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| 1 | Local people’s perceptions as decision support for protected area management in Wolong Biosphere Reserve, China显示文摘 | Jianying Xu Liding Chen Yihe Lu Bojie Fu | 2005 | Journal of Environmental Management2005，，4： | 1 |
| 2 | Efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection for the treatment of renal anemia in Chinese hemodialysis patients:A randomized,open-label,parallel-group,noninferiority phase III trial显示文摘Background:This study was to explore the clinical efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection(recombinant human erythropoietin injection,rHuEPO)for the treatment of anemia associated with chronic kidney failure in Chinese patients undergoing hemodialysis.Method:This study was a multicenter,randomized,open-label,intergroup parallel control phase III noninferiority trial from April 19,2013 to September 9,2014 at 25 sites.In this study,the members of the darbepoetin alfa group underwent intravenous administration once per week or once every two weeks.The members of the control drug epoetin alfa group underwent intravenous administration two or three times per week.All subjects underwent epoetin alfa administration during the 8-week baseline period.After that,subjects were randomly assigned to the darbepoetin alfa group or epoetin alfa group.The noninferiority in the changes of the average Hb concentrations from the baseline to the end of the evaluation period(noninferiority threshold:-1.0 g/dl)was tested between the two treatments.The time-dependent hemoglobin(Hb)concentration and the maintenance rate of the target Hb concentration(the proportion of subjects with Hb concentrations between 10.0 and 12.0 g/dl)were also evaluated.Iron metabolism,including changes in the serum iron,total iron-binding capacity,ferritin,transferrin saturation,and comparisons of the dose adjustments between the two groups during the treatment period were analyzed further.Adverse events(AEs)were also observed and compared,and the safety was analyzed between the two treatment groups.The conversion rate switching from epoetin alfa to darbepoetin alfa was also discussed.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:Four hundred and sixty-six patients were enrolled in this study,and ultimately 384 cases were analyzed for safety,including 267 cases in the darbepoetin alfa group and 117 cases in the epoetin alfa group.There were 211 cases in the per-protocol set,including 152 cases in the darbepoetin alfa group and 59 cases in the epoetin alfa group.The changes in the average Hb concentrations from the baseline to the end of the evaluation period were-0.07 and-0.15 g/dl in the darbepoetin alfa group and epoetin alfa group respectively.The difference between the two groups was 0.08 g/dl(95%confidence interval[CI]:-0.22 to 0.39),and the lower limit of the 95%CI was-0.22>-1.0 g/dl.The average Hb concentrations of the two groups were 10.88-11.43 g/dl(darbepoetin alfa)and 10.91-11.38 g/dl(epoetin alfa)during the study period of Weeks 0-28,with the maintenance rates of the target Hb concentration ranging within 71%-87%and 78%-95%in the darbepoetin alfa group and epoetin alfa group respectively.During the period of comparison between the two groups,the incidence of AEs in the darbepoetin alfa group was 61.42%,while in the epoetin alfa group it was 56.41%.All of the adverse events and reactions in the study were those commonly associated with hemodialysis.Conclusion:The overall efficacy and safety of darbepoetin alfa for the treatment of Chinese renal anemia patients undergoing hemodialysis are consistent with those of epoetin alfa. | Bicheng Liu Nan Chen Jinghong Zhao Aiping Yin Xiongfei Wu Changying Xing Gengru Jiang Junzhou Fu Mei Wang Rong Wang Jianying Niu Ping Fu Zhaohui Ni Fanfan Hou Jiuyang Zhao Jing Chen Yuqing Chen Wei Shi Jianghua Chen Wenge Li Gang Xu Ling Zhong Wenhu Liu Guohua Ding Yuichiro Kondo Changhe Yue Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，2： | 1 |
| 3 | Development of low-coherence high-power laser drivers for inertial confinement fusion显示文摘The use of low-coherence light is expected to be one of the effective ways to suppress or even eliminate the laser–plasma instabilities that arise in attempts to achieve inertial confinement fusion.In this paper,a review of low-coherence high-power laser drivers and related key techniques is first presented.Work at typical low-coherence laser facilities,including Gekko XII,PHEBUS,Pharos III,and Kanal-2 is described.The many key techniques that are used in the research and development of low-coherence laser drivers are described and analyzed,including low-coherence source generation,amplification,harmonic conversion,and beam smoothing of low-coherence light.Then,recent progress achieved by our group in research on a broadband low-coherence laser driver is presented.During the development of our low-coherence high-power laser facility,we have proposed and implemented many key techniques for working with low-coherence light,including source generation,efficient amplification and propagation,harmonic conversion,beam smoothing,and precise beam control.Based on a series of technological breakthroughs,a kilojoule low-coherence laser driver named Kunwu with a coherence time of only 300 fs has been built,and the first round of physical experiments has been completed.This high-power laser facility provides not only a demonstration and verification platform for key techniques and system integration of a low-coherence laser driver,but also a new type of experimental platform for research into,for example,high-energy-density physics and,in particular,laser–plasma interactions. | Yanqi Gao Yong Cui Lailin Ji Daxing Rao Xiaohui Zhao Fujian Li Dong Liu Wei Feng Lan Xia Jiani Liu Haitao Shi Pengyuan Du Jia Liu Xiaoli Li Tao Wang Tianxiong Zhang Chong Shan Yilin Hua Weixin Ma Xun Sun Xianfeng Chen Xiuguang Huang Jian Zhu Wenbing Pei Zhan Sui Sizu Fu | 2020 | Matter and Radiation at Extremes2020，5，6： | 1 |
