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| 1 | Structural basis of immunosuppression by the therapeutic antibody daclizumab显示文摘发信号的 Interleukin-2 (IL )-2 在小径被显示出为在有机关移植的病人的免疫力的抑制有效减轻 / 消除 allograft 拒绝的堵住这的有免疫力的回答,和药的激活起一个枢轴的作用。首先人性化的 monoclonal 抗体(mAb ) daclizumab 掉进这个范畴并且对 IL-2 受体建筑群的一个关键部件显示出高特性和亲密关系,也就是 IL-2R 伪。揭示由 daclizumab 表明小径的 IL-2 的抑制的分子的机制,我们在 2.6 和 2.8 点与 IL-2R 伪 ectodomain 在免费形式并且在建筑群决定了 daclizumab Fab 的水晶结构?分辨率分别地。daclizumab Fab 当面采用类似的符合构造或 IL-2R 伪 ectodomain 的缺席。daclizumab 的抗原绑定地点主要由决定形成大断然控告的表面消沉和通常是恐水病的二个 flanking 补丁的区域(CDR ) 的五补充组成。 conformational epitope 由 IL-2R 伪 ectodomain 的几个不连续的片断组成,哪个与与 IL-2 交往的区域重叠的大部分,建议到 IL-2R 伪 的 daclizumab 的绑定将阻止 IL-2 绑定到 IL-2R 伪 和 IL-2/IL-2R 伪尾纬c 建筑群的随后的形成,因此堵住表明小径的 IL-2 。这些结果也为指向 IL-2R 伪的改进 mAb 药的设计和发展有含意。 | Hui Yang Jianchuan Wang Jiamu Du Chen Zhong Dapeng Zhang Huaizu Guo Yajun Guo Jianping Ding | 2010 | Cell Research2010，20，12： | 5 |
| 2 | Structure and mechanism of plant histone mark readers显示文摘In eukaryotes, epigenetic-based mechanisms are involved in almost all the important biological processes. Amongst different epigenetic regulation pathways, the dynamic covalent modifications on histones are the most extensively investigated and characterized types. The covalent modifications on histone can be 'read' by specific protein domains and then subsequently trigger downstream signaling events. Plants generally possess epigenetic regulation systems similar to animals and fungi, but also exhibit some plant-specific features. Similar to animals and fungi, plants require distinct protein domains to specifically'read' modified histones in both modification-specific and sequence-specific manners. In this review, we will focus on recent progress of the structural studies on the recognition of the epigenetic marks on histones by plant reader proteins, and further summarize the general and exceptional features of plant histone mark readers. | Rui Liu Xueqin Li Wei Chen Jiamu Du | 2018 | Science China(Life Sciences)2018，61，2： | 4 |
| 3 | Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation显示文摘The transcription factor CONSTANS(CO)integrates day-length information to induce the expression of florigen FLOWERING LOCUS T(FT)in Arabidopsis.We recently reported that the C-terminal CCT domain of CO forms a complex with NUCLEAR FACTOR-YB/YC to recognize multiple cis-elements in the FT promoter,and the N-terminal tandem B-box domains form a homomultimeric assembly.However,the mechanism and biological function of CO multimerization remained unclear.Here,we report that CO takes on a head-to-tail oligomeric configuration via its B-boxes to mediate FT activation in long days.The crystal structure of B-boxesCOreveals a closely connected tandem B-box fold forming a continuous head-to-tail assembly through unique CDHH zinc fingers.Mutating the key residues involved in CO oligomerization resulted in a non-functional CO,as evidenced by the inability to rescue co mutants.By contrast,a transgene encoding a human p53-derived tetrameric peptide in place of the B-boxesCOrescued co mutant,emphasizing the essential role of BboxesCO-mediated oligomerization.Furthermore,we found that the four TGTG-bearing cis-elements in FT proximal promoter are required for FT activation in long days.Our results suggest that CO forms a multimer to bind to the four TGTG motifs in the FT promoter to mediate FT activation. | Xiaolin Zeng Xinchen Lv Rui Liu Hang He Shiqi Liang Lixian Chen Fan Zhang Liu Chen Yuehui He Jiamu Du | 2022 | Journal of Integrative Plant Biology2022，64，3： | 2 |
