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| 1 | Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer显示文摘Objective:Homeobox B9(HOXB9) is proposed to be involved in tumor angiogenesis and metastasis.We investigated the role of HOXB9 in the progression of colon cancer.Methods:HOXB9 expression was investigated by immunohistochemically and Western blotting in 128 colon cancer patients and the results were analyzed statistically associated with clinicopathological data and survival of the patients.The effect of HOXB9 on cell invasion and metastases abilities were analyzed in vitro and in vivo.Results:HOXB9 is overexpressed in colon cancer tissues and significantly correlated with metastasis and poor survival of patients(P<0.05,respectively).Additionally,high levels of expression of HOXB9 were observed in metastatic lymph nodes.The down-regulation of HOXB9 expression can inhibit the migration and invasive ability of colon cancer cells,while exogenous expression of HOXB9 in colon cancer cells enhanced cell migration and invasiveness.Moreover,stable knockdown of HOXB9 reduced the liver and lung metastasis of colon cancer in vivo.Conclusions:HOXB9 may play an important role in the invasion and metastasis of colon cancer cells and may be a useful biomarker for metastasis and prognostic of colon cancer. | Kai Huang Rongfa Yuan Kai Wang Junwen Hu Zixi Huang Chen Yan Wei Shen Jianghua Shao | 2014 | Chinese Journal of Cancer Research2014，26，1： | 6 |
| 2 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 3 | Finite Control Set Model Predictive Control with Feedback Correction for Power Converters显示文摘As an open-loop model predictive control algorithm,finite control set model predictive control(FCS-MPC)scheme in power converter system is based on assumption that responses of optimal control implemented on prediction model agree well with actual system.The influence of model parameter mismatches and environment disturbance on control performance of scheme is neglected.Then,based on feedback correction strategy in traditional model predictive control algorithm,we derive a finite control set model predictive control with feedback correction scheme(FCS-MPCFC)that allows us to adjust prediction model output at current instant by model prediction error at previous instant,and the closed-loop correction of prediction model output is achieved.Simulations comparison analyses on a two-level three-phase inverter with multi-type model parameter mismatches controlled by traditional and improved FCS-MPC scheme are presented.Experiments are carried out on DSP controller platform. | Kun Shen Jianghua Feng Jing Zhang | 2018 | CES Transactions on Electrical Machines and Systems2018，2，3： | 3 |
| 4 | Abnormal orientation relation between fcc and hcp structures revealed in a deformed high manganese steel显示文摘The crystallography of phase transformation is an important issue for studying metallic alloys.Here,we demonstrate an abnormal orientation relation between face-centered cubic(fcc) and hexagonal closepacked(hcp) phases due to the intersection of two ε_(hcp)-martensite variants in a high manganese steel.The corresponding crystallogra phic cha racteristics,including invariant line,habit plane and atomic steps,have been characterized by transmission electron micro scopy and the quasi-O-line model.In addition,the models of phase transfo rmation about the intersection are proposed based on transmission mechanisms of dislocations.Our findings enrich the theories of phase transformation and implicate the possibility to fabricate stro nger and tougher steel. | Pan Xie Shucheng Shen Cuilan Wu Jianghua Chen | 2021 | Journal of Materials Science & Technology2021，，1： | 2 |
