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| 1 | Paleostructural geomorphology of the Paleozoic central uplift belt and its constraint on the development of depositional facies in the Tarim Basin显示文摘Inclined eastward and consisting of the Hetianhe, Hetianhedong, Tazhong paleouplifts and Bachu paleoslope, the central paleouplift belt in the Tarim Basin was a large composite paleouplift and paleoslope belt with complicated palaeogeomorphic features during the Middle to early Late Ordovician. A number of paleostructural geomorphic elements have been identified in the paleouplift belt and surrounding areas, such as the high uplift belts, the faulted uplift platforms, the marginal slopes and slope break zones flanking the paleouplift belt, the surrounding shelf slopes or low relief ramps, the shelf slope break zones and deep basin plains. They exerted great influence on the development of paleogeography of the basin. The marginal slopes and slope break zones flanking the uplift belt constrained the formation and deposition of the high-energy facies including reefal and shoal deposits during the Late Ordovician, which comprise the major reservoirs of the Lower Paleozoic in the basin. Toward the end of the Ordovician, the Tazhong paleouplift hinged westward and became a westward-dipped nose as the southeastern margin of the basin was strongly compressed and uplifted. The tectono-paleogeomorphic framework of the central northern basin during the Early Silurian and the Late Devonian to Early Carboniferous changed remarkably in topography from the initial low in east and high in west to high in northeast and low in southwest. The major paleogeomorphic elements developed in these periods included the strong eroded uplift high, the uplift marginal slope, the gentle ramp of the depression margin and the depression belt. The sandstones of the lowstand and the early transgressive systems tracts were deposited along the uplift marginal slopes and the gentle ramps of the depressions comprise the prolific reservoirs in the basin. The study indicates that the distribution patterns of the unconformities within the basin are closely related to the paleogeomorphic features and evolution of the paleouplift belt. From the high uplift belt to the depression, we found the composed unconformity belts at the high uplift, the truncated and onlap triangular unconformity belts along the uplift marginal slopes, the minor angular unconformity or discontinuity belts along the transitional zones from the uplift marginal slopes to depression and the conformity belt in the central depression. The truncated and the onlap triangular unconformity belts are the favorable zones for the formation of stratigraphic trap reservoirs. | LIN ChangSong YANG HaiJun LIU JingYan PENG Li CAI ZhenZhong YANG XiaoFa YANG YongHeng | 2009 | Science China Earth Sciences2009，52，6： | 52 |
| 2 | Insights into the regulation of C-repeat binding factors in plant cold signaling显示文摘Cold temperatures, a major abiotic stress,threaten the growth and development of plants, worldwide. To cope with this adverse environmental cue, plants from temperate climates have evolved an array of sophisticated mechanisms to acclimate to cold periods,increasing their ability to tolerate freezing stress. Over the last decade, significant progress has been made in determining the molecular mechanisms underpinning cold acclimation, including following the identification of several pivotal components, including candidates for cold sensors, protein kinases, and transcription factors. With these developments, we have a better understanding of the CBF-dependent cold-signaling pathway. In this review,we summarize recent progress made in elucidating the cold-signaling pathways, especially the C-repeat binding factor-dependent pathway, and describe the regulatory function of the crucial components of plant cold signaling.We also discuss the unsolved questions that should be the focus of future work. | Jingyan Liu Yiting Shi Shuhua Yang | 2018 | Journal of Integrative Plant Biology2018，60，9： | 36 |
