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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK显示文摘Objective To explore the effects of resveratrol-induced apoptosis and autophagy in T-cell acute lymphoblastic leukemia(T-ALL) cells and potential molecular mechanisms. Methods The anti-proliferation effect of resveratrol-induced, apoptosis and autophagy on T-ALL cells were detected by using MTT test, immunofluorescence, electronic microscope, and flow cytometry, respectively. Western blotting was performed for detecting changes of apoptosis-associated proteins, cell cycle regulatory proteins and state of activation of Akt, mTOR, p70S6K, 4E-BP1, and p38-MAPK. Results Resveratrol inhibited the proliferation and induced apoptosis and autophagy in T-ALL cells in a dose and time-dependent manner. It also induced cell cycle arrest at G0/G1 phase via up regulating cyclin-dependent kinase(CDK) inhibitors p21 and p27 and down regulating cyclin A and cyclin D1. Western blotting revealed that resveratrol significantly decreased the expression of antiapoptotic proteins(Mcl-1 and Bcl-2) and increased the expression of proapoptotic proteins(Bax, Bim, and Bad), and induced cleaved-caspase-3 in a time-dependent manner. Significant increase in ratio of LC3-II/LC3-I and Beclin 1 was also detected. Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. When autophagy was suppressed by 3-MA, apoptosis in T-ALL cells induced by resveratrol was enhanced.Conclusion Our findings have suggested that resveratrol induces cell cycle arrest,apoptosis,and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways.Autophagy might play a role as a self-defense mechanism in T-ALL cells treated by resveratrol.Therefore,the reasonable inhibition of autophagy in T-ALL cells may serve as a promising strategy for resveratrol induced apoptosis and can be used as adjuvant chemotherapy for T-ALL. | GE Jiao LIU Yan LI Qiang GUO Xia GU Ling MA Zhi Gui ZHU Yi Ping | 2013 | Biomedical and Environmental Sciences2013，26，11： | 38 |
| 3 | The characteristics of CO_2 assimilation of photosynthesis and chlorophyll fluorescence in transgenic PEPC rice显示文摘With PEPC, PPDK, NADP-ME and PEPC+ PPDK transgenic and untransformed rice (Orysa sativa L.), the activities of related C4 photosynthesis enzymes, the chlorophyll fluorescence parameters, CO2 exchange and other physiological indexes were compared, in which the physiological characteristics of PEPC transgenic rice were mainly studied. The results were as follows: (i) The activities of PEPC in PEPC transgenic rice were 20-fold higher than those in untransformed rice; the light-saturation photosynthetic rates and the carboxylation efficiency of PEPC transgenic rice were increased by 55% and 50% more than those of untransformed rice, respectively, while the CO2 compensation point decreased by 27%. (ii) The PS II photochemical efficiency (Fv/Fm) and photochemical quenching (qp) of transgenic PEPC rice decreased less in comparison with those of untransformed rice after the treatment with high light intensity (3 h) or methyl viologen (MV), a photooxidative reagent, which demonstrated that the tolerance of PEPC | JIAO Demao, LI Xia, HUANG Xueqing, CHI Wei, KUANG Tingyun & Ku SB Maurice1. Institute of Agrobiological Genetics and Physiology, Jiangsu Academy of Agricultural Sciences, Nangjing 210014, China 2. Institute of Botany, the Chinese Academy of Sciences, Beijing 100093, China 3. Botany Department, Washington State University, Pullman, WA 99164-4236, USA | 2001 | Chinese Science Bulletin2001，46，13： | 29 |
