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| 1 | IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice显示文摘Strigolactones (SL ) ,一组类胡萝卜素导出 terpenoid 内酯,是压制射击由禁止腋的芽的长出分叉的 root-to-shoot 植物激素。矮子 53 (D53 ) ,表明小径的 SL 的关键抑压者,被推测调整 SL 反应的下游的 transcriptional 网络。然而, D53 指向的下游的抄写因素还都没被报导。这里,我们报导那理想的植物体系结构 1 (IPA1 ) ,在米饭的植物体系结构的一个关键管理者,在调整 tiller 数字和导致 SL 的基因表示作为 D53 的一个直接下游的部件工作。我们证明 D53 在 vivo 并且在 vitro 与 IPA1 交往并且压制 IPA1 的 transcriptional 激活活动。我们进一步证明 IPA1 能直接绑在 D53 倡导者并且在导致 SL 的 D53 表示的反馈规定起一个关键作用。这些调查结果表明 IPA1 是可能的与 D53 行动到的长推测的抄写因素之一调停在米饭的调整 SL 的 tiller 发展。 | Xiaoguang Song Zefu Lu Hong Yu Gaoneng Shao Jinsong Xiong Xiangbing Meng Yanhui Jing Guifu Liu Guosheng Xiong Jingbo Duan Xue-Feng Yao Chun-Ming Liu Hongqing Li Yonghong Wang Jiayang Li | 2017 | Cell Research2017，27，9： | 48 |
| 2 | Simulation of shock wave buffet and its suppression on an OAT15A supercritical airfoil by IDDES显示文摘In the present paper,extremely unsteady shock wave buffet induced by strong shock wave/boundary-layer interactions (SWBLI) on the upper surface of an OAT15A supercritical airfoil at Mach number of 0.73 and angle of attack of 3.5 degrees is first numerically simulated by IDDES,one of the most advanced RANS/LES hybrid methods.The results imply that conventional URANS methods are unable to effectively predict the buffet phenomenon on the wing surface;IDDES,which involves more flow physics,predicted buffet phenomenon.Some complex flow phenomena are predicted and demonstrated,such as periodical oscillations of shock wave in the streamwise direction,strong shear layer detached from the shock wave due to SWBLI and plenty of small scale structures broken down by the shear layer instability and in the wake.The root mean square (RMS) of fluctuating pressure coefficients and streamwise range of shock wave oscillation reasonably agree with experimental data.Then,two vortex generators (VG) both with an inclination angle of 30 degrees to the main flow directions are mounted in front of the shock wave region on the upper surface to suppress shock wave buffet.The results show that shock wave buffet can be significantly suppressed by VGs,the RMS level of pressure in the buffet region is effectively reduced,and averaged shock wave position is obviously pushed downstream,resulting in increased total lift. | HUANG JingBo XIAO ZhiXiang LIU Jian FU Song | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 24 |
| 3 | Prediction of separation flows around a 6:1 prolate spheroid using RANS/LES hybrid approaches显示文摘这篇论文论述混合平均 Reynolds 的 Navier 司烧(RANS ) 并且为在在 6:1 附近的攻击的高角度的分开的流动的 large-eddy-simulation (LES ) 方法延长球状体。在这个工作学习的 RANS/LES 混合方法基于 Spalart Allmaras ( S A )包括分开的旋涡模拟( DES ), Menter 的 k ω
shear-stress-transport ( SST )和有弱非线性的旋涡粘性明确的表达的 k ω
(威尔科克斯Durbin+,WD+)模型和 zonal-RANS/LES 方法基于 SST 和WD+模型。从到在核心流动区域的 LES 的墙附近的 RANS 的开关通过为带的混合方法混合功能的一个流动依赖者的实现是光滑的。所有混合方法被设计为依附的流动有一个 RANS 模式并且为分开的流动有 LES 行为。这篇论文的主要目的是使用混合方法因为高级雷纳兹数字在延长球状体附近分开了流动在高发生。有第四顺序的人工的粘性的一个第四顺序的中央计划被申请空间 differencing。充分含蓄更低上面对称 -- 有假时间亚重复的高斯 Seidel 作为时间的区别被拿。有可得到的大小的比较为速度的压力分发,皮肤磨擦,和侧面被执行,等等。对实验的合理同意,为格子和基本骚乱上的效果的财务当模特儿,为分离流动被获得。 | Zhixiang Xiao Yufei Zhang Jingbo Huang Haixin Chen Song Fu School of Aerospace Engineering,Tsinghua University,Beijing 100084,China | 2007 | Acta Mechanica Sinica2007，23，4： | 10 |
| 4 | Study of control effects of vortex generators on a supercritical wing显示文摘Flows around vortex generators(VGs),which serve as one of the important flow control methods,are investigated by solving Reynolds-averaged Navier-Stokes(RANS)equations.The influences on the main flow of VGs are intended to explore.Firstly, the flow around a single VG on a flat plane is computed to validate the schemes and to acquire basic knowledge of this kind of flow.Secondly,transonic flow past a standard model,named by ONERA-M6 wing,is predicted to investigate the flow features of shockwave/boundary-layer interactions(SWBLI).Thirdly,the effects of a row of VGs mounted about 25%local chord on a supercritical wing are analyzed in transonic condition with strong SWBLI.Lastly,VGs are mounted more upwind(about 3.5%local chord)to explore the effects at low speed and high incidence condition.The numerical results show that seven VGs can effectively suppress the separations behind the strong SWBLI and decrease spanwise flow and wing-tip vortex in transonic condition.VGs also can decrease the large scope of separation over the wing at low speed with high angle of attack. | HUANG JingBo 1 ,XIAO ZhiXiang 1 ,FU Song 1 &ZHANG Miao 2 1 School of Aerospace Engineering,Tsinghua University,Beijing 100084,China 2 Shanghai Aircraft Design and Research Institute of COMAC,Shanghai 200232,China | 2010 | Science China(Technological Sciences)2010，53，8： | 5 |