| 3 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 4 | Palaeogeomorphology and its control on the development of sequence stratigraphy and depositional systems of the Early Silurian in the Tarim Basin显示文摘The Silurian in the Tarim Basin was deposited on the basement deformed by the Caledonian tectonic movements at the end of the Late Ordovician. The development and distribution of sedimentary sequences of the Early Silurian have been clearly controlled by the palaeogeomorphology of the Late Ordovician. Based on unconformity characteristics and distribution of erosion, several zones can be differentiated including a high uplifted erosion zone, a transitional slope zone and a depression zone. The central and west Tabei Uplift zones show high angular unconformity and intense erosion. The Tarim Basin in the late Ordovician shows characteristics of higher in the west, lower in the east while higher in the south, lower in the north. The Early Silurian mainly developed transgressive and highstand systems tracts on the whole, while the lowstand systems tract only developed partly below the slope break. The palaeogeomorphology controlled the clastic source supply and deposit distribution. Braided delta system and tidal flat–estuary system were deposited. The duration of uplifting of the Tazhong paleouplift was longer than that of the Tabei paleo-uplift, and deposition was later. This led to the lower and middle members of the Kepingtage Formation missing in that area. As a large-scale transgression occurred during the deposition period of the upper member of the Kepingtage Formation, sediment from the west of the basin was transported and deposited by tides and waves, forming tidal–marine debris systems above the uplift. Proximal alluvial fan and fan delta coarse clastic deposits developed in proximal uplift zone in the east and southeast of the basin, and braided delta put forward to the transitional zone between the edge of uplift and the sea. Large-scale tidal channel, sub-distributary channel and mouth bar of the delta front can form favorable reservoirs, and they are primary targets for oil and gas exploration. This research on sequence–depositional systems development and distribution controlled by palaeogeomorphology is significant in guiding the prediction of reservoir sandstones. | Liu Jingyan Lin Changsong Cai Zhenzhong Zhu Yongfeng Yang Yongheng Peng Li Si Baoling Huang Zhen Li Huanpu Xu Yingcai Su Zhenzhen | 2010 | Petroleum Science2010，7，3： | 13 |
| 5 | A study on performance influences of airfoil aerodynamic parameters and evaluation indicators for the roughness sensitivity on wind turbine blade显示文摘The roughness increase on horizontal axis wind turbine(HAWT) blade surface,especially on the leading edge,can lead to an aerodynamic performance degradation of blade and power output loss of HAWT,so roughness sensitivity is an important factor for the HAWT blade design.However,there is no criterion for evaluating roughness sensitivity of blade currently.In this paper,the performance influences of airfoil aerodynamic parameters were analyzed by the blade element momentum(BEM) method and 1.5 MW wind turbine blade.It showed that airfoil lift coefficient was the key parameter to the power output and axial thrust of HAWT.Moreover,the evaluation indicators of roughness sensitivity for the different spanwise airfoils of the pitch-regulated HAWT blade were proposed.Those respectively were the lift-to-drag ratio and lift coefficient without feedback system,the maximum lift-to-drag ratio and design lift coefficient with feedback system for the airfoils at outboard section of blade,and lift coefficient without feedback,maximum lift coefficient with feedback for the airfoils at other sections under the pitch-fixed and variable-speed operation.It is not necessary to consider the roughness when HWAT can be regulated to the rated power output by the pitch-regulated and invariable-speed operation. | HUANG ChenWu YANG Ke LIU Qiang ZHANG Lei BAI JingYan XU JianZhong | 2011 | Science China(Technological Sciences)2011，54，11： | 13 |
| 6 | Depositional architecture of the late Ordovician drowned carbonate platform margin and its responses to sea-level fluctuation in the northern slope of the Tazhong region, Tarim Basin显示文摘The Tazhong Uplift of the late Ordovician is a drowned rimmed carbonate platform. The carbonate rock of the late Ordovician Lianglitage Formation in the northern slope of the Tazhong region is one of the significant petroliferous intervals. Based on petrofacies, depositional cycles, natural gammaray spectrometry and carbon/oxygen isotope data from the Lianglitage Formation, one 2nd-order, three 3rd-order and several 4th-order sequences have been recognized, and the late Ordovician relative sealevel fluctuation curve has been established. The sequences O 3 l-1 and O 3 l-2 on the platform are composed of highstand and transgressive systems tracts, but lack the lowstand systems tract. The sequence O 3 l-3 is a drowning sequence. The sequence O 3 l-1 overlapped the eroded slope and pinched out to the northwest and landward. The highstand systems tract in the sequence