| 4 | 显示文摘 | Huang Jiamu Li Yuexia Zhao Guodong | 2006 | Transactions of Nonferrous Metals Society of China2006，16，1： | 1 |
| 5 | Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide显示文摘 | Jiamu D Hao W Chen Z | 2008 | Mol Immunol2008，45，10： | 1 |
| 6 | In situ synthesis of SnO 2 nanosheet/graphene composite as anode materials for lithium-ion batteries显示文摘 | Hongdong Liu Jiamu Huang Chengjie Xiang Jia Liu Xinlu Li | 2013 | Journal of Materials Science: Materials in Electronics2013，，10： | 1 |
| 7 | Flower- like SnO2/grapheme composite for high capacity lithium storage显示文摘 | Liu Hongdong Huang Jiamu Li Xinlu | 2012 | Applied Surface Science2012，258，： | 1 |
| 8 | Acetylproteomics analyses reveal critical features of lysine-ε-acetylation in Arabidopsis and a role of 14-3-3 protein acetylation in alkaline response显示文摘Lysine-ε-acetylation(Kac)is a post-translational modification(PTM)that is critical for metabolic regulation and cell signaling in mammals.However,its prevalence and importance in plants remain to be determined.Employing high-resolution tandem mass spectrometry,we analyzed protein lysine acetylation in five representative Arabidopsis organs with 2~3 biological replicates per organ.A total of 2887 Kac proteins and 5929 Kac sites were identified.This comprehensive catalog allows us to analyze proteome-wide features of lysine acetylation.We found that Kac proteins tend to be more uniformly expressed in different organs,and the acetylation status exhibits little correlation with the gene expression level,indicating that acetylation is unlikely caused by stochastic processes.Kac preferentially targets evolutionarily conserved proteins and lysine residues,but only a small percentage of Kac proteins are orthologous between rat and Arabidopsis.A large portion of Kac proteins overlap with proteins modified by other PTMs including ubiquitination,SUMOylation and phosphorylation.Although acetylation,ubiquitination and SUMOylation all modify lysine residues,our analyses show that they rarely target the same sites.In addition,we found that“reader”proteins for acetylation and phosphorylation,i.e.,bromodomain-containing proteins and GRF(General Regulatory Factor)/14-3-3 proteins,are intensively modified by the two PTMs,suggesting that they are main crosstalk nodes between acetylation and phosphorylation signaling.Analyses of GRF6/14-3-3λreveal that the Kac level of GRF6 is decreased under alkaline stress,suggesting that acetylation represses plant alkaline response.Indeed,K56ac of GRF6 inhibits its binding to and subsequent activation of the plasma membrane H+-ATPase AHA2,leading to hypersensitivity to alkaline stress.These results provide valuable resources for protein acetylation studies in plants and reveal that protein acetylation suppresses phosphorylation output by acetylating GRF/14-3-3 proteins. | Jianfei Guo Xiaoqiang Chai Yuchao Mei Jiamu Du Haining Du Huazhong Shi Jian-Kang Zhu Heng Zhang | 2022 | Stress Biology2022，2，1： | 1 |
| 9 | Flower-like SnO2/graphene composite for highcapacity lithium storage显示文摘 | Liu Hongdong Huang Jiamu Li Xinlu | | 0，，11： | 1 |
| 10 | Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide显示文摘 | Jiamu D Hao W Chen Z | 2008 | Mol Immunol2008，45，10： | 1 |
