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| 1 | In situ simultaneous determination of trace elements,U-Pb and Lu-Hf isotopes in zircon and baddeleyite显示文摘This paper describes a combined method of simultaneously measuring U-Pb and Lu-Hf isotopes as well as trace elements in Phalaborwa baddeleyite and 91500, GJ-1, TEMORA-1 and SK10-2 zircons by means of Neptune MC-ICPMS and Agilent Q-ICPMS connected to a 193 nm excimer laser ablation system. Material ablated by laser was carried in different proportions into Q-ICPMS for U-Pb isotopic and trace elemental and MC-ICPMS for Lu-Hf isotopic compositions. Experiments indicate that different proportions of ablated material for the Q-ICPMS and MC-ICPMS (6:4, 5:5 and 4:6 respectively) do not show any bias for the zircon/baddeleyite U-Pb age, Lu-Hf isotope and trace elemental compositions within ana-lytical errors. Using 40―60 μm spot size, the obtained U-Pb ages of Phalaborwa baddeleyite, 91500, GJ-1, TEMORA and SK10-2 zircons are 2065±15 (2σ, n=20), 1063±6 (2σ, n=19), 613±6 (2σ, n=20), 416±5 (2σ, n=20) and 32.6±0.5 (2σ, n=20) Ma, respectively. The 176Hf/177Hf ratios are 0.281231±24 (2SD, n=20), 0.282310±35 (2SD, n=19), 0.282028±34 (2SD, n=20), 0.282687±34 (2SD, n=20) and 0.282752±53 (2SD, n=20), respectively. The obtained trace elemental compositions are identical to the reference values. Therefore, this kind of technique makes it possible to simultaneously obtain the U-Pb age, Lu-Hf iso-topes and trace elemental compositions of zircon and baddeleyite, which could be an important tool in solving problems in earth sciences. | XIE LieWen ZHANG YanBin ZHANG HuiHuang SUN JingFeng WU FuYuan | 2008 | Chinese Science Bulletin2008，53，10： | 97 |
| 2 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 3 | Processing of advanced thermoelectric materials显示文摘Last two decades have witnessed significant progress in thermoelectric research,to which materials processing has crucial contributions.Compared with traditional zone-melting method used for fabricating bismuth telluride alloys,new powder-based processes have more freedom for manipulating nanostructures and nanocomposites.Thermoelectric performance enhancement is realized in most thermoelectric materials by introducing fine-grained and nano-composite structures with accurately controlled compositions.This review gives a comprehensive summary on the processing aspects of thermoelectric materials with three focuses on the powder synthesis,advanced sintering process and the formation of nano structures in bulk materials. | LI JingFeng PAN Yu WU ChaoFeng SUN FuHua WEI TianRan | 2017 | Science China(Technological Sciences)2017，60，9： | 13 |
| 4 | Estimating biophysical parameters of rice with remote sensing data using support vector machines显示文摘Hyperspectral reflectance (350-2500 nm) measurements were made over two experimental rice fields containing two cultivars treated with three levels of nitrogen application.Four different transformations of the reflectance data were analyzed for their capability to predict rice biophysical parameters,comprising leaf area index (LAI;m-2 green leaf area m-2 soil) and green leaf chlorophyll density (GLCD;mg chlorophyll m 2 soil),using stepwise multiple regression (SMR) models and support vector machines (SVMs).Four transformations of the rice canopy data were made,comprising reflectances (R),first-order derivative reflectances (D1),second-order derivative reflectances (D2),and logarithm transformation of reflectances (LOG).The polynomial kernel (POLY) of the SVM using R was the best model to predict rice LAI,with a root mean square error (RMSE) of 1.0496 LAI units.The analysis of variance kernel of SVM using LOG was the best model to predict rice GLCD,with an RMSE of 523.0741 mg m-2.The SVM approach was not only superior to SMR models for predicting the rice biophysical parameters,but also provided a useful exploratory and predictive tool for analyzing different transformations of reflectance data. | YANG XiaoHua HUANG JingFeng WU YaoPing WANG JianWen WANG Pei WANG XiaoMing Alfredo R. HUETE | 2011 | Science China(Life Sciences)2011，54，3： | 12 |
