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| 1 | Recent advances of biomimetic nano-systems in the diagnosis and treatment of tumor显示文摘The lack of effective methods of diagnosis and treatment presents a major barrier to combat against tumor.The biomimetic concept is an emerging field that expresses great application potential in tumor fighting.Strategy for combining nano-systems with biomimetic technology has gained increasing attention that is proved bioinspired,environmentally benign,and promising.Herein,we provide an up-to-date review of biomimetic nanosystems as well as their applications in tumor therapy.In addition,the challenges and future directions of biomimetic nano-systems to achieve clinical translation are also pointed out. | Anning Li Jiawei Zhao Jingru Fu Jia Cai Peng Zhang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，2： | 1 |
| 2 | Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir显示文摘The outbreak of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has developed into an unprecedented global pandemic.Nucleoside analogs,such as Remdesivir and Favipiravir,can serve as the firstline broad-spectrum antiviral drugs by targeting the viral polymerases.However,the underlying mechanisms for the antiviral efficacies of these drugs are far from well understood.Here,we reveal that Favipiravir,as a pyrazine derivative,could be incorporated into the viral RNA products by mimicking both adenine and guanine nucleotides.This drug thus inhibits viral replication mainly by inducing mutations in progeny RNAs,different from Remdesivir or other RNA-terminating nucleoside analogs that impair the elongation of RNA products.We further determined the cryo-EM structure of Favipiravir bound to the replicating polymerase complex of SARSCoV-2 in the pre-catalytic state.This structure provides a missing snapshot for visualizing the catalysis dynamics of coronavirus polymerase,and reveals an unexpected base-pairing pattern between Favipiravir and pyrimidine residues that may explain its capacity for mimicking both adenine and guanine nucleotides.These findings shed light on the mechanism of coronavirus polymerase catalysis and provide a rational basis for developing antiviral drugs to combat the SARS-CoV-2 pandemic. | Qi Peng Ruchao Peng Bin Yuan Min Wang Jingru Zhao Lifeng Fu Jianxun Qi Yi Shi | 2021 | The Innovation2021，2，1： | 1 |
| 3 | Correction to:Efficient derivation of extended pluripotent stem cells from NOD-scid II2rg^-/-mice显示文摘Figure 1.Generation of NOD-scid II2rg^-1-extended pluripotent stem cells.(A)Schematic of two approaches used for generating NOD-scid II2rg^-1-extended pluripotent stem cells:de novo derivation from blastocysts(upper panels)and chemical reprogramming from embryonic fibroblasts(lower panels).(B)Phase-contrast images of de novo derived outgrowth and EPS colonies for 17 passages in LCDM medium.Scale bars,100 pm.(C)qRT-PCR analysis of XEN marker genes expression during the chemical induction process(day 16).Error bars indicate SEM(n=2).(D)Co-immunostaining of XEN marker genes during the chemical induction process(day 16).Upper panels:GATA6 and SALL4;lower panels:SOX17 and SALL4.Scale bars,100 pm. | Yaqin Du Ting Wang Jun Xu Chaoran Zhao Haibo Li Yao Fu Yaxing Xu Liangfu Xie Jingru Zhao Weifeng Yang Ming Yin Jinhua Wen Hongkui Deng | 2019 | Protein & Cell2019，10，2： | 1 |
| 4 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 5 | Systema- tic study on the coalescence and breakup behaviors of multiple parallel bubbles rising in power-law fluid 显示文摘 | LIU Jingru ZHU Chunying FU Taotao | 2014 | Industrial & Engineering Chemistry Research2014，53，12： | 1 |
| 6 | Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress显示文摘The negative effects of low temperature can readily induce a variety of diseases.We sought to understand the reasons why cold stress induces disease by studying the mechanisms of fine-tuning in macrophages following cold exposure.We found that cold stress triggers increased macrophage activation accompanied by metabolic reprogramming of aerobic glycolysis.The discovery,by genome-wide RNA sequencing,of defective mitochondria in mice macrophages following cold exposure indicated that mitochondrial defects may contribute to this process.In addition,changes in metabolism drive the differentiation of macrophages by affecting histone modifications.Finally,we showed that histone acetylation and lactylation are modulators of macrophage differentiation following cold exposure.Collectively,metabolism-related epigenetic modifications are essential for the differentiation of macrophages in cold-stressed mice,and the regulation of metabolism may be crucial for alleviating the harm induced by cold stress. | Jingjing LU Shoupeng FU Jie DAI Jianwen HU Shize LI Hong JI Zhiquan WANG Jiahong YU Jiming BAO Bin XU Jingru GUO Huanmin YANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，6： | 0 |
