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| 1 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 2 | Application of next-generation sequencing to screen for pathogenic mutations in 123 unrelated Chinese patients with Marfan syndrome or a related disease显示文摘Marfan syndrome(MFS) is a systemic connective tissue disease principally affecting the ocular, skeletal and cardiovascular systems. This autosomal dominant disorder carries a prevalence of 1:3,000 to 1:5,000. This study aims to define the mutational spectrum of MFS related genes in Chinese patients and to establish genotype-phenotype correlations in MFS. Panel-based targeted next-generation sequencing was used to analyze the FBN1, TGFBR1 and TGFBR2 genes in 123 unrelated Chinese individuals with MFS or a related disease. Genotype-phenotype correlation analyses were performed in mutation-positive patients. The results showed that 97 cases/families(78.9%;97/123) harbor at least one(likely) pathogenic mutation, most of which were in FBN1;four patients had TGFBR1/2 mutations;and one patient harbored a SMAD3 mutation. Three patients had two FBN1 mutations, and all patients showed classical MFS phenotypes. Patients with a dominant negative-FBN1 mutation had a higher prevalence of ectopia lentis(EL). Patients carrying a haploinsufficiency-FBN1 mutation tended to have aortic dissection without EL. This study extends the spectrum of genetic backgrounds of MFS and enriches our knowledge of genotype-phenotype correlations. | Jiacheng Li Chaoxia Lu Wei Wu Yaping Liu Rongrong Wang Nuo Si Xiaolu Meng Shuyang Zhang Xue Zhang | 2019 | Science China(Life Sciences)2019，62，12： | 4 |
| 3 | Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators显示文摘The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase,sirtuin 6(SIRT6)has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases.However,the mechanism underlying allosteric activation of SIRT6 by the activator MDL-801 remains largely elusive because no major conformational changes are observed upon activator binding.By combining molecular dynamics simulations with biochemical and kinetic analyses of wild-type SIRT6 and its variant M136 A,we show that conformational rotation of 2-methyl-4-fluoro-5-bromo substituent on the right phenyl ring(R-ring)of MDL-801,which uncovers previously unseen hydrophobic interactions,contributes to increased activating deacetylation activity of SIRT6.This hypothesis is further supported by the two newly synthesized MDL-801 derivatives through the removal of the 5-Br atom on the R-ring(MDL-801-D1)or the restraint of the rotation of the R-ring(MDL-801-D2).We further propose that the 5-Br atom serves as an allosteric driver that controls the ligand allosteric efficacy.Our study highlights the effect of allosteric enzyme catalytic activity by activator binding and provides a rational approach for enhancing deacetylation activity. | Shaoyong Lu Yingyi Chen Jiacheng Wei Mingzhu Zhao Duan Ni Xinheng He Jian Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 4 | Fabrication of Fe Nanoparticles into N-doped Mesoporous Carbon Nanotube Derived from Rice-Like Fe/N-MOF and Its ORR Catalytic Performance for MFC显示文摘The development of non-noble metal oxidation reduction catalysts(ORR)to improve microbial fuel cell(MFC)performance remains extremely challenging.Herein,the nitrogen-doped iron-based porous carbon nanotube Fe/N@MC-T ORR catalysts were derived from Fe/N-MOF by pyrolyzation using acetonitrile as the nitrogen precursor in a low-cost organic solvent.The Fe/N@MC-T catalysts under different pyrolysis temperatures were characterized by SEM,TEM,BET,XRD,and XPS techniques.Fe/N-MOF showed a smooth rice-like structure with a particle size of about 400×50 nm^(2).The Fe species in Fe/N@MC-T mainly exists in the form of zero-valent iron with a small amount of Fe3C.The results of electrochemical tests revealed that the onset and half-wave potentials of Fe/N@MC-700 were 0.89 V and 0.80 V,respectively,which were only slightly lower than those of the commercial Pt/C(0.92 V and 0.82 V).The MFC with Fe/N@MC-700 showed a highest power density of 864.1 mW/m^(2),which was about 2.25 times that of MFC with carbon cloth,and was slightly lower than that of MFC with Pt/C(20%)(1002.0 mW/m^(2)),which demonstrated that the Fe particles wrapped in carbon nanotubes possessed a relatively high ORR activity. | Lu Decheng Wang Wenyi Chang Jiacheng Wang Xueqin Wang Yuanyuan Song Hua | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，2： | 2 |