O 3 l-2 consists of low-angle sigmoid and high-angle shingled progradation configuration. Major sedimentary facies of the Lianglitage Formation include reef and shoal in the platform margin and lagoon, which can be subdivided into coral-sponge-stromatoporoid reef complex, sand shoal, lime mud mound, and intershoal sea. Reefs, sand shoals and their complex are potential reservoir facies. The reefs and sand shoals in the sequence O 3 l-1 developed in the upper of its highstand systems tract. In the sequence O 3 l-2, the highstand systems tract with an internal prograding configuration is a response to the lateral shifting of the complex of reef and sand shoal. The transgressive systems tract, in particular the sand shoals, developed widely on the slope of the platform margin and interior. The reefs in the sequence O 3 l-3 migrated towards high positions and formed retrograding reefs in the western platform and low relief in the platform interior. Basinward lateral migration of the reefs and pure carbonate rock both characterize highstand systems tract and show that the rise of the relative sea-level was very slow. Shingled prograding stacking pattern of the 4th-order sequences and reefs grow horizontally, which represents the late stage of highstand systems tract and implies relative sealevel stillstand. Reefs migrating towards high land and impure carbonate rock both indicate transgressive systems tract and suggest that the relative sea-level rose fast. Erosional truncation and epidiagenetic karstification represent a falling relative sea-level. The relative sea-level fluctuation and antecedent palaeotopography control the development and distribution of reef complexes and unconformity karst zones. Currently, the composite zone of epidiagenetic karstic intervals and high-energy complexes of reefs and sand shoals with prograding configuration is an important oil and gas reservoir in the northern slope of the Tazhong carbonate platform. | Yang Xiaofa Lin Changsong Yang Haijun Han Jianfa Liu Jingyan Zhang Yanmei Peng Li Jing Bing Tong Jianyu Wang Haiping Li Huanpu | 2010 | Petroleum Science2010，7，3： | 8 |
| 7 | The U-Pb chronologic evidence and sedimentary responses of Silurian tectonic activities at northeastern margin of Tarim Basin显示文摘U-Pb ages of Devonian detrital zircons from Tabei Uplift have been determined through LA-ICP-MS test technology.The results revealed that most zircon ages concentrate on 460-414 Ma,especially around 436-423 Ma,indicating possible occurrences of strong tectonic events at the northern margin of Tarim Basin during that period.Combined with previous researches on the basin marginal orogenic belts,intense tectonic activities developed at the northeast margin of Tarim Basin and its obvious sedimentary responses in basin during the end of Ordovician to Early-Middle Silurian are discussed.These include(1) several unconformities within the Late Ordovician-Silurian,showing truncation,erosion,and onlap characteristics,which reflected the local uplift formed during the surrounding extrusion process;(2) the Silurian fluvial delta system from northeast to southwest in Keping,Yingmaili,Hade,and Caohu areas,which reflected the partial uplift at the northeast margin and provided clastic supply to basin;and(3) as indicated by heavy mineral analysis,the Silurian sediments came mainly from the recycles of orogenic belts provenance,which indicated the compress tectonic setting.In addition,a wide range of red mudstone layer distribution in the upper part of the Silurian may be closely related to the surrounding tectonic uplift and the rapid decline of sea levels. | LIU JingYan YANG HaiJun YANG YongHeng CAI ZhenZhong LIU YongQuan RUI ZhiFeng SU ZhenZhen | 2012 | Science China Earth Sciences2012，55，9： | 7 |
| 8 | Novel circular RNA expression profile of uveal melanoma revealed by microarray显示文摘Objective: The present study aimed to investigate circular RNA(circRNA) expression in uveal melanoma(UM).Methods: First,we used microarray to compare the expression profiles of circRNA in five UM samples and five normal uvea tissues.Next,bioinformatics analyses,including gene ontology(GO) analysis and pathway analysis,were applied to study these differentially expressed circRNAs to predict pathogenic pathways that may be involved.Quantitative real-time polymerase chain reaction(qRT-PCR) in 20 UM samples and 20 normal uvea samples was used to confirm the circRNA expression profiles obtained from the microarray data.Finally,we analyzed the interaction between validated circRNAs and their potential cancer-associated miRNA targets.Results: In