| 5 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 6 | Micro-arc oxidation of magnesium alloys:A review显示文摘Magnesium(Mg)and its alloys present great potential to be extensively applied in different applications.However,the relatively poor resistance to corrosion and wear significantly restricts their applications in practice.As one of strategies of surface treatment,micro-arc oxidation(MAO)process attracts a lot of attention,since it does not use neither expensive equipment,nor complicated manipulation.This review systematically discusses MAO mechanism and some typical models,which still need to be further developed to provide a better understanding and guide for future researchers.Subsequently,main influencing factors of MAO process are analyzed in detail.Further,some popular applications of MAO coatings are respectively reviewed,including biomedical application,decoration,thermal control,corrosion and wear resistance,and industrial applications in practice.The existing issues and future perspectives are finally discussed to further accelerate extensive applications of Mg alloys. | Wenhui Yao Liang Wu Jingfeng Wang Bin Jiang Dingfei Zhang Maria Serdechnova Tatsiana Shulha Carsten Blawert Mikhail L.Zheludkevich Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，23： | 8 |
| 7 | 加拿大海盆的营养盐极大显示文摘根据 1 999年和 2 0 0 3年中国北极科学考察航次 ,从Canada海盆收集温、盐、深和营养盐浓度数据 ,用文献报道的低浓度1 2 9I和高浓度金属钡 (Ba)来指示太平洋源水、用相应的高浓度1 2 9I和低浓度Ba来指示大西洋源水 ,划分了该海盆物理化学特征的 4个水团。表层水 ( <40m)的盐度从 2 5至 31 .6;硝酸盐处于耗尽水平 ,而磷酸盐和硅酸盐处于最低水平。营养盐再生水大致位于 40— 2 0 0m ;盐度特征为 31 .6— 33.1 ;营养盐浓度一致增至最高 ;极大峰的盐度在 33.1附近 ,其位温则处于最低水平 (约 - 1 .5°C)。混合水 (深约 2 0 0— 385m)盐度从 33.1至 34.8;位温从局域最低升至整个水柱最高的 0 .5 0— 0 .65 7°C ;营养盐则逐渐降低。深层水深度变化较大 ( 385m至 1 90 0m以下海底 ) ;但其盐度变化较小 ( 34.8— 34.9) ;位温则从最高降低到 - 0 .4至 - 0 5 4°C ;营养盐均轻微增加。结合文献中对于营养盐极大的年际观测 ,1 2 9I、Ba与氯氟烃CFC 1 1的浓度及3H 3He示踪年龄的结果分析表明 ,营养盐再生水是无季节性变化的、高年龄 (约 8— 1 5年 )的太平洋源水 ;深层为大西洋源水 ;而混合水团即为上述 2大源水的混合层。硅酸盐和磷酸盐的强极大指示优势种硅藻及其再生主导太平洋源水。 | 金明明 Wu Jingfeng 陈建芳 赵进平 高郭平 张海生 | 2004 | 极地研究2004，16，3： | 7 |
| 8 | Development of a machine learning model to predict early recurrence for hepatocellular carcinoma after curative resection显示文摘Background:Early recurrence is common for hepatocellular carcinoma(HCC)after surgical resection,being the leading cause of death.Traditionally,the COX proportional hazard(CPH)models based on linearity assumption have been used to predict early recurrence,but predictive performance is limited.Machine learning models offer a novel methodology and have several advantages over CPH models.Hence,the purpose of this study was to compare random survival forests(RSF)model with CPH models in prediction of early recurrence for HCC patients after curative resection.Methods:A total of 4,758 patients undergoing curative resection from two medical centers were included.Fifteen features including age,gender,etiology,platelet count,albumin,total bilirubin,AFP,tumor size,tumor number,microvascular invasion,macrovascular invasion,Edmondson-Steiner grade,tumor capsular,satellite nodules and liver cirrhosis were used to construct the RSF model in training cohort.Discrimination,calibration,clinical usefulness and overall performance were assessed and compared with other models.Results:Five hundred survival trees were used to generate the RFS model.The five highest Variable Importance(VIMP)were tumor size,macrovascular invasion,microvascular invasion,tumor number and AFP.In training,internal and external validation cohort,the C-index of RSF model were 0.725[standard errors(SE)=0.005],0.762(SE=0.011)and 0.747(SE=0.016),respectively;the Gönen&Heller’s K of RSF model were 0.684(SE=0.005),0.711(SE=0.008)and 0.697(SE=0.014),respectively;the time-dependent AUC(2 years)of RSF model were 0.818(SE=0.008),0.823(SE=0.014)and 0.785(SE=0.025),respectively.The RSF model outperformed early recurrence after surgery for liver tumor(ERASL)model,Korean model,American Joint Committee on Cancer tumor-node-metastasis(AJCC TNM)stage,Barcelona Clinic Liver Cancer(BCLC)stage and Chinese stage.The RSF model is capable of stratifying patients into three different risk groups(low-risk,intermediate-risk,high-risk groups)in the training and two