| 11 | Insightful understanding of three-phase interface behaviors in 1T-2H MoS_(2)/CFP electrode for hydrogen evolution improvement显示文摘Hydrogen evolution reaction(HER)catalytic electrodes under actual working conditions show interesting mass transfer behaviors at solid(electrode)/liquid(electrolyte)/gas(hydrogen)three-phase interfaces.These behaviors are essential for forming a continuous and effective physical contact region between the electrolyte and the electrode and require further detailed understanding.Here,a case study on 1 T-2 H phase molybdenum disulfide(Mo S_(2))/carbon fiber paper(CFP)catalytic electrodes is performed.Rapid gas-liquid mass transfer at the interface for enhancing the working area stability and capillarity for increasing the electrode working area is found.The real scenario,wherein the energy utilization efficiency of the as-prepared non-noble metal catalytic electrode exceeds that of the noble metal catalytic electrode,is disclosed.Specifically,a fluid dynamics model is developed to investigate the behavior mechanism of hydrogen bubbles from generation to desorption on the catalytic electrode surface with different hydrophilic and hydrophobic properties.These new insights and theoretical evidence on the non-negligible three-phase interface behaviors will identify opportunities and motivate future research in high-efficiency,stability,and low-cost HER catalytic electrode development. | Jiamu Cao Jing Zhou Mingxue Li Junyu Chen Yufeng Zhang Xiaowei Liu | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 12 | Expression, purification, crystallization, and preliminary X-ray diffraction analysis of the human TLE1 Q domain显示文摘裂口 1 的人的象 transducin 一样 enhancer (TLE1 ) 在很多个发展过程起关键作用并且涉及恶意肿瘤的致病。TLE1 的 N 终端充满夫酸安的领域(Q 领域) 调停它有不同 DNA 有约束力的抄写因素到的 tetramerization 和相互作用调整槽口和 Wnt 发信号小径。更好理解分子的机制 TLE1 是在这些小径的函数,我们克隆,净化,并且结晶 TLE1 Q 域(TLE1-Q ) 。晶体属于空间组 C2221,与收集到 3.5 和 4.1 的土著人和 SeMet TLE1-Q 的完全的衍射数据吗?决定分别地。解决阶段并且模型造在进行中。 | Su Wang Jiamu Du Hua Tang Xinyu Ding Manwu Zha Zhifei Xu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 0 |
| 13 | Four Methods That Should Be Mastered in the Study of the Historical Experience of the People's Republic of China显示文摘研究中华人民共和国历史经验需要掌握一定的科学方法。既要研究新中国不同时期的经验,又要把各个历史时期的经验联系起来研究;既要研究新中国各个领域的历史经验,又要从宏观层面对历史经验作综合研究;既要研究新中国历史中的成功经验,又要注意对失误和挫折进行研究;既要用今天的眼光研究新中国历史的经验,又要把经验放到特定的历史条件下研究。 | Zhu Jiamu | 2011 | Social Sciences in China2011，32，4： | 0 |
| 14 | Highly efficient 1D p-Te/2D n-Bi_(2)Te_(3) heterojunction self-driven broadband photodetector显示文摘Broadband photodetectors with self-driven functions have attracted intensive scientific interest due to their low energy consumption and high optical gain.However,high-performance broadband self-driven photodetectors are still a significant challenge due to the complex fabrication processes,environmental toxicity,high production costs of traditional 3D semiconductor materials and sharply raised contact resistance,severe interfacial recombination of 2D materials and 2D/3D mixed dimension heterojunction.Here,1D p-Te/2D n-Bi_(2)Te_(3) heterojunctions are constructed by the simple and low-cost hydrothermal method.1D p-Te/2D n-Bi_(2)Te_(3) devices are applied in photoelectrochemical(PEC)photodetectors,with their high performance attributed to the good interfacial contacts reducing interface recombination.The device demonstrated a broad wavelength range(365–850 nm)with an Iph/Idark as high as 377.45.The R_(i),D^(*),and external quantum efficiency(EQE)values of the device were as high as 12.07 mA/W,5.87×10^(10) Jones,and 41.05%,respectively,which were significantly better than the performance of the prepared Bi_(2)Te_(3) and Te devices.A comparison of the freshly fabricated device and the device after 30 days showed that 1D p-Te/2D n-Bi_(2)Te_(3) had excellent stability with only 18.08%decay of photocurrent.It is anticipated that this work will provide new emerging material for future design and preparation of a high-performance self-driven broadband photodetector. | Chenchen Zhao Dongbo Wang Jiamu Cao Zhi Zeng Bingke Zhang Jingwen Pan Donghao Liu Sihang Liu Shujie Jiao Tianyuan Chen Gang Liu Xuan Fang Liancheng Zhao Jinzhong Wang | 2024 | Nano Research2024，17，3： | 0 |