| 5 | Engineering hollow core-shell hetero-structure box to induce interfacial charge modulation for promoting bidirectional sulfur conversion in lithium-sulfur batteries显示文摘Severe polysulfide shuttling and sluggish sulfur redox kinetics significantly decrease sulfur utilization and cycling stability in lithium-sulfur batteries(LSBs).Herein,we develop a hollow CoO/CoP-Box core-shell heterostructure as a model and multifunctional catalyst modified on separators to induce interfacial charge modulation and expose more active sites for promoting the adsorption and catalytic conversion ability of sulfur species.Theoretical and experimental findings verify that the in-situ formed core-shell hetero-interface induces the formation of P-Co-O binding and charge redistribution to activate surface O active sites for binding lithium polysulfides(LiPSs)via strong Li-O bonding,thus strongly adsorbing with Li PSs.Meanwhile,the strong Li-O bonding weakens the competing Li-S bonding in LiPSs or Li2S adsorbed on CoO/CoP-Box surface,plus the hollow heterostructure provides abundant active sites and fast electron/Li+transfer,so reducing Li2S nucleation/dissolution activation energy.As expected,LSBs with CoO/CoP-Box modified separator and traditional sulfur/carbon black cathode display a large initial capacity of 1240 mA h g^(-1)and a long cycling stability with 300 cycles(~60.1%capacity retention)at 0.5C.Impressively,the thick sulfur cathode(sulfur loading:5.2 mg cm^(-2))displays a high initial areal capacity of 6.9 mA h cm^(-2).This work verifies a deep mechanism understanding and an effective strategy to induce interfacial charge modulation and enhance active sites for designing efficient dual-directional Li-S catalysts via engineering hollow core-shell hetero-structure. | Weiliang Zhou Xinying Wang Jiongwei Shan Liguo Yue Dongzhen Lu Li Chen Jiacheng Zhang Yunyong Li | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 6 | Enhanced inhibitory control during re-engagement processing in badminton athletes:An event-related potential study显示文摘Purpose:The purpose of present study was to investigate the impact of sport experience on response inhibition and response re-engagement in expert badminton athletes during the stop-signal task and change-signal task.Methods:A total of 19 badminton athletes and 20 nonathletes performed both the stop-signal task and change-signal task.Reaction times(RTs)and event-related potentials were recorded and analyzed.Results:Behavioral results indicated that badminton athletes responded faster than nonathletes to go stimuli and to change signals,with faster change RTs and change-signal RTs,which take into consideration the variable stimulus onset time mean.During successful change trials in the change-signal task,the amplitudes of the event-related potential components N2 and P3 were smaller for badminton athletes than for nonathletes.Moreover,change-signal RTs and N2 amplitudes as well as change RTs and P3 amplitudes were significantly correlated in badminton athletes.A significant correlation was also found between the amplitude of the event-related potential component N1 and response accuracy to change signals in badminton athletes.Conclusion:Moderation of brain cortical activity in badminton athletes was more associated with their ability to rapidly inhibit a planned movement and re-engage with a new movement compared with nonathletes.The superior inhibitory control and more efficient neural mechanisms in badminton athletes compared with nonathletes might be a result of badminton athletes’ professional training experience. | Jiacheng Chen Yanan Li Guanghui Zhang Xinhong Jin Yingzhi Lu Chenglin Zhou | 2019 | Journal of Sport and Health Science2019，8，6： | 1 |
| 7 | In Situ Scattering Studies of Crystallization Kinetics in a Phase-Separated Zr-Cu-Fe-Al Bulk Metallic Glass显示文摘Thermal stability and the crystallization kinetics of a phase-separated Zr-Cu-Fe-Al bulk metallic glass were investigated using in situ high-energy synchrotron X-ray and neutron diffraction,as well as small-angle synchrotron X-ray scattering.It was revealed that this glass with excellent glass-forming ability possesses a two-step crystallization behavior.The crystalline products and their evolution sequence are more complicated than a homogeneous Zr-Cu-Al glass with average glass-forming ability.The experimental results indicate that a finely distributed nanometer-sized cubic Zr_(2)Cu phase forms first and then transforms to a tetragonal Zr_(2)Cu phase,while the matrix transforms to an orthorhombic Zr_(3)Fe phase.The strength of the Zr-Cu-Fe-Al composite containing cubic Zr_(2)Cu phase and glass matrix increases,and the plasticity also improves compared to the as-cast Zr-Cu-Fe-Al bulk metallic glass.Our results suggest that the formation of multiple and complex crystalline products would be the characteristics of the Zr-Cu-Fe-Al glass with better glass-forming ability.Our study may shed light on the synthesis of bulk-sized glass-nanocrystals composites of high strength and good plasticity. | Sinan Liu Jiacheng Ge Huiqaing Ying Chenyu Lu Dong Ma Xun-Li Wang Xiaobing Zuo Yang Ren Tao Feng Jun Shen Horst Hahn Si Lan | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，1： | 0 |