total,50,579 circRNAs [fold change(FC) ≥2.0; P<0.05],including 20,654 up-regulated and 29,925 down-regulated circRNAs,were identified as differentially expressed between UM tissues and normal uvea tissues.We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data,including hsa_circ_0119873,hsa_circ_0128533,hsa_circ_0047924,hsa_circ_0103232,hsa-circRNA10628-6,hsa_circ_0032148 and hsa_circ_0133460,which may be promising candidates to study future molecular mechanisms.Conclusions: This study explored,for the first time,the abnormal expression of circRNAs in UM and described the expression profile of circRNAs,providing a new potential target for the mechanism of UM and future treatment of UM. | Xuan Yang Yang Li Yueming Liu Xiaolin Xu Yingzhi Wang Yanni Yan Wenjia Zhou Jingyan Yang Wenbin Wei | 2018 | Chinese Journal of Cancer Research2018，30，6： | 6 |
| 9 | Characteristics and risk assessment of agricultural meteorological disasters based on 30 years’disaster data from Heilongjiang Province of China显示文摘To determine the influence of agricultural meteorological disasters on agriculture in Heilongjiang Province,the disaster areas associated with different types of disasters and their variation characteristics were analyzed based on the statistical data of agricultural disasters from 1983 to 2013 in Heilongjiang Province,China.The moving average and the Mann-Kendall test were applied to identify the variation trends of drought,flooding,hailstorms and freezing(based on the disaster ratio and the disaster intensity index).Then,the Morlet wavelet analysis method was used to identify the periodicity of these four kinds of agricultural meteorological disasters.Finally,a fuzzy comprehensive evaluation method was adopted to analyze the degrees of agricultural loss induced by these disasters.The following results were obtained:1)The disaster ratio and disaster intensity index for drought exhibited increasing trends;the disaster ratio and disaster intensity index for flooding exhibited decreasing trends;for hailstorms,the disaster ratio exhibited no obvious trend of change,whereas the disaster intensity index exhibited an increasing trend;and for freezing,the disaster ratio also exhibited no obvious trend of change,whereas the disaster intensity index exhibited a decreasing trend.2)Mutation points were observed in the disaster ratio series for drought,flooding and hailstorms,whereas no mutation point was evident in the disaster ratio series for freezing.3)Multiple time-scale characteristics were observed in the disaster ratio series for all four types of agricultural meteorological disasters.Furthermore,the disaster ratio series for the different types of disasters had different main periodicities.4)From the perspective of the degree of agricultural loss induced by each type of disaster,drought was identified as the most severe type of agricultural meteorological disaster,followed by flooding,freezing,and hailstorms.The degree of agricultural loss caused by each type of disaster was different during different periods.Finally,based on the results,several strategies were identified for mitigating the effect of agricultural meteorological disasters in Heilongjiang Province. | Xing Zhenxiang Yang Zhaorui Fu Qiang Li Heng Gong Xinglong Wu Jingyan | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 4 |
| 10 | Online single particle measurement of fireworks pollution during Chinese New Year in Nanning显示文摘Time-resolved single-particle measurements were conducted during Chinese New Year in Nanning, China. Firework displays resulted in a burst of SO_2, coarse mode, and accumulation mode(100–500 nm) particles. Through single particle mass spectrometry analysis, five different types of particles(fireworks-metal, ash, dust, organic carbon-sulfate(OC-sulfate), biomass burning) with different size distributions were identified as primary emissions from firework displays. The fireworks-related particles accounted for more than70% of the total analyzed particles during severe firework detonations. The formation of secondary particulate sulfate and nitrate during firework events was investigated on single particle level. An increase of sulfite peak(80SO_3^-) followed by an increase of sulfate peaks(97HSO_4^-+ 96SO_4^-) in the mass spectra during firework displays indicated the aqueous uptake and oxidation of SO_2 on particles. High concentration of gaseous SO_2, high relative humidity and high particle loading likely promoted SO_2 oxidation. Secondary nitrate formed through gas-phase oxidation of NO_2 to nitric acid, followed by the condensation into particles as ammonium nitrate. This study shows that under worm, humid conditions, both primary and secondary aerosols contribute to the particulate air pollution during firework displays. | Jingyan Li Tingting Xu Xiaohui Lu Hong Chen Sergey A.Nizkorodov Jianmin Chen Xin Yang Zhaoyu Mo Zhiming Chen Huilin Liu Jingying Mao Guiyun Liang | 2017 | Journal of Environmental Sciences2017，29，3： | 3 |
