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| 1 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 2 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 3 | Enhanced Electromagnetic Interference Shielding in a Duplex-Phase Mg-9Li-3Al-1Zn Alloy Processed by Accumulative Roll Bonding显示文摘High electromagnetic shielding performance was achieved in the Mg-9Li-3Al-1Zn alloy processed by accumulative roll bonding(ARB).The microstructure,electromagnetic interference shielding effectiveness(SE) in the frequency of 30-1500 MHz and mechanical properties of the alloy were investigated.A model based on the shielding of the electromagnetic plane wave was used to theoretically discuss the EMI shielding mechanisms of ARB-processed alloy.Results indicate that the SE of the material increases gradually with the increase in the ARB pass.The enhanced SE can be attributed to the obvious microstructure orientation caused by ARB,and the alternative arrangement of alpha(Mg) phase and beta(Li)phase.In addition,with the increase in ARB pass,the number of interfaces between layers increases and the grain orientation of each layer tends to alignment along c-axis,which is beneficial to the reflection loss and multiple reflection loss of the incident electromagnetic wave. | Jiahao Wang Lin Xu Ruizhi Wu Jing Feng Jinghuai Zhang Legan Hou Milin Zhang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，4： | 6 |
| 4 | DDX3X regulates cell survival and cell cycle during mouse early embryonic development显示文摘DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA transcription,RNA splicing,and mRNA transport,translation,and nucleo-cytoplasmic transport.It is highly expressed in metaphaseⅡ(MⅡ)oocytes and is the predominant DDX3 variant in the ovary and embryo.However,whether it is important in mouse early embryo development remains unknown.In this study,we investigated the function of DDX3X in early embryogenesis by cytoplasmic microinjection with its siRNA in zygotes or single blastomeres of 2-cell embryos.Our results showed that knockdown of Ddx3x in zygote cytoplasm led to dramatically diminished blastocyst formation,reduced cell numbers,and an increase in the number of apoptotic cells in blastocysts.Meanwhile,there was an accumulation of p53 in RNAi blastocysts.In addition,the ratio of cell cycle arrest during 2-cell to 4-cell transition increased following microinjection of Ddx3x siRNA into single blastomeres of 2-cell embryos compared with control.These results suggest that Ddx3x is an essential gene associated with cell survival and cell cycle control in mouse early embryos,and thus plays key roles in normal embryo development. | Qian Li Pan Zhang Chao Zhang Ying Wang Ru Wan Ye Yang Xuejiang Guo Ran Huo Min Lin Zuomin Zhou Jiahao Sha | 2014 | The Journal of Biomedical Research2014，28，4： | 4 |
| 5 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 6 | Natural variations in grain length 10(GL10)regulate rice grain size显示文摘Grain size is an important determinant of grain weight and yield in rice.Although several genes related to grain size have been identified,natural variations in these genes that affect grain size are poorly characterized.Here,we describe the grain length QTL GL10,encoding MADS56,which positively regulates grain length and grain weight.A natural allelic variation of NIL-gl10,containing an~1.0-kb deletion in the first exon that abolishes its transcription,results in shorter grain length,lower grain weight and delayed flowering in gl10 plants.The knockout of GL10 in the HJX74 background leads to grain phenotypes similar to that of NIL-gl10,while overexpression of GL10 results in increased grain length and weight and earlier heading date.GL10 regulates grain length by promoting greater longitudinal cell growth in the grain glume.Additionally,GL10 participates in the regulation of gibberellic acid(GA)signaling pathway genes in young panicle tissues.Analysis of GL10 haplotypes shows obvious divergence between the japonica and indica lineages.Our findings reveal an allelic variation of GL10 that may explain differences in grain length among modern cultivars and could be used to breed rice varieties with optimized grain shape. | Penglin Zhan Shuaipeng Ma Zhili Xiao Fangping Li Xin Wei Shaojun Lin Xiaoling Wang Zhe Ji Yu Fu Jiahao Pan Mi Zhou Yue Liu Zengyuan Chang Lu Li Suhong Bu Zupei Liu Haitao Zhu Guifu Liu Guiquan Zhang Shaokui Wang | 2022 | Journal of Genetics and Genomics2022，49，5： | 3 |
