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| 1 | Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene显示文摘Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival,and they play important roles in development,aging,and cancer.Cumulating evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene(hTERT)is a complex process in normal cells and many cancer cells.In addition to a number of transcriptional activators and repressors,the chromatin environment and epigenetic status of the endogenous hTERT locus are also pivotal for its regulation in normal human somatic cells and in tumorigenesis. | Jiyue Zhu Yuanjun Zhao Shuwen Wang | 2010 | Protein & Cell2010，1，1： | 5 |
| 2 | Nanomechanical Behaviour of the Membranous Wings of Dragonfly Pantala flavescens Fabricius显示文摘 | Yanru Zhao Dongsheng Wang Jin Tong Jiyu Sun | 2016 | Journal of Bionic Engineering2016，13，3： | 5 |
| 3 | Bio-inspired Superhydrophobic Self-healing Surfaces with Synergistic Anticorrosion Performance显示文摘The past decade has witnessed significant efforts in addressing the global metallic corrosion challenge,with a focus on avoiding or mitigating huge economic losses incurred by corrosion and on the development of protective coatings on metals.Herein,a synergistic anticorrosion coating with both superhydrophobicity and self-healing properties was reported,through a facile replica molding method by mixing the polyvinylidene fluoride(PVDF)matrix with nano-sized SiO2 particles and 2-mercaptobenzothiazole(MBT)loaded halloysites(HNTs).The surface exhibits robust self-cleaning behavior under harsh conditions and high liquid repellence to withstand the osmosis of corrosive ions.The self-healing performance of the coating,due to the introduction of MBT-loaded HNTs,enhances the anticorrosion capability,which is still valid once the protective layer is damaged.Potentiodynamic polarization(PDP)and Electrochemical Impedance Spectroscopy(EIS)measurements demonstrate that the synergetic effects in anticorrosion performances significantly enhance the long-term corrosion protection of metals.Hence,this type of dual-action coating may find unique applications in metal corrosion resistance where both super-repellency and self-healing properties are desired. | Xiaona Yang Limei Tian Wei Wang Yong Fan Jiyu Sun Jie Zhao Luquan Ren | 2020 | Journal of Bionic Engineering2020，17，6： | 4 |
| 4 | Evaluation of triage strategies for high-risk human papillomavirus-positive women in cervical cancer screening:A multicenter randomized controlled trial in different resource settings in China显示文摘Objective:We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus(hrHPV)-positive women in primary healthcare settings in China.Methods:This study was undertaken in 11 rural and 9 urban sites.Women aged 35-64 years old were enrolled.HrHPV-positive women were randomly allocated to liquid-based cytology(LBC),visual inspection with acetic acid and Lugol’s iodine(VIA/VILI)(rural only)triage,or directly referred to colposcopy(direct COLP).At 24 months,hrHPV testing,LBC and VIA/VILI were conducted for combined screening.Results:In rural sites,1,949 hrHPV-positive women were analyzed.A total of 852,218 and 480 women were randomly assigned to direct COLP,LBC and VIA/VILI.At baseline,colposcopy referral rates of LBC or VIA/VILI triage could be reduced by 70%-80%.LBC(n=3 and n=7)or VIA/VILI(n=8 and n=26)could significantly decrease the number of colposcopies needed to detect one cervical intraepithelial neoplasia(CIN)2 or worse and CIN3+compared with direct COLP(n=14 and n=23).For the 24-month cumulative detection rate of CIN2+,VIA/VILI triage was 0.50-fold compared with LBC triage and 0.46-fold with the direct COLP.When stratified by age,baseline LBC triage+performed best(P<0.001),peaking among women aged 35-44 years(Ptrend=0.002).In urban sites,1,728 women were hrHPV genotyping test positive.A total of 408,571 and 568women were randomly assigned to direct COLP for HPV16/18+,direct COLP for other hrHPV subtypes+,and LBC triage for other hrHPV subtypes+.LBC(n=12 and n=31)significantly decreased the number of colposcopies needed to detect one CIN2+and CIN3+compared with direct COLP(n=14 and n=44).HPV16/18+increased the 24-month cumulative detection rate of CIN2+(17.89%,P<0.001).Conclusions:LBC triage for hrHPV-positive women in rural settings and direct COLP for HPV16/18+women and LBC triage for other hrHPV subtype+women in urban settings might be feasible strategies. | Le Dang Linghua Kong Yuqian Zhao Yi Dai Li Ma Lihui Wei Shulan Zhang Jihong Liu Mingrong Xi Long Chen Xianzhi Duan Qing Xiao Guzhalinuer Abulizi Guonan Zhang Ying Hong Qi Zhou Xing Xie Li Li Mayinuer Niyazi Zhifen Zhang Jiyu Tuo Yiling Ding Youlin Qiao Jinghe Lang | 2022 | Chinese Journal of Cancer Research2022，34，5： | 2 |