| 15 | Electrospun composites of PHBV/pearl powder for bone repairing显示文摘Electrospun fi ber has highly structural similarity with natural bone extracelluar matrix(ECM). Many researches about fabricating organic–inorganic composite materials have been carried out in order to mimic the natural composition of bone and enhance the biocompatibility of materials. In this work, pearl powder was added to the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) and the composite nano fi ber scaffold was prepared by electrospinning. Mineralization ability of the composite scaffolds can be evaluated by analyzing hydroxyapatite(HA)formation on the surface of nano fi ber scaffolds. The obtained composite nano fi ber scaffolds showed an enhanced mineralization capacity due to incorporation of pearl powder. The HA formed amount of the composite scaffolds was raised as the increase of pearl powder in composite scaffolds. Therefore, the prepared PHBV/pearl composite nano fi ber scaffolds would be a promising candidate as an osteoconductive composite material for bone repairing. | Jingjing Bai Jiamu Dai Guang Li | 2015 | Progress in Natural Science:Materials International2015，25，4： | 0 |
| 16 | A novel protein complex that regulates active DNA demethylation in Arabidopsis显示文摘Active DNA demethylation is critical for altering DNA methylation patterns and regulating gene expression.The 5-methylcytosine DNA glycosylase/lyase ROS1 initiates a base-excision repair pathway for active DNA demethylation and is required for the prevention of DNA hypermethylation at 1000 s of genomic regions in Arabidopsis.How ROS1 is regulated and targeted to specific genomic regions is not well understood.Here,we report the discovery of an Arabidopsis protein complex that contains ROS1,regulates ROS1 gene expression,and likely targets the ROS1 protein to specific genomic regions.ROS1 physically interacts with a WD40 domain protein(RWD40),which in turn interacts with a methyl-DNA binding protein(RMB1)as well as with a zinc finger and homeobox domain protein(RHD1).RMB1 binds to DNA that is methylated in any sequence context,and this binding is necessary for its function in vivo.Loss-of-function mutations in RWD40,RMB1,or RHD1 cause DNA hypermethylation at several tested genomic regions independently of the known ROS1 regulator IDM1.Because the hypermethylated genomic regions include the DNA methylation monitoring sequence in the ROS1 promoter,plants mutated in RWD40,RMB1,or RHD1 show increased ROS1 expression.Importantly,ROS1 binding to the ROS1 promoter requires RWD40,RMB1,and RHD1,suggesting that this complex dictates ROS1 targeting to this locus.Our results demonstrate that ROS1 forms a protein complex with RWD40,RMB1,and RHD1,and that this novel complex regulates active DNA demethylation at several endogenous loci in Arabidopsis. | Pan Liu Wen-Feng Nie Xiansong Xiong Yuhua Wang Yuwei Jiang Pei Huang Xueqiang Lin Guochen Qin Huan Huang Qingfeng Niu Jiamu Du Zhaobo Lang Rosa Lozano-Duran Jian-Kang Zhu | 2021 | Journal of Integrative Plant Biology2021，63，4： | 0 |