| 4 | ABNORMAL FLOWER AND GRAIN 1 encodes OsMADS6 and determines palea identity and affects rice grain yield and quality显示文摘The palea and lemma are floral organ structures unique to grasses;these structures form the hull and directly affect grain size and quality. However, the molecular mechanisms controlling the development of the hull are not well understood. In this study, we characterized the rice(Oryza sativa) abnormal flower and grain1(afg1) mutant, a new allele of OsMADS6. Similar to previously characterized osmads6 alleles, in the afg1 floret, the palea lost its marginal region and acquired the lemma identity. However, in contrast to other osmads6 alleles, the afg1 mutant showed altered grain size and grain quality, with decreased total starch and amylose contents, and increased protein and soluble sugar contents. The analysis of transcriptional activity suggested that AFG1 is a transcriptional activator and may affect grain size by regulating the expression levels of several genes related to cell expansion and proliferation in the afg1 mutant. These results revealed that AFG1 plays an important role in determining palea identity and affecting grain yield and quality in rice. | Xiaoqi Yu Saisai Xia Qiankun Xu Yuanjiang Cui Ming Gong Dali Zeng Qiang Zhang Lan Shen Guiai Jiao Zhenyu Gao Jiang Hu Guangheng Zhang Li Zhu Longbiao Guo Deyong Ren Qian Qian | 2020 | Science China(Life Sciences)2020，63，2： | 10 |
| 5 | Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6, PGE2, and MMP-13 expression显示文摘 | Zhi-feng WEI Xiao-lan JIAO Ting WANG Qian LU Yu-feng XIA Zheng-tao WANG Qing-long GUO Gui-xin CHOU Yue DAI | 2013 | Acta Pharmacologica Sinica2013，34，3： | 10 |
| 6 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 7 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 8 | Can Cadmium Uptake by Chinese Cabbage be Reduced After Growing Cd-Accumulating Rapeseed?显示文摘Rapeseed (Brassica campestris L.), a Cd-accumulating crop, is effective in reducing plant-available Cd from soil. A pot experiment was conducted to test the hypothesis that the Cd uptake by Chinese cabbage (Brassica pekinensis Rupr.) grown in rotation with rapeseed would be reduced due to the efficient removal of bioavailable Cd from soil solution by the rapeseed crops. The Cd removal by shoot for the rapeseed cultivar Zhucang Huazi ranged from 0.24% to 0.99% in natural Cd-contaminated soil (soil A) and from 0.63% to 1.23% in artificial Cd-contaminated soil (soil B) during the growth period of 4–7 weeks; whereas that for the rapeseed cultivar Chuanyou II-93 ranged from 0.25% to 0.66% and from 0.38% to 1.02%, respectively. Chinese cabbage grown in the pots with soil A for five weeks after harvesting rapeseed exhibited a significantly lower Cd concentration compared to that grown in the control pots (uncropped with rapeseed). However, the rotation of rapeseed did not lower the Cd concentration of Chinese cabbage on soil B. Although an increase of Cd uptake was observed in the rapeseed cultivars with growth time, and the decrease of soil NH 4 OAc-extractable Cd was found only in the natural rather than artificial Cd-contaminated soil. | SU De-Chun , JIAO Wei-Ping, ZHOU Man and CHEN Xia College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193 (China) | 2010 | Pedosphere2010，20，1： | 9 |
| 9 | Large-Scale Membrane Bioreactors for Industrial Wastewater Treatment in China:Technical and Economic Features,Driving Forces,and Perspectives显示文摘Membrane bioreactors(MBRs)have been and will continue playing an important role in industrial wastewater treatment and reuse in China.The sustainable development of MBR technology in its mature-application stage requires reciprocal interactions between engineering and research participants.Thus,in this study,a total of 182 large-scale MBR projects treating industrial wastewater(with individual treatment capacities5000 m3d1)commissioned and under construction from 2003 to 2019 were analyzed comprehensively.Fast growth of the cumulative treatment