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| 1 | Technology and Experiments of 42CrMo Bearing Ring Forming Based on Casting Ring Blank显示文摘Bearing ring is the crucial component of bearing. With regard to such problems as material waste, low efficiency and high energy consumption in current process of producing large bearing ring, a new process named 'casting-rolling compound forming technology' is researched by taking the typical 42CrMo slew bearing as object. Through theoretical analysis, the design criteria of the main casting-rolling forming parameters are put forward at first. Then the constitutive relationship model of as-cast 42CrMo steel and its mathematical model of dynamic recrystallization are obtained according to the results of the hot compression experiment. By a coupled thermal-mechanical finite element model for radial-axial rolling of bearing ring, the fraction of dynamic recrystallization is calculated and recrystallized grains size are predicated. Meanwhile, the effects of the initial rolling temperature and feed rate of idle roll on material microstructure evolution are analyzed. Finally, the industrial rolling experiment is designed and performed, based on the simulation results. In addition, mechanical and metallographic tests are conducted on rolled bearing ring to get the mechanical parameters and metallographic structure. The experimental data and results show that the mechanical properties of bearing ring produced by casting-rolling compound forming technology are up to industrial standard, and a qualified bearing ring can be successfully formed by employing this new technology. Through the study, a process of forming large bearing ring directly by using casting ring blank is obtained, which could provide an effective theoretical guidance for manufacturing large ring parts. It also has an edge in saving material, lowering energy and improving efficiency. | LI Yongtang JU Li QI Huiping ZHANG Feng CHEN Guozhen WANG Mingli | 2014 | Chinese Journal of Mechanical Engineering2014，27，2： | 16 |
| 2 | Three-Dimensional Thermo-mechanical Coupled FEM Simulation for Hot Continuous Rolling of Large-Diameter Mandrel Bar显示文摘Based on the important boundary conditions of rolling simulation including friction, heat conduction and interactionsof the workpiece and rolls, the hot continuous rolling processes of large-diameter mandrel round bar (200 mm indiameter) in 6VH-stand hot tandem mill are successfully simulated by three-dimensional coupled thermomechanicalelastoplastic finite element method (FEM). The distributions of stress, strain, temperature and the rolling force andtorque for the two-pass and four-pass continuous rolling are calculated respectively. Thus, the two and four-passroll schedules are verified, respectively. The simulation results show that it is safe to produce 200 mm round barby the two-pass (oval pass and round pass) continuous rolling on the existing equipment compared to the four-passcontinuous rolling. There are concave surfaces and increased widths occurring at the end of rolled billet due touneven deformations between the outside and inside of the workpiece as well as the free spreading close to the rollgap of the final pass. | Huiping HONG Yonglin KANG Changtao FENG Xiqiang CHEN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 13 |
| 3 | Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing显示文摘Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene status.Methods:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene status.Results:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study patients.The clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT groups.The median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT group.Conclusions:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side effect.And we recommend that patients with advanced TNBC should have BRCA gene test. | Nan Wang Kun Li Wenfa Huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li | 2020 | Chinese Journal of Cancer Research2020，32，2： | 7 |
| 4 | Distribution of Microelements and Their Influence on the Corrosion Behavior of Aluminum Foil显示文摘The distribution of microelement Fe, Si, Cu and Mg in the surface layer of aluminum foil annealed at 300℃ and 500℃ were determined by secondary ion mass spectrometer. The corrosion structure produced by electrochemical etching was also observed. It was found that the Mg concentration at external surface was increased exponentially over the fourth degree and promoted by higher annealing temperature, which will increase the number of corrosion pits inside the large grains, and therefore the specific capacity of the foils for electrolytic capacitors. The similar effects of microelement Fe, Si and Cu were not so strong. | Weimin MAO, Heng JIANG, Ping YANG, Huiping FENG and Yongning YUDepartment of Materials, University of Science and Technology Beijing, Beijing 100083, ChinaProf., Ph.D., | 2005 | Journal of Materials Science & Technology2005，21，1： | 7 |