| 7 | Bilateral co-transfer for unsupervised domain adaptation显示文摘Labeled data scarcity of an interested domain is often a serious problem in machine learning.Leveraging the labeled data from other semantic-related yet co-variate shifted source domain to facilitate the interested domain is a consensus.In order to solve the domain shift between domains and reduce the learning ambiguity,unsupervised domain adaptation(UDA)greatly promotes the transferability of model parameters.However,the dilemma of over-fitting(negative transfer)and under-fitting(under-adaptation)is always an overlooked challenge and potential risk.In this paper,we rethink the shallow learning paradigm and this intractable over/under-fitting problem,and propose a safer UDA model,coined as Bilateral Co-Transfer(BCT),which is essentially beyond previous well-known unilateral transfer.With bilateral co-transfer between domains,the risk of over/under-fitting is therefore largely reduced.Technically,the proposed BCT is a symmetrical structure,with joint distribution discrepancy(JDD)modeled for domain alignment and category discrimination.Specifically,a symmetrical bilateral transfer(SBT)loss between source and target domains is proposed under the philosophy of mutual checks and balances.First,each target sample is represented by source samples with low-rankness constraint in a common subspace,such that the most informative and transferable source data can be used to alleviate negative transfer.Second,each source sample is symmetrically and sparsely represented by target samples,such that the most reliable target samples can be exploited to tackle underadaptation.Experiments on various benchmarks show that our BCT outperforms many previous outstanding work. | Fuxiang Huang Jingru Fu Lei Zhang | 2023 | Journal of Automation and Intelligence2023，2，4： | 0 |
| 8 | A Study of Genetic Polymorphism of Cassava Germplasms and ISSR Molecular Markers显示文摘[Objective] This study aimed to analyze the genetic polymorphism of 39 cassava varieties (lines) preserved in Guangxi Zhuang Autonomous Region Research Institute for Subtropical Crops. [Method] ISSR primers with good polymorphisms and amplification effects in cassava were selected for PCR amplification of 39 cassava germplasms, statistics and analysis of the amplified bands were conducted. In addition, cluster analysis was conducted by using UPGMA method based on the genetic similarity among cassava varieties (lines). [Result] Ten pairs of ISSR primers were selected. A total of 70 clear electrophoretic bands were amplified, each pair of primers had amplified 3-9 electrophoretic bands, with an average of 7, and the length of amplified bands ranged from 150 to 2,000 bp; cluster analysis showed that 39 cassava varieties (lines) were clustered into two categories by the similarity coefficient of 0.67; in addition, the genetic distance among cassava was very narrow, with genetic similarity coefficients ranging between 0.80 and 1.00. [Conclusion] This study laid foundation for breeding of high-quality cassava in China. | Jingru PENG Zhiyong GAN Ping LI Qiang HUANG Jinchun YANG Lanrong SHI Haitian FU | 2012 | Agricultural Biotechnology2012，1，1： | 0 |
| 9 | Prediction of Potential Distribution of the Genus Cricotopus(Diptera:Chironomidae)Based on MaxEnt Model显示文摘The prediction of suitable area is a method for predicting the potential distribution by using the maximum entropy model.This study predicted the potential suitable habitats for the genus Cricotopus of Chironomidae in China.The latitude and longitude information of 98 distribution sites of Cricotopus in China and the biological environmental factors and altitude distribution in China were collected,and suitable habitats for Cricotopus were predicted,obtaining the suitable ranges and areas of Cricotopus in China,which is consistent with the known living conditions of Cricotopus.The study on the diversity of Cricotopus and the prediction of its suitable habitats provide a theoretical basis for Cricotopus in water monitoring and paddy fields,as well as basic data for the study on the genus Cricotopus. | Zigang XU Yuanyuan YAO Qing CHEN Panpan XIANG Jingru SHANGGUAN Shiwang LIU Yue FU | 2023 | Agricultural Biotechnology2023，12，6： | 0 |
| 10 | Efficient derivation of extended pluripotent stem cells from NOD-scid II2rg-/-mice显示文摘Recently we have established a new culture condition enabling the derivation of extended pluripotent stem(EPS)cells,which,compared to conventional pluripotent stem cells,possess superior developmental potential and germline competence.However,it remains unclear whether this condition permits derivation of EPS cells from mouse strains that are refractory or non-permissive to pluripotent cell establishment.Here,we show that EPS cells can be robustly generated from non-permissive NOD-sc/d Il2rg 1 mice through de novo derivation from blastocysts.Furthermore,these cells can also be efficiently generated by chemical reprogramming from embryonic NOD-sc/d II2rg-/-fibroblasts.NOD-sc/d II2rg-/-EPS cells can be expanded for more than 20 passages with genomic stability and can be genetically modified through gene targeting.Notably,these cells contribute to both embryonic and extraembryonic lineages in vivo.More importantly,they can produce chimeras and integrate into the E13.5 genital ridge.Our study demonstrates the feasibility of generating EPS cells from refractory mouse strains,which could potentially be a general strategy for deriving mouse pluripotent cells.The generation of NOD-sc/d II2rg-/-Yaqin Du and Ting Wang contributed equally to this work.Electronic supplementary material The online version of this article(http://gffzzd3cc09b8251d45dfsncn556qvo9bx6x0v.ffgz.tsg.suse.edu.cn/10.1007/s13238-018-0558-z)contains supplementary material,which is available to authorized users.EPS cell lines permits sophisticated genetic modification in NOD-scid II2rg-/-mice,which may greatly advance the optimization of humanized mouse models for biomedical applications. | Yaqin Du Ting Wang Jun Xu Chaoran Zhao Haibo Li Yao Fu Yaxing Xu Liangfu Xie Jingru Zhao Weifeng Yang Ming Yin Jinhua Wen Hongkui Deng | 2019 | Protein & Cell2019，10，1： | 0 |
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