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| 1 | A huge oceanic-type UHP metamorphic belt in southwestern Tianshan, China: Peak metamorphic age and P-T path显示文摘Recent progress in the study of the UHP metamorphic belt in southwestern Tianshan,China,is summarized in this paper.This about 80-km-long and over 10-km-wide UHP belt has been recognized by the discovery of coesite,coesite pseudomorphs and other UHP minerals.It is the largest oceanic-type UHP metamorphic belt reported so far.It has formed due to northward subduction of the Tianshan Paleo-Ocean.U-Pb dating of metamorphic rims of zircons from a coesite-bearing garnet-phengite schist yields a peak UHP metamorphic ages of 320±3.7 Ma.Combined with ages of 233–226 Ma obtained from rims of zircons from retrograded eclogites,a long retrograde metamorphic evolution(>70 Ma)has been revealed.According to phase equilibria modeling,the P-T paths of both coesite-bearing eclogites and garnet-phengite schists are characterized by thermal relaxation,i.e.,the metamorphic temperature peak lags behind the pressure peak,indicating that the UHP rocks experienced slow and long heating and decompression during exhumation in the subduction channel.On the basis of the field observation that a small amount of eclogite lenses is wrapped in large volumes of metapelites,and the similar P-T paths of both rock types,we propose that the exhumation of the UHP eclogites from southwestern Tianshan,China,may have resulted from the exhumation of large volumes of low-density metapelites,which carried the denser eclogites to the Earth’s surface. | ZHANG LiFei DU JinXue Lü Zeng YANG Xin GOU LongLong XIA Bin CHEN ZhenYu WEI ChunJing SONG ShuGuang | 2013 | Chinese Science Bulletin2013，58，35： | 19 |
| 2 | A new type of plunge pool―Multi-horizontal submerged jets显示文摘Based on the understanding of the mechanism of energy dissipation,a new type of plunge pool is presented with the advantages of high rate of energy dissipation,low impact pressure,and small close-to-bed velocity on the soleplate of the plunge pool.The first advantage owes to enlarged shearing energy dissipation areas in the plunge pool,while the other two are caused by the jet that enters in a nearly horizontal level to keep the soleplate from being scoured directly.All of the above arrangements make this new type of energy dissipator distinct from the underflow energy dissipation.Through experiments on the physical model,the authors found that the water flow maintained stable and submerged in horizontal direction when the flow was narrow in horizontal but thick in vertical direction.However,the wide flat nappe was ready to submerge or float as the downstream water level rised or dropped.The entire flow fields of multi-horizontal submerged jets into plunge pool were also numerically simulated.The numerical results of water surface curve,close-to-bed velocity and floor pressure agree well with the experimental data.The flow pattern in the plunge pool was analyzed after combining the laboratory data and numerical simulation. | DENG Jun,XU WeiLin,ZHANG JianMing,QU JinXue & YANG YongQuan State Key Laboratory of Hydraulics and Mountain River Engineering,Sichuan University,Chengdu 610065,China | 2008 | Science China(Technological Sciences)2008，51，12： | 12 |
| 3 | A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection显示文摘Gene-edited pigs for agricultural and biomedical applications are typically generated using somatic cell nuclear transfer(SCNT).However, SCNT requires the use of monoclonal cells as donors, and the time-consuming and laborious monoclonal selection process limits the production of large populations of gene-edited animals. Here, we developed a rapid and efficient method named RE-DSRNP(reporter RNA enriched dual-sg RNA/CRISPR-Cas9 ribonucleoproteins) for generating gene-edited donor cells. RE-DSRNP takes advantage of the precise and efficient editing features of dual-sg RNA and the high editing efficiency, low off-target effects, transgene-free nature, and low cytotoxic characteristics of reporter RNA enriched RNPs(CRISPR-Cas9ribonucleoproteins), thus eliminating the need for the selection of monoclonal cells and thereby greatly reducing the generation time of donor cells from 3–4 weeks to 1 week, while also reducing the extent of apoptosis and chromosomal aneuploidy of donor cells. We applied RE-DSRNP to produce cloned pigs bearing a deletion edit of the wild-type p53-induced phosphatase 1(WIP1)gene: among 32 weaned cloned pigs, 31(97%) carried WIP1 edits, and 15(47%) were homozygous for the designed fragment deletion, and no off-target event was detected. The WIP1 knockout(KO) pigs exhibited male reproductive disorders, illustrating the utility of RE-DSRNP for rapidly generating precisely edited animals for functional genomics and disease research. REDSRNP's strong editing performance in a large animal and its marked reduction in the required time for producing SCNT donor cells support its application prospects for rapidly generating populations of transgene-free cloned animals. | Kui Xu Xiuling Zhang Zhiguo Liu Jinxue Ruan Changjiang Xu Jingjing Che Ziyao Fan Yulian Mu Kui Li | 2022 | Science China(Life Sciences)2022，65，8： | 9 |
