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| 1 | Why Lake Taihu continues to be plagued with cyanobacterial blooms through 10 years(2007–2017) efforts显示文摘With the expansion of urban, industry, and agriculture after World War II, eutrophication firstly emerged as a major water quality threat in small water bodies [1]. As the increasing magnitudes and scales of nutrient pollution and habitat alteration, many of the world's large lakes exhibit symptoms of eutrophication, e.g., toxic cyanobacterial blooms, deoxygenation, and habitat loss. | Boqiang Qin Hans W.Paerl Justin D.Brookes Jianguo Liu Erik Jeppesen Guangwei Zhu Yunlin Zhang Hai Xu Kun Shi Jianming Deng | 2019 | Science Bulletin2019，64，6： | 50 |
| 2 | Prediction of permafrost changes in Northeastern China under a changing climate显示文摘Northeastern China has the second largest expanse of permafrost in China,primarily known as Xing'an-Baikal permafrost.Located on the southeastern edges of the Eurasian cryolithozone,the permafrost is thermally unstable and ecologically sensitive to external changes.The combined impacts of climatic,environmental,and anthropogenic changes cause 3-dimensional degradation of the permafrost.To predict these changes on the southern limit and ground temperature of permafrost in Northeastern China,an equivalent latitude model (ELM) for the mean annual ground surface temperature (MAGSTs) was proposed,and further improved to take into account of the influences of vegetation and snow-cover based on observational data and using the SHAW model.Using the finite element method and assuming a climate warming rate of 0.048°C a-1,the ELM was combined with the unsteady-state heat conduction model to simulate permafrost temperatures at present,and to predict those after 50 and 100 a.The results indicate that at present,sporadic permafrost occurs in the zones with MAGSTs of 1.5°C or colder,and there would still be a significant presence of permafrost in the zones with the present MAGSTs of 0.5°C or colder after 50 a,and in those of-0.5°C or colder after 100 a.Furthermore,the total areal extent of permafrost would decrease from 2.57×105 km2 at present to 1.84×105 km2 after 50 a and to 1.29×105 km2 after 100 a,i.e.,a reduction of 28.4% and 49.8% in the permafrost area,respectively.Also the permafrost would degrade more substantially in the east than in the west.Regional warming and thinning of permafrost would also occur.The area of stable permafrost (mean annual ground temperature,or MAGT≤-1.0°C) would decrease from present 1.07×105 to 8.8×104 km2 after 50 a,and further decrease to 5.6×104 km2 after 100 a.As a result,the unstable permafrost and seasonally frozen ground would expand,and the southern limit of permafrost would shift significantly northwards.The changes in the permafrost environment may adversely affect on ecological environments and engineering infrastructures in cold regions.Avoidance of unnecessary anthropogenic changes in permafrost conditions is a practical approach to protect the permafrost environment. | WEI Zhi JIN HuiJun ZHANG JianMing YU ShaoPeng HAN XuJun JI YanJun HE RuiXia CHANG XiaoLi | 2011 | Science China Earth Sciences2011，54，6： | 15 |
| 3 | Analysis and Application of the Singularity Locus of the Stewart Platform显示文摘The direct use of the determinant of Jacobian matrix being equal to zero for the singularity analysis is generally difficult which is due to complexity of the Jacobian matrix of 6-DOF parallel manipulators,especially for Stewart platform.Recently,several scholars make their great contribution to the effective solution of this problem,but neither of them find the right answer.This paper gives a brief analysis of the kinematics of the Stewart platform and derives the Jacobian matrices of the system through the velocity equation.On the basis of the traditional classification of singularities,the second type of singularity is investigated.An assumption of any three of the six variables of the Stewart platform as constant is made,then the analytical expression of singularity locus equation of the second type singularity which contains another three pose variables is obtained.The singularity locus is represented in the three-dimensional space through the derived equation.The correctness and validity of the proposed method are verified through examples.Finally,the singularity analysis of an electric Stewart platform in its desired workspace and reachable workspace is implemented.Thus,one can easily identify whether singularity exists in a given workspace of a Stewart platform and determine whether the existed singularity can be avoided through the proposed method.The proposed method also provides theoretical principle for the design and application of the Stewart platform and has great significance for the trajectory planning and control. | MA Jianming HUANG Qitao XIONG Haiguo HAN Junwei | 2011 | Chinese Journal of Mechanical Engineering2011，24，1： | 10 |
