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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | Suppression or knockout of SaF/SaM overcomes the Sa-mediated hybrid male sterility in rice显示文摘Hybrids between the indica and japonica subspecies of rice(Oryza sativa) are usually sterile, which hinders utilization of heterosis in the inter-subspecific hybrid breeding. The complex locus Sa comprises two adjacently located genes, SaF and SaM, which interact to cause abortion of pollen grains carrying the japonica allele in japonica-indica hybrids. Here we showed that silencing of SaF or SaM by RNA interference restored male fertility in indica-japonica hybrids with heterozygous Sa. We further used clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9-based genome editing to knockout the SaF and SaM alleles, respectively, of an indica rice line to create hybrid-compatible lines. The resultant artificial neutral alleles did not affect pollen viability and other agricultural traits, but did break down the reproductive barrier in the hybrids. We found that some rice lines have natural neutral allele Sa-n, which was compatible with the typical japonica or indica Sa alleles in hybrids. Our results demonstrate that SaF and SaM are required for hybrid male sterility, but are not essential for pollen development. This study provides effective approaches for the generation of hybrid-compatible lines by knocking out the Sa locus or using the natural Sa-n allele to overcome hybrid male sterility in rice breeding. | Yongyao Xie Baixiao Niu Yunming Long Gousi Li Jintao Tang Yaling Zhang Ding Ren Yao-Guang Liu Letian Chen | 2017 | Journal of Integrative Plant Biology2017，59，9： | 11 |
| 3 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 4 | A density-based method for adaptive LDA model selection显示文摘 | Juan Cao Tian Xia Jintao Li Yongdong Zhang Sheng Tang | 2008 | Neurocomputing2008，，7： | 2 |
| 5 | Grape-seed proanthocyanidins ameliorate contact hypersensitivity induced by 2,4-dinitrofluorobenzene (DNFB) and inhibit T cell proliferation in vitro显示文摘 | Qiuqiong Tang Peng Zou Haifeng Jin Jun Fu Jintao Yang Lanqin Shang Xuetao Wei | 2012 | Toxicology Letters2012，，： | 1 |
| 6 | An experimental study on the dying kinetics of lignite inhigh temperature nitrogen atmosphere 显示文摘 | Zheng Hongjun Zhang Shouyu Guo Xi? Lu Junfu DongAixia Deng Wenxiang Tang Wenjiao Zhao Menghao JinTao | 2014 | Fuel2014，126，： | 1 |
| 7 | STI PCR: An efficient method for amplification and de novo synthesis of long DNA sequences显示文摘Despite continuous improvements,it is difficult to efficiently amplify large sequences from complex templates using current PCR methods.Here,we developed a suppression thermo-interlaced(STI)PCR method for the efficient and specific amplification of long DNA sequences from genomes and synthetic DNA pools.This method uses site-specific primers containing a common 50 tag to generate a stem-loop structure,thereby repressing the amplification of smaller non-specific products through PCR suppression(PS).However,large target products are less affected by PS and show enhanced amplification when the competitive amplification of non-specific products is suppressed.Furthermore,this method uses nested thermointerlaced cycling with varied temperatures to optimize strand extension of long sequences with an uneven GC distribution.The combination of these two factors in STI PCR produces a multiplier effect,markedly increasing specificity and amplification capacity.We also developed a webtool,calGC,for analyzing the GC distribution of target DNA sequences and selecting suitable thermo-cycling programs for STI PCR.Using this method,we stably amplified very long genomic fragments(up to 38 kb)from plants and human and greatly increased the length of de novo DNA synthesis,which has many applications such as cloning,expression,and targeted genomic sequencing.Our method greatly extends PCR capacity and has great potential for use in biological fields. | Zhe Zhao Xianrong Xie Weizhi Liu Jingjing Huang Jiantao Tan Haixin Yu Wubei Zong Jintao Tang Yanchang Zhao Yang Xue Zhizhan Chu Letian Chen Yao-Guang Liu | 2022 | Molecular Plant2022，15，4： | 1 |
| 8 | Study on the Preparation Process Optimization of Plywood Based on a Full Biomass Tannin-Sucrose Wood Adhesive显示文摘Biomass adhesive is conducive to decreasing the dependence of the wood adhesive industry on synthetic resin based on fossil resources and improving the market competitiveness of adhesives.It is also a critical breakthrough to realize the goal of carbon peaking and carbon neutrality in the wood industry.In this study,a full biomass wood adhesive composed of tannin and sucrose was developed and applied successfully to the preparation of ply-wood.The preparation technique of plywood was optimized,and the chemical structure,curing performance,crystallization property and thermal performance of the adhesive were investigated.Results showed that:(1)hot-pressing temperature played a decisive role in the performances of tannin-sucrose composite adhesives and it also had a very significant influence on the water resistance of plywood.