| 4 | GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia显示文摘The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with schizophrenia.We used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched controls.Quantitative real-time PCR was used to assess the differential levels of GABA-related transcripts in brain regions.Concurrently,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of schizophrenia.Significant correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout mice.Furthermore,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic patients.The psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in patients.Our study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia. | Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li | 2020 | Neuroscience Bulletin2020，36，2： | 9 |
| 5 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 6 | Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats显示文摘OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of C.paliurus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity. | XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 7 | Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer’s disease显示文摘Gene therapy represents a promising treatment for the Alzheimer’s disease(AD). However,gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have developed an siRNA nanocomplex able to be specifically delivered to the amyloid plaques through surface modification with both CGN peptide for the blood–brain barrier(BBB)penetration and QSH peptide for β-amyloid binding. But, whether the as-designed nanocomplex could indeed improve the gene accumulation in the impaired neuron cells and ameliorate AD-associated symptoms remains further study. Herein, we prepared the nanocomplexes with an siRNA against β-site amyloid precursor protein-cleaving enzyme 1(BACE1), the rate-limiting enzyme of Aβ production, as the therapeutic siRNA of AD. The nanocomplexes exhibited high distribution in the Aβ deposits-enriched hippocampus, especially in the neurons near the amyloid plaques after intravenous administration. In APP/PS1 transgenic mice, the nanocomplexes down-regulated BACE1 in both mRNA and protein levels,as well as Aβ and amyloid plaques to the level of wild-type mice. Moreover, the nanocomplexes significantly increased the level of synaptophysin and rescued memory loss of the AD transgenic mice without hematological or histological toxicity. Taken together, this work presented direct evidences that the design of precise gene delivery to the AD lesions markedly improves the therapeutic outcome. | Qian Guo Xiaoyao Zheng Peng Yang Xiaoying Pang Kang Qian Pengzhen Wang Shuting Xu Dongyu Sheng Liuchang Wang Jinxu Cao Wei Lu Qizhi Zhang Xinguo Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 2 |
| 8 | The advancements,challenges,and future implications of the CRISPR/Cas9 system in swine research显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR/Cas9)genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds,thus improving yields.In addition,CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research.In this review,we present the advancements of the CRISPR/Cas9 system in swine research,such as animal breeding,vaccine development,xenotransplantation,and disease modeling.We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies. | Jinfu Zhang Emmanuel M.Khazalwa Hussein M.Abkallo Yuan Zhou Xiongwei Nie Jinxue Ruan Changzhi Zhao Jieru Wang Jing Xu Xinyun Li Shuhong Zhao Erwei Zuo Lucilla Steinaa Shengsong Xie | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 9 | Characterization of the archaeal community fouling a membrane bioreactor显示文摘Biofilm formation, one of the primary causes of biofouling, results in reduced membrane flux or increased transmembrane pressure and thus represents a major impediment to the wider implementation of membrane bioreactor(MBR) technologies for water purification. Most studies have focused on the role of bacteria in membrane fouling as they are the most dominant and best studied organisms present in the MBR. In contrast, there is limited information on the role of the archaeal community in biofilm formation in MBRs. This study investigated the composition of the archaeal community during the process of biofouling in an MBR. The archaeal community was observed to have lower richness and diversity in the biofilm than the sludge during the establishment of biofilms at low transmembrane pressure(TMP). Clustering of the communities based on the Bray–Curtis similarity matrix indicated that a subset of the sludge archaeal community