| 4 | Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer显示文摘Identifying sensitive and specific biomarkers for early detection of cancer is immensely imperative for early diagnosis and treatment and better clinical outcome of cancer patients. This study aimed to construct a specific DNA methylation pattern of cancer suppressor genes and explore the feasibility of applying cell-free DNA based methylation as a biomarker for early diagnosis of esophageal squamous cell carcinoma(ESCC). We recruited early stage ESCC patients from Yangzhong County, China. The Illumina Infinium 450 K Methylation BeadChip was used to construct a genome-wide DNA methylation profile. Then, differentiated genes were selected for the validation study using the Sequenom MassARRAY platform. The frequency of methylation was compared between cancer tissues, matched cell-free DNAs and normal controls. The specific methylation profiles were constructed, and the sensitivity and specificity were calculated. Seven CG sites in three genes CASZ1, CDH13 and ING2 were significantly hypermethylated in ESCC as compared with normal controls. A significant correlation was found between the methylation of DNA extracted from cancer tissues and matched plasma cell-free DNA, either for individual CG site or for cumulative methylation analysis. The sensitivity and specificity reached 100% at an appropriate cut-point using these specific methylation biomarkers. This study revealed that aberrant DNA methylation is a promising biomarker for molecular diagnosis of esophageal cancer. Hypermethylation of CASZ1,CDH13 and ING2 detected in plasma cell-free DNA can be applied as a potential noninvasive biomarker for diagnosis of esophageal cancer. | Huanqiang Wang Congying Yang Siyuan Wang Tian Wang Jingling Han Kai Wei Fucun Liu Jida Xu Xianzhen Peng Jianming Wang | 2018 | The Journal of Biomedical Research2018，32，6： | 6 |
| 5 | Polluted lake restoration to promote sustainability in the Yangtze River Basin,China显示文摘China has sought to address water pollution in the last decade by introducing a wide range of laws and regulations(Table S1), which led to nationwide water quality improvement ^([1]). However, recent quantitative assessment of progress toward Sustainable Development Goals (SDGs) in China suggests that some SDGs underpinning goals for water pollution and biodiversity have not been met ^([2]). | Boqiang Qin Yunlin Zhang Jianming Deng Guangwei Zhu Jianguo Liu David P.Hamilton Hans W.Paerl Justin D.Brookes Tingfeng Wu Kai Peng Yizhou Yao Kan Ding Xiaoyan Ji | 2022 | National Science Review2022，9，1： | 4 |
| 6 | Casein kinase Ⅱ interacts with prion protein in vitro and forms complex with native prion protein in vivo显示文摘最必要、关键的步在能递送的海绵状的 encephalopathy 的致病期间是到病理学的 isoform 的细胞的 prion 蛋白质的 conformational 变化。酷蛋白 kinase II (CK2 ) 是一无所不在地表示了并且 evolutionarily 保存了为生存能力是必要的多种的蛋白质 kinase。探索在 CK2 和 prion 蛋白质(PrP ) 之间的可能的分子的相互作用,人的 CK2α 和 CK2β 的全身的序列互补 DNA 作为模板从房间线 SH-SY5Y 用彻底的送信人 RNA 与反向的抄写聚合酶链反应被放大;然后,熔化蛋白质 histidine-CK2α 和谷胱甘肽 S-transferase-histidine-CK2β 在 Escherichia 关口 i 被表示。在 CK2 和 PrP 之间的相互作用与 co-immunoprecipitation 和下拉试金被评估。结果证明 recombinant PrP 与 CK2α ,然而并非与 CK2β 明确地跳了。在仓鼠大脑的本国的 CK2 和 PrP 与对方一起交往了,形成蛋白质建筑群。从正常大脑的 PrP (diglycosylated, monoglycosylated 和 unglycosylated PrP ) 的三种不同 glycosylated 形式与 CK2α 子单元交往了,尽管 unglycosylated PrP 似乎与 CK2α 子单元有一个更强壮的有约束力的能力。负责与 CK2α 交往的领域在 PrP 的 C 终端片断被定位(残余 91 231 ) 。这研究为在 PrP 和 CK2α 之间的分子的相互作用建议了可靠试验性的数据(两个在 recombinant 和本国的范畴) ,为进一步估计 PrP-CK2 相互作用的潜在的生物意义的科学线索,和在 prion 疾病的致病的 CK2 的可能的角色。 | Jianming Chen Chen Gao Qi Shi Guirong Wang Yanjun Lei Bing Shan Baoyun Zhang Chenfang Dong SongShi Xin Wang Chan Tian Jun Han Xiaoping Dong | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 3 |