| 5 | Application of MXenes in lithium-sulfur batteries显示文摘Although lithium-sulfur batteries are considered one of the most potential next-generation energy storage systems owing to their high-energy density, the dissolution and shuttle of intermediate lithium polysulfides primarily limit their commercial applications. Currently, the search for new materials for high-performance lithium-sulfur batteries has become a global research hotspot.MXenes, two dimensional inorganic compound comprising several layers of transition metal carbide, nitride, or car-bonitride,are actively investigated owing to their large specific surface area, good conductivity, and excellent cycle and rate performance.This article firstly reviews the breakthrough of MXenes in lithium-sulfur batteries, introduces the preparation methods and structural characteristics, and summarizes the specific applications and modification mechanisms in lithium-sulfur batteries.Then, the characteristics and advantages of MXenes as a composite electrode material for lithium-sulfur batteries are highlighted. Finally, the potential in future commercial applications is summarized. | HOU JiYue WANG Ying YANG WenHao WANG Fei YANG Dong ZHANG YiYong LIANG Feng LI Xue ZHANG YingJie ZHAO JinBao | 2022 | Science China(Technological Sciences)2022，65，10： | 2 |
| 6 | Clinical characteristics and clinicopathological correlations of bilateral breast cancer in China:A multicenter study from Chinese Society of Breast Surgery(CSBrS-006)显示文摘Objective:To investigate the clinical characteristics and clinicopathological correlations of bilateral breast cancer(BBC)in China.Methods:Data of 440 patients diagnosed with BBC in 2018 were collected from 33 centers of the Chinese Society of Breast Surgery.Demographic characteristics,bilateral tumor characteristics,and comprehensive treatment data were obtained.Correlations between the clinicopathological characteristics of bilateral tumors were analyzed.Results:The proportion of BBC was 0.22%-3.08%.A total of 33(7.5%)patients had a family history of malignant tumors,304(69.1%)patients had synchronous BBC.Only 1(0.2%)patient was male.More than half of all patients received concurrent or asynchronous endocrine/chemotherapy,32.5%of all human epidermal growth factor receptor 2(HER2)-positive patients received HER2-targeted therapy,and approximately 21.6%of all patients received radiotherapy.The most common pathological cancer type was invasive ductal cancer(>60%).Approximately 70%of all patients had bilateral hormone receptor(HR)-positive tumors and presented with a single breast mass.Significant correlations were found with pathological type,histological grade,locations of tumor,molecular subtype,Ki-67 index,tumor site and size of bilateral tumors.Results of the subgroup analysis showed more clinicopathological characteristics when synchronous BBC was compared with metachronous BBC.Conclusions:In China,the clinicopathological characteristics of bilateral tumors showed significant correlations,and more significant clinicopathological correlations were observed when synchronous BBC was compared with metachronous BBC. | Xuelu Li Yitong Wang Bo Pan Man Li Jiyue Gao Yi Zhao Zuowei Zhao Chinese Society of Breast Surgery | 2021 | Chinese Journal of Cancer Research2021，33，1： | 2 |
| 7 | Nanomechanical properties of the stigma of dragonfly Anax parthenope julius Brauer显示文摘 | Tong Jin Zhao Yanru Sun Jiyu | 2007 | Journal of Materials Science2007，42，： | 1 |