| 5 | Spreading of Human Babesiosis in China:Current Epidemiological Status and Future Challenges显示文摘Human babesiosis is an infection caused by intraerythrocytic protozoa of the genus Babesia and is a worldwide emerging tick-borne disease(1).Babesia is mainly parasitized in erythrocytes of human or other vertebrates and transmitted by the bite of ticks,blood transfusion,or organ transplantation(1).Humans are generally susceptible to Babesia,especially those who are immunocompromised with conditions such as splenectomy or splenic dysfunction,as well as those of old age,with infirmity,or with other severe diseases. | Muxin Chen Qin Liu Jingbo Xue Shaohong Chen Dana Huang Yingfang Yu Yuchun Cai Yan Lu Peng Song Renli Zhang Lin Ai Jiaxu Chen | 2020 | China CDC weekly2020，2，33： | 3 |
| 6 | High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide显示文摘High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitative and quantitative analysis of metabolites.This study used the established Yang Huang syndrome(YHS)mouse model to evaluate the efficacy of geniposide(GEN).Urine metabolic data were quantified by ultraperformance liquid chromatography-tandem mass spectrometry.The non-target screening of the massive biological information dataset was performed,and a total of 33 metabolites,including tyramine glucuronide,aurine,and L-cysteine,were identified relating to YHS.These differential metabolites directly participated in the disturbance of phase I reaction and hydrophilic transformation of bilirubin.Interestingly,they were completely reversed by GEN.While,as the auxiliary technical means,we also focused on the molecular prediction and docking results in network pharmacological and integrated analysis part.We used integrated analysis to communicate the multiple results of metabolomics and network pharmacology.This study is the first to report that GEN indirectly regulates the metabolite“tyramine glucuronide”through its direct effect on the target heme oxygenase 1 in vivo.Meanwhile,heme oxygenase-1,a prediction of network pharmacology,was the confirmed metabolic enzyme of phase I reaction in hepatocytes.Our study indicated that the combination of high-throughput metabolomics and network pharmacology is a robust combination for deciphering the pathogenesis of the traditional Chinese medicine(TCM)syndrome. | Heng Fang Aihua Zhang Xiaohang Zhou Jingbo Yu Qi Song Xijun Wang | 2020 | Frontiers of Medicine2020，14，5： | 3 |
| 7 | Regulation of innate immune responses by rabies virus显示文摘Rabies virus(RABV)is an infectious and neurotropic pathogen that causes rabies and infects humans and almost all warm-blooded animals,posing a great threat to people and public safety.It is well known that innate immunity is the critical first line of host defense against viral infection.It monitors the invading pathogens by recognizing the pathogen-associated molecular patterns and danger-associated molecular patterns through pattern-recognition receptors,leading to the production of type I interferons(IFNα/β),inflammatory cytokines,and chemokines,or the activation of autophagy or apoptosis to inhibit virus replication.In the case of RABV,the innate immune response is usually triggered when the skin or muscle is bitten or scratched.However,RABV has evolved many ways to escape or even hijack innate immune response to complete its own replication and eventually invades the central nervous system(CNS).Once RABV reaches the CNS,it cannot be wiped out by the immune system or any drugs.Therefore,a better understanding of the interplay between RABV and innate immu-nity is necessary to develop effective strategies to combat its infection.Here,we review the innate immune responses induced by RABV and illustrate the antagonism mechanisms of RABV to provide new insights for the control of rabies. | Haili Zhang Jingbo Huang Yumeng Song Xingqi Liu Meichen Qian Pei Huang Yuanyuan Li Ling Zhao Hualei Wang | 2022 | Animal Models and Experimental Medicine2022，5，5： | 2 |