| 17 | The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis显示文摘DNA methylation,a conserved epigenetic mark,is critical for tuning temporal and spatial gene expression.The Arabidopsis thaliana DNA glycosylase/lyase REPRESSOR OF SILENCING 1(ROS1)initiates active DNA demethylation and is required to prevent DNA hypermethylation at thousands of genomic loci.However,how ROS1 is recruited to specific loci is not well understood.Here,we report the discovery of Arabidopsis AGENET Domain Containing Protein 3(AGDP3)as a cellular factor that is required to prevent gene silencing and DNA hypermethylation.AGDP3 binds to H3K9me2 marks in its target DNA via its AGD12 cassette.Analysis of the crystal structure of the AGD12 cassette of AGDP3 in complex with an H3K9me2 peptide revealed that dimethylated H3 K9 and unmodified H3 K4 are specifically anchored into two different surface pockets.A histidine residue located in the methyllysine binding aromatic cage provides AGDP3 with pH-dependent H3K9me2 binding capacity.Our results uncover a molecular mechanism for the regulation of DNA demethylation by the gene silencing mark H3K9me2. | Xuelin Zhou Mengwei Wei Wenfeng Nie Yue Xi Li Peng Qijie Zheng Kai Tang Viswanathan Satheesh Yuhua Wang Jinyan Luo Xuan Du Rui Liu Zhenlin Yang Honggui La Yingli Zhong Yu Yang Jian-Kang Zhu Jiamu Du Mingguang Lei | 2022 | Journal of Integrative Plant Biology2022，64，12： | 0 |
| 18 | Spurious-free dynamic range improvement in a photonic time-stretched analog-to-digital converter based on third-order predistortion显示文摘Spurious-free dynamic range(SFDR)limited by intermodulation distortions is a usually accepted measure for dynamic performance of a photonic time-stretched analog-to-digital converter(ADC).In this paper,SFDR improvement in a photonic time-stretched ADC based on third-order predistortion is proposed.The third-order predistortion is achieved optically within an integrated dual-parallel Mach–Zehnder modulator(DPMZM).The mechanism of SFDR improvement with third-order predistortion in the DPMZM is theoretically analyzed.Compared with a conventional scheme without predistortion,the experimental results show that the SFDR improvement of∼26 dB in the proposed scheme is proved. | Boyu Xu Wulue Lv Jiamu Ye Jinhai Zhou Xiaofeng Jin Xianmin Zhang Hao Chi Shilie Zheng | 2014 | Photonics Research2014，2，5： | 0 |
| 19 | Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2显示文摘RNA-directed DNA methylation(Rd DM) is a plant-specific de novo DNA methylation pathway,which has extensive cross-talk with histone modifications. Here, we report that the maize RdDM regulator SAWADEE HOMEODOMAIN HOMOLOG 2(SHH2) is an H3 K9 me1 reader. Our structural studies reveal that H3 K9 me1 recognition is achieved by recognition of the methyl group via a classic aromatic cage and hydrogen-bonding and salt-bridge interactions with the free protons of the mono-methyllysine. The di-and tri-methylation states disrupt the polar interactions, decreasing the binding affinity. Our study reveals a monomethyllysine recognition mechanism which potentially links RdDM to H3 K9 me1 in maize. | Yuhua Wang Xuelin Zhou Jinyan Luo Suhui Lv Rui Liu Xuan Du Bei Jia Fengtong Yuan Heng Zhang Jiamu Du | 2021 | Journal of Integrative Plant Biology2021，63，6： | 0 |
| 20 | Cofactor-assisted dicing:insights from structural snapshots显示文摘Two recent cryo-EM publications in Nature by Su et al.and Yamaguchi et al.have captured snapshots of structures of Drosophila Dicer-2 bound to target dsRNA in the presence of protein cofactors Loquacious-PD or R2D2 along the small RNA biogenesis pathway,thereby highlighting the stepwise molecular mechanism underlying dicing-mediated precise small RNA production. | Jiamu Du Dinshaw J.Patel | 2022 | Cell Research2022，32，11： | 0 |
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