validation cohorts(all P<0.0001).A web-based prediction tool was built to facilitate clinical application(http://gffzz8caf4f582aa3478esnncfn5oxbbc06xnp.ffgz.tsg.suse.edu.cn/surgery_predict/).Conclusions:The RSF model is a reliable tool to predict early recurrence for patients with HCC after curative resection because it exhibited superior performance compared with other models.This novel model will be helpful to guide postoperative follow-up and adjuvant therapy. | Jianxing Zeng Jinhua Zeng Kongying Lin Haitao Lin Qionglan Wu Pengfei Guo Weiping Zhou Jingfeng Liu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 6 |
| 9 | Nutrient maximums related to low oxygen concentrations in the southern Canada Basin显示文摘The phenomenon of nutrient maximums at 70~200 m occurred only in the region of the Canada Basin among the world oceans. The prevailing hypothesis was that the direct injection of the low-temperature high-nutrient brines from the Chukchi Sea shelf (<50 m) in winter provided the nutrient maximums. However, we found that there are five problems in the direct injection process. Formerly Jin et al. considered that the formation of nutrient maximums can be a process of locally long-term regeneration. Here we propose a regeneration-mixture process. Data of temperature, salinity, oxygen and nutrients were collected at three stations in the southern Canada Basin during the summer 1999 cruise. We identified the cores of the surface, near-surface, potential temperature maximum waters and Arctic Bottom Water by the diagrams and vertical profiles of salinity, potential temperature, oxygen and nutrients. The historical 129I data indicated that the surface and near-surface waters were Pacific-origin, but the waters below the potential temperature maximum core depth was Atlantic-origin. Along with the correlation of nutrient maximums and very low oxygen contents in the near-surface water, we hypothesize that, the putative organic matter was decomposed to inorganic nutrients; and the Pacific water was mixed with the Atlantic water in the transition zone. The idea of the regeneration-mixture process agrees with the historical observations of no apparent seasonal changes, the smooth nutrient profiles, the lowest saturation of CaCO3 above 400 m, low rate of CFC-11 ventilation and 3H-3He ages of 8~18 a around the nutrient maximum depths. | JIN Ming-ming SHI Jiuxin LU Yong CHEN Jianfang GAO Guoping WU Jingfeng ZHANG Haisheng | 2005 | Acta Oceanologica Sinica2005，24，6： | 5 |
| 10 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 11 | Functions of p53 in pluripotent stem cells显示文摘Pluripotent stem cells(PSCs)are capable of unlimited self-renewal in culture and differentiation into all functional cell types in the body,and thus hold great promise for regenerative medicine.To achieve their clinical potential,it is critical for PSCs to maintain genomic stability during the extended proliferation.The critical tumor suppressor p53 is required to maintain genomic stability of mammalian cells.In response to DNA damage or oncogenic stress,p53 plays multiple roles in maintaining genomic stability of somatic cells by inducing cell cycle arrest,apoptosis,and senescence to prevent the passage of genetic mutations to the daughter cells.p53 is also required to maintain the genomic stability of PSCs.However,in response to the genotoxic stresses,a primary role of p53 in PSCs is to induce the differentiation of PSCs and inhibit pluripotency,providing mechanisms to maintain the genomic stability of the self-renewing PSCs.In addition,the roles of p53 in cellular metabolism might also contribute to genomic stability of PSCs by limiting oxidative stress.In summary,the elucidation of the roles of p53 in PSCs will be a prerequisite for developing safe PSC-based cell therapy. | Xuemei Fu Shouhai Wu Bo Li Yang Xu Jingfeng Liu | 2020 | Protein & Cell2020，11，1： | 4 |
