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| 1 | Oxidative stress in neurodegenerative diseases显示文摘Reactive oxygen species are constantly produced in aerobic organisms as by-products of normal oxygen metabolism and include free radicals such as superoxide anion (O2-) and hydroxyl radical (OH-), and non-radical hydrogen peroxide (H2O2). The mitochondrial respiratory chain and enzymatic reactions by various enzymes are endogenous sources of reactive oxygen species. Exogenous reactive oxygen species -inducing stressors include ionizing radiation, ultraviolet light, and divergent oxidizing chemicals. At low concentrations, reactive oxygen species serve as an important second messenger in cell signaling; however, at higher concentrations and long-term exposure, reactive oxygen species can damage cellular macromolecules such as DNA, proteins, and lipids, which leads to necrotic and apoptotic cell death. Oxidative stress is a condition of imbalance between reactive oxygen species formation and cellular antioxidant capacity due to enhanced ROS generation and/or dysfunction of the antioxidant system. Biochemical alterations in these macromolecular components can lead to various pathological conditions and human diseases, especially neurodegenerative diseases. Neurodegenerative diseases are morphologically featured by progressive cell loss in specific vulnerable neuronal cells, often associated with cytoskeletal protein aggregates forming inclusions in neurons and/or glial cells. Deposition of abnormal aggregated proteins and disruption of metal ions homeostasis are highly associated with oxidative stress. The main aim of this review is to present as much detailed information as possible that is available on various neurodegenerative disorders and their connection with oxidative stress. A variety of therapeutic strategies designed to address these pathological processes are also described. For the future therapeutic direction, one specific pathway that involves the transcription factor nuclear factor erythroid 2-related factor 2 is receiving considerable attention. | Xueping Chen Chunyan Guo Jiming Kong | 2012 | Neural Regeneration Research2012，7，5： | 12 |
| 2 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 3 | Single Point Positioning with Sequential Least-Squares Filter and Estimated Real-Time Stochastic Model显示文摘获得更高精确的位置估计,随机的模型被估计由用观察的剩余,,因此随机的模型更写实地在大小描述噪音和偏爱。由使用 GPS 数据和广播位置推算历,在亚米水平显示精确位置估计的数字结果是可获得的。 | WU Yun GUO Jiming | 2008 | Geo-Spatial Information Science2008，11，1： | 7 |
| 4 | The Laplacian spectral radii of unicyclic and bicyclic graphs with n vertices and k pendant vertices显示文摘In this paper,we determine graphs with the largest Laplacian spectral radius among the unicyclic and the bicyclic graphs on n vertices with k pendant vertices,respectively. | GUO JiMing Department of Applied Mathematics,China University of Petroleum,Dongying 257061,China | 2010 | Science China Mathematics2010，53，8： | 6 |
| 5 | 2019年度大气科学领域项目评审与研究成果分析显示文摘2018年6月,第八届国家自然科学基金委员会(以下简称自然科学基金委)第一次全体委员会议审议通过了新时代基金深化改革的总体目标和改革思路,通过确立基于“鼓励探索、突出原创;聚焦前沿、独辟蹊径;需求牵引、突破瓶颈;共性导向、交叉融通”4类科学问题属性分类的资助导向。“大气科学”学科被列为而上项冃分类评审试点改革学科。因此,大气学科处2019年的分类评审工作主要以“落实资助导向、推动精准资助”为总体思路,以鼓励和支持原创性、交叉性的科学研究,扶持薄弱学科.促进各学科均衡、协调和可持续发展为原则.开展相关工作。 | 李积明 刘哲 郭郁葱 彭怡然 闻新宇 Li Jiming Liu Zhe Guo Yucong Peng Yiran Wen Xinyu | 2019 | 地球科学进展2019，34，11： | 5 |
| 6 | Fine particulate matter(PM_(2.5)/PM_(1.0)) in Beijing,China: Variations and chemical compositions as well as sources显示文摘Particulate matter(i.e.,PM_(1.0) and PM_(2.5)),considered as the key atmospheric pollutants,exerts negative effects on visibility,global climate,and human health by associated chemical compositions.However,our understanding of PM and its chemical compositions in Beijing under the current atmospheric environment is still not complete after witnessing marked alleviation during 2013–2017.Continuous measurements can be crucial for further air quality improvement by better characterizing PM pollution and chemical compositions in Beijing.Here,we conducted simultaneous measurements on PM in Beijing during 2018–2019.Results indicate that annualmean PM_(1.0) and PM_(2.5) concentrations were 35.49±18.61μg/m^(3) and 66.58±60.17μg/m^(3),showing a positive response to emission controls.The contribution of sulfate,nitrate,and ammonium(SNA)played an enhanced role with elevated PM loading and acted as the main contributors to pollution episodes.Discrepancies observed among chemical species between PM_(1.0) and PM_(2.5) in spring suggest that sand particles trend to accumulate in the range of 1–2.5μm.Pollution episodes occurred accompanied with southerly clusters and high formation of SNA by heterogeneous reactions in summer and winter,respectively.Results from positive matrix factorization(PMF)combined with potential source contribution function(PSCF)models showed that potential