| 8 | On Dual-Mode Driving Control Method for a Novel Unmanned Tractor With High Safety and Reliability显示文摘Due to the non-standardization and complexity of the farmland environment,it is always a huge challenge for tractors to achieve fully autonomy(work at Self-driving mode)all the time in agricultural industry.Whereas,when tractors work in the Tele-driving(or Remote driving)mode,the operators are prone to fatigue because they need to concentrate for long periods of time.In response to these,a dual-mode control strategy was proposed to integrate the advantages of both approaches,i.e.,by combing Self-driving at most of the time with Tele-driving under special(complex and hazardous)conditions through switching control method.First,the state switcher was proposed,which is used for smooth switching the driving modes according to different working states of a tractor.Then,the state switching control law and the corresponding subsystem tracking controllers were designed.Finally,the effectiveness and superiority of the dualmode control method were evaluated via actual experimental testing of a tractor whose results show that the proposed control method can switch smoothly,stably,and efficiently between the two driving modes automatically.The average control accuracy has been improved by 20%and 15%respectively,compared to the conventional Tele-driving control and Self-driving control with low-precision navigation.In conclusion,the proposed dualmode control method can not only satisfy the operation in the complex and changeable farmland environment,but also free drivers from high-intensity and fatiguing work.This provides a perfect application solution and theoretical support for the intelligentization of unmanned farm agricultural machinery with high safety and reliability. | Wei Lu Jiacheng Li Huanhuan Qin Lei Shu Aiguo Song | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，1： | 0 |
| 9 | Effect of traditional Chinese medicine on anthracycline-induced cardiotoxicity in animal models:A systematic review and metaanalysis显示文摘Objective:To evaluate the effect of traditional Chinese medicine(TCM)on anthracycline-induced cardiotoxicity(AIC)in animal models.Methods:Separate systematic searches for preclinical studies were performed in the PubMed,EMBASE,Web of Science,Chinese National Knowledge Infrastructure,Chinese Biomedical Database,Chinese Scientific Journal Database,and Wanfang Data from inception to August 2019.The primary outcomes were echocardiography,serum assays for myocardial enzymograms,histological assessments,and electrocardiograms.The secondary outcomes mainly included body weight and safety evaluations.The protocol is registered on PROSPERO(CRD42019145819).RevMan(V.5.3)was used for meta-analysis.Results:We identified 10 studies from 9 international scientific publications describing the efficacy of TCM on AIC animal models.All the included studies reported that,compared with animal model without any intervention,TCM significantly improved ventricular function,cardiac biomarkers,electrocardiograph results,and cardiac fibrosis.Improved survival rates and body mass indices were also observed with TCM.We further pooled the available data from four studies(63 animals)for the meta-analysis and the results showed that,compared with models without any intervention,TCM significantly increased the ejection fraction by 14.13%(95%CI,9.96e18.29)and fraction shortening by 8.66%(95%CI,6.05 e11.26).Creatine kinase-MB(SMD=2.49,95%CI:-3.12 to-1.85)and lactate dehydrogenase(SMD=-2.78,95%CI:-3.45 to-2.12)were also significantly decreased by TCM.Conclusions:TCM is effective in improving AIC in animal models and has tremendous potential to be translated to treat AIC in clinical practice.Additionally,the systematic review and meta-analysis of animal experiments may be valuable in enhancing and guiding animal experiments and promoting the transformation of the results. | Xiaoguang Lu Yili Zhang Yong Wang Jingen Li Jiacheng Zuo Wei Wang | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，1： | 0 |
| 10 | Microwave-assisted pyrolysis of waste plastics for their resource reuse:A technical review显示文摘Rapidly increasing plastics have been used and finally become wastes,resulting in increasing pressures to the environment.Microwave-assisted pyrolysis is a promising technology for converting organic wastes as waste plastics into value-added products.At present,many works on microwave-assisted pyrolysis of plastics have been published,but the achievements,challenges,and future directions of microwave-assisted pyrolysis of waste plastics have not been well summarized and discussed.In this work,the principle of microwave-assisted pyrolysis technology is introduced.Then,the progress of its application to recover useful products from plastics is reviewed and discussed in terms of key parameters including microwave power,pyrolysis temperature,reaction time,types of catalyst,microwave absorbents and feedstock mixing ratio.Especially,the yields and properties of the produced oil,gas and char are correlated with the process parameters.Finally,the existing challenges and prospects of disposal/reuse of waste plastics by microwave-assisted pyrolysis technology are discussed. | Xuan Hu Dachao Ma Guangyi Zhang Mengxue Ling Qiaoling Hu Kangyi Liang Jiacheng Lu Yifan Zheng | 2023 | Carbon Resources Conversion2023，6，3： | 0 |