| 8 | Garment embedded sweat-activated batteries in wearable electronics for continuous sweat monitoring显示文摘Thin,soft,and skin-integrated electronic system has great advantages for realizing continuous human healthcare monitoring.Here,we report an ultra-thin,flexible,and garment-based microelectronics powered by sweat-activated batteries(SABs)and applications of powering biosensors and microelectronic systems for real time sweat monitoring.The SAB cell is ultra-thin(1.25 mm)with excellent biocompatibility.The SAB has good electricity output with high capacity(14.33 mAh)and maximum power density(3.17 mW cm^(−2))after being activated by the sweat volume of 0.045 mL cm^(−2),which could continuously power 120 light emitting diodes over 3 h.The outputs could maintain stable after repeatable bending.Wireless microelectronics system could be continuously powered by the SABs for 3 h to monitor sweat and physiological information,including sweat Na+concentration,pH,and skin impedance.The reported integrated system provides a potential for solving the power issues of flexible wearable electronics and realizing personalized medicine. | Xingcan Huang Yiming Liu Jingkun Zhou Sina Khazaee Nejad Tsz Hung Wong Ya Huang Hu Li Chun Ki Yiu Wooyoung Park Jian Li Jingyou Su Ling Zhao Kuanming Yao Mengge Wu Zhan Gao Dengfeng Li Jiyu Li Rui Shi Xinge Yu | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 9 | Superior single-mode lasing in a self-assembly CsPbX3 microcavity over an ultrawide pumping wavelength range显示文摘All-inorganic perovskite micro/nanolasers are emerging as a class of miniaturized coherent photonic sources for many potential applications,such as optical communication,computing,and imaging,owing to their ultracompact sizes,highly localized coherent output,and broadband wavelength tunability.However,to achieve singlemode laser emission in the microscale perovskite cavity is still challenging.Herein,we report unprecedented single-mode laser operations at room temperature in self-assembly Cs Pb X3 microcavities over an ultrawide pumping wavelength range of 400–2300 nm,covering one-to five-photon absorption processes.The superior frequency down-and upconversion single-mode lasing manifests high multiphoton absorption efficiency and excellent optical gain from the electron–hole plasma state in the perovskite microcavities.Through direct compositional modulation,the wavelength of a single-mode Cs Pb X3 microlaser can be continuously tuned from blue-violet to green(427–543 nm).The laser emission remains stable and robust after long-term high-intensity excitation for over 12 h(up to 4.3×107 excitation cycles)in the ambient atmosphere.Moreover,the pump-wavelength dependence of the threshold,as well as the detailed lasing dynamics such as the gain-switching and electron–hole plasma mechanisms,are systematically investigated to shed insight into the more fundamental issues of the lasing processes in Cs Pb X3 perovskite microcavities. | GUOEN WENG JIYU YAN SHENGJIE CHEN CHUNHU ZHAO HANBING ZHANG JIAO TIAN YUEJUN LIU XIAOBO HU JIAHUA TAO SHAOQIANG CHEN ZIQIANG ZHU HIDEFUMI AKIYAMA JUNHAO CHU | 2021 | Photonics Research2021，9，1： | 1 |
| 10 | A fieldwork study on the diurnal changes of urban mi- croelimate in four types of ground cover and urban heat island of Nanjing, China显示文摘 | Liangmei Huang JianLong Li Dehua Zhao Jiyu Zhu | 2008 | Building and Envi- ronment2008，43，： | 1 |
| 11 | A fieldwork study on the diurnal changes of urban microclimate in four types of ground cover and urban heat island of Nanjing,China显示文摘 | Liangmei Huang Jianlong Li Dehua Zhao Jiyu Zhu | 2008 | Building and Environment ?Volume 43 Issue 12008，2008，： | 1 |
| 12 | Nanomechanical properties of the stigma of dragonfly Anax parthenope julius Brauer显示文摘 | Tong Jin Zhao Yanru Sun Jiyu | 2007 | Journal of Materials Science2007，42，8： | 1 |
| 13 | Favorable prognostic role of IL-26 in HCC patients associated with JAK-STAT3-dependent autophagy显示文摘Interleukin-26(IL-26),originally called AK155,is one of the cytokines of the IL-10 cytokine family,and its gene is located in human chromosome region 12q15.IL-26 signals through the receptors IL-20R1 and IL-10R2,which form a heterodimer,targets specific cells and induces activation of the JAK-STAT pathway,allowing the rapid phosphorylation of STAT1 and STAT3 and the initiation of their effects.1 This signaling plays an important role in the regulation of host defense and inflammatory diseases.However,whether the role of IL-26 in the progression of hepatocellular carcinoma(HCC)occurs via autophagy remains unclear.Here,we analyzed the association between IL-26 levels and the clinicopathological characteristics of 115 patients with HCC and found that IL-26 levels were particularly associated with tumor stage and survival.We found that IL-26 levels were associated with the prognosis of HCC patients.Furthermore,we found that increased autophagy by IL-26 was dependent on the JAK-STAT3 signaling pathway,which could result in the inhibition of the migration and invasion abilities of these HCC cells.These findings suggest that the levels of IL-26 may be a useful prognostic marker for HCC patients and may offer insights into the clinical application of IL-26 in the future. | Qihong Zhao Chen Wang Kexin Wang Yue He Anla Hu Min Tang Wanshui Yang Jiyu Cao Dexiang Xu Hua Wang | 2022 | Genes & Diseases2022，9，1： | 0 |