areas were seasonal dependent,secondary and vehicular sources became much more important compared with previous studies in Beijing.Our study presented a continuous investigation on PM and sources origins in Beijing,which provides a better understanding for further emission control as well as a reference for other cities in developing countries. | Lining Luo Xiaoxuan Bai Shuhan Liu Bobo Wu Wei Liu Yunqian Lv Zhihui Guo Shumin Lin Shuang Zhao Yan Hao Jiming Hao Kai Zhang Aihua Zheng Hezhong Tian | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 7 | Data Transformation for Super-totalstation Positioning System Integrated by GPS and Totalstation显示文摘This paper focuses on the integration and data transformation between GPS and totalstation.It emphasizes on the way to transfer the WGS84 Cartesian coordinates to the local two_dimensional plane coordinates and the orthometric height GPS receiver,totalstation,radio,notebook computer and the corresponding software work together to form a new surveying system,the super_totalstation positioning system(SPS) and a new surveying model for terrestrial surveying.With the help of this system,the positions of detail points can be measured. | GUO Jiming ZHANG Zhenglu LUO Nianxue HUANG Quanyi | 2003 | Geo-Spatial Information Science2003，6，1： | 2 |
| 8 | Evaluating the air quality impacts of the 2008 Beijing Olympic Games: On-road emission factors and black carbon profiles显示文摘 | Xing Wang Dane Westerdahl Lung Chi Chen Ye Wu Jiming Hao Xiaochuan Pan Xinbiao Guo K. Max Zhang | 2009 | Atmospheric Environment2009，，30： | 2 |
| 9 | Numerical analysis of the effects of downhole dynamic conditions on formation testing while drilling显示文摘Formation testing while drilling is an innovative technique that is replacing conventional pressure testing in which the fluid sampling is conducted in a relatively short time following the drilling. At this time, mud invasion has just started, mudcake has not formed entirely and the formation pressure is not stable. Therefore, it is important to study the influence of the downhole dynamic environment on pressure testing and fluid sampling. This paper applies an oil-water two phase finite element model to study the influence of mudcake quality and mud filtrate invasion on supercharge pressure, pretest and sampling in the reservoirs of different permeability. However, the study is only for the cases with water based mud in the wellbore. The results illustrate that the mudcake quality has a significant influence on the supercharge pressure and fluid sampling, while the level of mud filtrate invasion has a strong impact on pressure testing and sampling. In addition, in-situ formation pressure testing is more difficult in low permeability reservoirs as the mud filtrate invasion is deeper and therefore degrades the quality of fluid sampling. Finally, a field example from an oil field on the Alaskan North Slope is presented to validate the numerical studies of the effects of downhole dynamic conditions on formation testing while drilling. | DI Dejia TAO Guo WANG Bing CHEN Xu SUN Jiming | 2014 | Petroleum Science2014，11，3： | 2 |
| 10 | Development and evaluation of the refined zenith tropospheric delay(ZTD)models显示文摘The tropospheric delay is a significant error source in Global Navigation Satellite System(GNSS)positioning and navigation.It is usually projected into zenith direction by using a mapping function.It is particularly important to establish a model that can provide stable and accurate Zenith Tropospheric Delay(ZTD).Because of the regional accuracy difference and poor stability of the traditional ZTD models,this paper proposed two methods to refine the Hopfield and Saastamoinen ZTD models.One is by adding annual and semi-annual periodic terms and the other is based on Back-Propagation Artificial Neutral Network(BP-ANN).Using 5-year data from 2011 to 2015 collected at 67 GNSS reference stations in China and its surrounding regions,the four refined models were constructed.The tropospheric products at these GNSS stations were derived from the site-wise Vienna Mapping Function 1(VMP1).The spatial analysis,temporal analysis,and residual distribution analysis for all the six models were conducted using the data from 2016 to 2017.The results show that the refined models can effectively improve the accuracy compared with the traditional models.For the Hopfield model,the improvement for the Root Mean Square Error(RMSE)and bias reached 24.5/49.7 and 34.0/52.8 mm,respectively.These values became 8.8/26.7 and 14.7/28.8 mm when the Saastamoinen model was refined using the two methods.This exploration is conducive to GNSS navigation and positioning and GNSS meteorology by providing more accurate tropospheric prior information. | Fei Yang Xiaolin Meng Jiming Guo Debao Yuan Ming Chen | 2021 | Satellite Navigation2021，2，1： | 2 |