capacity was observed,with extension to diverse industries,and the super large-scale was enhanced recently.The treatment processes,pollutant removal efficiencies,and actual operational parameters were summarized regarding the particularity of industrial wastewater compared to municipal wastewater.Economic features including the total investment costs of the projects,their total footprint,and their operational energy consumption were analyzed as well.A vigorous MBR market has formed in China with the fast development of membrane elements and engineering suppliers,continuously increasing official oriented projects,and responsive and innovative business modes.MBR technology has been mostly applied in specific economic zones and water-deficient areas,but its widespread use all over China is foreseeable considering the vast future market for industrial wastewater treatment and recycling.The policy–economy and market–technology driving forces revealed that MBR is consistent with the national development demand.According to the survey and analysis,prospective development in both engineering and research aspects of MBR is proposed to maintain its competitive edge. | Jiao Zhang Kang Xiao Ziwei Liu Tingwei Gao Shuai Liang Xia Huang | 2021 | Engineering2021，7，6： | 9 |
| 10 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 11 | A preliminary study of chronology for a newly-discovered ancient city and five archaeological sites in Lop Nor, China显示文摘In the past century, it has long been debated in the archeological, historical, geographical, and many other related communities where the capital of the Luolan and Shanshan states was in the Lop Nor region. This paper presents three AMS radiocarbon ages from a newly-discovered ancient city at about 6.3 km to the northwest of the Xiaohe Graveyard, and fifteen new radiocarbon ages from the Loulan (LA), LE, Qieerqiduke, Milan, and Tuyin sites in Lop Nor. The new investigation shows that the age of newly-discovered ancient city is at ca. 440–500 AD, belonging to the Northern Wei Dynasty (386–534 AD). This is about 100–300 years younger than Loulan (ca. 100–230 AD), LE (ca. 230–300 AD), Qieerqiduke (ca. 200 AD), and Tuyin (ca. 100 AD). A wooden beam from Milan fortress is dated to ca. 370 AD, while the age on north wall at west gate of the fortress is younger, around 770 AD, suggesting that its construction time might be at the Tang Dynasty. According to 14C ages, cultural relic style, and the geographical location, the newly-discovered ancient city is probably attributed to 'Zhubin City', as documented in the historical literature. Temporally, we name the city 'ancient Zhubin River City'. However, the characteristics and functions of this ancient city are largely unknown and need more detailed archaeological excavation and investigation in the future. Given its location near the ancient postal relay of Alagan on the crossroad, there is no doubt that the newly-discovered city was at an important geographical position on the Silk Road, no matter whether it was called 'Zhubin City', or 'Lielo City', or the capital of Loulan state–'Yuni City'. Our findings provide new evidence for the temporal and spatial distribution of ancient relic sites and the development of civilization in western China, thus contributing to our understanding of the relationship between human activities and environmental change in the Lop Nor region. | LU HouYuan XIA XunCheng LIU JiaQi QIN XiaoGuang WANG FuBao YIDILISI Abuduresule ZHOU Li Ping MU GuiJin JIAO YingXin LI JingZhi | 2010 | Chinese Science Bulletin2010，55，1： | 8 |