| 5 | Unusual relationship between impact toughness and grain size in a high-manganese steel显示文摘The high-manganese steels are important structural materials,owing to their excellent toughness at low temperatures.However,the microstructural causes for their unusual properties have not adequately been understood thus far.Here,we report a reversal relationship between impact toughness and grain size in a high-manganese steel and its unrevealed microscopic mechanisms,which result in an excellent low-temperature toughness of the steel.Our investigations show that with increasing grain size the impact toughness of the steel can be improved drastically,especially at low-temperatures.Advanced electron microscopy characterization reveals that the enhanced impact toughness of the coarse-grained steel is attributed to the twinning induced plasticity and transformation induced plasticity effects,which produce large quantities of deformation twins,ε_(hcp)-martensite andα'_(bcc)-martensite.Inversely,in the fine-grained steels,the formation of deformation twins and martensite is significantly inhibited,leading to the decrease of impact toughness.Microstructural characterizations also indicate thatε_(hcp)-martensite becomes more stable thanα'_(bcc)-martensite with decreasing temperature,resulting in characteristic microstructures in the coarse-grained samples after impact deformation at liquid nitrogen temperature.In the coarse-grained samples under impact deformation at-80℃,ε_(hcp)-martensite transformation,α'_(bcc)-martensite transformation and deformation twinning all occur simultaneously,which greatly improves the toughness of the steel. | Pan Xie Shucheng Shen Cuilan Wu Jiehua Li Jianghua Chen | 2021 | Journal of Materials Science & Technology2021，，30： | 2 |
| 6 | Salivary proteomic and genomic biomarkers for primary Sjogren's syndrome显示文摘 | HU Shen WANG Jianghua MEIJER J | 2007 | Arthritis and Rheumatism2007，56，11： | 1 |
| 7 | Tacrolimus Versus Intravenous Pulse Cyclophosphamide Therapy in Chinese Adults With Steroid-Resistant Idiopathic Minimal Change Nephropathy: A Multicenter, Open-Label, Nonrandomized Cohort Trial显示文摘 | Heng Li Xiangdong Shi Hong Shen Xiayu Li Huiping Wang Hongmei Li Guangbiao Xu Jianghua Chen | 2012 | Clinical Therapeutics2012，，5： | 1 |
| 8 | Gut microbisal methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract显示文摘Dear Editor,Circadian rhythms are the periodic turmover of biological behaviors and physiological functions of many organisms(Allada and Bass,2021).In mammals,circadian rhythms are maintained by the clock system,involving central clock in suprachiasmatic nucleus and peripheral clock in organs like intestine;and at cellular level a cell-autonomous transcriptional and translational feedback loop involving clock genes like BMAL1(brain and muscle ARNT-Like 1,also known as ARNTL),CLOCK(clock circadian regulator),PER1/2/3(period circadian regulator 1/2/3)and CRY1/2(cryptochrome circadian regulator 1/2)(Allada and Bass,2021). | Xiaolin Liu Yue Ma Ying Yu Wenhui Zhang ingjing Shi Xuan Zhang Min Dai Yuhan Wang Hao Zhang Jiahe Zhang Jianghua Shen Faming Zhang Moshi Song Jun Wang | 2023 | Protein & Cell2023，14，4： | 1 |
| 9 | Tacrolimus Versus Intravenous Pulse Cyclophosphamide Therapy in Chinese Adults With Steroid-Resistant Idiopathic Minimal Change Nephropathy: A Multicenter, Open-Label, Nonrandomized Cohort Trial显示文摘 | Heng Li Xiangdong Shi Hong Shen Xiayu Li Huiping Wang Hongmei Li Guangbiao Xu Jianghua Chen | 2012 | Clinical Therapeutics2012，，5： | 1 |
| 10 | A facile approach to synthesize novel oxygen-doped g-C3N4with superior visible-light photoreactivity显示文摘 | LI Jianghua SHEN Biao HONG Zhenhua | 2012 | Chem Commun2012，48，12： | 1 |
| 11 | Influences of Oxide Additions on Formation Reaction of Iron Carbide at 1023K显示文摘 | Guangqiang Li Jianghua Ma Hongwei Ni Qiaozhen Shen and Fumitaka TSUKIHASHI | 2006 | ISIJ International2006，46，7： | 1 |