| 12 | Optimization of mechanical and damping properties of Mg-0.6Zr alloy by different extrusion processing显示文摘In this study,the optimization of mechanical and damping capacities of Mg-0.6 wt.%Zr alloys by controlling the recrystallized(DRXed)grain size under varying extrusion processing parameters including extrusion temperature T and strain rate was investigated.The relationship between the DRXed grain size and damping properties of the studied alloy was also discussed.The DRXed grain size of the as-extruded Mg-Zr alloys decreased as the extrusion temperature T decreased and the strain rateεincreased.As the DRXed grain size decreased,the strength and elongation of the as-extruded alloys exhibited improved performance through the grain refinement mechanism,while the damping properties deteriorated.The extrusion temperature of the Mg-Zr alloy had relatively greater effects on the mechanical and damping properties than the strain rate.The results of the present work indicate that alloys with appropriate mechanical and damping properties may be obtained from controlling the DRXed grain size by careful tailoring of the extrusion process parameters. | Jingfeng Wang Zhongshan Wu Shan Gao Ruopeng Lu Dezhao Qin Wenxiang Yang Fusheng Pan | 2015 | Journal of Magnesium and Alloys2015，3，1： | 4 |
| 13 | Development of metal-organic framework(MOF) decorated graphene oxide/Mg Al-layered double hydroxide coating via microstructural optimization for anti-corrosion micro-arc oxidation coatings of magnesium alloy显示文摘An efcient and simple in-situ growth strategy has been discovered for the preparation of highly reproducible and continuous symbiotic ZIF-8-based anticorrosion coating by using graphene oxide(GO)/Mg AlNO3layered double hydroxides(G/LDHs) buffer layer as a new type of connecting carrier based on micro-arc oxide(MAO) coating of AZ31 magnesium alloy. The components of ZIF-8 were adsorbed and bounded to the surface of the G/LDHs buffer layer-modified substrates to promote the nucleation of ZIF-8,thus growing a phase-pure, uniform, and good symbiosis ZIF-8 membrane. ZIF-8 particles with different growth times compensate for the grain boundary defects of the G/LDHs coating precursor buffer layer to different degrees. The prepared ZIF-8-based coating has excellent stability and corrosion resistance. The results demonstrate that the G/LDHs buffer layer provides a new channel for the MOF-modified MAO substrate of AZ31 magnesium alloy. It also proves that it is feasible to build high-performance anticorrosive coatings with MOF materials. | Yanning Chen Liang Wu Wenhui Yao Jiahao Wu Jianpeng Xiang Xiaowei Dai Tao Wu Yuan Yuan Jingfeng Wang Bin Jiang Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，35： | 3 |
| 14 | Enhanced Damping Capacities of Mg–Ce Alloy by the Special Microstructure with Parallel Second Phase显示文摘Microstructure evolution and damping capacities of Mg–Ce binary alloys with three different Ce contents(0.5, 1, or 2 wt%) have been systematically investigated in this work. Numerous fine parallel second phases in Mg–2Ce alloy are obtained, as well as a large number of dislocations around them, but few dislocations appear around the reticular second phase in the Mg–1Ce alloy. Among the three alloys, two internal friction peaks(P_1 and P_2) are detected at about 78 and 167?C in both the Mg–0.5Ce and Mg–1Ce alloys.In addition, the alloy with special parallel second phase structure exhibits excellent damping capacity in both strain amplitude and temperature-dependent regions. These results may be ascribed to the stress concentration and the formation of abundant parallel and uniform dislocation configurations in the ?-Mg matrix without the influence of crystal orientation. The obtained results may provide a novel idea to prepare high-damping magnesium alloys by tailoring their microstructure. | Zhongshan Wu Jingfeng Wang Haibo Wang She Ma Song Huang Shun Li Fusheng Pan | 2017 | Journal of Materials Science & Technology2017，33，9： | 3 |