| 12 | Predictive validity of BODE index for anxious and depressive symptoms in patients with chronic obstructive pulmonary disease显示文摘背景焦虑和消沉是长期的妨碍的肺的疾病(COPD ) 的二最普通、很可修改的 comorbidities 并且在健康和预后上有独立效果。FEV1% 被显示了是焦虑和消沉的一个差的预言者。身体团索引,气流阻塞的度,呼吸困难,和锻练能力(预示) 索引是可以在 COPD 病人预言健康结果的一个多维的评价系统。这研究的目的是在这是的 COPD patients.Methods 为焦急、压抑的症状调查 BODE 索引的预兆的有效性 multicenter 在有稳定的 COPD 的 256 个病人的未来的代表性的学习。焦急、压抑的症状用医院焦虑和消沉规模(HADS ) 被估计。在焦虑,消沉和潜在的预言者之间的关系(包括 BODE 索引) 被一个二进制逻辑回归模型分析。焦急、压抑的结果题目走了更短的六分钟的走距离(6MWD ) ,有更多的呼吸困难,一更高预示索引,并且降低生活的健康相关的质量(P < 0.01 ) 。焦虑和萧条分数显著地被相关与预示指数,分别地(r=0.335, P < 0.001;r=0.306, P < 0.001 ) 。焦虑和消沉的流行增加了与预示舞台增加(P < 0.05 ) 。根据二进制逻辑回归,因为它包括了呼吸困难和 6MWD, BODE 索引是焦虑和消沉的一个好、独立的预言者,它被显示是主要 determinants.Conclusions 为焦虑和消沉的 BODE 索引的预兆的有效性被表明。我们建议 BODE 索引应该在对 COPD 严厉的评价被包括。 | AN Li LIN Ying-xiang YANG Ting ZHANG Hong JIAO Xia ZHANG Shu CHANG Xiao-hong WANG Zhao-mei WANG Chen | 2010 | Chinese Medical Journal2010，，14： | 8 |
| 13 | 15-Deoxy-△12,14 -prostaglandtn J2 alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy显示文摘肝的 ischemia-reperfusion (I/R ) 损害是在许多情形发生并且导致差的预后的一个普通临床的缺陷。apoptosis 和 autophagy 被显示了在肝的 I/R 损害贡献房间死亡。15-Deoxy-12,14-prostaglandin J 2(15d-PGJ2 ) 是学习最好的反煽动性的前列腺素之一,它被验证了在细胞和动物模型的各种各样的类型施加反煽动性、房间保护的功能。在这研究,我们在老鼠在 apoptosis 和 autophagy 上探索了 15d-PGJ2 的效果肝的 I/R 损害和它的可能的机制。一个模型部分(70%)肝的温暖的局部缺血在 Balb/c 老鼠被建立,并且在浆液的病理学的变化和肝纸巾在 6 , 12 ,和 24 h 被检测外科以后 15d-PGJ2 ( 2.5 , 7.5 , 15 g , iv )被管理 30 min 优先外科。有 15d-PGJ2 的预告的处理(7.5, 15 g ) 浆液中高音和著名计算机生产厂商层次的剂量依赖者减小象减轻的织物一样证实的显著地改善的 I/R-induced 肝的损害损坏。15d-PGJ2 预告的处理显著地减少了浆液 TNF-1 和 IL-1 层次和 F4/80 的肝的表示,巨噬细胞的主要 biomarker。15d-PGJ2 预告的处理 upregulated Bcl-2/Bax 比率,因此在肝减少 apoptotic 房间的数字。15d-PGJ2 预告的处理更加压制了 Beclin-1 和 LC3 的表示,因此减少在肝的 autophagosomes 的数字。而且, 15d-PGJ2 预告的处理激活 Nrf2 并且在肝禁止了一条 ROS/HIF1/BNIP3 小径。有 PPAR 受体 blocker GW9662 的预告的处理(2 g, ip ) 部分在肝的 I/R 损害上颠倒了 15d-PGJ2 的保护的效果。在结论,我们的结果在肝的 I/R 损害,可以在 Kupffer 房间并且在 Nrf2 小径的激活上的激活依靠减小的效果,它导致 ROS 产生的抑制, apoptosis,和 autophagy 上证实 15d-PGJ2 的保护的效果。 | Kan CHEN Jing-jing LI Sai-nan LI Jiao FENG Tong LIU Fan WANG Wei-qi DAI Yu-jing XIA Jie LU Ying-qun ZHOU Chuan-yong GUO | 2017 | Acta Pharmacologica Sinica2017，38，5： | 8 |
| 14 | New insight into adsorption characteristics and mechanisms of the biosorbent from waste activated sludge for heavy metals显示文摘The adsorption characteristics and mechanisms of the biosorbent from waste activated sludge were investigated by adsorbing Pb2+and Zn2+in aqueous single-metal solutions. A p H value of the metal solutions at 6.0 was beneficial to the high adsorption quantity of the biosorbent. The optimal mass ratio of the biosorbent to metal ions was found to be 2. A higher adsorption quantity of the biosorbent was achieved by keeping the reaction temperature below 55°C. Response surface methodology was applied to optimize the biosorption processes, and the developed mathematical equations showed high determination coefficients(above 0.99 for both metal ions) and insignificant lack of fit(p = 0.0838 and 0.0782 for Pb2+and Zn2+, respectively). Atomic force microscopy analyses suggested that the metal elements were adsorbed onto the biosorbent surface via electrostatic interaction. X-ray photoelectron spectroscopy analyses indicated the presence of complexation(between –NH2,-CN and metal ions) and ion-exchange(between –COOH and metal ions). The adsorption mechanisms could be the combined action of electrostatic interaction, complexation and ion-exchange between functional groups and metal ions. | Yun Zhou Zhiqiang Zhang Jiao Zhang Siqing Xia | 2016 | Journal of Environmental Sciences2016，28，7： | 7 |
| 15 | The gas sensing properties of TiO_2 nanotubes synthesized by hydrothermal method显示文摘在这份报纸, TiO2 nanotubes 被热水的方法在 150 点用 10 mol/L NaOH | Yan Li Wang Shun Tan Jia Wang Zhi Jin Tan Qiu Xia Wu Zheng Jiao Ming Hong Wu | 2011 | Chinese Chemical Letters2011，22，5： | 7 |