| 7 | PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress显示文摘One of the physiological functions of cellular prion protein(PrP C )is believed to work as a cellular resistance to oxidative stress,in which the octarepeats region within PrP plays an important role.However,the detailed mechanism is less clear.In this study,the expressing plasmids of wild-type PrP (PrP-PG5)and various PrP mutants containing 0(PrP-PG0),9(PrP-PG9)and 12(PrP-PG12)octarepeats were generated and PrP proteins were expressed both in E.coli and in mammalian cells.Protein aggregation and formation of carbonyl groups were clearly seen in the recombinant PrPs expressed from E.coli after treatment of H2O2.MTT and trypan blue staining assays revealed that the cells expressing the mutated PrPs within octarepeats are less viable than the cells expressing wild-type PrP.Statistically significant high levels of intracellular free radicals and low levels of glutathione peroxidase were observed in the cells transfected with plasmids containing deleted or inserted octarepeats.Remarkably more productions of carbonyl groups were detected in the cells expressing PrPs with deleted and inserted octarepeats after exposing to H2O2.Furthermore,cells expressing wild-type PrP showed stronger resistant activity to the challenge of H2O2 at certain extent than the mutated PrPs and mock. These data provided the evidences that the octarepeats number within PrP is critical for maintaining its activity of antioxidation.Loss of its protective function against oxidative stress may be one of the possible pathways for the mutated PrPs to involve in the pathogenesis of familial Creutzfeldt-Jacob diseases. | AN Run1 ,2,DONG ChenFang 2,LEI YanJun 1,2,HAN Lu 2,LI Ping 2,CHEN JianMing 2,WANG GuiRong 2, SHI Qi 2 ,GAO Chen 2 ,JIANG HuiYing 2 ,ZHOU Wei 2 ,HAN Jun 2 ,CHU YongLie 1 ,DONG XiaoPing 2 1School of Medicine,Xi’an JiaoTong University,Xi’an 710061,China 2State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,YingXin Rd 100,Beijing 100052,China | 2008 | Science China(Life Sciences)2008，51，7： | 3 |
| 8 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5h9owu5nfx66v966fv.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 9 | Spatial and seasonal variability of organic carbon transport in the Yellow River, China显示文摘 | Lishan Ran X.X. Lu Huiguo Sun Jingtai Han Ronghua Li Jianming Zhang | 2013 | Journal of Hydrology2013，，： | 2 |
| 10 | Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression显示文摘 | Motoyuki Otsuka Qing Jing Philippe Georgel Liguo New Jianming Chen Johann Mols Young Jun Kang Zhengfan Jiang Xin Du Ryan Cook Subash C. Das Asit K. Pattnaik Bruce Beutler Jiahuai Han | 2007 | Immunity2007，，1： | 2 |
| 11 | Two-Dimensional Borophene:Properties,Fabrication,and Promising Applications显示文摘Monoelemental two-dimensional(2D)materials(Xenes)aroused a tremendous attention in 2D science owing to their unique properties and extensive applications.Borophene,one emerging and typical Xene,has been regarded as a promising agent for energy,sensor,and biomedical applications.However,the production of borophene is still a challenge because bulk boron has rather intricate spatial structures and multiple chemical properties.In this review,we describe its excellent properties including the optical,electronic,metallic,semiconducting,photoacoustic,and photothermal properties.The fabrication methods of borophene are also presented including the bottom-up fabrication and the top-down fabrication.In the end,the challenges of borophene in the latest applications are presented and perspectives are discussed. | Zhongjian Xie Xiangying Meng Xiangnan Li Weiyuan Liang Weichun Huang Keqiang Chen Jianming Chen Chenyang Xing Meng Qiu Bin Zhang Guohui Nie Ni Xie Xiaobing Yan Han Zhang | 2020 | Research2020，，1： | 2 |
| 12 | Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors显示文摘 | Sai Li Yanfang Zhao Kewen Wang Yali Gao Jianming Han Bingbing Cui Ping Gong | 2013 | Bioorganic & Medicinal Chemistry2013，，11： | 1 |
| 13 | The Distributional Mobilization and Management of Multi-sourced Super Special Information in the Internet显示文摘 | Han Haiyang Huang Jianming Gong Jianya etc | 1999 | Journal of the Wuhan University of Mapping Technology1999，24，20： | 1 |
| 14 | Analyzing the mechanisms of fatigue crack initiation and propagation in CRH EMU brake discs显示文摘 | YANG Zhiyong HAN Jianming LI Weijing | 2013 | Engineering Failure Analysis2013，34，8： | 1 |
| 15 | A boundary face method for potential problems in three dimensions显示文摘 | ZHANG Jianming QIN Xianyun HAN Xu | 2009 | Int J Numer Meth Eng2009，80，3： | 1 |