| 15 | Molecular imaging of tumor angiogenesis using RGD-labeled iron oxide nanoparticles显示文摘Integrin is often significantly up-regulated in activated endothelial cells during tumor angiogenesis.The arginine-glycine-aspartic acid(RGD)peptide sequence is a specific recognition motif toανβ3 integrin.In this study,a RGD labeled,Poly lactic acid(PLA) coated ultrasmall paramagnetic iron oxide(USPIO)(referred to as RGD-PLA-USPIO)were developed and the ability to detect tumor angiogenesis was investigated in vitro and in vivo.Increased uptake of RGD-PLA-USPIO by human umbilical vein endothelial cells(HUVECs)was detected by Prussian blue stain and transmission electronic microscopy(TEM).Pronounced signal decrease in T2*-weighted magnetic resonance image(MRI)and heterogeneous arrangement of neovasculature of tumor tissue were clearly identified in Vx-2 tumor model.The MR signal of contralateral muscle only could be seen a slight background change after either RGD-PLA-USPIO or PLA-USPIO injection.These studies demonstrate the efficiency of RGD-PLA-USPIO to visualizeανβ3 integrin in activated tumor endothelial cells and its potential for detecting and monitoring tumor vasculature change after therapy. | WU XinYing ZHANG JingFeng LIN BingYing ZHANG MinMing | 2010 | Chinese Science Bulletin2010，55，24： | 3 |
| 16 | CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now,which is time-consuming and requires expensive instrumentation,and the confirmation of variants relies on further sequencing techniques.Herein,we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid,highly sensitivity and specificity for the detection of SARS-CoV-2 variant.To enhance the sensing capability,gold electrodes are uniformly decorated with electro-deposited gold nanoparticles.Using DNA template identical to SARS-CoV-2 Delta spike gene sequence as model,our biosensor exhibits excellent analytical detection limit(50 fM)and high linearity(R2=0.987)over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification assays.The detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas system.Furthermore,based on the wireless micro-electrochemical platform,the proposed biosensor reveals promising application ability in point-of-care testing. | Chenshuo Wu Zhi Chen Chaozhou Li Yabin Hao Yuxuan Tang Yuxuan Yuan Luxiao Chai Taojian Fan Jiangtian Yu Xiaopeng Ma Omar AAl-Hartomy SWageh Abdullah GAl-Sehemi Zhiguang Luo Yaqing He Jingfeng Li Zhongjian Xie Han Zhang | 2022 | Nano-Micro Letters2022，14，10： | 2 |
| 17 | miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells显示文摘 | Ke Jin Yonghua Xiang Jing Tang Guangchun Wu Junwei Li Huaichun Xiao Chunwang Li Yuxiang Chen Jingfeng Zhao | 2014 | Tumor Biology2014，，2： | 1 |
| 18 | Transpacific transport and evolution of the optical properties of Asian dust显示文摘 | Zhaoyan Liu T. Duncan Fairlie Itsushi Uno Jingfeng Huang Dong Wu Ali Omar Jayanta Kar Mark Vaughan Raymond Rogers David Winker Charles Trepte Yongxiang Hu Wenbo Sun Bing Lin Anning Cheng | 2013 | Journal of Quantitative Spectroscopy and Radiative Transfer2013，，： | 1 |
| 19 | Multifunctional PEG modified DOX loaded mesoporous silica nanoparticle@CuS nanohybrids as photo-thermal agent and thermal-triggered drug release vehicle for hepatocellular carcinoma treatment显示文摘 | Lingjie Wu Ming Wu Yongyi Zeng Da Zhang Aixian Zheng Xiaolong Liu Jingfeng Liu | 2015 | Nanotechnology2015，，2： | 1 |
| 20 | RapamLycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia显示文摘Rapamycin 可以由于它禁止 OSA 的变形行为的能力作为新 anti-osteosarcoma (OSA ) 服务代理人。然而,仅仅有限的利益在 OSA 的处理作为一个单个代理人在啮齿类动物研究和临床的 trials using rapamycin 被观察。rapamycin 的目标, rapamycin 的哺乳动物的目标有多重生物功能并且可以与 kinases 被连接调停周期的安培应答的元素绑定(CREB ) 的 phosphorylation 蛋白质,在肿瘤的一个进口因素前进。由采用 OSA 房间线 MG-63,我们调查了 rapamycin 怎么在 Ser133 和二个通常认为的 CREB 目标的表情调整 CREB (pCREB ) 的 phosphorylation, B 房间淋巴瘤 2 (Bcl-2 ) 并且脉管的 endothelial 生长因素 -- 一(VEGF -- 一) 。在 normoxia 下面,我们发现 rapamycin (100 nM ) 导致了被激活 mitogen 的蛋白质 kinase (MEK ) 阻止的 pCREB 的增加 /extracellular 调整信号的 kinase (英皇家空军之阶级最低之兵) 禁止者 U0126 或营地依赖者蛋白质 kinase (PKA ) 禁止者 H89。然而, H89 提高了 Akt phosphorylation 并且没减少在 rapamycin 处理之上的房间生存能力。相反, U0126 没提高 Akt phosphorylation 并且减少在 rapamycin 处理之上的房间生存能力。而且, U0126 阻止了 Bcl-2 和 VEGF 的导致 rapamycin 的增加 -- 一层次。在组织缺氧下面, rapamycin 有效地阻止了 pCREB, Bcl-2,和 VEGF 的导致组织缺氧的增加 -- 一。我们的学习证明 rapamycin 可能在在 normoxia 下面对待 OSA 房间是不太有效的并且在 OSA 的处理为 rapamycin 和 MEK/ERK 禁止者的联合提供基本原理。 | Yudong Liu Qixin Zheng Hongbin Wu Xiaodong Guo Jingfeng Li Shaofei Hao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 1 |
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