| 12 | TiO_(2)@C catalyzed hydrogen storage performance of Mg-Ni-Y alloy with LPSO and ternary eutectic structure显示文摘A designed Mg_(88.7)Ni_(6.3)Y_(5)hydrogen storage alloy containing 14H type LPSO(long-period stacking ordered)and ternary eutectic structure was prepared by regulating the alloy composition and casting.The hydrogen storage performance of the alloy was improved by adding nano-flower-like TiO_(2)@C catalyst.The decomposition of the LPSO structure during hydrogenation led to the formation of plenty of nanocrystals which provided abundant interphase boundaries and activation sites.The nanoscale TiO_(2)@C catalyst was uniformly dispersed on the surface of alloy particles,and the'hydrogen overflow''effect of TiO_(2)@C accelerated the dissociation and diffusion of hydrogen on the surface of the alloy particles.As a result,the in-situ endogenous nanocrystals of the LPSO structure decomposition and the externally added flower-like TiO_(2)@C catalyst uniformly dispersed on the surface of the nanoparticles played a synergistic catalytic role in improving the hydrogen storage performance of the Mg-based alloy.With the addition of the TiO_(2)@C catalyst,the beginning hydrogen desorption temperature was reduced to 200℃.Furthermore,the saturated hydrogen absorption capacity of the sample was 5.32 wt.%,and it reached 4.25 wt.%H_(2) in 1 min at 200℃and 30 bar. | Wenjie Song Wenhao Ma Shuai He Wei Chen Jianghua Shen Dalin Sun Qiuming Wei Xuebin Yu | 2024 | Journal of Magnesium and Alloys2024，12，2： | 0 |
| 13 | Tuning dual-atom mediator toward high-rate bidirectional polysulfide conversion in Li-S batteries显示文摘An emerging practice in the realm of Li-S batteries lies in the employment of single-atom catalysts(SACs)as effective mediators to promote polysulfide conversion,but monometallic SACs affording isolated geometric dispersion and sole electronic configuration limit the catalytic benefits and curtail the cell performance.Here,we propose a class of dual-atom catalytic moieties comprising hetero-or homo-atomic pairs anchored on N-doped graphene(NG)to unlock the liquid–solid redox puzzle of sulfur,readily realizing Li-S full cell under high-rate-charging conditions.As for Fe-Ni-NG,in-depth experimental and theoretical analysis reveal that the hetero-atomic orbital coupling leads to altered energy levels,unique electronic structures,and varied Fe oxidation states in comparison with homo-atomic structures(FeFe-NG or Ni-Ni-NG).This would weaken the bonding energy of polysulfide intermediates and thus enable facile electrochemical kinetics to gain rapid liquid-solid Li_(2)S_(4)?Li_(2)S conversion.Encouragingly,a Li-S battery based on the S@Fe-Ni-NG cathode demonstrates unprecedented fast-charging capability,documenting impressive rate performance(542.7 mA h g^(-1)at 10.0 C)and favorable cyclic stability(a capacity decay of 0.016%per cycle over 3000 cycles at 10.0 C).This finding offers insights to the rational design and application of dual-atom mediators for Li-S batteries. | Yifan Ding Zhongti Sun Jianghua Wu Tianran Yan Lin Shen Zixiong Shi Yuhan Wu Xiaoqing Pan Liang Zhang Qiang Zhang Jingyu Sun | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 14 | A thermal activation based constitutive model for the dynamic deformation of AA5083 processed by large-scale equal-channel angular pressing显示文摘Aluminum alloy 5083(AA5083)processed by large-scale Equal-channel angular pressing(ECAP)is an excellent engineering material with great prospects for industrial applications.An accurate assessment of the underlying constitutive relationships with easily determined material constants is critical for the predictive design and informed processing of such structural materials.To develop such a design framework,uniaxial dynamic compressive tests over a wide range of temperatures(293-573 K)were carried out for an ECAP-processed AA5083 alloy.Additionally,the microstructure before and after dynamic loading was characterized by SEM and TEM.Based on the experimental results,a new dynamic constitutive model,based on thermal activation theory,was established to describe the plastic flow behavior of the AA5083 alloy that incorporates the effects of plastic strain,temperature,and strain rate.The input parameters of the new model were determined using a particle swarm optimization(PSO)method.The model predictions show excellent agreement with experimental results,which suggests that the current predictive constitutive model is highly effective in reproducing the dynamic deformation behavior of the large-scale ECAP-processed AA5083. | Yunfei WANG Minjie WANG Biao CHEN Huijie SUN Katsuyoshi KONDOH Laszlo JKECSKES Jianghua SHEN | 2023 | Chinese Journal of Aeronautics2023，36，5： | 0 |