| 11 | Enzymatic hydrolysis of silkworm pupa and its allergenicity evaluation by animal model with different immunization routes显示文摘Silkworm pupa is a nourishing food with high nutritional value,but its consumption has been greatly limited given its allergenicity.Enzyme hydrolytic technique is recognized as an effective method to reduce the allergenicity of protein.In this study,we aimed to investigate the effect of enzymolysis on the allergenicity of silkworm pupa.Crude silkworm pupa protein was extracted through alkali extraction and acid precipitation,which included 5 proteins with the molecular weights ranging from 34 kDa to 76 kDa,and silkworm pupa were then hydrolyzed by alkaline protease.The allergenicity of silkworm pupa protein and its enzymatic hydrolysates was evaluated by establishing BALB/c mice model,and the mice were immunized via intragastric gavage and intraperitoneal injection,respectively.The results indicated that the intraperitoneal inj ection immunization route induced more by detecting with antibodies,histamine and Th2-related cytokines.Moreover,mice treated with silkworm pupa protein peptide displayed no obvious allergic symptoms,indicating that enzyme hydrolytic technique could significantly reduce the allergenicity of silkworm pupa. | Yan Dai Meijia Huang Yujuan Xu Lixia Mu Jingyan Gao Hongbing Chen Zhihua Wu Anshu Yang Yong Wu Xin Li | 2023 | Food Science and Human Wellness2023，12，3： | 3 |
| 12 | Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression显示文摘Neurogenesis decline in hippocampal dentate gyrus(DG)participates in stress-induced depressive-like behaviors,but the underlying mechanism remains poorly understood.Here,we observed low-expression of NOD-like receptor family pyrin domain containing 6(NLRP6)in hippocampus of stress-stimulated mice,being consistent with high corticosterone level.NLRP6 was found to be abundantly expressed in neural stem cells(NSCs)of DG.Both Nlrp6 knockout(Nlrp6^(-/-))and NSCconditional Nlrp6 knockout(Nlrp6CKO)mice were susceptible to stress,being more likely to develop depressive-like behaviors.Interestingly,NLRP6 was required for NSC proliferation in sustaining hippocampal neurogenesis and reinforcing stress resilience during growing up.Nlrp6 deficiency promoted esophageal cancer-related gene 4(ECRG4)expression and caused mitochondrial dysfunction.Corticosterone as a stress factor significantly down-regulated NLRP6 expression,damaged mitochondrial function and suppressed cell proliferation in NSCs,which were blocked by Nlrp6 overexpression.ECRG4 knockdown reversed corticosterone-induced NSC mitochondrial function and cell proliferation disorders.Pioglitazone,a well-known clinical drug,up-regulated NLRP6 expression to inhibit ECRG4 expression in its protection against corticosterone-induced NSC mitochondrial dysfunction and proliferation restriction.In conclusion,this study demonstrates that NLRP6 is essential to maintain mitochondrial homeostasis and proliferation in NSCs,and identifies NLRP6 as a promising therapeutic target for hippocampal neurogenesis decline linked to depression. | Chuanfeng Tang Qiaona Wang Jingyan Shen Congying Wang Hong Ding Shiyu Wen Fan Yang Ruiqing Jiao Xingxin Wu Jianmei Li Lingdong Kong | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 13 | Reciprocal regulation between the negative regulator PP2CG1 phosphatase and the positive regulator OST1 kinase confers cold response in Arabidopsis显示文摘Protein phosphorylation and dephosphorylation have been reported to play important roles in plant cold responses.In addition,phospho-regulatory feedback is a conserved mechanism for biological processes and stress responses in animals and plants.However,it is less well known that a regulatory feedback loop is formed by the protein kinase and the protein phosphatase in plant responses to cold stress.Here,we report that OPEN STOMATA 1(OST1)and PROTEIN PHOSPHATASE 2C G GROUP 1(PP2CG1)reciprocally regulate the activity during the cold stress response.The interaction of PP2CG1 and OST1 is inhibited by cold stress,which results in the release of OST1 at the cytoplasm and nucleus from suppression by PP2CG1.Interestingly,cold-activated OST1 phosphorylates PP2CG1 to suppress its phosphatase