formed the initial biofilms. The archaeal community in the biofilm was mainly composed of Thermoprotei, Thermoplasmata,Thermococci, Methanopyri, Methanomicrobia and Halobacteria. Among them, the Thermoprotei and Thermoplasmata were present at higher relative proportions in the biofilms than they were in the sludge. Additionally, the Thermoprotei, Thermoplasmata and Thermococci were the dominant organisms detected in the initial biofilms at low TMP, while as the TMP increased, the Methanopyri, Methanomicrobia, Aciduliprofundum and Halobacteria were present at higher abundances in the biofilms at high TMP. | Jinxue Luo Jinsong Zhang Xiaohui Tan Diane McDougald Guoqiang Zhuang Anthony G.Fane Staffan Kjelleberg Yehuda Cohen Scott A.Rice | 2015 | Journal of Environmental Sciences2015，27，3： | 2 |
| 10 | Highly Thermally Conductive Polymer/Graphene Composites with Rapid Room‑Temperature Self‑Healing Capacity显示文摘Composites that can rapidly self-healing their structure and function at room temperature have broad application prospects.However,in view of the complexity of composite structure and composition,its self-heal is facing challenges.In this article,supramolecular effect is proposed to repair the multistage structure,mechanical and thermal properties of composite materials.A stiff and tough supramolecular frameworks of 2-[[(butylamino)carbonyl]oxy]ethyl ester(PBA)–polydimethylsiloxane(PDMS)were established using a chain extender with double amide bonds in a side chain to extend prepolymers through copolymerization.Then,by introducing the copolymer into a folded graphene film(FGf),a highly thermally conductive composite of PBA–PDMS/FGf with self-healing capacity was fabricated.The ratio of crosslinking and hydrogen bonding was optimized to ensure that PBA–PDMS could completely self-heal at room temperature in 10 min.Additionally,PBA–PDMS/FGf exhibits a high tensile strength of 2.23±0.15 MPa at break and high thermal conductivity of 13±0.2 W m^(−1)K^(−1);of which the self-healing efficiencies were 100%and 98.65%at room temperature for tensile strength and thermal conductivity,respectively.The excellent self-healing performance comes from the efficient supramolecular interaction between polymer molecules,as well as polymer molecule and graphene.This kind of thermal conductive self-healing composite has important application prospects in the heat dissipation field of next generation electronic devices in the future. | Huitao Yu Can Chen Jinxu Sun Heng Zhang Yiyu Feng Mengmeng Qin Wei Feng | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 11 | Pressure-induced photoluminescence enhancement and ambient retention in confined carbon dots显示文摘Piezochromic luminescent materials have shown great potential in advanced optoelectronic applications.However,most of luminescent materials usually undergo emission quenching under external stimuli.Herein,we demonstrate for the first time that the photoluminescence of carbon dots(CDs)confined within sodium hydroxide can be enhanced when high pressure is applied.They exhibit a 1.6-fold fluorescence enhancement compared with pristine CDs.Importantly,the enhanced fluorescence intensity can be retained after the release of pressure to ambient conditions.A combination of experimental analysis and theoretical simulations indicates that such an enhanced emission is mainly attributed to the strong confinement resulting from the sodium hydroxide matrix,which can separate the CDs spatially and restrict the nonradiative pathway.These results provide a rational strategy for manipulating the optical properties of CDs with enhanced and retainable photoluminescence(PL)performance,thus opening up a venue for designing luminescent CDs-based materials. | Qing Lou Xigui Yang Kaikai Liu Zhongzheng Ding Jinxu Qin Yizhe Li Chaofan Lv Yuan Shang Yuewen Zhang Zhuangfei Zhang Jinhao Zang Lin Dong Chong-Xin Shan | 2022 | Nano Research2022，15，3： | 1 |
| 12 | Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer’s disease显示文摘Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis,which represents a hallmark of Alzheimer’s disease(AD)and other age-related neurodegenerative disorders.Growing evidence has implicated that modulating autophagic flux,instead of inducing autophagosome formation alone,would be more reliable to rescue neuronal proteostasis.Concurrently,selectively enhancing drug concentrations in the leision areas,instead of the whole brain,will maximize therapeutic efficacy while reduing non-selective autophagy induction.Herein,we design a ROS-responsive targeted micelle system(TT-NM/Rapa)to enhance the delivery efficiency of rapamycin to neurons in AD lesions guided by the fusion peptide TPL,and facilitate its intracellular release via ROS-mediated disassembly of micelles,thereby maximizing autophagic flux modulating efficacy of rapamycin in neurons.Consequently,it promotes the efficient clearance of intracellular neurotoxic proteins,β-amyloid and hyperphosphorylated tau proteins,and ameliorates memory defects and neuronal damage in 3×Tg-AD transgenic mice.Our studies demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD. | Shuting Xu Peng Yang Kang Qian Yixian Li Qian Guo Pengzhen Wang Ran Meng Jing Wu Jinxu Cao Yunlong Cheng Minjun Xu Qizhi Zhang | 2022 | Bioactive Materials2022，7，5： | 1 |