| 15 | Characterization of putative mannoprotein in Kluyveromyces lactis for lactase production显示文摘Lactase is a member of theβ-galactosidase family of enzymes that can hydrolyze lactose into galactose and glucose.However,extracellular lactase production was still restricted to the process of cell lysis.In this study,lactase-producing Kluyveromyces lactis JNXR-2101 was obtained using a rapid and sensitive method based on the fluorescent substrate 4-methylumbelliferyl-β-D-galactopyranoside.The purified enzyme was identified as a neutral lactase with an optimum pH of 9.To facilitate extracellular production of lactase,a putative mannoprotein KLLA0_E01057g of K.lactis was knocked out.It could effectively promote cell wall degradation and lactase production after lyticase treatment,which showed potential on other extracellular enzyme preparation.After optimizing the fermentation conditions,the lactase yield from mannoprotein-deficient K.lactis JNXR-2101ΔE01057g reached 159.62 U/mL in a 5-L fed-batch bioreactor. | Xiuru Shen Lingtong Liao Guoqiang Zhang Jingwen Zhou Jianghua Li Guocheng Du | 2023 | Synthetic and Systems Biotechnology2023，8，1： | 0 |
| 16 | Cross-linked polyelectrolyte reinforced SnO_(2)electron transport layer for robust flexible perovskite solar cells显示文摘SnO_(2)electron transport layer(ETL)is a vital component in perovskite solar cells(PSCs),due to its excellent photoelectric properties and facile fabrication process.In this study,we synthesized a water-soluble and adhesive polyelectrolyte with ethanolamine(EA)and poly-acrylic acid(PAA).The linear PAA was crosslinked by EA,forming a 3D network that stabilized the SnO_(2)nanoparticle dispersion.An organic–inorganic hybrid ETL is developed by introducing the cross-linked PAA-EA into SnO_(2)ETL,which prevents nano particle agglomeration and facilitates uniform SnO_(2)film formation with fewer defects.Additionally,the PAA-EA-modified SnO_(2)facilitated a uniform and compact perovskite film,enhancing the interface contact and carrier transport.Consequently,the PAA-EA-modified PSCs exhibited excellent PCE of 24.34%and 22.88%with high reproducibility for areas of 0.045 and 1.00 cm~2,respectively.Notably,owing to structure reinforce effect of PAA-EA in SnO_(2)ETL,flexible device demonstrated an impressive PCE of 23.34%while maintaining 90.1%of the initial PCE after 10,000 bending cycles with a bending radius of 5 mm.This successful approach of polyelectrolyte reinforced hybrid organic–inorganic ETL displays great potential for flexible,large-area PSCs application. | Zhihao Li Zhi Wan Chunmei Jia Meng Zhang Meihe Zhang Jiayi Xue Jianghua Shen Can Li Chao Zhang Zhen Li | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 17 | Potential approaches for intervening aging显示文摘Though immortality and regeneration were ludicrous and far-fetched in an age of ignorance and superstition,people have never stopped looking for the elixir of longevity.As a result of advancements in lifestyle and medical care,the average human life expectancy has risen in recent decades,along with the increasingly higher incidence of aging-related diseases.With the advance in biological techniques,our understanding of aging and aging-related diseases has expanded significantly. | Jianghua Shen Guang-Hui Liu Moshi Song | 2022 | National Science Open2022，1，2： | 0 |