| 14 | Rapid fatty acids detection of vegetable oils by Raman spectroscopy based on competitive adaptive reweighted sampling coupled with support vector regression显示文摘Objectives:The composition and content of fatty acids are critical indicators of vegetable oil quality.To overcome the drawbacks of traditional detection methods,Raman spectroscopy was investigated for the fast determination of the fatty acids composition of oil.Materials and Methods:Rapeseed and soybean oil at different depths of the oil tank at different storage times were collected and an eighth-degree polynomial function was used to fit the Raman spectrum.Then,the multivariate scattering correction,standard normal variable transformation(SNV),and Savitzky–Golay convolution smoothing methods were compared.Results:Polynomial fitting combined with SNV was found to be the optimal pretreatment method.Characteristic wavelengths were selected by competitive adaptive reweighted sampling.For monounsaturated fatty acids(MUFAs),polyunsaturated fatty acids(PUFAs),and saturated fatty acids(SFAs),44,75,and 92 characteristic wavelengths of rapeseed oil,and 60,114,and 60 characteristic wavelengths of soybean oil were extracted.Support vector regression was used to establish the prediction model.The R^(2)values of the prediction results of MUFAs,PUFAs,and SFAs for rapeseed oil were 0.9670,0.9568,and 0.9553,and the root mean square error(RMSE)values were 0.0273,0.0326,and 0.0340,respectively.The R^(2)values of the prediction results of fatty acids for soybean oil were respectively 0.9414,0.9562,and 0.9422,and RMSE values were 0.0460,0.0378,and 0.0548,respectively.A good correlation coefficient and small RMSE value were obtained,indicating the results to be highly accurate and reliable.Conclusions:Raman spectroscopy,based on competitive adaptive reweighted sampling coupled with support vector regression,can rapidly and accurately analyze the fatty acid composition of vegetable oil. | Linjiang Pang Hui Chen Liqing Yin Jiyu Cheng Jiande Jin Honghui Zhao Zhihao Liu Longlong Dong Huichun Yu Xinghua Lu | 2022 | Food Quality and Safety2022，6，4： | 0 |
| 15 | Short telomeres impede germ cell specification by upregulating MAPK and TGFβsignaling显示文摘Functional telomeres protect chromosome ends and play important roles in stem cell maintenance and differentiation. Short telomeres negatively impact germ cell development and can contribute to age-associated infertility. Moreover, telomere syndrome resulting from mutations of telomerase or telomere-associated genes exhibits short telomeres and reduced fertility. It remains elusive whether and how telomere lengths affect germ cell specification. We report that functional telomere is required for the coordinated germ cell and somatic cell fate decisions. Using telomerase gene Terc deficient mice as a model, we show that short telomeres restrain germ cell specification of epiblast cells but promote differentiation towards somatic lineage. Short telomeres increase chromatin accessibility to elevate TGFβ and MAPK/ERK signaling for somatic cell differentiation. Notably,elevated Fst expression in TGFβ pathway represses the BMP4-pSmad signaling pathway, thus reducing germ cell formation. Reelongation of telomeres by targeted knock-in of Terc restores normal chromatin accessibility to suppress TGFβ and MAPK signaling, thereby facilitating germ cell formation. Taken together, our data reveal that functional telomeres are required for germ cell specification by repressing TGFβ and MAPK signaling. | Chenglei Tian Dai Heng Nannan Zhao Linlin Liu Xiaoyan Sheng Jiyu Chen &Lin Liu | 2023 | Science China(Life Sciences)2023，66，2： | 0 |
| 16 | Mass Measurement of ^(168)Dy by Heavy Ion Transfer Reaction | Lu Xiuqin Guo Jiyu Zhao Kui Cheng Yehao Ma Yong Li Zhichang Li Shuyuan Ruan Ming China Institule of Atomic Energy,P.O.Box 275-10,Beijing 102413 | 1996 | Chinese journal of nuclear physics1996，，4： | 0 |