| 5 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 6 | Application of isotopic and hydro-geochemical methods in identifying sources of mine inrushing water显示文摘Isotopic and hydro-geochemical surveys were carried out to identify the source of mine inrushing water at the #73003 face in the Laohutai Mine. Based on the analysis of isotopes and hydro-chemical features of surface water, groundwater from different levels and the inrushing water, a special relationship between water at the #73003 face and cretaceous water has been found. The results show that the isotopic and hydro-chemical features of the inrushing water are completely different from those of other groundwater bodies, except for the cretaceous water. The isotopic and hydrochemical characteristics of cretaceous water are similar to the inrushing water of the #73003 face, which aided with obtaining the evidence for the possible source of the inrushing water at the #73003 face. The isotope calculations show that the inrushing water at the #73003 face is a mixture of cretaceous water and Quaternary water. Water from the cretaceous conglomerate is the main source, accounting for 67% of the inrushing water, while the Quaternary water accounts for 33%. The conclusion is also supported by a study of inrushing-water channels and an active fault near the inrushing-water plot on the #73003 face. | Dou Huiping Ma Zhiyuan Cao Haidong Liu Feng Hu Weiwei Li Ting | 2011 | Mining Science and Technology2011，21，3： | 3 |
| 7 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 8 | Complex Helmholtz Coils for Producing Uniform Magnetic Fields显示文摘In imaging experiments in ion-atom collisions, due to its small mass, the electron is easy to escape from the extraction electrostatic field, and this makes the complete collection difficult. In order to improve the solid angle for imaging of electrons, a uniform magnetic field is needed to restrict the electron trajectories .Usually, a pair of same coils, called Helmholtz coils, is employed to produce magnetic field. In | Feng Wentian, Ma Xinwen, Liu Huiping, Chen Lanfang, Li Bin and Cao Shiping | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 3 |
| 9 | Effect of Trace Sn on Pitting Behaviors of High Voltage Anode Aluminum Foil显示文摘The effect of trace Sn on the pitting morphology of high voltage anode aluminum foils was investigated.The distributions of microelement Sn,Fe,Si,Cu and Mg in the surface layer of aluminum foils with different Sn content were determined by using a secondary ion mass spectrometer.It was found that the micro-alloyed Sn is enriched at the external surface.The mechanism of pitting behavior of trace Sn on aluminum surface is similar with that of lead.Enrichment of Sn in the surface layer provides large numbers of sites for initiation of pitting corrosion,while pitting sites appeared relatively inhomogenously in the foils without Sn.Sn,as an eco-friendly microelement,can be applied to replace Pb in improving the homogenous pitting behaviors of high voltage aluminum foils,in which the volume fraction of cube texture is not reduced. | Jingbo SONG Weimin MAO Hong YANG Huiping FENG | 2008 | Journal of Materials Science & Technology2008，24，5： | 2 |
| 10 | Investigation of ion-atom collision dynamics through imaging techniques显示文摘The principle and technique details of recoil ion momentum imaging are discussed and summarized. The recoil ion momentum spectroscopy built at the Institute of Modern Physics (Lanzhou) is presented. The first results obtained at the setup are analyzed. For 30 keV He2+ on He collision, it is found that the capture of single electron occurs dominantly into the first excited states, and the related scattering angle results show that the ground state capture occurs at large impact parameters, while the capture into excited states occurs at small impact parameters. The results manifest the collision dynamics for the sub-femto-second process can be studied through the techniques uniquely. Finally, the future possibilities of applications of the recoil ion momentum spectroscopy in other fields are outlined. | MA XinWen ZHU XiaoLong LIU HuiPing LI Bin ZHANG ShaoFeng CAO ShiPing FENG WenTian XU ShenYue | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，7： | 2 |