| 16 | Overview of CCKS 2020 Task 3: Named Entity Recognition and Event Extraction in Chinese Electronic Medical Records显示文摘The China Conference on Knowledge Graph and Semantic Computing(CCKS)2020 Evaluation Task 3 presented clinical named entity recognition and event extraction for the Chinese electronic medical records.Two annotated data sets and some other additional resources for these two subtasks were provided for participators.This evaluation competition attracted 354 teams and 46 of them successfully submitted the valid results.The pre-trained language models are widely applied in this evaluation task.Data argumentation and external resources are also helpful. | Xia Li Qinghua Wen Hu Lin Zengtao Jiao Jiangtao Zhang | 2021 | Data Intelligence2021，3，3： | 6 |
| 17 | Identification of Serum Exosomal MicroRNA Expression Profiling in Menopausal Females with Osteoporosis by High-throughput Sequencing显示文摘Estrogen deficiency,which mainly occurs in postmenopausal women,is a primary reason for osteoporosis in clinical diagnosis.However,the molecular regulation of osteoporosis in menopausal females is still not adequately explained in the literature,with the diagnosis and treatment for osteoporosis being limited.Herein,exosomal microRNAs(miRNAs)were used to evaluate their diagnosis and prediction effects in menopausal females with osteoporosis.In this study,6 menopausal females without osteoporosis and 12 menopausal females with osteoporosis were enrolled.The serum exosomes were isolated,and the miRNA expression was detected by miRNA high-throughput sequencing.Exosomal miRNA effects were analyzed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses.The miRNA-targeted genes were evaluated by Targetscan 7.2 and the protein-protein interactions(PPI)by STRING.Hub genes were analyzed by the CytoHubba app of Cytoscape.The results showed that 191 aberrant miRNAs were found in the group of menopausal females with osteoporosis,including 72 upregulated miRNAs and 121 downregulated miRNAs.Aberrant miRNAs were involved in many signaling pathways,such as the Wnt,MAPK,and Hippo pathways.Based on PPI network analysis,FBXL3,FBXL13,COPS2,UBE2D3,DCUN1D1,DCUN1D4,CUL3,FBXO22,ASB6,and COMMD2 were the 10 most notable genes in the PPI network.In conclusion,aberrant serum exosomal miRNAs were associated with an altered risk of osteoporosis in menopausal females and may act as potential biomarkers for the prediction of risk of osteoporosis in menopausal females. | Jian-li SHAO Heng LI Xiao-rong ZHANG Xia ZHANG Zhi-zhong LI Gen-long JIAO Guo-dong SUN | 2020 | Current Medical Science2020，40，6： | 6 |
| 18 | Nanoparticle monolayer-based flexible strain gauge with ultrafast dynamic response for acoustic vibration detection显示文摘The relatively poor dynamic response of current flexible strain gauges has prevented their wide adoption in portable electronics. In this work, we present a greatly improved flexible strain gauge, where one strip of Au nanoparticle (NP) monolayer assembled on a polyethylene terephthalate film is utilized as the active unit. The proposed flexible gauge is capable of responding to applied stimuli without detectable hysteresis via electron tunneling between adjacent nanoparticles within the Au NP monolayer. Based on experimental quantification of the time and frequency domain dependence of the electrical resistance of the proposed strain gauge, acoustic vibrations in the frequency range of 1 to 20,000 Hz could be reliably detected. In addition to being used to measure musical tone, audible speech, and creature vocalization, as demonstrated in this study, the ultrafast dynamic response of this flexible strain gauge can be used in a wide range of applications, including miniaturized vibratory sensors, safe entrance guard management systems, and ultrasensitive pressure sensors. | Lizhi Yi Weihong Jiao Ke Wu Lihua Qian Xunxing Yu Qi Xia Kuanmin Mao Songliu Yuan Shuai Wang Yingtao Jiang | 2015 | Nano Research2015，8，9： | 6 |