| 18 | Corrigendum to“Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-kB signaling pathways through Angiopoietin-like protein 4”[Genes&Diseases 9(2022)443e455]显示文摘The authors regret that some statistical errors were made in“Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-kB signaling pathways through Angiopoietin-like protein 4”(Genes Dis,http://gffzzd3cc09b8251d45dfs9vvoq06059xo6quo.ffgz.tsg.suse.edu.cn/10.1016/j.gendis.2020.07.005)at Figure 2G,Figure 3B and F,and Figure 4C and D for Angptl4 expression,Figure 5E for CaN expression. | Xiujin Shen Chunhua Weng Yucheng Wang Cuili Wang Shi Feng Xiayu Li Heng Li Hong Jiang Haibing Wang Jianghua Chen | 2022 | Genes & Diseases2022，9，6： | 0 |
| 19 | Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury显示文摘Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion(I/R)injury.However,a genome-wide map of histone modifications and the underlying epigenetic signatures in myocardial I/R injury have not been established.Here,we integrated transcriptome and epigenome of histone modifications to characterize epigenetic signatures after I/R injury.Disease-specific histone mark alterations were mainly found in H3K27me3-,H3K27ac-,and H3K4me1-marked regions 24 and 48 h after I/R.Genes differentially modified by H3K27ac,H3K4me1 and H3K27me3 were involved in immune response,heart conduction or contraction,cytoskeleton,and angiogenesis.H3K27me3 and its methyltransferase polycomb repressor complex 2(PRC2)were upregulated in myocardial tissues after I/R.Upon selective inhibition of EZH2(the catalytic core of PRC2),the mice manifest improved cardiac function,enhanced angiogenesis,and reduced fibrosis.Further investigations confirmed that EZH2 inhibition regulated H3K27me3 modification of multiple pro-angiogenic genes and ultimately enhanced angiogenic properties in vivo and in vitro.This study delineates a landscape of histone modifications in myocardial I/R injury,and identifies H3K27me3 as a key epigenetic modifier in I/R process.The inhibition of H3K27me3 and its methyltransferase might be a potential strategy for myocardial I/R injury intervention. | Le Ni Bowen Lin Yanping Zhang Lingjie Hu Jianghua Lin Fengmei Fu Meiting Shen Can Li Lei Chen Jian Yang Dan Shi Yi-Han Chen | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 20 | Helper T Cell(CD4^(+))Targeted Tacrolimus Delivery Mediates Precise Suppression of Allogeneic Humoral Immunity显示文摘Antibody-mediated rejection(ABMR)is a major cause of dysfunction and loss of transplanted kidney.The current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma cells.However,the prognosis of patients following current treatment is poor.T follicular helper cells(Tfh)play an important role in allograft-specific antibodies secreting plasma cell(PC)development.Tfh cells are therefore considered to be important therapeutic targets for the treatment of antibody hypersecretion disorders,such as transplant rejection and autoimmune diseases.Tacrolimus(Tac),the primary immunosuppressant,prevents rejection by reducing T cell activation.However,its administration should be closely monitored to avoid serious side effects.In this study,we investigated whether Tac delivery to helper T(CD4^(+))cells using functionalized mesoporous nanoparticles can block Tfh cell differentiation after alloantigen exposure.Results showed that Tac delivery ameliorated humoral rejection injury in rodent kidney graft by suppressing Tfh cell development,PC,and donor-specific antibody(DSA)generation without causing severe side effects compared with delivery through the drug administration pathway.This study provides a promising therapeutic strategy for preventing humoral rejection in solid organ transplantation.The specific and controllable drug delivery avoids multiple disorder risks and side effects observed in currently used clinical approaches. | Jia Shen Chang Liu Pengpeng Yan Meifang Wang Luying Guo Shuaihui Liu Jianghua Chen Jessica MRosenholm Hongfeng Huang Rending Wang Hongbo Zhang | 2022 | Research2022，，3： | 0 |
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