(2)The preparation of tannin-sucrose composite adhesive was a process in which sucrose was transformed into furan aldehydes and then made cross-linking reaction with tannin.These composite adhesives could only get good bonding performances when the curing temperature was above 210℃.(3)The optimal plywood preparation technique was:hot-pressing tem-perature of 220℃,hot-pressing time of 1.2 min/mm,m(tannin):m(sucrose)of 60:40,and adhesive loading of 160 g/m^(2).The wet bonding strength in boiling water of the prepared plywood was 0.83 MPa,meeting the strength requirements of Type-I plywood in the standard of GB/T 17657-2013.(4)The curing temperature of tannin-sucrose composite adhesive was further decreased by lowering the temperature during the transformation of sucrose into 5-HMF,which was a key in subsequent research. | Wen Gu Xinyue Ding Min Tang Feiyan Gong Shuangshuang Yuan Jintao Duan | 2023 | Journal of Renewable Materials2023，11，8： | 0 |
| 9 | Fraud detection on payment transaction networks via graph computing and visualization显示文摘With the fast development of Internet technology,more and more payments are fulfilled by mobile Apps in an electrical way which significantly saves time and efforts for payment.Such a change has benefited a large number of individual users as well as merchants,and a few major players for payment service have emerged in China.As a result,the payment service competition becomes even fierce,and various promotion activities have been launched for attracting more users by the payment service providers.In this paper,the problem focused on is fraud payment detection,which in fact has been a major concern for the providers who spend a significant amount of money to popularize their payment tools.This paper tries the graph computing-based visualization to the behavior of transactions occuring between the individual users and merchants.Specifically,a network analysisbased pipeline has been built.It consists of the following key components:transaction network building based on daily records aggregation;transaction network filtering based on edge and node removal;transaction network decomposition by community detection;detected transaction community visualization.The proposed approach is verified on the real-world dataset collected from the major player in the payment market in Asia and the qualitative results show the efficiency of the method. | 孙权 Tang Tao Zheng Jianbin Lin Jiale Zhao Jintao Liu Hongbao | 2020 | High Technology Letters2020，26，3： | 0 |
| 10 | The Stirring Time for Textile显示文摘1.The overall development & achievements of the textile Exposure to the international envi- ronment,China's textile industry's policy has experienced great transform from self-satisfaction and import substitution to export-oriented industry in the past thirty years.In accordance with the | Tang Jintao | 2008 | China's Foreign Trade2008，，22： | 0 |
| 11 | Developing Chinese Heavy Truck Industry显示文摘Strong economic recovery=Great opportunity in heavy trucks Based on the four trillion investment expansionary fiscal policy and the loose monetary policy,China's economy is stimulated.Meanwhile,the CITIC Securities Research Dept. estimated that the economic growth will be better than expected in 2009 and 2010.Macro-economic expectations | Tang Jintao | 2009 | China's Foreign Trade2009，，20： | 0 |
| 12 | Rapid-acting antidepressants targeting modulation of the glutamatergic system: clinical and preclinical evidence and mechanisms显示文摘Major depressive disorder(MDD)is a devastating mental illness that affects approximately 20%of the world's population.It is a major disease that leads to disability and suicide,causing a severe burden among communities.Currently available medications for treating MDD target the monoaminergic systems.The most prescribed medications include selective serotonin reuptake inhibitors and selective norepinephrine reuptake inhibitors.However,these medications have serious drawbacks,such as a delayed onset requiring weeks ormonths to reach efficacy and drug resistance,as one-third of patients are unresponsive to the medications.Therefore,it is imperative to develop novel therapies with rapid action,high efficacy and few adverse effects.The discovery of the rapid antidepressant effect of ketamine has triggered tremendous enthusiasm for studying new antidepressants that target the glutamatergic system in the central nervous system.Many agents that directly or indirectly modulate the glutamatergic system have been shown to provide rapid and lasting antidepressant action.Among these agents,ketamine,an antagonist of metabotropic glutamate 2/3 receptors,and scopolamine,an unspecific muscarinic acetylcholine receptor antagonist,have been extensively studied.In this review,we discuss the clinical and preclinical evidence supporting theantidepressant efficacy of these agents and the current understanding of the underlying mechanisms. | Shikai Wang Sufang Tang Jintao Huang Huanxin Chen | 2022 | General Psychiatry2022，35，6： | 0 |