| 16 | Fe-based amorphous coating prepared using high-velocity oxygen fuel and its corrosion behavior in static lead-bismuth eutectic alloy显示文摘The Fe_(949.7)Cr_(18)Mn_(1.9)Mo_(7.4)W_(1.6)B_(15.2)C_(3.8)Si_(2) amorphous coating was deposited on T91 steel substrate by using the high-velocity oxygen fuel(HVOF)spray technique to enhance the corrosion resistance of T91 stainless steel in liquid lead-bismuth eutectic(LBE).The corrosion behavior of the T91 steel and coating exposed to oxygen-saturated LBE at 400℃ for 500 h was investigated.Results showed that the T91 substrate was severely corroded and covered by a homogeneously distributed dual-layer oxide on the interface contacted to LBE,consisting of an outer magnetite layer and an inner Fe-Cr spinel layer.Meanwhile,the amorphous coating with a high glass transition temperature(Tg=550℃)and crystallization temperature(T_(x)=600℃)exhibited dramatically enhanced thermal stability and corrosion resistance.No visible LBE penetration was observed,although small amounts of Fe_(3)O_(4),Cr_(2)O_(3),and PbO were found on the coating surface.In addition,the amorphicity and interface bonding of the coating layer remained unchanged after the LBE corrosion.The Fe-based amorphous coating can act as a stable barrier layer in liquid LBE and have great application potential for long-term service in LBE-cooled fast reactors. | Xiangyang Peng Yuhai Tang Xiangbin Ding Zhichao Lu Shuo Hou Jianming Zhou Shuyin Han Zhaoping Lü Guangyao Lu Yuan Wu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，11： | 1 |
| 17 | Aboundary face method for potential problems in threedimensions 显示文摘 | ZHANG Jianming QIN Xianyun HAN Xu | 2009 | International Journal for NumericalMethods in Engineering2009，80，： | 1 |
| 18 | A boundary face method for potential problems in three dimensions显示文摘 | Zhang Jianming Qin Xianyun Xu Han | | 0，，： | 1 |
| 19 | Does nitrogen fertilization impact nonstructural carbohydrate storage in evergreen Podocarpus macrophyllus saplings?显示文摘Nonstructural carbon(NSC),which represents the relationship between the carbon source and carbon sink,is an important factor that reflects the functions and performance of a tree.However,little is known regarding the timeseries responses of NSC storage in evergreen species to different nitrogen(N)fertilization regimes.This study,which was based on a pot experiment,examined the response of the NSC(soluble sugars and starch storage to different N addition intensities[light N addition(LN):6.5 g N m^(-2)a^(-1);moderate N addition(MN):13.0 g N m^(-2)a^(-1);and heavy N addition(HN):26.0 g N m^(-2)a^(-1))]in saplings of the evergreen species Podocarpus macrophyllus.Our results showed that the net photosynthetic rate(P_(n))under MN was significantly higher than that under LN,but was comparable to that under HN.Moreover,saplings subject to MN had a significant higher leaf biomass than that to LN and HN.These results indicated that the C supply via photosynthesis under MN was greater than that under LN and HN.The NSCs reserve under MN was considerable with that under LN,which suggested that saplings in MN group consumed higher and stored lower properties of NSCs than those in LN group.However,saplings under HN stored higher properties of NSCs than those under MN considering that no difference in NSCs pools was found between the two treatments.The leaf N concentrations were found in the increasing sequence of LN | Renshan Li Jianming Han Liqiong Zhu Lijun Zhao Xiangling Huang Mingyue Zhang Qingpeng Yang Weidong Zhang | 2021 | Journal of Forestry Research2021，32，4： | 1 |
| 20 | The Warming Climate Aggravates Atmospheric NitrogenPollution in Australia显示文摘Australia is a warm country with well-developed agriculture and a highly urbanized population.How these specific features impact the nitrogen cycle,emissions,and consequently affect environmental and human health is not well understood.Here,we find that the ratio of reactive nitrogen(Nr)losses to air over losses to water in Australia is 1.6 as compared to values less than 1.1 in the USA,the European Union,and China.Australian Nr emissions to air increased by more than 70%between 1961 and 2013,from 1.2 Tg N yr^(-1) to 2.1 Tg N yr^(-1).Previous emissions were substantially underestimated mainly due to neglecting the warming climate.The estimated health cost from atmospheric Nr emissions in Australia is 4.6 billion US dollars per year.Emissions of Nr to the environment are closely correlated with economic growth,and reduction of Nr losses to air is a priority for sustainable development in Australia. | Yi Sun Baojing Gu Hans JMvan Grinsven Stefan Reis Shu Kee Lam Xiuying Zhang Youfan Chen Feng Zhou Lin Zhang Rong Wang Deli Chen Jianming Xu | 2021 | Research2021，，1： | 1 |
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