| 4 | Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority Phase III trail显示文摘Background:Erythropoietin is a glycoprotein that mainly regulates erythropoiesis.In patients with chronic renal failure with anemia,darbepoetin alfa can stimulate erythropoiesis,correct anemia,and maintain hemoglobin levels.This study was designed to demonstrate the efficacy and safety of darbepoetin alfa injections as being not inferior to epoetin alfa injections(Recombinant Human Erythropoietin injection,rHuEPO)when maintaining hemoglobin(Hb)levels within the target range(10.0-12.0 g/dL)for the treatment of renal anemia.Methods:Ninety-five patients were enrolled in this study from April 15,2013 to April 10,2014 at 25 sites.In this study,patients(n=95)aged 18-70 years were randomized into a once per week intravenous darbepoetin alfa group(n=56)and a twice or three times per week intravenous epoetin alfa group(n=39)for 28 weeks,who had anemia with hemoglobin levels between 6 g/dL and 10 g/dL due to chronic kidney disease(CKD)and were undergoing hemodialysis or hemofiltration with ESA-naive(erythropoiesis stimulating agent-naive).The primary efficacy profile was the mean Hb level(the non-inferiority margin was-1.0 g/dL,week 21-28);the secondary efficacy profiles were the Hb increase rate(week 0-4),the target Hb achievement cumulative rate and time,the change trends of the Hb levels,and the target Hb maintenance ratio.Adverse events(AEs)were observed and compared,and the efficacy and safety were analyzed between the two treatment groups.Additionally,the frequencies of dose adjustments between the darbepoetin alfa and epoetin alfa groups were compared during the treatment period.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:The mean Hb level was 11.3 g/dL in the darbepoetin alfa group and 10.7 g/dL in the epoetin alfa group,respectively;the difference of the lower limits of the 95%confidence intervals(CI)between the two groups was 0.1 g/dL(>-1.0 g/dL),and non-inferiority was proven;the Hb levels started to increase in the first four weeks at a similar increase rate;no obvious differences were observed between the groups in the target Hb achievement cumulative rates,and the Hb levels as well as the target Hb level maintenance rate changed over time.The incidence of AEs was 62.5%in the darbepoetin alfa group and 76.9%in the epoetin alfa group.All the adverse events observed in the study were those commonly associated with hemodialysis.Conclusion:Darbepoetin alfa intravenously once per week can effectively increase Hb levels and maintain the target Hb levels well,which makes it not inferior to epoetin alfa intravenously twice or three times per week.Darbepoetin alfa shows an efficacy and safety comparable to epoetin alfa for the treatment of renal anemia. | Nan Chen Changying Xing Jianying Niu Bicheng Liu Junzhou Fu Jiuyang Zhao Zhaohui Ni Mei Wang Wenhu Liu Jinghong Zhao Ling Zhong Xiongfei Wu Wenge Li Yuqing Chen Wei Shi Jianghua Chen Aiping Yin Ping Fu Rong Wang Gengru Jiang Fanfan Hou Guohua Ding Jing Chen Gang Xu Yuichiro Kondo Yuliang Su Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 1 |
| 5 | Development and evaluation on a RFID-based traceability system for cattle/beef quality safety in China显示文摘 | Jianying Feng Zetian Fu Zaiqiong Wang Mark Xu Xiaoshuan Zhang | 2013 | Food Control2013，，2： | 1 |
| 6 | Superparamagnetic Iron Oxide is Suitable to Label Tendon Stem Cells and Track Them In Vivo with MR Imaging显示文摘 | Yunfa Yang Jianying Zhang Yongxian Qian Shiwu Dong He Huang Fernando E. Boada Freddie H. Fu James H-C. Wang | 2013 | Annals of Biomedical Engineering2013，，10： | 1 |
| 7 | Wide dissemination of OXA - 23 - producing carbapenem - resistant Acinetobacter bauman- nii clonal complex 22 in multiple cities of China 显示文摘 | Yiqi Fu Jianying Zhou Hua Zhou | 2010 | J Antimicrob Chemother2010，65，： | 1 |
| 8 | Low-intensity pulsed ultrasound prompts tissue-engineered bone formation after implantation surgery显示文摘 | Wang Juyong Wang Juqiang Asou Yoshinori Paul Fu Shen Huiliang Chen Jiani Sotome Shinichi | 2014 | Chinese Medical Journal2014，，4： | 1 |
| 9 | Fabrication of superhydrophobic coating via a facile and versatile method based on nanoparticle aggregates显示文摘 | Zhoukun He Meng Ma Xiangchuan Xu Jianying Wang Feng Chen Hua Deng Ke Wang Qin Zhang Qiang Fu | 2011 | Applied Surface Science2011，，7： | 1 |
| 10 | Local people's perceptions as decision support for protected area management in Wolong Biosphere Reserve,China显示文摘 | Jianying Xu Liding Chen Yihe Lu Bojie Fu | 2006 | Journal of Environmental Management2006，78，： | 1 |