| 13 | The Steel Industry Revitalization Plan显示文摘Rectify the market order and standardize the system of steel sales,establish producing and marketing risk-sharing mechanism—Automotive and steel industry adjust revitalization planning…Interpretation of the policy On January 14,2008,the Premier Wen Jiabao chaired a State Council Executive Meeting and in the meeting the adjustment of the steel industry revitalization planning was approved.The | Tang Jintao | 2009 | China's Foreign Trade2009，，4： | 0 |
| 14 | Extended Consumption Chain显示文摘Expo consumption will drive retail sales,hotel and catering, transportation,real estate, tourism and other industries. The housing rental market began to heat up.In addition,it will also benefit from the whole Yangtze River Delta to the whole China. | Tang Jintao | 2010 | China's Foreign Trade2010，，8： | 0 |
| 15 | When Oil Prices Encounter the Financial Crisis显示文摘The oil market is just like the sea;it is never quiet for a single moment.Facing the sea to observe the tide, we must behave calm in order to act correctly. The oil in the country is like the blood of the econo- my,and the oil prices in the economy is like a barometer. Under the mysterious veil,there are oil supply changes, the pattern of political restructuring... | Tang Jintao | 2008 | China's Foreign Trade2008，，23： | 0 |
| 16 | Chinese M&A,Opportunities & Risks显示文摘Recently,the cases of Chinese enterprises' merger and acquisition are emerging in multitude.It is believed that M&A will provide opportunities for China enterprises to go global and act in the global economic environment.China enterprises also want high margin profits that are accessible in Western Europe and North America.Judging from the current situation, | Tang Jintao | 2009 | China's Foreign Trade2009，，15： | 0 |
| 17 | Auto Aftermarket,Independent Brand in Need显示文摘By the year 2010,China's auto after-sales service market will attain RMB 300 billion. The first vehicle was sold out due to its look or function, while the second and the third vehicles would be easily sold out due to the sound after-sales service.From this old saying,we can see the importance of the | Tang Jintao China Asset Management CO.,Ltd. | 2008 | China's Foreign Trade2008，，21： | 0 |
| 18 | Urban Configuration Analysis of Idle Land Market Based on Game Model显示文摘In recent years, the speed of urban development becomes faster and faster with expanding of land construction scale, and a lot of idle lands lead to serious land waste. This paper builds game model by carrying out a market allocation analysis and applying economic game theory to the analysis of current idle land problem; it gets six kinds of results through analyzing the game model of idle land market, and the final Nash equilibrium is(system innovation, publicly traded) through contrastive to help balance the game relationship between government and the user of idle land and raise some new scientific and rational institutions to serve as future references for effective usage of idle land. | Jintao LI Yixue LI Yuling GONG Zhanyong QI Lijing TANG | 2014 | Agricultural Science & Technology2014，15，9： | 0 |
| 19 | Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer’s disease:a phaseⅠ/Ⅱclinical trial显示文摘Background There have been no effective treatments for slowing or reversing Alzheimer’s disease(AD)until now.Growing preclinical evidence,including this study,suggests that mesenchymal stem cells-secreted exosomes(MSCs-Exos)have the potential to cure AD.Aims The first three-arm,drug-intervention,phase I/II clinical trial was conducted to explore the safety and efficacy of allogenic human adipose MSCs-Exos(ahaMSCs-Exos)in patients with mild to moderate AD.Methods The eligible subjects were assigned to one of three dosage groups,intranasally administrated with ahaMSCs-Exos two times per week for 12 weeks,and underwent follow-up visits at weeks 16,24,36 and 48.Results No adverse events were reported.In the medium-dose arm,Alzheimer’s Disease Assessment Scale–Cognitive section(ADAS-cog)scores decreased by 2.33(1.19)and the basic version of Montreal Cognitive Assessment scores increased by 2.38(0.58)at week 12 compared with baseline levels,indicating improved cognitive function.Moreover,the ADAS-cog scores in the medium-dose arm decreased continuously by 3.98 points until week 36.There were no significant differences in altered amyloid or tau deposition among the three arms,but hippocampal volume shrank less in the medium-dose arm to some extent.Conclusions Intranasal administration of ahaMSCs-Exos was safe and well tolerated,and a dose of at least 4×10^(8)particles could be selected for further clinical trials. | Xinyi Xie Qingxiang Song Chengxiang Dai Shishuang Cui Ran Tang Suke Li Jing Chang Ping Li Jintao Wang Jianping Li Chao Gao Hongzhuan Chen Shengdi Chen Rujing Ren Xiaoling Gao Gang Wang | 2023 | General Psychiatry2023，36，5： | 0 |
| 20 | Secret in Exchange Rate & Foreign Trade?显示文摘China's import and export growth in November has dropped drastically. Year-on-year export growth rate dropped from 19.2 percent to-2.2 percent and the year-on-year import growth rate dropped from 15.6 percent to-17.9 per- cent.The trade surplus amounted to 40.09 billion U.S.dollars.This is the first time | Tang Jintao | 2009 | China's Foreign Trade2009，，3： | 0 |
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