| 13 | Polygalacturonase isozymes produced by Phomopsis cucurbitae in relation to postharvest decay of cantaloupe fruit显示文摘 | Zhang Jinxu Bruton B D Biles C L | 1997 | Phytopathology1997，87，10： | 1 |
| 14 | Electron diffraction study on iron-zinc Г1 intermetallic phase in a galvannealed IF steel sheet 显示文摘 | Yu Jinshan Liu Junliang Zhang Jinxu | 2005 | Materials Letters2005，59，： | 1 |
| 15 | An analysis of the multi-fold method for GPR exploration显示文摘多种的技术广泛地作为提高有用信号并且压制噪音干扰极大地增加信号到噪音比率(S/N ) 的一个方法在地震探索被使用。作者把它介绍给渗透地面的雷达(GPR ) 调查并且把试验性的结果比作常规介绍方法为 GPR 表明这种技术的可行性和优点探索。基于试验性的数据,作者总结 GPR 波浪繁殖规则和多种的获得的参数并且处理。是一次有用尝试充实 GPR 调查技术被证明。 | Wang Bangbing Tian Gang Sun Bo Guo Jinxue Zhang Xiangpei | 2006 | Applied Geophysics2006，3，3： | 1 |
| 16 | EBSD Investigation on Oriented Nucleation in IF Steels显示文摘为再结晶质地的形成负责的机制 搅浑incold 的 Ti 适用空隙免费(如果)钢表用electronback散布衍射( EBSD )被调查 .In 增加,有再结晶质地的特定的取向 wasstudied.The 形成的原子核的起源被有包围的 25-55 ° 的一个高错误取向角度使变形了的面向的 nucleation.Most nucleihave 解释在原子核之间的错误取向轴的矩阵,而是没有 specificorientation | Shengquan CAO Youyuan LI Jinxu ZHANG Jiansheng WU | 2007 | Journal of Materials Science & Technology2007，23，2： | 1 |
| 17 | METASTABLE STATE TRANSFOR MATIONS OF Al_3Ti BASE ALLOYS DURING MECHANICAL MILLING AND SUBSEQUENT ANNEALING显示文摘Developing multi phase alloy is an effective approach for the strengthening and toughening of the L1 2 Al 3Ti alloy. A Nb modified Al 3Ti base alloy which has a L1 2 matrix and the precipitated second phase has been developed. Since the effect of second phase is strongly influenced by its size and distribution, high energy ball milling was employed to fabricate the alloy in comparison with the conventional casting process. It was found that structure evolution during mechanical milling is different for DO 22 , L1 2 and L1 2+DO 22 two phase alloys. The DO 22 Al 3Ti transformed only to a FCC structure even after long time milling. The ordering of L1 2 Al 67 Ti 25 Mn 8 decreased quickly and changed into a FCC structure after short time milling, subsequent milling led to the amorphous transition. The DO 22 phase in Al 3Ti Mn Nb alloys dissolved into the L1 2 matrix quickly in the early stage of milling and the matrix changed into a FCC supersaturated solid solution after 10 h milling, further milling led to the amorphous transition. Reordering of the metastable structures occurred during the annealing process. The consolidated materials consisting of fine equiaxed grains with dispersed particles exhibited remarkable improvement of strength and promising ductility. | Qian Wang, Yunyi Fu, Jinxu Zhang, Rong Shi and Gengxiang Hu The Education Ministry of China Open Research Lab for High Temperature Materials and Testing, Shanghai Jiao Tong University, Shanghai 200030, China | 1999 | 中国有色金属学会会刊:英文版1999，9，S1： | 1 |
| 18 | Electron diffraction study on iron-zinc G1 intermetallic phase 显示文摘 | Yu Jinshan Liu Junliang Zhang Jinxu | 2005 | Mater Lett2005，59，： | 1 |
| 19 | Effects of Specific Surface Area and Impurities of Reactive Alumina on Properties of Corundum Based Castables显示文摘Effects of specific surface area and tiny amount of impurities of reactive alumina on the workability,sintering and high temperature mechanical strength of corundum based castables were investigated. The results show that the presence of reactive alumina with high specific surface area leads to accelerating of the hydration of calcium aluminate cement,thus shortening the working time and setting time of the castables,which can be ascribed that the critical energy barrier for stable nuclei of hydration products of cement can be reduced by the high specific surface area of reactive alumina. The sintering of the corundum based castables can be accelerated by the reactive alumina with high specific surface area and high amount of impurities, however, the reactive alumina with too high specific surface area and impurities can also lead to noticeable shrinkage of castables. In addition,high temperature mechanical strength of corundum based castables can be decreased by the higher amount of trace impurities of reactive alumina due to formation of lowmelting phase at high temperatures. | ZHANG Ju ZHOU Yunpeng LONG Bin ZHANG Lanyin LIU Jinxue Andreas BUHR JIA Quanli YE Guotian | 2017 | China's Refractories2017，26，4： | 1 |
| 20 | TEM investigation of FIB induced damages in preparation of metal material TEM specimens by FIB 显示文摘 | Yu Jinshan Liu Junliang Zhang Jinxu | 2006 | Mater Lett2006，60，2： | 1 |
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