| 8 | Effect of Trace Sn on Pitting Behaviors of High Voltage Anode Aluminum Foil显示文摘The effect of trace Sn on the pitting morphology of high voltage anode aluminum foils was investigated.The distributions of microelement Sn,Fe,Si,Cu and Mg in the surface layer of aluminum foils with different Sn content were determined by using a secondary ion mass spectrometer.It was found that the micro-alloyed Sn is enriched at the external surface.The mechanism of pitting behavior of trace Sn on aluminum surface is similar with that of lead.Enrichment of Sn in the surface layer provides large numbers of sites for initiation of pitting corrosion,while pitting sites appeared relatively inhomogenously in the foils without Sn.Sn,as an eco-friendly microelement,can be applied to replace Pb in improving the homogenous pitting behaviors of high voltage aluminum foils,in which the volume fraction of cube texture is not reduced. | Jingbo SONG Weimin MAO Hong YANG Huiping FENG | 2008 | Journal of Materials Science & Technology2008，24，5： | 2 |
| 9 | Synergy of a hierarchical porous morphology and anionic defects of nanosized Li_(4)Ti_(5)O_(12) toward a high-rate and large-capacity lithium-ion battery显示文摘Exploring electrode materials with a high volumetric energy density and high rate capability remains of a great challenge for nanosized-Li_(4)Ti_(5)O_(12)(LTO)batteries.Here,hierarchical porous Ti^(3+)-C-N-Br co-doped LTO(LTOCPB-CC)is synthesized using carboxyl-grafted nanocarbon(CC)and cetylpyridinium bromide(CPB)as combined structure-directing agents.Ti^(4+)-O-CPB/Li^(+)-CC is designed as a new molecular chelate,in which CPB and CC promote the uniform mixing of Li^(+)and Ti^(4+)and control the morphology of TiO_(2) and the final product.The defects(oxygen vacancies and ion dopants)formed during the annealing process increase the electron/hole concentration and reduce the band gap,both of which enhance the n-type electron modification of LTO.As-prepared LTOCPB-CC has a large specific surface area and high tap density,as well as a high electronic conductivity(2.84×10^(-4) S cm^(-1))and ionic conductivity(3.82×10^(-12)cm^(2) s^(-1)),which are responsible for its excellent rate capability(157.7 mA h g^(-1) at 20 C)and stable long-term cycling performance(0.008% fade per cycle after 1000 cycles at 20 C). | Yanan Li Qianlin Chen Qiangqiang Meng Shulai Lei Fangxiang Song Jingbo Ma | 2021 | Journal of Energy Chemistry2021，30，3： | 2 |
| 10 | Design, Synthesis, Antifungal Activities and SARs of (R)-2-Aryl-4,5-dihydrothiazole-4-carboxylic Acid Derivatives显示文摘基于自然产品 2-aryl-4,5-dihydrothiazole-4-carboxylic 酸的结构,一系列新奇(R)-2-aryl-4,5-dihydrothiazole-4-carboxylic 酸衍生物被设计并且综合。他们的结构被 1 H NMR, 13 C NMR 和 HRMS。复合 9b 的单个水晶结构被 X 光检查衍射分析决定。抗真菌的活动第一次被评估。生物鉴定结果显示展出的大多数混合物节制到好抗真菌的活动。复合 13a 的抗真菌的活动(对 Cercospora arachidicola Hori ) , 13d (对 Alternaria solani ) ,并且 16e (对 Cercospora arachidicola Hori ) 分别地,是 61.9% , 67.3% 和 61.9% 它比商业杀真菌剂 chlorothalonil 和 carbendazim 的那些高。而且,复合 13d 对测试的 7 种真菌展出了优秀抗真菌的活动(66.7% , 77.3% , 63.0% , 87.9% , 70.0% , 70.0% 和 80.0% 在 50 µg ? mL ) 。因此, 13d 能为抗真菌的代理人的发展被用作新铅结构。 | Jingbo Liu Yuxin Li Youwei Chen Xuewen Hua Yingying Wan Wei Wei Haibin Song Shujing Yu Xiao Zhang Zhengming Li | 2015 | Chinese Journal of Chemistry2015，33，11： | 2 |