| 11 | Tensile behavior of AA3104 aluminum sheets at low deformation degree显示文摘The texture of a rolled AA3104 aluminum sheet was measured by the X-ray transmission method. The Lankford values or r values (ratio of plastic strain) and yield strengths in directions of 0, 15, 30, 45, 60, 75, and 90° to RD (rolling direction) of the sheet were tested during tensile loading at a strain of 2%. r values were predicted by the Sachs model and the reaction stress model in con- sideration of the measured texture. The simulated results indicate that r values calculated by the Sachs model are more exactly ap- proaching with the experimental values on the whole than those predicted by the reaction stress model. The deformation behavior of the AA3104 aluminum sheet reveals characteristic predicted by the Sachs model, which should be resulted from the sheet geometry different from bulk material as well as the low tensile deformation degree. | Quancang Ma Weimin Mao Huiping Feng | 2005 | Journal of University of Science and Technology Beijing2005，12，5： | 2 |
| 12 | A Case Study of Applying Metagenomic Sequencing in Precise Epidemiology for the COVID-19 Pandemic-Sichuan Province, China, 2020显示文摘Introduction:Determining the transmission chain of a virus in its incipient stages is extremely time consuming in traditional approaches that rely mainly on case incidence and interview-based contact data.With the development of high-throughput sequencing technology,genome-based epidemiology approach is showing promise in detecting viral transmission.However,there is still insufficient evidence for the relationship between the viral genetic variations and real viral transmission.Methods:To explore the possible relationship between transmission chains and viral genetic variations,we combined both epidemiological data and viral genomes of COVID-19 virus collected from Sichuan Province.A phylogenetic approach was used to infer the transmission chain,which was then compared to the transmission chain that came from epidemiological data.Results:We found that the putative transmission chains were highly concordant to the true transmission chains from epidemiological data,suggesting a strong correlation between viral genetic variations and the viral transmission chain.Discussion:Our results showed advantages of viral genomic sequencing in tracking and perceiving pathogen transmission,which allowed for potential improvements in the design and implementation of population-level public health interventions. | Jianan Xu Ye Wang You Li Huiping Yang Ming Pan Jian Liu Lina Shi Yuliang Feng Li Liu Jin Li Li Zhang Shusen He | 2020 | China CDC weekly2020，2，47： | 2 |
| 13 | Detection and toxicity assessment of nitrosamines migration from latex gloves in the Chinese market显示文摘 | Di Feng Huiping Wang Xuelian Cheng Jiedong Wang Lifeng Ning Qingfeng Zhou Yue Zhou Quanli Yang | 2009 | International Journal of Hygiene and Environmental Health2009，，5： | 1 |
| 14 | Inhibition of LPS‐induced production of inflammatory factors in the macrophages by mono‐carbonyl analogues of curcumin显示文摘 | Guang Liang Huiping Zhou Yi Wang Emily C. Gurley Biao Feng Li Chen Jian Xiao Shulin Yang Xiaokun Li | 2009 | Journal of Cellular and Molecular Medicine (b)2009，，9： | 1 |
| 15 | Efficient Semi‑Transparent Wide‑Bandgap Perovskite Solar Cells Enabled by Pure‑Chloride 2D‑Perovskite Passivation显示文摘Wide-bandgap(WBG)perovskite solar cells suffer from severe non-radiative recombination and exhibit relatively large opencircuit voltage(V_(OC))deficits,limiting their photovoltaic performance.Here,we address these issues by in-situ forming a well-defined 2D perovskite(PMA)_(2)PbCl_(4)(phenmethylammonium is referred to as PMA)passivation layer on top of the WBG active layer.The 2D layer with highly pure dimensionality and halide components is realized by intentionally tailoring the side-chain substituent at the aryl ring of the post-treatment reagent.First-principle calculation and single-crystal X-ray diffraction results reveal that weak intermolecular interactions between bulky PMA cations and relatively low cation-halide hydrogen bonding strength are crucial in forming the well-defined 2D phase.The(PMA)_(2)PbCl_(4)forms improved type-I energy level alignment with the WBG perovskite,reducing the electron recombination at the perovskite/hole-transport-layer interface.Applying this strategy in fabricating semi-transparent WBG perovskite solar cells(indium tin oxide as the back electrode),the V_(OC)deficits can be reduced to 0.49 V,comparable with the reported state-of-the-art WBG perovskite solar cells using metal electrodes.Consequently,we obtain hysteresis-free 18.60%-efficient WBG perovskite solar cells with a high V_(OC)of 1.23 V. | Liu Yang Yongbin Jin Zheng Fang Jinyan Zhang Ziang Nan Lingfang Zheng Huihu Zhuang Qinghua Zeng Kaikai Liu Bingru Deng Huiping Feng Yujie Luo Chengbo Tian Changcai Cui Liqiang Xie Xipeng Xu Zhanhua Wei | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 16 | Rational tuning