| 11 | Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells显示文摘SIRT6 belongs to the conserved NAD^(+)-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the selectivity problem caused by the structural similarity of orthosteric sites among deacetylases.Here,developing a reversed allosteric strategy Allo Reverse,we identified a cryptic allosteric site,Pocket Z,which was only induced by the bi-directional allosteric signal triggered upon orthosteric binding of NAD^(+).Based on Pocket Z,we discovered an SIRT6 allosteric inhibitor named JYQ-42.JYQ-42 selectively targets SIRT6 among other histone deacetylases and effectively inhibits SIRT6 deacetylation,with an IC50 of 2.33μmol/L.JYQ-42 significantly suppresses SIRT6-mediated cancer cell migration and pro-inflammatory cytokine production.JYQ-42,to our knowledge,is the most potent and selective allosteric SIRT6 inhibitor.This study provides a novel strategy for allosteric drug design and will help in the challenging development of therapeutic agents that can selectively bind SIRT6. | Qiufen Zhang Yingyi Chen Duan Ni Zhimin Huang Jiacheng Wei Li Feng Jun-Cheng Su Yingqing Wei Shaobo Ning Xiuyan Yang Mingzhu Zhao Yuran Qiu Kun Song Zhengtian Yu Jianrong Xu Xinyi Li Houwen Lin Shaoyong Lu Jian Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
| 12 | Persistent Data Layout in File Systems显示文摘Data layout in a file system is the organization of data stored in external storages. The data layout has a huge impact on performance of storage systems. We survey three main kinds of data layout in traditional file systems: in-place update file system, log-structured file system, and copy-on-write file system. Each file system has its own strengths and weaknesses under different circumstances. We also include a recent usage of persistent layout in a file system that combines both flash memory and byte-addressable non-volatile memory.With this survey, we conclude that persistent data layout in file systems may evolve dramatically in the era of emerging non-volatile memory. | LUO Shengmei LU Youyou YANG Hongzhang SHU Jiwu ZHANG Jiacheng | 2018 | ZTE Communications2018，16，3： | 0 |
| 13 | Secrecy Rate Analysis for RIS-Aided Multi-User MISO System over Rician Fading Channel显示文摘The reconfigurable intelligent surface(RIS),which is composed of multiple passive reflective components,is now considered as an effective mean to improve security performance in wireless communications,as it can enhance the signal of legitimate users and suppress the power leakage at eavesdroppers by adjusting signal phases.In this paper,we maximize the downlink ergodic secrecy sum rate of a RIS-aided multi-user system over Rician fading channels,where we assume that only imperfect channel state information(CSI)is available at the base station(BS).Firstly,we obtain the deterministic approximate expression for the ergodic secrecy sum rate by resorting to the large-system approximation theory.Then the problem is formulated to maximize the downlink ergodic secrecy sum rate by optimizing the regularization coefficient of regularized zero-forcing(RZF)precoding and the phase-shifting matrix of the RIS.By using the particle swarm optimization(PSO)method,we propose an alternate optimization(AO)algorithm to solve this non-convex problem.Finally,the numerical simulations illustrate the accuracy of our large-system approximate expression as well as the effectiveness of the proposed algorithm. | Jiaping Wang Jun Zhang Jiacheng Lu Jue Wang Qi Zhang Dongqian Wang | 2023 | Journal of Communications and Information Networks2023，8，1： | 0 |
| 14 | Residential Energy Consumption Forecasting Based on Federated Reinforcement Learning with Data Privacy Protection显示文摘Most studies have conducted experiments on predicting energy consumption by integrating data formodel training.However, the process of centralizing data can cause problems of data leakage.Meanwhile,many laws and regulationson data security and privacy have been enacted, making it difficult to centralize data, which can lead to a datasilo problem. Thus, to train the model while maintaining user privacy, we adopt a federated learning framework.However, in all classical federated learning frameworks secure aggregation, the Federated Averaging (FedAvg)method is used to directly weight the model parameters on average, which may have an adverse effect on te model.Therefore, we propose the Federated Reinforcement Learning (FedRL) model, which consists of multiple userscollaboratively training the model. Each household trains a local model on local data. These local data neverleave the local area, and only the encrypted parameters are uploaded to the central server to participate in thesecure aggregation of the global model. We improve FedAvg by incorporating a Q-learning algorithm to assignweights to each locally uploaded local model. And the model has improved predictive performance. We validatethe performance of the FedRL model by testing it on a real-world dataset and compare the experimental results withother models. The performance of our proposed method in most of the evaluation metrics is improved comparedto both the centralized and distributed models. | You Lu Linqian Cui YunzheWang Jiacheng Sun Lanhui Liu | 2023 | Computer Modeling in Engineering & Sciences2023，，10： | 0 |
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