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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 3 | Quantitative trait loci for Fusarium head blight resistance in wheat cultivars Yangmai 158 and Zhengmai 9023显示文摘Fusarium head blight(FHB)is one of the prevalent fungal diseases of wheat worldwide.Exploring new FHB resistance quantitative trait loci(QTL)in adapted wheat cultivars is a critical step for breeding new FHB-resistant cultivars.In this study,we developed a population of 236 F5:7 recombinant inbred lines(RILs)using two popular Chinese wheat cultivars,Yangmai 158 and Zhengmai 9023,with moderate FHB resistance to identify the QTL for FHB type II resistance.This population was evaluated for percentage of symptomatic spikelets per spike(PSS)using single floret injection in repeated greenhouse experiments.Mean PSSs were 33.2%for Yangmai 158 and 30.3%for Zhengmai 9023.A genetic linkage map of 1002 single nucleotide polymorphisms(SNPs)generated by genotyping-by-sequencing(GBS)was constructed for the RIL population.Six QTL were identified for FHB resistance,and three of them were repeatable in the both experiments.Zhengmai 9023 contributed the resistance allele at one repeatable QTL,designated as Qfhb.7D,whereas Yangmai 158 contributed the resistance alleles at the other two repeatable QTL,Qfhb.3AL and Qfhb.2DS.The additional QTL,Qfhb.4AS was significant in the mean PSS,and Qfhb.2DL and Qfhb.7AS were significant in only one experiment.Replacement of each allele individually at the three repeatable QTL significantly changed PSSs.Qfhb.3AL,Qfhb.2DS,and Qfhb.7D explained 8.35%to 9.89%,5.13%to 7.43%,and 6.15%to 9.32%of the phenotypic variations,respectively.The three repeatable QTL contributed by the two parents were additive and stacking the resistance alleles from all the three repeatable QTL showed the highest level of resistance in the current RIL population.Ten SNPs in the QTL regions of Qfhb.3AL,Qfhb.2DS,and Qfhb.7D were converted into KBioscience competitive allele-specific PCR(KASP)assays.One KASP marker for Qfhb.3AL was validated in a panel of wheat cultivars from China.Some of these KASP markers could be useful for marker-assisted selection to stack these QTL. | Pingping Zhang Chenjin Guo Zhao Liu Amy Bernardo Hongxiang Maa Hongxiang Ma Peng Jiang Guicheng Song Guihua Bai | 2021 | The Crop Journal2021，9，1： | 8 |
| 4 | Application of ~1H NMR-based metabolomics for discrimination of different parts and development of a new processing workflow for Cistanche deserticola显示文摘Cistanche deserticola(CD) is one of the two authoritative source plants of Cistanches Herba, a well-known medicinal plant. Herein,~1H NMR spectroscopy was employed to characterize the chemical profile and to distinguish the different parts, as well as to propose a new processing workflow for CD.Signal assignment was achieved by multiple one and two dimensional NMR spectroscopic techniques in combination with available databases and authentic compounds. The upper parts of the plant were distinguished from the lower parts by combining ~1H NMR spectroscopic dataset with multivariate statistical analysis. A new processing method that hyphenated steaming with freeze-drying, was demonstrated to be superior to either steaming coupled with oven-drying or direct freeze-drying via holistic ~1H NMR-based metabolomic characterization. Phenylethanoid glycosides, mainly echinacoside and acteoside, were screened out and confirmed as the chemical markers responsible for exhibiting the superiority of the new processing workflow, whereas serial primary metabolites, especially carbohydrates and tricarboxylic acid cycle metabolites, were found as the primary molecules governing the discrimination between the upper and lower parts of the plant. Collectively,~1H NMR spectroscopy was demonstrated as a versatile analytical tool to characterize the chemical profile and to guide the indepth exploitation of CD by providing comprehensive qualitative and quantitative information. | Pingping Zou Yuelin Song Wei Lei Jun Li Pengfei Tu Yong Jiang | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 7 |
| 5 | A novel localization method for noninvasive monitoring capsule显示文摘 | 何文辉 Yan Guozheng Jiang Pingping Cuo Xudong | 2006 | High Technology Letters2006，12，3： | 3 |