| 11 | Bioinspired molecules design for bilateral synergistic passivation in buried interfaces of planar perovskite solar cells显示文摘Trap-mediated energy loss in the buried interface with non-exposed feature constitutes one of the serious challenges for achieving high-performance perovskite solar cells(PSCs).Inspired by the adhesion mechanism of mussels,herein,three catechol derivatives with functional Lewis base groups,namely 3,4-Dihydroxyphenylalanine(DOPA),3,4-Dihydroxyphenethylamine(DA)and 3-(3,4-Dihydroxyphenyl)propionic acid(DPPA),were strategically designed.These molecules as interfacial linkers are incorporated into the buried interface between perovskite and SnO_(2) surface,achieving bilateral synergetic passivation effect.The crosslinking can produce secondary bonding with the undercoordinated Pb^(2+) and Sn^(4+) defects.The PSCs treated with DOPA exhibited the best performance and operational stability.Upon the DOPA passivation,a stabilized power conversion efficiency(PCE)of 21.5%was demonstrated for the planar PSCs.After 55 days of room-temperature storage,the unencapsulated devices with the DOPA crosslinker could still maintain 85%of their initial performance in air under relative humidity of-15%.This work opens up a new strategy for passivating the buried interfaces of perovskite photovoltaics and also provides important insights into designing defect passivation agents for other perovskite optoelectronic devices,such as light-emitting diodes,photodetectors,and lasers. | Bin Wang Junjie Ma Zehua Li Gangshu Chen Qiang Gu Shuyao Chen Yiqiang Zhang Yanlin Song Jingbo Chen Xiaodong Pi Xuegong Yu Deren Yang | 2022 | Nano Research2022，15，2： | 1 |
| 12 | COLD1 Confers Chilling Tolerance in Rice显示文摘 | Yun Ma Xiaoyan Dai Yunyuan Xu Wei Luo Xiaoming Zheng Dali Zeng Yajun Pan Xiaoli Lin Huanhuan Liu Dajian Zhang Jun Xiao Xiaoyu Guo Shujuan Xu Yuda Niu Jingbo Jin Hui Zhang Xun Xu Legong Li Wen Wang Qian Qian Song Ge Kang Chong | 2015 | Cell2015，，6： | 1 |
| 13 | Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population显示文摘Objective:Hereditary colorectal cancer(CRC)accounts for approximately 5%–10%of all CRC cases.The full profile of CRC-related germline mutations and the corresponding somatic mutational profile have not been fully determined in the Chinese population.Methods:We performed the first population study investigating the germline mutation status in more than 1,000(n=1,923)Chinese patients with CRC and examined their relationship with the somatic mutational landscape.Germline alterations were examined with a 58-gene next-generation sequencing panel,and somatic alterations were examined with a 605-gene panel.Results:A total of 92 pathogenic(P)mutations were identified in 85 patients,and 81 likely pathogenic(LP)germline mutations were identified in 62 patients,accounting for 7.6%(147/1,923)of all patients.MSH2 and APC was the most mutated gene in the Lynch syndrome and non-Lynch syndrome groups,respectively.Patients with P/LP mutations had a significantly higher ratio of microsatellite instability,highly deficient mismatch repair,family history of CRC,and lower age.The somatic mutational landscape revealed a significantly higher mutational frequency in the P group and a trend toward higher copy number variations in the non-P group.The Lynch syndrome group had a significantly higher mutational frequency and tumor mutational burden than the nonLynch syndrome group.Clustering analysis revealed that the Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Population risk analysis indicated that the overall odds ratio was 11.13(95%CI:8.289–15.44)for the P group and 20.68(95%CI:12.89–33.18)for the LP group.Conclusions:Distinct features were revealed in Chinese patients with CRC with germline mutations.The Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Patients with P/LP germline mutations exhibited higher CRC risk. | Jianfei Yao Yunhuan Zhen Jing Fan Yuan Gong Yumeng Ye Shaohua Guo Hongyi Liu Xiaoyun Li Guosheng Li Pan Yang Xiaohui Wang Danni Liu Tanxiao Huang Huiya Cao Peisu Suo Yuemin Li Jingbo Yu Lele Song | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 14 | An inactivated recombinant rabies virus chimerically expressed RBD induces humoral and cellular immunity against SARS-CoV-2 and RABV显示文摘Many studies suggest that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can infect various animals and transmit among animals,and even to humans,posing a threat to humans and animals.There is an urgent need to develop inexpensive and efficient animal