| 19 | Germline mutation analysis of hPMS2 gene in Chinese families with hereditary nonpolyposis colorectal cancer显示文摘AIM: To study the germline mutation of hPMS2 gene in 26 unrelated Chinese hereditary nonpolyposis colorectal cancer (HNPCC) probands and to fulfill the screening strategy for HNPCC in Chinese. METHODS: Genomic DNA was extracted from the peripheral blood. To avoid the interference of pseudogene in detection of the remaining 11 exons (exon 1-5, 9, 11-15), long-range polymerase chain reaction (PCR) was conducted to amplify the complete coding region of hPMS2 gene firstly. Then 1/8 of the PCR productswere used as template to amplify the individual exon respectively and DNA sequencing was done. Direct DNA sequencing of the conventional PCR products of exon 6, 7, 8 and 10 of hPMS2 gene was performed. The same analysis was made in 130 healthy persons without family histories of HNPCC to further investigate the pathological effects of the detected missense mutation. RESULTS: One HNPCC proband fulf illed Bethesda guidelines and was found to carry the germline mutation of hPMS2 gene, which has not been reported in Chinese HNPCC families. It was a missense mutation at c.1532C>T of exon 11. It was detected in three controls as well with an occurrence rate of 2.3% (3/130). Since it could not be found in the PMS2-single nucleotide polymorphism (SNP) database, this missense mutation is a new SNP unreported up to date. Meanwhile, 260 reported SNPs of hPMS2 gene were detected in the 26 HNPCC probands. The 2nd and 5th exons were probably the hot SNP regions of hPMS2 gene in Chinese HNPCC families involving 53.1% of all reported SNP. CONCLUSION: The germline mutation of hPMS2 gene may be rare in Chinese HNPCC families. The 2nd and 5th exons are hot SNP regions of hPMS2 gene. | Xia Sheng, Xiao-Yan Zhou, Xiang Du, Tai-Ming Zhang, WeiQi Sheng, Da-Ren Shi, Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai 200032, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China Heng-Hua Zhou, Department of Pathology, Shanghai Ninth People’s Hospital Affi liated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China San-Jun Cai, Department of Abdominal Surgery, Cancer Center, Fudan University, Shanghai 200032, China | 2010 | World Journal of Gastroenterology2010，16，30： | 6 |
| 20 | Image Segmentation via Mean Shift and Loopy Belief Propagation显示文摘This paper presents a novel approach that can quickly and effectively partition images based on fully exploiting the spatially coherent property. We propose an algorithm named iterative loopy belief propagation(iLBP) to integrate the homogenous regions and prove its convergence. The image is first segmented by mean shift(MS) algorithm to form over-segmented regions that preserve the desirable edges and spatially coherent parts. The segmented regions are then represented by region adjacent graph(RAG) . Motivated by k-means algorithm,the iLBP algorithm is applied to perform the minimization of the cost function to integrate the over-segmented parts to get the final segmentation result. The image clustering based on the segmented regions instead of the image pixels reduces the number of basic image entities and enhances the image segmentation quality. Comparing the segmentation result with some existing algorithms,the proposed algorithm shows a better performance based on the evaluation criteria of entropy especially on complex scene images. | JIA Jianhua,JIAO Licheng,CHANG Xia Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China/Institute of Intelligent Information Processing,Xidian University,Xi’an 710071,Shaanxi,China | 2010 | Wuhan University Journal of Natural Sciences2010，15，1： | 5 |
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