| 6 | Advances in Enantioselective Construction of Trifluoromethoxylated Stereogenic Carbon Centers显示文摘In recent years,the trifluoromethoxy(OCF3)functional group has received extensive attention in phar-maceuticals,agrochemicals and material sciences.However,the methods for the enantioselective syn-thesis of trifluoromethoxylated stereogenic carbon centers are rare owing to the nature of easy decom-position of OCF3 anion and limited OCF3 reagent.And the asymmetric trifluoromethoxylation will be a hot research topic in near future due to the unique biological properties of a single isomer.This article mainly focuses on the recent advances in the enantioselectiveconstruction of trifluoromethoxylated stereogenic carbon centers. | Xiaohuan Jiang Pingping Tang | 2020 | Chinese Journal of Chemistry2020，38，1： | 2 |
| 7 | Preparation of micron-size crosslinked microspheres by dispersion copolymerization of polystyrene/2,2′-oxy-bisethanol diacrylate显示文摘 | Jinxia Huang Hongtao Zhang Junli Hou Pingping Jiang | 2002 | Reactive and Functional Polymers2002，，1： | 1 |
| 8 | Preparation of NiMoO 2 S 2 nanoparticle and investigation of its tribological behavior as additive in lubricating oils显示文摘 | Pingping Ye Xiaoxia Jiang Shu Li Shizhuo Li | 2002 | Wear2002，，5： | 1 |
| 9 | Preparation properties of a γ-Al2O3 washcoat deposited on a ceramic honeycomb显示文摘 | Jiang Pingping Lu Guanzhong Guo Yanglong | 2005 | Surface & Coatings Technology2005，190，23： | 1 |
| 10 | Zinc glycerolate with lanthanum stearate to inhibit the thermal degradation of poly(vinyl chloride)显示文摘 | Jiang Pingping Song Yinyin Dong Yuming | 2013 | Appl Polym Sci2013，127，36： | 1 |
| 11 | Study onde-colorization of dyestuff wastewater显示文摘 | Jiang Baonan Xue Kaiquan Zhang Pingping | 2007 | Environmental Sci Techn2007，30，6： | 1 |
| 12 | A novel waste water scale-derived solid base catalyst for biodiesel production显示文摘 | Pingbo Zhang Qiuju Han Mingming Fan Pingping Jiang | 2014 | Fuel2014，，： | 1 |
| 13 | Novdtwophase catalysis with organometallic compounds for epoxidation of vegetable oils by hydrogen peroxide显示文摘 | Jiang Pingping Chen Min DongYuming | | 0，，： | 1 |
| 14 | Novel Ti and Mn Mesoporous Molecular Sieves: Synthesis, Characterization and Catalytic Activity in the Epoxidation of Vegetable Oil 显示文摘 | Ye Xia Jiang Pingping Zhang Pingbo | 2010 | Catalysis Letters2010，137，： | 1 |
| 15 | Novel Two- Phase Catalysis with Organometallic Compounds for Epoxidation of Vegetable Oils by Hydrogen Peroxide显示文摘 | Jiang Pingping Chen Min Dong Yuming | 2010 | J Am Oil Soc2010，87，： | 1 |
| 16 | Multiuser Pre-Coding Aided Quadrature Spatial Modulation for Large-Scale MIMO Channels显示文摘Pre-coding aided quadrature spatial modulation(PQSM) is a promising multiple input multiple output(MIMO) transmission technology. The multiuser(MU) detection in PQSM system is investigated in this paper. Based on the known channel state information, pre-coding matrix is designed to pre-process the in-phase and quadrature signals of quadrature spatial modulation(QSM) to reduce the inter-channel interference. In order to lower the complexity at the receiver brought by the orthogonality of the PQSM system, an orthogonal matching pursuit(OMP) detection algorithm and a reconstructed model are proposed. The analysis and simulation results show that the proposed algorithm can obtain a similar bit error rate(BER) performance as the maximum likelihood(ML) detection algorithm with more than 80% reduction of complexity. | Fatang Chen Kang Yang Pingping Xing Huan Zhang Yanan Jiang | 2018 | China Communications2018，15，11： | 1 |
| 17 | Efficiency optimization of wireless power transmission systems for active capsule endoscopes 显示文摘 | Jia Zhiwei Yan Guozheng Jiang Pingping | 2011 | Physiological Measurement2011，32，10： | 1 |
| 18 | Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts显示文摘 | Haisong Liu Fangfang Zhu Jun Yong Pengbo Zhang Pingping Hou Honggang Li Wei Jiang Jun Cai Meng Liu Kai Cui Xiuxia Qu Tingting Xiang Danyu Lu Xiaochun Chi Ge Gao Weizhi Ji Mingxiao Ding Hongkui Deng | 2008 | Cell Stem Cell2008，，6： | 1 |
| 19 | Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts显示文摘 | Haisong Liu Fangfang Zhu Jun Yong Pengbo Zhang Pingping Hou Honggang Li Wei Jiang Jun Cai Meng Liu Kai Cui Xiuxia Qu Tingting Xiang Danyu Lu Xiaochun Chi Ge Gao Weizhi Ji Mingxiao Ding Hongkui Deng | 2008 | Cell Stem Cell2008，，6： | 1 |
| 20 | Zinc glycerolate with lanthanum stearate to inhibit the thermal degradation of poly (vinyl chlorlde) 显示文摘 | Jiang Pingping Song Yinyin Dong Yuming | 2013 | Journal of Applied Polymer Science2013，127，5： | 1 |
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