vaccines to prevent and control coronavirus disease 2019(COVID-19)in animals.Rabies virus(RABV)is another important zoonotic pathogen that infects almost all warmblooded animals and poses a great public health threat.The present study constructed two recombinant chimeric viruses expressing the S1 and RBD proteins of the SARS-CoV-2 Wuhan01 strain based on a reverse genetic system of the RABV SRV9 strain and evaluated their immunogenicity in mice,cats and dogs.The results showed that both inactivated recombinant viruses induced durable neutralizing antibodies against SARS-CoV-2 and RABV and a strong cellular immune response in mice.Notably,inactivated SRV-nCoV-RBD induced earlier antibody production than SRV-nCoV-S1,which was maintained at high levels for longer periods.Inactivated SRV-nCoV-RBD induced neutralizing antibodies against both SARS-CoV-2 and RABV in cats and dogs,with a relatively broadspectrum cross-neutralization capability against the SARS-CoV-2 pseudoviruses including Alpha,Beta,Gamma,Delta,and Omicron,showing potential to be used as a safe bivalent vaccine candidate against COVID-19 and rabies in animals. | Haili Zhang Hongli Jin Feihu Yan Yumeng Song Jiaxin Dai Cuicui Jiao Yujie Bai Jingxuan Sun Di Liu Shen Wang Mengyao Zhang Jilong Lu Jingbo Huang Pei Huang Yuanyuan Li Xianzhu Xia Hualei Wang | 2023 | Virologica Sinica2023，38，2： | 0 |
| 15 | Identification of important factors influencing nonlinear counting systems显示文摘Identifying factors that exert more influence on system output from data is one of the most challenging tasks in science and engineering.In this work,a sensitivity analysis of the generalized Gaussian process regression(SA-GGPR)model is proposed to identify important factors of the nonlinear counting system.In SA-GGPR,the GGPR model with Poisson likelihood is adopted to describe the nonlinear counting system.The GGPR model with Poisson likelihood inherits the merits of nonparametric kernel learning and Poisson distribution,and can handle complex nonlinear counting systems.Nevertheless,understanding the relationships between model inputs and output in the GGPR model with Poisson likelihood is not readily accessible due to its nonparametric and kernel structure.SA-GGPR addresses this issue by providing a quantitative assessment of how different inputs affect the system output.The application results on a simulated nonlinear counting system and a real steel casting-rolling process have demonstrated that the proposed SA-GGPR method outperforms several state-of-the-art methods in identification accuracy. | Xinmin ZHANG Jingbo WANG Chihang WEI Zhihuan SONG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，1： | 0 |
| 16 | Design and Synthesis of 3-Triazolo-coumarins and Their Applications in Scavenging Radicals and Protecting DNA显示文摘 | LIU Zhihui WANG Yingnan SUN Jingbo YANG Yang LIU Qingwen LIU Zaiqun SONG Zhiguang | 2015 | Chemical Research in Chinese Universities2015，31，4： | 0 |
| 17 | Expression Regulation of Starch and Storage Protein Synthesis Related Genes in Rice Grains显示文摘Starch and the storage proteins are the main nutritious substances in crop grains,and their composition and content in grains play a decisive role in the grain quality of rice and other staple food crops.This review has mainly summarized the new advances in the expression regulation of starch and storage protein synthesis related genes in rice grains.Moreover,the challenges of the starch and storage protein synthesis substances in rice genetic improvement were also discussed.This review will provide important information for genetic improvement of grain quality in rice and,potentially,other staple cereals. | Bo PENG Dongyan KONG Yu PENG Lulu HE Yue JIANG Jingbo YU Mengshi SUN Qin DAI Yuchen LIU Qingqing XIN Ruihua PANG Yanfang SUN Xiaohua SONG Huilong LI Juan PENG Qiying ZHOU Jintao LI Quanxiu WANG Bin DUAN Shizhi SONG Hongyu YUAN | 2019 | Asian Agricultural Research2019，11，1： | 0 |
