | ZHANG Yao LU Lin LI Hui-qin LIU Wei TANG Zhi-rong FANG Hua Jennifer Y. Chen MA Ye ZHAO Yan Ray Y. Chen ZHANG Fu-jie | 2011 | Chinese Medical Journal2011，，10： | 5 |
| 7 | The Compositae Tree of Life in the age of phylogenomics显示文摘包括超过 25000 种类,葵花家庭(Compositae 或 Asteraceae ) 是 flowering 植物的最大的家庭。许多它的系经历了最近、快速的放射,和家庭有大规模基因复制和 polyploidy 的深、普遍的历史。许多由于对发展史的主要节点的支持的差的分辨率和缺乏关于家庭差异的最重要的进化问题仍然保持未答复。我们的组用包括定序 1000 低拷贝的数字的 Hyb-Seq 采用了一条 phylogenomics 途径原子标记,为大量种类的正部分 plastomes。这里,我们讨论我们的进步标明日期并且介绍包括九个亚科和 25 个部落用的二发展史并置并且基于结合的分析。我们为合并高质量的参考染色体和 transcriptomes 在 Compositae 推进系统、进化的研究讨论未来计划。当我们向为采用 phylogenomics 并且在 Compositae 以内解决关系开发工具做了大迈进时,许多工作留下。最近形成的全球合伙将工作 megafamily 为这解决未答复的进化问题。 | Jennifer R. Mandel Michael S. Barker Randall J. Bayer Rebecca B. Dikow Tian-Gang Gao Katy E. Jones Sterling Keeley Norbert Kilian Hong Ma Carolina M. Siniscalchi Alfonso Susanna Ramhari Thapa Linda Watson Vicki A. Funk | 2017 | Journal of Systematics and Evolution2017，55，4： | 4 |
| 8 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 9 | Informing management of rare species with an approach combining scenario modeling and spatially explicit risk assessment显示文摘Wildlife managers are tasked with identifying and managing stressors that threaten persistence of populations.We demonstrate an approach to land-use planning that combines scenario modeling and ecological risk assessment to map and quantify risk to population persistence for three rare prairie species in Washington State,USA.Following corroboration of model output,we found that of the management scenarios considered,only a scenario with year-round restrictions on use of off-road vehicles,digging,and camping enforced in all potential habitat reduces risk to the species.Decreased risk is focused primarily in two patches of prairie habitat in our study area,indicating stringent restrictions need not be applied broadly.However,one area is not easily accessed by two of the three species considered,suggesting reintroductions to suitable but inaccessible habitat may play an important role in management of these species.Our analyses suggest changes in land use and management that might improve habitat for rare species,with options for minimizing monetary and social costs.Because the proposed approach relies on hypothetical management scenarios and uses a model flexible in data requirements to provide spatially explicit output,it can be used to inform adaptive management of rare species in diverse land-planning processes and will be especially useful when management decisions must be made under time or cost constraints. | Jennifer M.Duggan Bradley A.Eichelberger Shan Ma Joshua J.Lawler Guy Ziv | 2015 | Ecosystem Health and Sustainability2015，1，6： | 2 |
| 10 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，7： | 2 |
| 11 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，： | 2 |
| 12 | Supply chain channel strategies with quality and marketing effort-dependent demand显示文摘 | Peng Ma Haiyan Wang Jennifer Shang | 2013 | International Journal of Production Economics2013，，2： | 2 |
| 13 | An increase in the expression of ribonucleotide reductase large subunit1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines显示文摘 | Jennifer D Davidson Liandong Ma | 2004 | Cancer Research2004，64，： | 1 |
| 14 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 15 | Imagining Stereotypes Away: The Moderation of Implicit Stereotypes Through Mental Imagery 显示文摘 | Irene V Blair Jennifer E Ma Alison P Lenton | 2001 | Journal of Personality and Social Psychology2001，，81： | 1 |
| 16 | MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells显示文摘 | Enders K. O. Ng Rufina Li Vivian Y. Shin Jennifer M. Siu Edmond S. K. Ma Ava Kwong | 2014 | Tumor Biology2014，，3： | 1 |
| 17 | ICTs and Internet Adoption in China's Tourism Industry显示文摘 | Jennifer X Ma D Buhalis H Song | 2003 | International Journal of Information Management2003，，23： | 1 |
| 18 | Protein disulfide isomerase: the structure of oxidative folding显示文摘 | Christian W. Gruber Ma?a ?ema?ar Bego?a Heras Jennifer L. Martin David J. Craik | 2006 | Trends in Biochemical Sciences2006，，8： | 1 |
| 19 | Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation显示文摘 | Alvin Pratama Roybel R. Ramiscal Diego G. Silva Souvik K. Das Vicki Athanasopoulos Jessica Fitch Natalia K. Botelho Pheh-Ping Chang Xin Hu Jennifer J. Hogan Paula Ma?a David Bernal Heinrich Korner Di Yu Christopher C. Goodnow Matthew C. Cook Carola G. Vin | 2013 | Immunity2013，，4： | 1 |
| 20 | An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gcmcitabine resistance in non small cell lung cancer 显示文摘 | Jennifer D Davidson Liandong Ma | 2004 | Cancer Res2004，64，： | 1 |
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