| 17 | Port-site metastasis after retroperitoneal laparoscopic nephroureterectomy for renal pelvic cancer显示文摘With the increased use of laparoscopic surgery in the treatment of urological cancer,there is rising concern regarding the development of recurrent disease at laparoscopic port sites.However,there is a paucity of published data addressing port-site metastasis (PSM) following laparoscopic surgery for urological malignancy.Here,we reported a case of isolated PSM that occurred 21 months after laparoscopic nephroureterectomy. | Tian Xiquan Zhao Jiyu Wang Yue Xing Nianzeng | 2014 | Chinese Medical Journal2014，，20： | 0 |
| 18 | Field-induced anisotropic magnetic phase transitions and tricritical phenomena in GdCr_(6)Ge_(6)显示文摘The interaction between complex magnetic structures and non-trivial band structures in ternary rare-earth GdCr_(6)Ge_(6) induces exotic and abundant electro-magnetic phenomena.In this work,we perform a systematical investigation on critical behaviors and magnetic properties of the single-crystal GdCr_(6)Ge_(6).The temperature,field,and angle dependence of magnetization unveils strong magnetic anisotropy along the c-axis and isotropic characteristic in the ab-plane.Critical exponentsβ=0.252(1),γ=0.905(9),δ=4.606(3)for H//ab,andβ=0.281(3),γ=0.991(8),δ=4.541(5)for H//c are obtained by the modified Arrott plot method(MAP)and critical isotherm(CI)analysis.The determined exponents for both directions are consistent with the theoretical prediction of a tricritical mean-field model.Based on detailed magnetization measurements and universality scaling,comprehensive magnetic phase diagrams of GdCr6Ge6for H//ab and H//c are constructed,which reveal that the external field induces a ferromagnetic(FM)transition for H//ab while a ferrimagnetic(FIM)one for H//c.Two tricritical points are determined for H//ab(11.2 K,266.3 Oe)and H//c(11.3 K,3.3 kOe)on the phase diagrams,respectively.The field-induced anisotropic magnetic configurations and multiple phases are clarified,where the moments of Gd and Cr form FM coupling for H//ab while FIM one for H//c via the interaction between Gd and Cr sublattices. | Zan Du Azizur Rahman Jiangpeng Song Jun Zhao Wei Liu Jiyu Fan Chunlan Ma Min Ge Yimin Xiong Li Pi Lei Zhang Yuheng Zhang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 0 |
| 19 | Recent advances in memristors based on two-dimensional ferroelectric materials显示文摘In this big data era, the explosive growth of information puts ultra-high demands on the data storage/computing, such as high computing power, low energy consumption, and excellent stability. However, facing this challenge, the traditional von Neumann architecture-based computing system is out of its depth owing to the separated memory and data processing unit architecture. One of the most effective ways to solve this challenge is building brain inspired computing system with in-memory computing and parallel processing ability based on neuromorphic devices. Therefore, there is a research trend toward the memristors, that can be applied to build neuromorphic computing systems due to their large switching ratio, high storage density, low power consumption, and high stability. Two-dimensional (2D) ferroelectric materials, as novel types of functional materials, show great potential in the preparations of memristors because of the atomic scale thickness, high carrier mobility, mechanical flexibility, and thermal stability. 2D ferroelectric materials can realize resistive switching (RS) because of the presence of natural dipoles whose direction can be flipped with the change of the applied electric field thus producing different polarizations, therefore, making them powerful candidates for future data storage and computing. In this review article, we introduce the physical mechanisms, characterizations, and synthetic methods of 2D ferroelectric materials, and then summarize the applications of 2D ferroelectric materials in memristors for memory and synaptic devices. At last, we deliberate the advantages and future challenges of 2D ferroelectric materials in the application of memristors devices. | Wenbiao Niu Guanglong Ding Ziqi Jia Xin-Qi Ma JiYu Zhao Kui Zhou Su-Ting Han Chi-Ching Kuo Ye Zhou | 2024 | Frontiers of physics2024，19，1： | 0 |
| 20 | High Resolution ERDA显示文摘 | Lu Xiuqin Fu changbo Guo Jiyu Zhao Kui Liang Gang LiShuyuan Liu Jiancheng Jiang Hua | 1998 | Annual Report of China Institute of Atomic Energy1998，，0： | 0 |
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