| 7 | Effect of homogenization annealing on internal residual stress distribution and texture in ME21 magnesium alloy extruded plates显示文摘The distribution of residual stresses through thickness of 5 mm-thick ME21 magnesium alloy extruded plates was analyzed non-destructively using short-wavelength X-ray diffraction(SWXRD),and the effect of homogenization annealing before extrusion on the residual stress was discussed.The classic d 0 method with an annealed stress-free reference specimen was employed to determine the residual stress of the extruded plates.The residual stress results showed that the gradient of residual stress in the transverse direction was larger than that of the extrusion direction.The homogenization process prior to extrusion weaken the formed sample’s texture.The maximum residual stress of the as-extruded plate was reduced,and the residual stress distribution was homogenized. | Yong Lian Pengfei Ji Jin Zhang Xiaomin Yuan Weisheng Xu Yongle Zhao Jiahao Mo Lin Zheng Shitao Dou | 2019 | Journal of Magnesium and Alloys2019，7，1： | 3 |
| 8 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 9 | A fast CQC algorthm of PSD matrices for random seismic responses显示文摘 | Lin Jiahao | 1992 | Computers & Structures1992，44，3： | 1 |
| 10 | Structural response to arbitrarily coherent stationary random excitations显示文摘 | Lin Jiahao Zhang Wenshou Li Jianjun | 1994 | Computers & Structures1994，50，5： | 1 |
| 11 | Accurate high speed coinputation of nonstationary random seismic response显示文摘 | LIN Jiahao SHEN Weiping WILLIAMS F W | 1997 | Engineering Structures1997，19，7： | 1 |
| 12 | A high precision direct integration scheme for structures subjected to transient dynamic loading 显示文摘 | Lin Jiahao Shen Weiping Williams F W | 1995 | Computers & Structures1995，56，1： | 1 |
| 13 | Non-stationary random vibration analysis for train bridge systems subjected to horizontal earthquakes显示文摘 | ZHANG Zhichao LIN Jiahao ZHANG Yahui | 2010 | Engineering Structures2010，32，11： | 1 |
| 14 | Structural responses to non-uniformly modulated evolutionary random seismic excitations显示文摘 | Lin Jiahao Sun Dongke Sun Yong | 1997 | Communications in Numerical Methods in Engineering1997，13，： | 1 |
| 15 | Nonstationary random seismic responses of multi-support structures in evolutionary inhomogeneous random fields 显示文摘 | Lin Jiahao Li Jianjun Zhang Wenshou | 1997 | Earthquake Engineering and Structural Dynamics1997，26，： | 1 |
| 16 | A Fast CQC Algorithm of PSD Matrices for Randora Seismic Responses显示文摘 | Lin Jiahao | 1992 | Computer & Structures1992，44，3： | 1 |
| 17 | Pseudo-excitation algorithm for nonstationary random seismic responses显示文摘 | Lin Jiahao Zhang Wenshou Williams F W | 1994 | Engineering Structures1994，16，： | 1 |
| 18 | Strctural Response to Arbitarily Coherent Stationary Random Excitations 显示文摘 | LIN Jiahao ZHAN Wenshou LI Jianjun | 1994 | Computer and Structures1994，50，5： | 1 |
| 19 | Experimental and numerical investigation on temperature characteristics of high-speed railway’s embankment in seasonal frozen regions显示文摘 | Hua Liu Fujun Niu Yonghong Niu Zhanju Lin Jiahao Lu Jing Luo | 2012 | Cold Regions Science and Technology2012，，： | 1 |
| 20 | Structural responses to arbitrarily coherent stationary random excitations显示文摘 | Lin Jiahao Zhang Wenshou Li Jianjun | 1994 | Computers and Structures1994，50，5： | 1 |
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