| 18 | An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity显示文摘Hepatocellular carcinoma(HCC)is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy.A new modality of epigenetic regulation has emerged involving RNA-RNA crosstalk networks where two or more competing endogenous RNAs(ceRNAs)bind to the same microRNAs.However,the contribution of such mechanisms in HCC has not been well studied.Herein,potential HMGB1-driven RNA-RNA crosstalk networks were evaluated at different HCC stages,identifying the mT0RC2 component RICTOR as a potential HMGB1 ceRNA in HBV^(+)early stage HCC.Indeed,elevated HMGB1 mRNA was found to promote the expressio n of RICTOR mRNA through competitively bin ding with the miR-200 family,especially miR-429.Functio nal assays emplo ying overexpressi on or in terference strategies dem on strated that the HMGB1 and RICTOR 3zuntra nslated regions(UTR)epigenetically promoted the malignant proliferation,self-renewal,and tumorigenesis in HCC cells.Intriguingly,in terference agai nst HMGB1 and RICTOR in HCC cells promoted a stron ger an ti-PD-L1 immuno therapy resp on se,which appeared to associate with the production of PD-L1^(+)exosomes.Mechanistically,the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms,activating a positive feedback loop involving mT0RC2-AKT-C-MYC to upregulate glutamine synthetase(GS)expression,and inducing mTORCI signaling to derepress SIRT4 on glutamate dehydrogenase(GDH).Meanwhile,this crosstalk network could impede the efficacy of immunotherapy through mTORCI-P70S6K dependent PD-L1 production and PD-L1^(+)exosomes activity.In conclusion,our study highlights the non-coding regulatory role of HMGB1 with implicatio ns for RNA-based therapeutic targeting together with a predictio n of an ti-PD-L1 immuno therapy in HCC. | Yanping Wei Xuewu Tang Yibin Ren Yun Yang Fengliang Song Jingbo Fu Shuowu Liu Miao Yu Jing Chen Suyang Wang Kecheng Zhang Yexiong Tan Zhipeng Han Lixjn Wei Baohua Zhang Zhangjun Cheng Liang Li Hongyang Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 19 | Severe graft-versus-host disease post allogeneic hematopoietic stem cell transplantation due to loss of HLA heterozygosity in recipient lymphocytes after full graft rejection显示文摘Germ cell tumors complicated by hematological malignancy(HM)are a rare clinical phenomenon.Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is a potentially effective therapy,but graft-versus-host disease(GVHD)is a life-threatening complication.We report a case of a 13-year-old female patient diagnosed with germ cell tumors followed by acute lymphoblastic leukemia.After chemotherapy,she received allo-HSCT and her chimerism rate decreased rapidly to near zero by 6 months without evidence of HM recurrence.However,she developed severe,multiorgan GVHD-like manifestations.DNA analysis revealed the pathogenesis of GVHD to be loss of HLA heterozygosity in recipient hematopoietic cells. | Song Xue Lili Miao Zimu Gong Wenqiu Huang Yongping Zhang Fuhong Liu Jingbo Wang | 2023 | Cancer Innovation2023，2，4： | 0 |
| 20 | Integrative regulatory mechanisms of stomatal movements under changing climate显示文摘Global climate change-caused drought stress,high temperatures and other extreme weather profoundly impact plant growth and development,restricting sustainable crop production.To cope with various environmental stimuli,plants can optimize the opening and closing of stomata to balance CO_(2)uptake for photosynthesis and water loss from leaves.Guard cells perceive and integrate various signals to adjust stomatal pores through turgor pressure regulation.Molecular mechanisms and signaling networks underlying the stomatal movements in response to environmental stresses have been extensively studied and elucidated.This review focuses on the molecular mechanisms of stomatal movements mediated by abscisic acid,light,CO_(2),reactive oxygen species,pathogens,temperature,and other phytohormones.We discussed the significance of elucidating the integrative mechanisms that regulate stomatal movements in helping design smart crops with enhanced water use efficiency and resilience in a climate-changing world. | Jingbo Zhang Xuexue Chen Yajing Song Zhizhong Gong | 2024 | Journal of Integrative Plant Biology2024，66，3： | 0 |
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