| 11 | Development of urban underground space in coastal cities in China:A review显示文摘The development of urban underground space is a critical way to alleviate the lack of urban resources,and improve environmental conditions as well as residents'quality of life,which has important practical significance.As the most densely populated and economically developed areas,coastal cities face many challenges in underground space development owing to their unique environmental geological conditions.This study examined the current situation of underground space development,academic research,technology application,evaluation methods,planning,and legislation in coastal cities in China.On this basis,it analyzed the future development trends,and presented reasonable suggestions for the critical scientific and technical problems faced by the development of underground space in coastal cities.The key suggestions are as follows:it is necessary to define and clarify the critical geological issues,distributions,and hazards that affect underground space development and major engineering construction in coastal cities;the land-sea integrated detection technology for sea crossing bridges and submarine tunnels needs to be studied;in evaluating the suitability of underground space in coastal cities,the land and sea area evaluation factors should be integrated;and the evaluation system of landsea integration needs to be established. | Peng Yu Honghua Liu Zhongsheng Wang Jiani Fu Hui Zhang Jia Wang Qi Yang | 2023 | Deep Underground Science and Engineering2023，2，2： | 0 |
| 12 | Clinical research of biphenotypic acute leukemia witht(8;21)(q22;q22)显示文摘Objective:To report 4 cases of biphenotypic acute leukemia(BAL)with t(8;21)(q22;q22),and analyze the characteristics of morphology,immune phenotype,chromosome karyotype(MIC)and clinical manifestations.Methods:The BAL patients with t(8;21)(q22;q22)(group A)were compared with the randomly selected BAL patients with other clonical chromo- somal changes(group B)and acute myeloid leukemia M2 cases with t(8;21)(q22;q22)(group C)in MIC and clinical features. Results:BAL with t(8;21)(q22;q22)showed acute myeloid leukemia with high percentages of blast cells morphologically; revealed co-positive to B-lymphoid and myeloid lineages,frequent and high expressions of CD34 and CD33;were responsive to chemotherapy for myeloid and lymphocytic leukemia simultaneously well.Conclusion:A new subset of BAL with t(8;21)(q22;q22)was reported,and this suggests that the leukemia colony with t(8;21)(q22;q22)might originate from early phase of hematopoiesis. | Guangsheng He Ling Zhou Depei Wu Yongquan Xue Mingqing Zhu Jianying Liang Aining Sun Zhengming Jin Huiying Qiu Miao Miao Xiaowen Tang Zhengzheng Fu Xiao Ma Xiuli Wang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 0 |
| 13 | Research on China’s technology lists for addressing climate change显示文摘The compilation of technology lists addressing climate change has a guiding effect on promoting technological research and development,demonstration,and popularization.It is also crucial for China to strengthen ecological civilization construction,achieve the carbon emission peak and carbon neutrality target,and enhance global climate governance capabilities.This study first proposes the existing classification outline of the technology promotion lists,technology demand lists,and future technology lists.Then,different methodologies are integrated on the basis of the existing outline of four technology lists:China’s existing technological promotion list for addressing climate change,China’s demand list for climate change mitigation technology,China’s key technology list for addressing climate change,and China’s future technology list for addressing climate change.What’s more,core technologies are analyzed in the aspects of technology maturity,carbon reduction cost,carbon reduction potential,economic benefits,social influence,uncertainty,etc.The results show that:key industries and sectors in China already have relatively mature mitigation/adaptation technologies to support the achievement of climate change targets.The multi-sectoral system of promoting climate friendly technologies has been established,which has played an active role in tackling climate change.Currently,climate technology needs are concentrated in the traditional technology and equipment upgrading,renewable energy technology,and management decision-making support technology.The key technologies are concentrated in 3 major areas and 12 technological directions that urgently need a breakthrough.For carbon emmission peak and nentrality,carbon depth reduction and zero carbon emissions and geoengineering technology(CDR and SRM)have played an important role in forming the structure of global emissions and achieving carbon neutrality in the future.Thus,the uncertainty assessment for the comprehensive technology cost effectiveness,technology integration direction,technical maturity,ethics and ecological impacts is supportive to the national technology strategy.Finally,the presented study proposes several policy implications for medium-and long-term technology deployment,improving technology conversion rate,promoting the research and development of core technologies,and forming a technology list collaborative update and release mechanism. | Can Wang Jianhui Cong Ke Wang Yue Qi Wenjian Cai Yulong Li Sha Fu Wentao Wang Yuanyuan Wei Xinzhu Zheng Jiani Jiang Mingpeng Chen Wenling Liu Yongxiang Zhang Zhibing Tian Ji Chen Rui Li Haiqing Zuo | 2021 | Chinese Journal of Population,Resources and Environment2021，19，2： | 0 |
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