activity,thereby amplifying cold signaling in plants.Mutations of PP2CG1 and its homolog PP2CG2 enhance freezing tolerance,whereas overexpression of PP2CG1 decreases freezing tolerance.Moreover,PP2CG1 negatively regulates protein levels of C-REPEAT BINDING FACTORs(CBFs)under cold stress.Our results uncover a phosphor/dephosphor-regulatory feedback loop mediated by PP2CG1 phosphatase and OST1 protein kinase in plant cold responses. | Jian Lv Jingyan Liu Yuhang Ming Yiting Shi Chunpeng Song Zhizhong Gong Shuhua Yang Yanglin Ding | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 14 | Therapeutic revolution for inoperable stage III non-small cell lung cancer in the immune era显示文摘The PACIFIC study ushered in a“tsunami-like”therapeutic revolution for stage III inoperable non-small cell lung cancer(NSCLC)In the past,chemoradiotherapy(CRT)has been the standard of care for inoperable stage III NSCLC.Concurrent chemoradiotherapy(cCRT),if tolerable in patients,is the optimal treatment regimen.A meta-analysis has shown that cCRT results in a 5-year survival rate 4.5%longer than that with sequential chemoradiotherapy(sCRT)1.However,within 2 years after cCRT,approximately 30%of patients experience local recurrence,and approximately 40%develop distant metastasis2.Clinicians have explored induction chemotherapy3,consolidation chemotherapy4,and combination use with targeted drugs2,and found that none improve the prognosis. | Jiakang Li Jingyan Xu Mingyi Yang Qing Zhou | 2022 | Cancer Biology & Medicine2022，19，5： | 2 |
| 15 | ,Sequence architecture and depositional evolution of the Ordovician carbonate platform margins in theTarim Basin and its response to tectonism and sealevel change显示文摘 | LIN Changsong YANG Haijun LIU Jingyan | 2012 | Basin Research2012，24，5： | 1 |
| 16 | Minichromosome maintenance complex component 7 has an important rolein the invasion of papillary urothelial neoplasia显示文摘 | Bingxin Guan Xiaoying Wang Jingyan Yang Chengjun Zhou Yan Meng | 2015 | Oncology Letters2015，，2： | 1 |
| 17 | Bioadaptation of implants to In vitro and In vivo oxidative stress pathological conditions via nanotopography-induced FoxO1 signaling pathways to enhance Osteoimmunal regeneration显示文摘Varieties of pathological conditions,including diabetes,are closely related to oxidative stress(OS),but the osseointegration or bioadaptation of implants to OS and the related mechanism remain poorly explored.In this study,the antioxidation and osteoimmune regeneration of titanium implants with micro/nanotopographies were evaluated under H2O2-,lipopolysaccharide(LPS)-and hyperglycemia-mediated cellular OS models and in diabetic rats as a representative animal model of OS.TiO2 nanotube(TNT)coating on titanium implants directly induced superior osteogenic differentiation of bone mesenchymal stem cells(MSCs)and osseointegration compared with microscale sand blasted-acid etched topography(SLA)under OS,attributed to higher superoxide dismutase 2 activity,the neutralization of intracellular reactive oxygen species(ROS),and less apoptosis.Mechanistically,the oxidation resistance on TNT is driven by upregulated forkhead box transcription factor O1(FoxO1),which is abolished after knockdown of FoxO1 via shRNA in MSCs.Indirectly,TNT also alleviates OS in macrophages,therefore inducing a higher portion of the M2 phenotype under OS with increased secretion of the anti-inflammatory cytokine IL-10,further promoting the osseoimmunity capacity compared with SLA.The current study not only suggests the potential application of TiO2 nanotube-coated titanium implants in compromised conditions but also provides a systematic evaluation strategy for the future development of bone biomaterials. | Jingyan Huang Ruoqi Li Jinghong Yang Min Cai Yichen Lee Anxun Wang Bin Cheng Yan Wang | 2021 | Bioactive Materials2021，6，10： | 1 |
| 18 | Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells显示文摘 | Juhong Yang Nan Wang Jingyan Li Jiaojiao Zhang Ping Feng | 2010 | Endocrine2010，，2： | 1 |
| 19 | Antimicrobial activity against Shigella sonnei and probiotic properties of wild lactobacilli from fermented food显示文摘 | Yingchun Zhang Lanwei Zhang Ming Du Huaxi Yi Chunfeng Guo Yanfeng Tuo Xue Han Jingyan Li Lili Zhang Lin Yang | 2011 | Microbiological Research2011，，1： | 1 |
| 20 | Sequence architecture and depositional evolution of the O rdovician carbonate platform margins in the T arim B asin and its response to tectonism and sea‐level change显示文摘 | Changsong Lin Haijun Yang Jingyan Liu Zhifeng Rui Zhenzhong Cai Sitian Li Bingsong Yu | 2011 | Basin Res2011，，： | 1 |
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