| 11 | High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and nausea.This disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of disease.Recently,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be delineated.Here,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs). | Wenjing Wang Bin Su Lijun Pang Luxin Qiao Yingmei Feng Yabo Ouyang Xianghua Guo Hongbo Shi Feili Wei Xiaogang Su Jiming Yin Ronghua Jin Dexi Chen | 2020 | Cellular & Molecular Immunology2020，17，6： | 2 |
| 12 | Upper Jaramillo polarity transition and short geomagnetic event recorded in a loess section at Jingbian, northern China显示文摘Detailed rock-magnetic and paleomagnetic investigations have been carried out in a loess-paleosol sequence from the lower part ot unit S9 to the bottom of L11 at Jingbian (37.4° N, 108.8°E), which demonstrates that the Upper Jaramillo polarity reversal and a short geomagnetic event bounded within the Jaramillo normal subchron have been revealed. The duration of this short event was about 8.5 ka. The statistical analysis showed that the virtual geomagnet- | Bin Guo Rixiang Zhu Zhongli Ding Jiming Sun | 1999 | Chinese Science Bulletin1999，44，20： | 2 |
| 13 | Air quality for metals and sulfur in Shanghai, China, determined with moss bags显示文摘 | Tong Cao Min Wang Li An Yinghao Yu Yuxia Lou Shuiliang Guo Benrong Zuo Yan Liu Jiming Wu Yang Cao Zhirui Zhu | 2008 | Environmental Pollution2008，，： | 1 |
| 14 | A new upper bound for the Laplacian spectral radius of graphs显示文摘 | Guo Jiming | 2005 | Linear Algebra Appl2005，400，： | 1 |
| 15 | On the Laplacian spectral radius of a tree显示文摘 | Guo Jiming | 2003 | Linear Algebra Appl2003，368，： | 1 |
| 16 | On the second largest Laplacian eigenvalue of trees 显示文摘 | Guo Jiming | 2005 | Linear Algebra Appl2005，404，： | 1 |
| 17 | On the spectrual radius of trees显示文摘 | GUO Jiming TAN Shangwang | 2001 | Linear Algebra Appl2001，，329： | 1 |
| 18 | Investigation of Ionosphere TEC Distribution in China Region by GIM Model显示文摘In this paper, the TEC in China region is calculated by final GIM model and plotted as contour maps, the TEC value calculated from dual frequency GPS measurements(carrier-phase and pseudorange) is used as the reference truth and the TEC values from GIM models are then compared with the reference truth, and the accuracy and performance of GIM model in China region are analyzed and concluded. | GUO Jiming LIN Hui | 2005 | Geo-Spatial Information Science2005，8，3： | 1 |
| 19 | Tumor extracellular vesicles mediate anti-PD-L1 therapyresistance by decoying anti-PD-L1显示文摘PD-L1+tumor-derived extracellular vesicles(TEVs)cause systemic immunosuppression and possibly resistance to anti-PD-L1 antibody(αPD-L1)blockade.However,whether and how PD-L1+TEVs mediateαPD-L1 therapy resistance is unknown.Here,we show that PD-L1+TEVs substantially decoyαPD-L1 and that TEV-boundαPD-L1 is more rapidly cleared by macrophages,causing insufficient blockade of tumor PD-L1 and subsequentαPD-L1 therapy resistance.Inhibition of endogenous production of TEVs by Rab27a or Coro1a knockout reversesαPD-L1 therapy resistance.Either an increasedαPD-L1 dose or macrophage depletion mediated by the clinical drug pexidartinib abolishesαPD-L1 therapy resistance.Moreover,in the treatment cycle with the same total treatment dose ofαPD-L1,high-dose and low-frequency treatment had better antitumor effects than low-dose and highfrequency treatment,induced stronger antitumor immune memory,and eliminatedαPD-L1 therapy resistance.Notably,in humanized immune system mice with human xenograft tumors,both increasedαPD-L1 dose and high-dose and low-frequency treatment enhanced the antitumor effects ofαPD-L1.Furthermore,increased doses ofαPD-L1 andαPD-1 had comparable antitumor effects,butαPD-L1 amplified fewer PD-1+Treg cells,which are responsible for tumor hyperprogression.Altogether,our results reveal a TEV-mediated mechanism ofαPD-L1-specific therapy resistance,thus providing promising strategies to improveαPD-L1 efficacy. | Jiming Chen Jie Yang Wenhui Wang Danfeng Guo Chengyan Zhang Shibo Wang Xinliang Lu Xiaofang Huang Pingli Wang Gensheng Zhang Jing Zhang Jianli Wang Zhijian Cai | 2022 | Cellular & Molecular Immunology2022，19，11： | 1 |
| 20 | The Least Eigenvalue of Unicyclic Graphs with Application to Spectral Spread显示文摘Let U^(g)_(n)be the set of connected unicyclic graphs of order n and girth g.Let C(T_(1),T_(2),…,T_(g))∈U^(g)_(n)be obtained from a cycle v_(1)v_(2)…v_(g)v_(1)(in an anticlockwise direction)by identifying v_(i)with the root of a rooted tree T_(i)of order n_(i)for each i=1,2,…,g,where n_(i)≥1 and∑^(g)_(i=1)n_(i)=n.In this note,the graph with the minimal least eigenvalue(and the graph with maximal spread)in C(T_(1),T_(2),…,T_(g))is determined. | Jiming Guo Gege Zhang Zhiwen Wang Panpan Tong | 2022 | Algebra Colloquium2022，29，2： | 1 |
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