of thorium-organic frameworks by reticular chemistry for boosting radionuclide sequestration显示文摘The reticular chemistry strategy presents a powerful molecule-design tool to tailor the physical and chemical properties of metal-organic framework(MOF).In this work,we for the first time investigated the effect of organic ligands on the radionuclide sequestration(TcO_(4)^(-))of thorium-organic framework.Through a coordination modulation technique,two novel isoreticular thorium-organic frameworks,namely Th-MOF-67 and Th-MOF-68,were obtained.Relative to the antetype MOF of Th-MOF-66 that shows extremely low uptake of ReO_(4)^(-)(a chemical surrogate of radioactive TcO_(4)^(-)),the isoreticular MOFs of Th-MOF-67 and Th-MOF-68 enable ultrahigh uptake of ReO_(4)^(-),giving an impressively 36.8-fold or 56-fold enhancement,respectively.The adsorption capacity of Th-MOF-68 is as high as 560 mg/g,exceeding most reported adsorbents for such use.The mechanism for such exceptional outstanding performance,as unveiled by both the single crystal X-ray diffraction and theoretical calculation,is due to coordination interaction for Th-MOF-67,when a tetrazolate ligand was used,or a combined effect from both coordination interaction and anion-exchange for Th-MOF-68,if using a triazolate ligand. | Han Feng Xiaohong Xiong Lele Gong Huiping Zhang Ying Xu Xuefeng Feng Feng Luo | 2022 | Nano Research2022，15，2： | 1 |
| 17 | Measurement and Simulation of Grain Size in Strong Textured and Coarse-Grained Metal Sheets显示文摘An X-ray diffractometer that equipped with a two-dimensional detector is used for developing the technique of grainsize measurement for strong textured and coarse-grained Si steel sheet. The method is based on the concept thatthe position of diffraction spots depends on the orientation of individual grains. The two-dimensional detector hasthe ability to collect abundant diffraction information in seconds, thus it can be determined rapidly and accuratelywhether a series of diffraction spots come from the same grain. The experimental results show that this method canbe used for measuring grain size and its distribution in strong textured and coarse-grained metal sheets. | Leng CHEN Weimin MAO Yongning YU Huiping FENG | 2003 | Journal of Materials Science & Technology2003，19，z1： | 1 |
| 18 | Novel structural annotation and functional expression analysis of GTP_EFTU conserved genes in pepper based on the PacBio sequencing data显示文摘Genes containing GTP_EFTU domain mainly express elongation factors(EF),Small GTPases,and GTP-binding proteins,which are closely related to protein synthesis,extension and ATP synthesis.In this study,we identified 39 genes containing GTP_EFTU domains from peppers.The evolutionary trees constructed from capsicum,Arabidopsis,rice,and tomato are mainly divided into 7 subfamilies.Using PacBio(Pacific Biosciences)sequencing and assembly data,we extracted these 39 gene sequences,fromwhich 25 genes had alternative splicing.Particularly,the Capana08g000545 had 16 alternative splicing processes.Accordingly,we performed promoter sequence analysis,subcellular location prediction,the expression analysis of different tissues and periods,and also the GO(Gene ontology)analysis of co-expressed genes.Lastly we did the qRTPCR analysis in 5 stages of pepper fruit development.These analyses revealed important structural and functional information for the identified 39 genes that contain GTP_EFTU domains,providing important references for further follow-up experiments to verify the genes function on plants or their unique roles in peppers. | Bingqian Tang Lingling Xie Xuefeng Li Huiping Yang Yi Liu Xiang Cheng Chenliang Liang Juan Chen Shudong Zhou Duanhua Wang Jingyuan Zheng Xiongze Dai Xuexiao Zou Feng Liu | 2021 | Horticultural Plant Journal2021，7，5： | 1 |
| 19 | The First Case of COVID-19 by an A.27 Lineage Variant Detected in a Returning Employee—Sichuan Province,China,January 7,2021显示文摘On January 7,2021,a 32-year-old returning employee arrived in Chengdu from Algeria via airplane and tested positive for coronavirus disease 2019(COVID-19)by nucleic acid tests.He was transferred to the designated hospital for further diagnosis and treatment.The patient was diagnosed as a mild COVID-19 case on January 16.After medical treatment,this patient recovered and left the hospital on February 18. | Li Liu Tao Luo Gaopeng Lei Yuliang Feng Xiang Zhao Huiping Yang Jianan Xu Ming Pan Linlin Zhou | 2021 | China CDC weekly2021，3，34： | 1 |
| 20 | Morphology evolution of ZrB 2 nanoparticles synthesized by sol–gel method显示文摘 | Yun Zhang Ruixing Li Yanshan Jiang Bin Zhao Huiping Duan Junping Li Zhihai Feng | 2011 | Journal of Solid State Chemistry2011，，8： | 1 |
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